DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bt and MYOM1

DIOPT Version :9

Sequence 1:	NP_001162825.1	Gene:	bt / 43814	FlyBaseID:	FBgn0005666	Length:	8933	Species:	Drosophila melanogaster
Sequence 2:	XP_024307049.1	Gene:	MYOM1 / 8736	HGNCID:	7613	Length:	1718	Species:	Homo sapiens

Alignment Length:	2232	Identity:	474/2232 - (21%)
Similarity:	757/2232 - (33%)	Gaps:	719/2232 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  5681 CHLTWNVP--DDDGGSPILHYIIEKMDLSRSTWSDAGMSTHIVHDVTRLVHRKE-YLFRVKAVNA 5742
            ||..:::.  :.|..|.:.||..||...:..|......|:.     :...||:| ..||..:.::
Human     9 CHQHYDLSYRNKDVRSTVSHYQREKKRSAVYTQGSTAYSSR-----SSAAHRRESEAFRRASASS 68

  Fly  5743 IGESDPLEAVNTII---AKNEFDEPDAPGKPIITDWDRDHIDLQWAVPKSDGGAPISEYIIQKKE 5804
            ..:.....|:::.:   |.:.:|...:.|                   .:|....:.:|    ..
Human    69 SQQQASQHALSSEVSRKAASAYDYGSSHG-------------------LTDSSLLLDDY----SS 110

  Fly  5805 KGSPYWTNVRHVPSNKNTTTIPELTEGQEYEFRVIAVNQAGQSEPSEPSDMIMAKPRYLPPKIIT 5869
            |.||.....:|           .|..|:|.|                          .||...:.
Human   111 KLSPKPKRAKH-----------SLLSGEEKE--------------------------NLPSDYMV 138

  Fly  5870 PLNEVRI---KCGLIFHTDIHFIGEPAPEATWTLNSNPLLSNDRSTITSIGHHSVVHTVNC--QR 5929
            |:...||   :||                   |||...||    :.||:| |:..:..:.|  |:
Human   139 PIFSGRIQCLRCG-------------------TLNLVKLL----NLITAI-HNIYILPLLCFSQK 179

  Fly  5930 SDSGIYHLLLRNSSGIDEGSFELVVLDRPGPPEGPMEYEEITANSVTISWKPPKDNGGSEISSYV 5994
            ..|||..   .....|.|.:..:...:.....||....::.||:..|.:.|....:..|..|...
Human   180 HVSGITD---TEEERIKEAAAYIAQRNLLASEEGITTSKQSTASKQTTASKQSTASKQSTASKQS 241

  Fly  5995 IEKRDLTHGGGWVPAVNYVSA--------KYNHAVVPR-----------LLEGTMYELRVMAENL 6040
            ...|..|.....|.:....||        |.:..||.|           |.|...|..::..::|
Human   242 TASRQSTASRQSVVSKQATSALQQEETSEKKSRKVVIREKAERLSLRKTLEETETYHAKLNEDHL 306

  Fly  6041 --------QGRSDPLTSDQPVVAKSQYTVPGAPGKPELTDSDKNHITIKWKQPISNGGSPIIG-Y 6096
                    :.||..:...:.|  |...::.|.| :|.:| ..||.:      ||:...:|  | |
Human   307 LHAPEFIIKPRSHTVWEKENV--KLHCSIAGWP-EPRVT-WYKNQV------PINVHANP--GKY 359

  Fly  6097 DIERR-DVNTGRWIKINGQPVPTAEYQDDRVTSNHQYQYRISAVNAAGN---------------- 6144
            .||.| .::|   ::|||     .:::|..       |||.||:|..|.
Human   360 IIESRYGMHT---LEING-----CDFEDTA-------QYRASAMNVKGELSAYASVVVKRYKGEF 409

  Fly  6145 -------GKTSEPSAIFNARPLREKPRF------YFDGLIGKRIKVRAGEPVNLNIPISGAP--- 6193
                   |.::.|.: |...|.....||      .||...|     |.||.::|...:...|
Human   410 DETRFHAGASTMPLS-FGVTPYGYASRFEIHFDDKFDVSFG-----REGETMSLGCRVVITPEIK 468

  Fly  6194 --TPTIEWKRGDLKLEEGKRISYETNSERTLFRIDDSNRRDSGKYTVT----------AANEFGK 6246
              .|.|:|.|..:.|...|.:....:.||........|:.|.|.||:.          :|..|.:
Human   469 HFQPEIQWYRNGVPLSPSKWVQTLWSGERATLTFSHLNKEDEGLYTIRVRMGEYYEQYSAYVFVR 533

  Fly  6247 DTADIEVIVVDKPSPPEGPLSY--TETAPDHISLHWYSPKDDGGSDITGYIIEFTEFGVDDWKPV 6309
            | ||.|:     ...|..||..  .|...|:|.:.|..|..||||.|.||.|:..|.|.|.|
Human   534 D-ADAEI-----EGAPAAPLDVKCLEANKDYIIISWKQPAVDGGSPILGYFIDKCEVGTDSW--- 589

  Fly  6310 PGTCPNT-----NFTVKNLVEGKKYVFRIRAENIYGAS-EALEGKPVLAKSPFDP---------- 6358
             ..|.:|     .|.|..|:||:.|:||:||.|..|.. .:...:||.|..|.:.
Human   590 -SQCNDTPVKFARFPVTGLIEGRSYIFRVRAVNKMGIGFPSRVSEPVAALDPAEKARLKSRPSAP 653

  Fly  6359 -----------------PGAPSQPTISAYTPNSANLEWHPPDDCGGKPITGYIVERRERGGE-WI 6405
                             ||.|:..:::..|.:...|.|.||...|.:.|. |.||:.|.|.| |.
Human   654 WTGQIIVTEEEPSEGIVPGPPTDLSVTEATRSYVVLSWKPPGQRGHEGIM-YFVEKCEAGTENWQ 717

  Fly  6406 KCN-NYPTPNTSYTVSNLRDGARYEFRVLAVNEAGPGHPSKPSDPMTAEHQRYRPDPPEPPKPDR 6469
            :.| ..|..:..:.:.:|.:|..|.|||...|.||.|.||:.::......:...|..|....|.|
Human   718 RVNTELPVKSPRFALFDLAEGKSYCFRVRCSNSAGVGEPSEATEVTVVGDKLDIPKAPGKIIPSR 782

  Fly  6470 ITRNGVTLSWRPPRTDGKSRIKGYYVEMRPKNGKDWKTVNDIPINSTVYTVPSLKEGEEYSFRVV 6534
            .|...|.:||...: |.|..: |||:|........|:..|:.|:..:.:|...|..|:.|.|||.
Human   783 NTDTSVVVSWEESK-DAKELV-GYYIEASVAGSGKWEPCNNNPVKGSRFTCHGLVTGQSYIFRVR 845

  Fly  6535 AENEVGRSDPSKPSQPITIEEQPNKPCMELGKVRDIVCRAGDDFSIHVPYLAFPKPNAFWYSNDN 6599
            |.|..|.|:.|:.|:.|.::....      |.|...||.|..|           :|.....|
Human   846 AVNAAGLSEYSQDSEAIEVKAAIG------GGVSPDVCPALSD-----------EPGGLTAS--- 890

  Fly  6600 MLDDNNRVHKHLTDDAASVVVKNSKRADSGQYRLQLKNTSGFDTATINVRVLDRPSPPTRLRADE 6664
                ..|||:                                            .||||
Human   891 ----RGRVHE--------------------------------------------ASPPT------ 901

  Fly  6665 FSGDSLTLYWNPPNDDGGSAIQNYIIEKKEARSSTWSKVSSF----CTVPFVRIRNLVLNKEYDF 6725
            |..|:| |...|......|:.||  :.:.|.     ||||..    .|.|..:
Human   902 FQKDAL-LGSKPNKPSLPSSSQN--LGQTEV-----SKVSETVQEELTPPPQK------------ 946

  Fly  6726 RVIAENKYGQSDPANTSEPILARHPFDIPNTPGIPHGIDSTEDSITIAWTKPKHDGGSPITGYII 6790
              .|.....:|||......   |.|   |:.|.....::|..||:.:.|.:|...||:.||||.:
Human   947 --AAPQGKSKSDPLKKKTD---RAP---PSPPCDITCLESFRDSMVLGWKQPDKIGGAEITGYYV 1003

  Fly  6791 EKRLLSD---DKWTKAVHALCPDLSCKIPNLIENAEYEFRVAAVNAAGQSAYSGSSDLIFCRRPP 6852
            ..|.:.|   .||.:|......:.:.||.||.||..|:|:|||:|.||..|.|..|:...|.
Human  1004 NYREVIDGVPGKWREANVKAVSEEAYKISNLKENMVYQFQVAAMNMAGLGAPSAVSECFKCE--- 1065

  Fly  6853 HAPKITSDLSIRDMTVIAGDEFRITVPYHASPRPTASWSLNGLEVIPGERIKFDSNDYASMYYNK 6917
                                                .|::    .:||
Human  1066 ------------------------------------EWTI----AVPG----------------- 1073

  Fly  6918 SAKRDETGSYTITLTNNKGSDTASCHVTVVDRPLPPQGPLNAYDITPDTCTLAWKTPLDDGGSPI 6982
                                              ||.. |...::..|:..|.||.|:..|.:|:
Human  1074 ----------------------------------PPHS-LKCSEVRKDSLVLQWKPPVHSGRTPV 1103

  Fly  6983 TNYVV---EKLDNSGSWVKIS-SFVRNTHYDVMGLEPHYKYNFRVRAENQYGLSDPLDIIEPIVA 7043
            |.|.|   |.......|..:: :.::|.:..|.||:....|.|||||.||.|:..|.|:..|:||
Human  1104 TGYFVDLKEAKAKEDQWRGLNEAAIKNVYLKVRGLKEGVSYVFRVRAINQAGVGKPSDLAGPVVA 1168

  Fly  7044 KHQFTVPDEPGQPKV---IDWDSGNVTLIWTRPLSDGGSRIQGYQIEYRDILNDSSWNAYDYIIK 7105
            :      ..||..:|   :| |.|.::|              .::.:.....::.||:. ||:
Human  1169 E------TRPGTKEVVVNVD-DDGVISL--------------NFECDKMTPKSEFSWSK-DYV-- 1209

  Fly  7106 DTKYQLYNLINGSEYEFRIKAKNAAGLSKPSSPSLRFKLKGKFTVPSPPGAPQVTRVGKNYVDLK 7170
                                       |...||.|..:.||..|        ::|     :.||.
Human  1210 ---------------------------STEDSPRLEVESKGNKT--------KMT-----FKDLG 1234

  Fly  7171 WEKPLRDGGSRITGYIIERRDIGGAVWVKCNDYNVLDTEYTVMN-LIEMGDYEFRVFAVNSAGRS 7234
            .:                  |:|   ...|   :|.||:....: ||:..:.: |:.|::    .
Human  1235 MD------------------DLG---IYSC---DVTDTDGIASSYLIDEEELK-RLLALS----H 1270

  Fly  7235 EPSLCTMPIK---VCEVL-GGKKPDWITRLQDKVAPFGKDYTLQCAASGKPSPTARWLRNGKEIQ 7295
            |....|:|:|   ..|:| .|:...|:.  .:|::...|               ..::.|.|||
Human  1271 EHKFPTVPVKSELAVEILEKGQVRFWMQ--AEKLSGNAK---------------VNYIFNEKEI- 1317

  Fly  7296 MNGG--RMTCDSKDGVFRLHISNVQTGDDGDYTCEAMNSLGFVNTSGYLKIGSPPIINRCPSELK 7358
            ..|.  :|..|...|:..:.:..:|..|:|.||.:..:... .|.|..:.:|.  :..:...|.:
Human  1318 FEGPKYKMHIDRNTGIIEMFMEKLQDEDEGTYTFQLQDGKA-TNHSTVVLVGD--VFKKLQKEAE 1379

  Fly  7359 L-------PEGDNSKIKIFYSGDQPLTVILKKNNEVICDSNDDTHV-------------KVNIFD 7403
            .       .:|.:....:.:.......|:||..   :.:...:||:             |.:..|
Human  1380 FQRQEWIRKQGPHFVEYLSWEVTGECNVLLKCK---VANIKKETHIVWYKDEREISVDEKHDFKD 1441

  Fly  7404 DYVAIYIRNIVKSDGGPYQIEFTNESGSATGEFYVHITGMPSAPTGPMGISYINKNSCMLNWRPP 7468
            ....:.|....|.|.|.|::...::.|.                         :|:...|
Human  1442 GICTLLITEFSKKDAGIYEVILKDDRGK-------------------------DKSRLKL----- 1476

  Fly  7469 SYDGGLKVSHYVIERKDVSSPHWITVSST---CKDTAFNVQGLIENQEYIFRVMAVN--ENGMGP 7528
             .|...|.....:.:|       |.:|:|   .:.||..:| |.....|....:.||  .||
Human  1477 -VDEAFKELMMEVCKK-------IALSATDLKIQSTAEGIQ-LYSFVTYYVEDLKVNWSHNG--- 1529

  Fly  7529 PLEGLNPIRAKDPIDPPSPPGSPQITEIGGDFVHLEWEKP-ESDGGAHIQGYWIDKREVGSNTWQ 7592
                 :.||..|.:.          |.:.|:.:.|:..:| .:|.|.::...:..|    :...:
Human  1530 -----SAIRYSDRVK----------TGVTGEQIWLQINEPTPNDKGKYVMELFDGK----TGHQK 1575

  Fly  7593 RVNATICAANQINCINLIEGRQY-----EFRIFAQNVAGLSTESSASQAVKIIDPQAASPPLIVK 7652
            .|:              :.|:.|     ||:...|  |.::.::.|.               ::.
Human  1576 TVD--------------LSGQAYDEAYAEFQRLKQ--AAIAEKNRAR---------------VLG 1609

  Fly  7653 PLRDANCIQNHNA-QFTCTINGVPKPTISWYKGAREISNGARYHM-YSEGDNHFLNINDVFGEDA 7715
            .|.|...||...| ..||.:.|.|.|.:||.|..:.:::....:: :..|...:..||.|...|:
Human  1610 GLPDVVTIQEGKALNLTCNVWGDPPPEVSWLKNEKALASDDHCNLKFEAGRTAYFTINGVSTADS 1674

  Fly  7716 DEYVCRAVNKAGAKSTRATLAI 7737
            .:|.....||.|::::..|:::
Human  1675 GKYGLVVKNKYGSETSDFTVSV 1696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bt	NP_001162825.1	I-set	9..101	CDD:254352
		Ig	26..100	CDD:143165
		I-set	119..210	CDD:254352
		Ig	136..209	CDD:143165
		I-set	228..320	CDD:254352
		IGc2	242..312	CDD:197706
		I-set	335..425	CDD:254352
		Ig	350..423	CDD:143165
		Ig	436..530	CDD:299845
		I-set	438..532	CDD:254352
		I-set	545..636	CDD:254352
		Ig	560..633	CDD:143165
		Ig	657..731	CDD:143165
		I-set	746..835	CDD:254352
		Ig	1496..1586	CDD:299845
		IG_like	1503..1588	CDD:214653
		I-set	1639..1724	CDD:254352
		IG	1750..1821	CDD:214652
		IGc2	1750..1806	CDD:197706
		I-set	1826..1909	CDD:254352
		Ig	1831..1897	CDD:299845
		I-set	1914..1998	CDD:254352
		Ig	2020..2095	CDD:299845
		FN3	2100..2194	CDD:238020
		FN3	2203..2292	CDD:238020
		I-set	2311..2395	CDD:254352
		Ig	2321..2395	CDD:299845
		FN3	2399..2493	CDD:238020
		FN3	2501..2590	CDD:238020
		I-set	2602..2693	CDD:254352
		Ig	2619..2693	CDD:299845
		FN3	2697..2793	CDD:238020
		FN3	2801..2893	CDD:238020
		I-set	2902..2995	CDD:254352
		Ig	2919..2993	CDD:299845
		FN3	2999..3088	CDD:238020
		FN3	3102..3191	CDD:238020
		I-set	3208..3292	CDD:254352
		Ig	3219..3292	CDD:299845
		FN3	3296..3390	CDD:238020
		FN3	3400..3489	CDD:238020
		I-set	3494..3590	CDD:254352
		Ig	3516..3590	CDD:299845
		FN3	3594..3682	CDD:238020
		FN3	3694..3781	CDD:238020
		I-set	3795..3885	CDD:254352
		Ig	3813..3885	CDD:299845
		FN3	3889..3980	CDD:238020
		FN3	3990..4082	CDD:238020
		I-set	4090..4181	CDD:254352
		Ig	4108..4181	CDD:299845
		FN3	4185..4271	CDD:238020
		FN3	4285..4383	CDD:238020
		Ig	4404..4480	CDD:299845
		FN3	4484..4571	CDD:238020
		FN3	4584..4677	CDD:238020
		I-set	4685..4775	CDD:254352
		Ig	4703..4775	CDD:299845
		FN3	4779..4863	CDD:238020
		FN3	4879..4970	CDD:238020
		IG	4989..5069	CDD:214652
		Ig	4996..5069	CDD:299845
		FN3	5073..5166	CDD:238020
		FN3	5175..5265	CDD:238020
I-set	5276..5366	CDD:254352
Ig	5293..5366	CDD:299845
FN3	5370..5462	CDD:238020
FN3	5470..5561	CDD:238020
Ig	5559..5654	CDD:299845
I-set	5570..5660	CDD:254352
FN3	5664..5755	CDD:238020	16/76 (21%)
FN3	5764..5853	CDD:238020	11/88 (13%)
I-set	5865..5954	CDD:254352	21/93 (23%)
Ig	5882..5954	CDD:299845	16/73 (22%)
FN3	5958..6049	CDD:238020	23/117 (20%)
FN3	6062..6153	CDD:238020	28/115 (24%)
I-set	6173..6255	CDD:254352	24/96 (25%)
Ig_Titin_like	6182..6255	CDD:143225	21/87 (24%)
FN3	6259..6350	CDD:238020	34/98 (35%)
FN3	6359..6451	CDD:238020	31/93 (33%)
FN3	6470..6552	CDD:238020	26/81 (32%)
I-set	6564..6650	CDD:254352	11/85 (13%)
Ig_Titin_like	6577..6650	CDD:143225	6/72 (8%)
FN3	6654..6745	CDD:238020	23/94 (24%)
FN3	6754..6840	CDD:238020	33/88 (38%)
I-set	6855..6946	CDD:254352	3/90 (3%)
Ig	6874..6946	CDD:299845	3/71 (4%)
FN3	6950..7042	CDD:238020	31/95 (33%)
FN3	7050..7139	CDD:238020	13/91 (14%)
FN3	7151..7237	CDD:238020	14/86 (16%)
I-set	7254..7334	CDD:254352	16/81 (20%)
Ig	7272..7339	CDD:143165	14/68 (21%)
IG_like	7354..7440	CDD:214653	15/105 (14%)
Ig	7366..7440	CDD:299845	13/86 (15%)
FN3	7444..7531	CDD:238020	17/91 (19%)
FN3	7545..7637	CDD:238020	15/97 (15%)
I-set	7648..7737	CDD:254352	23/90 (26%)
Ig	7665..7734	CDD:143165	18/70 (26%)
Ig	7760..7833	CDD:299845
FN3	7837..7927	CDD:238020
STKc_Twitchin_like	7986..8244	CDD:271016
S_TKc	7989..8244	CDD:214567
Ig	8311..8394	CDD:299845
I-set	8312..8401	CDD:254352
I-set	8437..8525	CDD:254352
Ig	8455..8519	CDD:143165
I-set	8632..8721	CDD:254352
IGc2	8646..8711	CDD:197706
I-set	8740..8831	CDD:254352
Ig	8757..8826	CDD:143165
I-set	8839..8922	CDD:254352
Ig	8845..>8909	CDD:299845
MYOM1	XP_024307049.1	IG	316..402	CDD:214652	30/112 (27%)
		I-set	450..517	CDD:333254	18/66 (27%)
		FN3	543..633	CDD:238020	34/93 (37%)
		FN3	671..764	CDD:238020	31/93 (33%)
		FN3	772..862	CDD:238020	30/91 (33%)
		FN3	967..1061	CDD:238020	35/93 (38%)
		FN3	1072..1161	CDD:238020	31/140 (22%)
		I-set	1188..1254	CDD:333254	21/146 (14%)
		I-set	1407..1476	CDD:333254	14/96 (15%)
		Ig_Myomesin_like_C	1605..1696	CDD:319300	24/105 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0613
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13817
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.000