DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bt and Kalrn

DIOPT Version :9

Sequence 1:	NP_001162825.1	Gene:	bt / 43814	FlyBaseID:	FBgn0005666	Length:	8933	Species:	Drosophila melanogaster
Sequence 2:	XP_038944566.1	Gene:	Kalrn / 84009	RGDID:	621865	Length:	2989	Species:	Rattus norvegicus

Alignment Length:	1965	Identity:	412/1965 - (20%)
Similarity:	663/1965 - (33%)	Gaps:	583/1965 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  6485 DGKSRIK-GYYVEMR-PKNGKDWKTVNDIPINSTVYTVPSLKEGEEYSFRVVAENEVGRSDPSKP 6547
            :||..:| |..|.:. ||...|...|             |:.||.:.:..|  :.|:...|..:.
  Rat  1437 EGKGELKDGLEVMLSVPKKANDAMHV-------------SMLEGFDENLDV--QGELILQDAFQV 1486

  Fly  6548 SQPITIEEQPNKPCMELGKVRDIVCRAGDDFSIHVPYLAFPKPNAFWYSNDNMLDDNNRVHKHLT 6612
            ..|.::..:..:..:.|.::..:..:...|.|.|..|:         |.| .:|.....|.:|:.
  Rat  1487 WDPKSLIRKGRERHLFLFEISLVFSKEIKDSSGHTKYV---------YKN-KLLTSELGVTEHVE 1541

  Fly  6613 DDAASVVVKNSKRADSGQYRLQLKNTSGFDT---------ATINVRV----------LDRPSPPT 6658
            .|.....:. |.|..|...:..|| .|..:|         ..|..|:          :..|..|.
  Rat  1542 GDPCKFALW-SGRTPSSDNKTVLK-ASNIETKQEWIKNIREVIQERIIHLKGALKEPIQLPKTPA 1604

  Fly  6659 RLRADE-----FSGDSLTLYWNPPNDDGGSAIQNYIIEKKEARSSTWS-KVSSFCTVPFVRIRNL 6717
            :||.:.     ..|||        ..||.|......|..:.::::..| |:|..|.:      .:
  Rat  1605 KLRNNSKRDGVEDGDS--------QGDGSSQPDTISIASRTSQNTVESDKLSGGCEL------TV 1655

  Fly  6718 VLNKEYDFRVIAENKYGQSDPANTSE-PILARHPFDIPNTPGIPHG---IDSTEDSITIAWTKPK 6778
            ||.   ||           ..|::|| .|......::...|....|   :.:||.|       |.
  Rat  1656 VLQ---DF-----------SAAHSSELSIQVGQTVELLERPSERPGWCLVRTTERS-------PP 1699

  Fly  6779 HDGGSPITGYIIEKRLLSDDKWTKAVHALCPDLSCKIPNLIENAEYEFRVAAVNAAGQSAYSGSS 6843
            .:|..|.:...|.....|            .::.|..| |:::: |.      :::|::  .|.|
  Rat  1700 QEGLVPSSTLCISHSRSS------------VEMDCFFP-LVKDS-YS------HSSGEN--GGKS 1742

  Fly  6844 DLIFCRRPPHAPKITSDLSIRDMTVIAGDEFRITVPYHASPRPTASWSLNGLE---VIPGERI-- 6903
            :.:        ..:.|..|:..:              |:||.|..  |.|.|:   ..|..|:
  Rat  1743 ESV--------ANLQSQPSLNSI--------------HSSPGPKR--STNTLKKWLTSPVRRLNS 1783

  Fly  6904 -KFDSNDYASMYYNKSAKRDETGSYTITLTNNKGSDTASCHVTVVDR-----------------P 6950
             |.|.|       .|..|:...|..:..|.:.|..|..:......|.                 |
  Rat  1784 GKADGN-------IKKQKKVRDGRKSFDLGSPKPGDETTPQGDSADEKSKKGWGEDEPDEESHTP 1841

  Fly  6951 LPPQGPLNAYDITP-----DTCTLAWKTPLD-----DGGSPITNYVVEKLD-NSGSW---VKISS 7001
            |||  |:..:|..|     .:...|.:.|.|     |..|.|...|..||. ..||:   :|..:
  Rat  1842 LPP--PMKIFDNDPTQDEMSSLLAARQAPTDVPTAADLVSAIEKLVKSKLTLEGGSYRGSLKDPT 1904

  Fly  7002 FVRNTHYDVMGLEP-------------------HYKYNFRVRAENQYGLSDPLDIIEPIVAK-HQ 7046
            ...|.     |:.|                   .:..|..|:.|..| :.|...::|..:.: .:
  Rat  1905 VCLNE-----GMAPPTPPRNLEEEQKAKALRGRMFVLNELVQTEKDY-VKDLGIVVEGFMKRIEE 1963

  Fly  7047 FTVP-DEPGQPKVIDWDSGNVTLI--WTRPLSDGGSRIQGYQIEYRDILNDSSWNAYDYIIKDTK 7108
            ..|| |..|:.|::   .||:..|  |.:..         :..|....:.:....|..:|..:.|
  Rat  1964 KGVPEDMRGKEKIV---FGNIHQIYDWHKDF---------FLAELEKCIQEQDRLAQLFIKHERK 2016

  Fly  7109 YQLYNLINGSEYEFRIKAKNAAGLSKPSSPSLRFKLKGKFTVPSPPGAPQVTRVGKNYVDLKWE- 7172
            ..:|...          .:|     ||.|..:                  |......:.::|.|
  Rat  2017 LHIYVWY----------CQN-----KPRSEYI------------------VAEYDAYFEEVKQEI 2048

  Fly  7173 -----------KPLRDGGSRITGYI--------------IERRDIGGAVWV------KCNDYNVL 7206
                       ||::    |||.|.              :|..||..||.:      :|||
  Rat  2049 NQRLTLSDFLIKPIQ----RITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLVPKRCND---- 2105

  Fly  7207 DTEYTVMNLIEMGDYEFRVFAVNSAGRSEPSLCTMPIKVCEVLGGKKPDWITR---LQDKVAPFG 7268
                 :|||..:..:|..:.|.....:.:      ...|.|:..|.:.....|   |.:::..|.
  Rat  2106 -----MMNLGRLQGFEGTLTAQGKLLQQD------TFYVIELDAGMQSRTKERRVFLFEQIVIFS 2159

  Fly  7269 KDYTLQCAASGKPSPTARWLRNGKEIQMNGGRMTCDSKDGVFRLHISNVQTGDDGDYTCEAMNSL 7333
                 :....|..:|...:.|:   |:||...:..|..|...:..:.|.:|.:
  Rat  2160 -----ELLRKGSLTPGYMFKRS---IKMNYLVLEEDVDDDPCKFALMNRETSE------------ 2204

  Fly  7334 GFVNTSGYLKIGSPPIINRCPSEL-KLPEGDNSKIKIFYSGDQPLTVILKKNNEVICDSNDDTHV 7397
                 ...|:..:|.|......:: ::.|.....:....|   |:....|:.:..:..|...
  Rat  2205 -----RVILQAANPDIQQAWVQDINQVLETQRDFLNALQS---PIEYQRKERSTAVIRSQPP--- 2258

  Fly  7398 KVNIFDDYVAIYIRNIVKSDGGPYQIEFTNESGSATGEFYVHITGMPSAPTGPMGISYINKNSCM 7462
                          .:.::...||............|..|       :.|..|:.||..|.:
  Rat  2259 --------------RVPQASPRPYSSVPVGSEKPPKGSSY-------NPPLPPLKISTSNGS--- 2299

  Fly  7463 LNWRPPSYD---GGLKVSHYVIERKDVSSPHWITVSSTCKD-TAFNVQGLIENQEYIFRVMAVNE 7523
                 |.:|   .|.|..  ..::.|:...:..:..:..|| .|.....:..:|..:.:|:|||:
  Rat  2300 -----PGFDYHQPGDKFD--ASKQNDLGGCNGTSTMAVIKDYYALKENEICVSQGEVVQVLAVNQ 2357

  Fly  7524 NGM----------GPPLEGLNPIRAKDPIDPPSPPGSPQITEIGGDFVHLEWEKPESDGGAHIQG 7578
            ..|          .|..||..|.....|:...:.|..                  .||.......
  Rat  2358 QNMCLVYQPASDHSPAAEGWVPGSILAPLTKATAPAE------------------SSDESIKKSC 2404

  Fly  7579 YW----IDKREVGSNTWQRVNATICAANQINCINLIEGRQYEFRIFAQNVAGLSTESSASQAVKI 7639
            .|    :.||....||.:               |...|.:....|.....:...|.||.......
  Rat  2405 SWHTLRMRKRADVENTGK---------------NEATGPRKPKDILGNKASVKETNSSEESECDD 2454

  Fly  7640 IDP------------QAASPPLIVKPLRDANCIQNHNAQFTCTINGVPKPTISWYKGAREISNGA 7692
            :||            |..:|..:| ||.|..|:........|...|.|||||:| ||..:
  Rat  2455 LDPNTSMEILNPNFIQEVAPEFLV-PLVDVTCLLGDTVLLQCKACGRPKPTITW-KGPDQ----- 2512

  Fly  7693 RYHMYSEGDNHFLNINDVFGEDADEYVCRAVNKAGAKSTRATLAIMTAPKLNVPPRFRDTAYFDK 7757
                         ||.|.....|...:      :...|..:||.|     .|:.|:
  Rat  2513 -------------NILDTDNSSATYTI------SSCDSGESTLKI-----CNLMPQ--------- 2544

  Fly  7758 GENVVIKIPFTGFPKPRIHWVRDGENIESGGHYTVEVKERHAVLIIRDGSHLDSGPYRITAENEL 7822
                                                                |||.|...|.|:.
  Rat  2545 ----------------------------------------------------DSGIYTCIATNDH 2557

  Fly  7823 GSDTAIIQVQISDRPDPPRFPLIESIGTESLSLSWKAPVWDGCSDITNYYVERREHPLSSWIR-V 7886
            |:.:....|::...|..|..|:.:.....|:.|.|..|...|...|:.|.||.||.....|.: |
  Rat  2558 GTASTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPASTGNCTISGYTVEYREEGSQVWQQSV 2622

  Fly  7887 GNTRFTSMAVSGLTPGKEYDFRIFADNVYGRSDASDTSTLIKTKESVKKKPIERKWEIDANGRKL 7951
            .:|..|.:.:..|:||..|.||:.|.|.:|.|..|:.|..:...|          ::..|:|..:
  Rat  2623 ASTLDTYLVIEDLSPGCPYQFRVSASNPWGISLPSEPSEFVHLPE----------YDAAADGATI 2677

  Fly  7952 RGKADGPVKDYDSYVFDIYSKFVPQPVEISQQSVYDRYDILEEIGTGAFGVVHRCRERSTGNIFA 8016
            ..|     :::||                       .|..|.|||.|.|.:|.:|..::|....|
  Rat  2678 SWK-----ENFDS-----------------------AYTELNEIGRGRFSIVKKCIHKATRKDVA 2714

  Fly  8017 AKFIPVSHSVEKDLIRREIDIMNQLHHQKLINLHDAFEDDDEMILILEFLSGGELFERITAEGYV 8081
            .||:. ....:|:....|..::..|.|.:.:.|||.:|.....|||||.:..|.|.:.:.....:
  Rat  2715 VKFVS-KKMKKKEQAAHEAALLQHLQHPQYVTLHDTYESPTSYILILELMDDGRLLDYLMNHDEL 2778

  Fly  8082 MTEAEVINYMRQICEGIRHMHEQNIIHLDIKPENIMCQTRSST-NVKLIDFGLATRLDPNEVVKI 8145
            | |.:|..|:|.|.|.::::|...:.||||||||::...|... .|||||...|.::..:..:..
  Rat  2779 M-EEKVAFYIRDIMEALQYLHNCRVAHLDIKPENLLIDLRIPVPRVKLIDLEDAVQISGHFHIHH 2842

  Fly  8146 TTGTAEFAAPEIVNREPVGFYTDMWATGVLSYVLLSGLSPFAGDNDVQTLKNVKACDWDFDVESF 8210
            ..|..||||||::...||...||:|:.|||:||:|||:|||..::..:|..||...|:.|..|.|
  Rat  2843 LLGNPEFAAPEVIQGIPVSLGTDIWSIGVLTYVMLSGVSPFLDESKEETCINVCRVDFSFPHEYF 2907

  Fly  8211 KYISEEAKDFIRKLLVRNKEKRMTAHECLLHPWL---TGDHSAMKQEINRDRYLAYREKLRRKYE 8272
            ..:|..|:|||..:|..:..:|.||..||.||||   .|.:|  |..::..|...:.|  |||::
  Rat  2908 CGVSNAARDFINVILQEDFRRRPTAATCLQHPWLQPHNGSYS--KIPLDTSRLACFIE--RRKHQ 2968

  Fly  8273 DFERFLLPIGRLSEY 8287
            :..|   ||..:..|
  Rat  2969 NDVR---PIPNVKSY 2980

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bt	NP_001162825.1	I-set	9..101	CDD:254352
		Ig	26..100	CDD:143165
		I-set	119..210	CDD:254352
		Ig	136..209	CDD:143165
		I-set	228..320	CDD:254352
		IGc2	242..312	CDD:197706
		I-set	335..425	CDD:254352
		Ig	350..423	CDD:143165
		Ig	436..530	CDD:299845
		I-set	438..532	CDD:254352
		I-set	545..636	CDD:254352
		Ig	560..633	CDD:143165
		Ig	657..731	CDD:143165
		I-set	746..835	CDD:254352
		Ig	1496..1586	CDD:299845
		IG_like	1503..1588	CDD:214653
		I-set	1639..1724	CDD:254352
		IG	1750..1821	CDD:214652
		IGc2	1750..1806	CDD:197706
		I-set	1826..1909	CDD:254352
		Ig	1831..1897	CDD:299845
		I-set	1914..1998	CDD:254352
		Ig	2020..2095	CDD:299845
		FN3	2100..2194	CDD:238020
		FN3	2203..2292	CDD:238020
		I-set	2311..2395	CDD:254352
		Ig	2321..2395	CDD:299845
		FN3	2399..2493	CDD:238020
		FN3	2501..2590	CDD:238020
		I-set	2602..2693	CDD:254352
		Ig	2619..2693	CDD:299845
		FN3	2697..2793	CDD:238020
		FN3	2801..2893	CDD:238020
		I-set	2902..2995	CDD:254352
		Ig	2919..2993	CDD:299845
		FN3	2999..3088	CDD:238020
		FN3	3102..3191	CDD:238020
		I-set	3208..3292	CDD:254352
		Ig	3219..3292	CDD:299845
		FN3	3296..3390	CDD:238020
		FN3	3400..3489	CDD:238020
		I-set	3494..3590	CDD:254352
		Ig	3516..3590	CDD:299845
		FN3	3594..3682	CDD:238020
		FN3	3694..3781	CDD:238020
		I-set	3795..3885	CDD:254352
		Ig	3813..3885	CDD:299845
		FN3	3889..3980	CDD:238020
		FN3	3990..4082	CDD:238020
		I-set	4090..4181	CDD:254352
		Ig	4108..4181	CDD:299845
		FN3	4185..4271	CDD:238020
		FN3	4285..4383	CDD:238020
		Ig	4404..4480	CDD:299845
		FN3	4484..4571	CDD:238020
		FN3	4584..4677	CDD:238020
		I-set	4685..4775	CDD:254352
		Ig	4703..4775	CDD:299845
		FN3	4779..4863	CDD:238020
		FN3	4879..4970	CDD:238020
		IG	4989..5069	CDD:214652
		Ig	4996..5069	CDD:299845
		FN3	5073..5166	CDD:238020
		FN3	5175..5265	CDD:238020
I-set	5276..5366	CDD:254352
Ig	5293..5366	CDD:299845
FN3	5370..5462	CDD:238020
FN3	5470..5561	CDD:238020
Ig	5559..5654	CDD:299845
I-set	5570..5660	CDD:254352
FN3	5664..5755	CDD:238020
FN3	5764..5853	CDD:238020
I-set	5865..5954	CDD:254352
Ig	5882..5954	CDD:299845
FN3	5958..6049	CDD:238020
FN3	6062..6153	CDD:238020
I-set	6173..6255	CDD:254352
Ig_Titin_like	6182..6255	CDD:143225
FN3	6259..6350	CDD:238020
FN3	6359..6451	CDD:238020
FN3	6470..6552	CDD:238020	16/68 (24%)
I-set	6564..6650	CDD:254352	19/94 (20%)
Ig_Titin_like	6577..6650	CDD:143225	18/81 (22%)
FN3	6654..6745	CDD:238020	22/97 (23%)
FN3	6754..6840	CDD:238020	15/88 (17%)
I-set	6855..6946	CDD:254352	20/96 (21%)
Ig	6874..6946	CDD:299845	18/77 (23%)
FN3	6950..7042	CDD:238020	28/124 (23%)
FN3	7050..7139	CDD:238020	17/91 (19%)
FN3	7151..7237	CDD:238020	22/117 (19%)
I-set	7254..7334	CDD:254352	13/82 (16%)
Ig	7272..7339	CDD:143165	10/66 (15%)
IG_like	7354..7440	CDD:214653	9/86 (10%)
Ig	7366..7440	CDD:299845	8/73 (11%)
FN3	7444..7531	CDD:238020	20/100 (20%)
FN3	7545..7637	CDD:238020	14/95 (15%)
I-set	7648..7737	CDD:254352	22/88 (25%)
Ig	7665..7734	CDD:143165	15/68 (22%)
Ig	7760..7833	CDD:299845	8/72 (11%)
FN3	7837..7927	CDD:238020	30/90 (33%)
STKc_Twitchin_like	7986..8244	CDD:271016	94/258 (36%)
S_TKc	7989..8244	CDD:214567	94/255 (37%)
Ig	8311..8394	CDD:299845
I-set	8312..8401	CDD:254352
I-set	8437..8525	CDD:254352
Ig	8455..8519	CDD:143165
I-set	8632..8721	CDD:254352
IGc2	8646..8711	CDD:197706
I-set	8740..8831	CDD:254352
Ig	8757..8826	CDD:143165
I-set	8839..8922	CDD:254352
Ig	8845..>8909	CDD:299845
Kalrn	XP_038944566.1	SEC14	42..180	CDD:214706
		SPEC	193..413	CDD:238103
		SPEC	314..539	CDD:238103
		SPEC	540..769	CDD:238103
		SPEC	894..1132	CDD:238103
		SPEC	1138..1238	CDD:197544
		RhoGEF	1287..1457	CDD:238091	7/19 (37%)
		PH1_Kalirin_Trio_like	1464..1586	CDD:270060	25/135 (19%)
		SH3_Kalirin_1	1652..1711	CDD:212786	16/85 (19%)
		SH3-RhoG_link	1708..1892	CDD:406906	46/238 (19%)
		RhoGEF	1935..2104	CDD:395496	38/218 (17%)
		PH2_Kalirin_Trio_p63RhoGEF	2109..2243	CDD:270061	25/167 (15%)
		SH3_Kalirin_2	2327..2385	CDD:212787	13/57 (23%)
		Ig strand A	2466..2469	CDD:409353	0/2 (0%)
		I-set	2474..2568	CDD:400151	34/185 (18%)
		Ig strand A'	2482..2485	CDD:409353	1/2 (50%)
		Ig strand B	2491..2498	CDD:409353	1/6 (17%)
		Ig strand C	2504..2512	CDD:409353	5/8 (63%)
		Ig strand C'	2515..2517	CDD:409353	0/1 (0%)
		Ig strand D	2523..2532	CDD:409353	0/14 (0%)
		Ig strand E	2534..2538	CDD:409353	2/3 (67%)
		Ig strand F	2547..2555	CDD:409353	3/7 (43%)
		Ig strand G	2558..2568	CDD:409353	2/9 (22%)
		FN3	2572..2663	CDD:238020	30/90 (33%)
		STKc_Kalirin_C	2693..2940	CDD:271017	90/248 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0613
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810