DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bt and camk2g2

DIOPT Version :9

Sequence 1:	NP_001162825.1	Gene:	bt / 43814	FlyBaseID:	FBgn0005666	Length:	8933	Species:	Drosophila melanogaster
Sequence 2:	XP_021336506.1	Gene:	camk2g2 / 793359	ZFINID:	ZDB-GENE-070323-2	Length:	637	Species:	Danio rerio

Alignment Length:	742	Identity:	176/742 - (23%)
Similarity:	286/742 - (38%)	Gaps:	205/742 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  7987 DRYDILEEIGTGAFGVVHRCRERSTGNIFAAKFIPVSHSVEKD--LIRREIDIMNQLHHQKLINL 8049
            |.|.:.||:|.|||.||.||.::|||..:|||.|.......:|  .:.||..|...|.|..::.|
Zfish    12 DEYQLYEELGKGAFSVVRRCVKKSTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRL 76

  Fly  8050 HDAFEDDDEMILILEFLSGGELFERITAEGYVMTEAEVINYMRQICEGIRHMHEQNIIHLDIKPE 8114
            ||:..::....|:.:.::||||||.|.|..| .:|::..:.:.||.|.:.|:|:.:|:|.|:|||
Zfish    77 HDSIAEEGFHYLVFDLVTGGELFEDIVAREY-YSESDASHCINQILESVSHIHQHDIVHRDLKPE 140

  Fly  8115 NIMCQTR-SSTNVKLIDFGLATRLDPNEVVKI-TTGTAEFAAPEIVNREPVGFYTDMWATGVLSY 8177
            |::..:: ....|||.|||||..:..::.... ..||..:.:||::.::|.|...|:||.||:.|
Zfish   141 NLLLASKMKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILY 205

  Fly  8178 VLLSGLSPFAGDNDVQTLKNVKACDWDFDVESFKYISEEAKDFIRKLLVRNKEKRMTAHECLLHP 8242
            :||.|..||..::..:..:.:||..:||....:..::.|||:.|.::|..|..||:||.:.|.||
Zfish   206 ILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHP 270

  Fly  8243 WLTGDHSAMKQEINRD------RYLAYREKLR----------RKYEDFERFLLPIGRLSEYSSL- 8290
            |:. ..|.:...::|.      |....|.||:          |.:....:...|....:..::|
Zfish   271 WVC-QRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSVGRQHTSPATPTTSTAALA 334

  Fly  8291 ----RKLLMEKYKIHDAVFDRRQAAPRFVIRPSSQFCYEGQSVKFYCRCIAIAT-----PTLTWS 8346
                :.||.:|   .|.|..|:.::..:::..::.  .:...|....:..:|::     |..|..
Zfish   335 QEACKSLLNKK---SDGVKKRKSSSSVYLMPQTNN--NKNSVVSSSTKDSSISSTAPMEPQTTVV 394

  Fly  8347 HN------------NIELRQSVKFMKRYVGDDYYFIINRVKLDDRGEYIIRAENHYGSREEVVFL 8399
            ||            |....:.:|..|..||.        |..|.     .......||.|
Zfish   395 HNPADGTKGSTESCNTTEEEDMKGRKVSVGG--------VSSDS-----AVVSQCSGSEE----- 441

  Fly  8400 NVQPLPKEQPRYRTESTPVRRREPLPYTFWQEESETAPSFTFLLRPRVMQARDTCKLLCCLSGKP 8464
                 |...|:.:||::|     |.|           |:                      |..|
Zfish   442 -----PSPAPQAQTEASP-----PCP-----------PA----------------------SDPP 463

  Fly  8465 --VPNVRWYKDGRELSKYEYAMTHSDGVVTMEIIDCKPSDSGKYSCKATNCHGTDETDCVVIVEG 8527
              |.||.|                              |.||:.||
Zfish   464 HDVKNVAW------------------------------SSSGQSSC------------------- 479

  Fly  8528 EWVTPEQAQLAHNFLYSGDRKYIEQPIKPAPLPIVTSRQYTSSSVQNTSEPQGDKVNVSNSNSSG 8592
                |:.                 :|..|||    .|.....|||......:.:.:.::......
Zfish   480 ----PDL-----------------EPAVPAP----ASTTAGGSSVNRQQSRKQEIIKITEQLIEA 519

  Fly  8593 ISNKKKYASNSLQAPGSPSRSRSATKELILPPD------DSLMCKPEFTKPLHDLTIHDGEQLI- 8650
            |:|....|...:..||..|....|...|:...|      ::|:.|.  :||:|...::....||
Zfish   520 INNGDFEAYTRICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKN--SKPVHTTILNPHVHLIG 582

  Fly  8651 ----------LTCYVKGDPEPQISWSK 8667
                      ||.|:.|...|:.|.|:
Zfish   583 EDAACIAYIRLTQYIDGQGRPRSSQSE 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bt	NP_001162825.1	I-set	9..101	CDD:254352
		Ig	26..100	CDD:143165
		I-set	119..210	CDD:254352
		Ig	136..209	CDD:143165
		I-set	228..320	CDD:254352
		IGc2	242..312	CDD:197706
		I-set	335..425	CDD:254352
		Ig	350..423	CDD:143165
		Ig	436..530	CDD:299845
		I-set	438..532	CDD:254352
		I-set	545..636	CDD:254352
		Ig	560..633	CDD:143165
		Ig	657..731	CDD:143165
		I-set	746..835	CDD:254352
		Ig	1496..1586	CDD:299845
		IG_like	1503..1588	CDD:214653
		I-set	1639..1724	CDD:254352
		IG	1750..1821	CDD:214652
		IGc2	1750..1806	CDD:197706
		I-set	1826..1909	CDD:254352
		Ig	1831..1897	CDD:299845
		I-set	1914..1998	CDD:254352
		Ig	2020..2095	CDD:299845
		FN3	2100..2194	CDD:238020
		FN3	2203..2292	CDD:238020
		I-set	2311..2395	CDD:254352
		Ig	2321..2395	CDD:299845
		FN3	2399..2493	CDD:238020
		FN3	2501..2590	CDD:238020
		I-set	2602..2693	CDD:254352
		Ig	2619..2693	CDD:299845
		FN3	2697..2793	CDD:238020
		FN3	2801..2893	CDD:238020
		I-set	2902..2995	CDD:254352
		Ig	2919..2993	CDD:299845
		FN3	2999..3088	CDD:238020
		FN3	3102..3191	CDD:238020
		I-set	3208..3292	CDD:254352
		Ig	3219..3292	CDD:299845
		FN3	3296..3390	CDD:238020
		FN3	3400..3489	CDD:238020
		I-set	3494..3590	CDD:254352
		Ig	3516..3590	CDD:299845
		FN3	3594..3682	CDD:238020
		FN3	3694..3781	CDD:238020
		I-set	3795..3885	CDD:254352
		Ig	3813..3885	CDD:299845
		FN3	3889..3980	CDD:238020
		FN3	3990..4082	CDD:238020
		I-set	4090..4181	CDD:254352
		Ig	4108..4181	CDD:299845
		FN3	4185..4271	CDD:238020
		FN3	4285..4383	CDD:238020
		Ig	4404..4480	CDD:299845
		FN3	4484..4571	CDD:238020
		FN3	4584..4677	CDD:238020
		I-set	4685..4775	CDD:254352
		Ig	4703..4775	CDD:299845
		FN3	4779..4863	CDD:238020
		FN3	4879..4970	CDD:238020
		IG	4989..5069	CDD:214652
		Ig	4996..5069	CDD:299845
		FN3	5073..5166	CDD:238020
		FN3	5175..5265	CDD:238020
I-set	5276..5366	CDD:254352
Ig	5293..5366	CDD:299845
FN3	5370..5462	CDD:238020
FN3	5470..5561	CDD:238020
Ig	5559..5654	CDD:299845
I-set	5570..5660	CDD:254352
FN3	5664..5755	CDD:238020
FN3	5764..5853	CDD:238020
I-set	5865..5954	CDD:254352
Ig	5882..5954	CDD:299845
FN3	5958..6049	CDD:238020
FN3	6062..6153	CDD:238020
I-set	6173..6255	CDD:254352
Ig_Titin_like	6182..6255	CDD:143225
FN3	6259..6350	CDD:238020
FN3	6359..6451	CDD:238020
FN3	6470..6552	CDD:238020
I-set	6564..6650	CDD:254352
Ig_Titin_like	6577..6650	CDD:143225
FN3	6654..6745	CDD:238020
FN3	6754..6840	CDD:238020
I-set	6855..6946	CDD:254352
Ig	6874..6946	CDD:299845
FN3	6950..7042	CDD:238020
FN3	7050..7139	CDD:238020
FN3	7151..7237	CDD:238020
I-set	7254..7334	CDD:254352
Ig	7272..7339	CDD:143165
IG_like	7354..7440	CDD:214653
Ig	7366..7440	CDD:299845
FN3	7444..7531	CDD:238020
FN3	7545..7637	CDD:238020
I-set	7648..7737	CDD:254352
Ig	7665..7734	CDD:143165
Ig	7760..7833	CDD:299845
FN3	7837..7927	CDD:238020
STKc_Twitchin_like	7986..8244	CDD:271016	93/260 (36%)
S_TKc	7989..8244	CDD:214567	92/258 (36%)
Ig	8311..8394	CDD:299845	15/99 (15%)
I-set	8312..8401	CDD:254352	16/105 (15%)
I-set	8437..8525	CDD:254352	12/89 (13%)
Ig	8455..8519	CDD:143165	11/65 (17%)
I-set	8632..8721	CDD:254352	12/47 (26%)
IGc2	8646..8711	CDD:197706	9/33 (27%)
I-set	8740..8831	CDD:254352
Ig	8757..8826	CDD:143165
I-set	8839..8922	CDD:254352
Ig	8845..>8909	CDD:299845
camk2g2	XP_021336506.1	STKc_CaMKII	12..303	CDD:270988	100/292 (34%)
camk2g2	XP_021336506.1	CaMKII_AD	505..632	CDD:285524	23/107 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910