DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bt and Htra3

DIOPT Version :9

Sequence 1:	NP_001162825.1	Gene:	bt / 43814	FlyBaseID:	FBgn0005666	Length:	8933	Species:	Drosophila melanogaster
Sequence 2:	XP_006504249.1	Gene:	Htra3 / 78558	MGIID:	1925808	Length:	467	Species:	Mus musculus

Alignment Length:	534	Identity:	110/534 - (20%)
Similarity:	163/534 - (30%)	Gaps:	208/534 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly  4569 LETLGSI-IAKDPFSVPTKPGVPEPTDWTANKVELAWPEPASDGG-------------------- 4612
            |.||..: :|::|      |..|.|.....::.    |.|...||
Mouse    14 LATLAVLALAREP------PAAPCPARCDVSRC----PSPRCPGGYVPDLCNCCLVCAASEGEPC 68

  Fly  4613 -----SPIQGYIVEVKDKYSPLWEKALETNSPTPTATVQGLIEGNEYQFRVVALNKGG------- 4665
                 ||....:..|:......|           |.||.| .:|:.|. .|.||....
Mouse    69 GRPLDSPCGDSLECVRGVCRCRW-----------THTVCG-TDGHTYA-DVCALQAASRRALQVS 120

  Fly  4666 ------LSEPSDPSKIF-TAKPRY-----------LAPKIDRRNL--------RNITLSSGT--- 4701
                  |.:.:.||.:. ...|||           :||.:....|        ||:.||||:
Mouse   121 GTPVRQLQKGACPSGLHQLTSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFI 185

  Fly  4702 ------------ALKLDANITGEPAPKVEWKLSNYHLQSGK--NVTIETPDY---YTKLVIRPTQ 4749
                        .:...:..:|....||:       ||:|.  ..||:..|.   ...:||.|.:
Mouse   186 MSEAGLIVTNAHVVSSSSTASGRQQLKVQ-------LQNGDAYEATIQDIDKKSDIATIVIHPKK 243

  Fly  4750 R---------SD--SGEYLVTATNTSGKDSVLVNVVITDKPSPPNGPLQISDVHKEGCHLKWKRP 4803
            :         :|  .||::|..    |....|.|.|.|.         .:|...::|..| ..|.
Mouse   244 KLPVLLLGHSADLRPGEFVVAI----GSPFALQNTVTTG---------IVSTAQRDGKEL-GLRD 294

  Fly  4804 SDDGGTPIEYFQIDKLEPETGCWIPSCRSTEPQVDVTGLSPGNEYKFRVSAVN----AEGESQPL 4864
            ||     ::|.|.|.:       |....|..|.|::.|         .|..:|    |.|.|..:
Mouse   295 SD-----MDYIQTDAI-------INYGNSGGPLVNLDG---------EVIGINTLKVAAGISFAI 338

  Fly  4865 VGDESIVARNPFDE---PGKPENLKATDWDKDHVDLAW---TPPLIDGGSPISCYIIEKQDKYGK 4923
            ..|......:.|..   .|| |..:..||.|..:.:..   ||.|:
Mouse   339 PSDRITRFLSEFQNKHVKGK-ELSRGADWKKRFIGIRMRTITPSLV------------------- 383

  Fly  4924 WERALDVPADQCKATIPDL--VEGQTYKFRVSAVNAAGTGEPSDSTPPIIAKARNKP-------- 4978
                     ::.||..||.  |....|...|...:.:..|...|.  .||.|...:|
Mouse   384 ---------EELKAANPDFPAVSSGIYVQEVVPNSPSQRGGIQDG--DIIVKVNGRPLADSSELQ 437

  Fly  4979 -PIIDRSS-LVEVR 4990
             .:::.|| |:|||
Mouse   438 EAVLNESSLLLEVR 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bt	NP_001162825.1	I-set	9..101	CDD:254352
		Ig	26..100	CDD:143165
		I-set	119..210	CDD:254352
		Ig	136..209	CDD:143165
		I-set	228..320	CDD:254352
		IGc2	242..312	CDD:197706
		I-set	335..425	CDD:254352
		Ig	350..423	CDD:143165
		Ig	436..530	CDD:299845
		I-set	438..532	CDD:254352
		I-set	545..636	CDD:254352
		Ig	560..633	CDD:143165
		Ig	657..731	CDD:143165
		I-set	746..835	CDD:254352
		Ig	1496..1586	CDD:299845
		IG_like	1503..1588	CDD:214653
		I-set	1639..1724	CDD:254352
		IG	1750..1821	CDD:214652
		IGc2	1750..1806	CDD:197706
		I-set	1826..1909	CDD:254352
		Ig	1831..1897	CDD:299845
		I-set	1914..1998	CDD:254352
		Ig	2020..2095	CDD:299845
		FN3	2100..2194	CDD:238020
		FN3	2203..2292	CDD:238020
		I-set	2311..2395	CDD:254352
		Ig	2321..2395	CDD:299845
		FN3	2399..2493	CDD:238020
		FN3	2501..2590	CDD:238020
		I-set	2602..2693	CDD:254352
		Ig	2619..2693	CDD:299845
		FN3	2697..2793	CDD:238020
		FN3	2801..2893	CDD:238020
		I-set	2902..2995	CDD:254352
		Ig	2919..2993	CDD:299845
		FN3	2999..3088	CDD:238020
		FN3	3102..3191	CDD:238020
		I-set	3208..3292	CDD:254352
		Ig	3219..3292	CDD:299845
		FN3	3296..3390	CDD:238020
		FN3	3400..3489	CDD:238020
		I-set	3494..3590	CDD:254352
		Ig	3516..3590	CDD:299845
		FN3	3594..3682	CDD:238020
		FN3	3694..3781	CDD:238020
		I-set	3795..3885	CDD:254352
		Ig	3813..3885	CDD:299845
		FN3	3889..3980	CDD:238020
		FN3	3990..4082	CDD:238020
		I-set	4090..4181	CDD:254352
		Ig	4108..4181	CDD:299845
		FN3	4185..4271	CDD:238020
		FN3	4285..4383	CDD:238020
		Ig	4404..4480	CDD:299845
		FN3	4484..4571	CDD:238020	1/1 (100%)
		FN3	4584..4677	CDD:238020	23/131 (18%)
		I-set	4685..4775	CDD:254352	27/128 (21%)
		Ig	4703..4775	CDD:299845	19/87 (22%)
		FN3	4779..4863	CDD:238020	19/87 (22%)
		FN3	4879..4970	CDD:238020	18/95 (19%)
		IG	4989..5069	CDD:214652	2/2 (100%)
		Ig	4996..5069	CDD:299845
		FN3	5073..5166	CDD:238020
		FN3	5175..5265	CDD:238020
I-set	5276..5366	CDD:254352
Ig	5293..5366	CDD:299845
FN3	5370..5462	CDD:238020
FN3	5470..5561	CDD:238020
Ig	5559..5654	CDD:299845
I-set	5570..5660	CDD:254352
FN3	5664..5755	CDD:238020
FN3	5764..5853	CDD:238020
I-set	5865..5954	CDD:254352
Ig	5882..5954	CDD:299845
FN3	5958..6049	CDD:238020
FN3	6062..6153	CDD:238020
I-set	6173..6255	CDD:254352
Ig_Titin_like	6182..6255	CDD:143225
FN3	6259..6350	CDD:238020
FN3	6359..6451	CDD:238020
FN3	6470..6552	CDD:238020
I-set	6564..6650	CDD:254352
Ig_Titin_like	6577..6650	CDD:143225
FN3	6654..6745	CDD:238020
FN3	6754..6840	CDD:238020
I-set	6855..6946	CDD:254352
Ig	6874..6946	CDD:299845
FN3	6950..7042	CDD:238020
FN3	7050..7139	CDD:238020
FN3	7151..7237	CDD:238020
I-set	7254..7334	CDD:254352
Ig	7272..7339	CDD:143165
IG_like	7354..7440	CDD:214653
Ig	7366..7440	CDD:299845
FN3	7444..7531	CDD:238020
FN3	7545..7637	CDD:238020
I-set	7648..7737	CDD:254352
Ig	7665..7734	CDD:143165
Ig	7760..7833	CDD:299845
FN3	7837..7927	CDD:238020
STKc_Twitchin_like	7986..8244	CDD:271016
S_TKc	7989..8244	CDD:214567
Ig	8311..8394	CDD:299845
I-set	8312..8401	CDD:254352
I-set	8437..8525	CDD:254352
Ig	8455..8519	CDD:143165
I-set	8632..8721	CDD:254352
IGc2	8646..8711	CDD:197706
I-set	8740..8831	CDD:254352
Ig	8757..8826	CDD:143165
I-set	8839..8922	CDD:254352
Ig	8845..>8909	CDD:299845
Htra3	XP_006504249.1	IGFBP	31..82	CDD:365955	7/54 (13%)
		Kazal_2	<95..132	CDD:369449	8/38 (21%)
		degP_htrA_DO	149..>440	CDD:273938	73/363 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910