DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment bt and Fndc3b

DIOPT Version :9

Sequence 1:NP_001162825.1 Gene:bt / 43814 FlyBaseID:FBgn0005666 Length:8933 Species:Drosophila melanogaster
Sequence 2:NP_001343882.1 Gene:Fndc3b / 72007 MGIID:1919257 Length:1207 Species:Mus musculus


Alignment Length:1120 Identity:256/1120 - (22%)
Similarity:398/1120 - (35%) Gaps:330/1120 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly  3856 PKVKRADRGIYIVTAKNDSGSDTVEVELEV------LCKPSKPKGPLAVSNVTAETLHLKWEKP- 3913
            |.:|:.:|...  ::...|.||..|.||||      |....||:    |||:.|..:.|.|..| 
Mouse   245 PGIKKTERRAR--SSPKSSDSDLQEYELEVKRVQDILSGIEKPQ----VSNIQARAVVLSWAPPV 303

  Fly  3914 --------------------EDDGGDPIEQYLVERMDTETGRWVPVLTTKTPEADVTGLTEGKEY 3958
                                .|.|.|              |::..:.:.:..|.::..|....:|
Mouse   304 GLSCGPHGGLSFPYSYEVALSDKGRD--------------GKYKIIYSGEELECNLKDLRPATDY 354

  Fly  3959 LFRVKAV-NS-EGE-SEPLVTDIPTKAKNPFDAADTPGKPQIVDWSGNHCDLKWRAPEDDGGASI 4020
            ..||.|| || :|. |||:  ...|.:..|    :.|..|::...|.:...|:|:||.|: |:.|
Mouse   355 HVRVYAVYNSVKGSCSEPV--SFTTHSCAP----ECPFPPKLAHRSKSSLTLQWKAPIDN-GSKI 412

  Fly  4021 TGYIVERKD--PNTGKWQKALETSTPDCKARVNDLIAGNKYQFRIMAVNKAGKSKPSEP------ 4077
            |.|::|..:  .|:| :::....|...||  :..|.....|.||:.|.|..|.|..|:.      
Mouse   413 TSYLLEWDEGKRNSG-FRQCFFGSQKHCK--LTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTL 474

  Fly  4078 --SDQMTAKDRFAPPKIDRTNIKDITIKAGQHIRFDIKVSGEPPATKVWLHNKARLENDDSNYNI 4140
              ..||.     ..|::.|..:..||::..       :..|..|...:......:.:.:||:::.
Mouse   475 GNIPQMP-----LAPRLVRAGVTWITLQWS-------RPEGCSPEEVITYTLDIQEDENDSHFHP 527

  Fly  4141 DMESYRTKLTVPISKRFHSGKYTLKAENESGRDEASFEVIVL----DKPGPPEGPLRVTDVHKEG 4201
            .........||...||....|:.|.|.|..|:...| ||:|.    |:||||..||....|...|
Mouse   528 KYTGEDLTCTVKNLKRSTQYKFRLTASNMEGKSCPS-EVLVCTTSPDRPGPPTRPLIKGPVTSHG 591

  Fly  4202 CKLKWNAPLDDGGLPIDHYIIEKMD--VESGRWLPSGRFKESFAE--LNNLEPSHEYKFRVLAVN 4262
            ..:||:||.|:||..|..|::|..|  .|:|:|  ...:..|..|  ..:|:|...||.|...::
Mouse   592 FSVKWDAPKDNGGSEILKYLLEITDGTSEAGQW--EVAYSGSATEYVFTHLKPGTLYKLRACCIS 654

  Fly  4263 TEGESEPLTGEQSVIAKNPFDEPGKPGTPEAVDWDKDH-VDLVWRPPINDGGSPITGYVVEKREK 4326
            |.|.|:   ..:|:..:.....||:...|..:...|.. |.|.|..|.::.|..::.|.||..|.
Mouse   655 TGGHSQ---CSESLPVRTLSLAPGQCRPPRVLGRPKHKGVHLEWDVPASESGCEVSEYSVEMTEP 716

  Fly  4327 GTDKWIKGTEITIPCLGEECKATVPTLNENCEYEFRVKAINAAGPGEPSDASKPIITKPRKLAPK 4391
            ..    ..:|:   ..|.|.:.||..|.....|.|||:|:|..|.|..||.|:            
Mouse   717 EN----VASEV---YHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSE------------ 762

  Fly  4392 IDRKNIRTYNFKSGEPIFLDINISGEPAPDVTWNQNNKSVQTTSFSHIENLPYNTKYINNNPERK 4456
                                                                             
Mouse   763 ----------------------------------------------------------------- 762

  Fly  4457 DTGLYKISAHNFYGQDQVEFQINIITKPGKPEGPLEVSEVH--KDGCKL-KWKKPKDDGGEPVES 4518
                                    ||....|.|......|.  .|||.| .|:.|...|.: :..
Mouse   763 ------------------------ITTAAGPPGQCRAPRVSFTPDGCVLVGWESPASPGAD-ISE 802

  Fly  4519 YLVEKFDPDTGIWLPVGRSDGPE--YNVDGLVPGHDYKFRVKAVNKEGES--------------- 4566
            |.:|..:.:..:.|..   .||:  :.:..|:|...|..|::|.|..|..               
Mouse   803 YRLEWGEDEQSLELVY---HGPDTCFEMRDLLPAAQYCCRLQAFNPAGAGPYSELVHCQTPASAP 864

  Fly  4567 EPLETLGSIIAKDPFSVPTKPGVPEPTDWTANKVELAWPEPASDGGSPIQGYIVEVKDKYSPLWE 4631
            :|:.||..:..:.|.:.|..|.|         .:.|.|.||.:: ||.|..|.:::.|       
Mouse   865 DPVSTLCVLEEEPPSAHPDSPSV---------CLVLNWEEPCNN-GSEILAYNIDLGD------- 912

  Fly  4632 KALETNSPTPTATVQGLIEGNEYQFRVVALNKGGLSEPSDP-SKIFTAKPRYLAPKIDRRNLRNI 4695
             :..|...|.|..::.|:....|:.|:.|:|:.|:.    | |:...||.|.|.|...|      
Mouse   913 -SCITVGNTTTHVMKNLLPETTYRIRIQAINEIGVG----PFSQFIKAKTRPLPPSPPR------ 966

  Fly  4696 TLSSGTALKLDANITGEPAPKVEWKLSN----------YHLQ----SGKNVTIETPDYYTKLVIR 4746
                     |:...:|..:.|::|..||          |.||    :.:.::|.....:|..|.|
Mouse   967 ---------LECAASGPQSLKLKWGDSNSKTHAAGDMVYTLQLEDRNKRFISIYRGPSHTYKVQR 1022

  Fly  4747 PTQ----------RSDSGEYLVTATNTSGKDSVLVNVVITDKPSPP--NGPLQISDVHKEGCHLK 4799
            .|:          .|::||...:.|.|..          |.|..||  ..| :::.:....|.:.
Mouse  1023 LTEFTCYSFRIQAMSEAGEGPYSETYTFS----------TTKSVPPTLKAP-RVTQLEGNSCEIF 1076

  Fly  4800 WKRPSDDGGTPI------------EYFQIDKLEPETGCWIPSCRSTEPQVDVTGLSPGNEYKFRV 4852
            |:......|.|:            ||.|:.|.|             |....::||....:|:|||
Mouse  1077 WETVPPMRGDPVSYVLQVLVGRDSEYKQVYKGE-------------EATFQISGLQSNTDYRFRV 1128

  Fly  4853 SAV-NAEGESQPLVG 4866
            .|. .....||.|.|
Mouse  1129 CACRRCVDTSQELSG 1143

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
btNP_001162825.1 I-set 9..101 CDD:254352
Ig 26..100 CDD:143165
I-set 119..210 CDD:254352
Ig 136..209 CDD:143165
I-set 228..320 CDD:254352
IGc2 242..312 CDD:197706
I-set 335..425 CDD:254352
Ig 350..423 CDD:143165
Ig 436..530 CDD:299845
I-set 438..532 CDD:254352
I-set 545..636 CDD:254352
Ig 560..633 CDD:143165
Ig 657..731 CDD:143165
I-set 746..835 CDD:254352
Ig 1496..1586 CDD:299845
IG_like 1503..1588 CDD:214653
I-set 1639..1724 CDD:254352
IG 1750..1821 CDD:214652
IGc2 1750..1806 CDD:197706
I-set 1826..1909 CDD:254352
Ig 1831..1897 CDD:299845
I-set 1914..1998 CDD:254352
Ig 2020..2095 CDD:299845
FN3 2100..2194 CDD:238020
FN3 2203..2292 CDD:238020
I-set 2311..2395 CDD:254352
Ig 2321..2395 CDD:299845
FN3 2399..2493 CDD:238020
FN3 2501..2590 CDD:238020
I-set 2602..2693 CDD:254352
Ig 2619..2693 CDD:299845
FN3 2697..2793 CDD:238020
FN3 2801..2893 CDD:238020
I-set 2902..2995 CDD:254352
Ig 2919..2993 CDD:299845
FN3 2999..3088 CDD:238020
FN3 3102..3191 CDD:238020
I-set 3208..3292 CDD:254352
Ig 3219..3292 CDD:299845
FN3 3296..3390 CDD:238020
FN3 3400..3489 CDD:238020
I-set 3494..3590 CDD:254352
Ig 3516..3590 CDD:299845
FN3 3594..3682 CDD:238020
FN3 3694..3781 CDD:238020
I-set 3795..3885 CDD:254352 9/28 (32%)
Ig 3813..3885 CDD:299845 9/28 (32%)
FN3 3889..3980 CDD:238020 26/114 (23%)
FN3 3990..4082 CDD:238020 28/101 (28%)
I-set 4090..4181 CDD:254352 20/90 (22%)
Ig 4108..4181 CDD:299845 16/72 (22%)
FN3 4185..4271 CDD:238020 32/89 (36%)
FN3 4285..4383 CDD:238020 30/98 (31%)
Ig 4404..4480 CDD:299845 0/75 (0%)
FN3 4484..4571 CDD:238020 23/106 (22%)
FN3 4584..4677 CDD:238020 23/93 (25%)
I-set 4685..4775 CDD:254352 21/113 (19%)
Ig 4703..4775 CDD:299845 19/95 (20%)
FN3 4779..4863 CDD:238020 21/98 (21%)
FN3 4879..4970 CDD:238020
IG 4989..5069 CDD:214652
Ig 4996..5069 CDD:299845
FN3 5073..5166 CDD:238020
FN3 5175..5265 CDD:238020
I-set 5276..5366 CDD:254352
Ig 5293..5366 CDD:299845
FN3 5370..5462 CDD:238020
FN3 5470..5561 CDD:238020
Ig 5559..5654 CDD:299845
I-set 5570..5660 CDD:254352
FN3 5664..5755 CDD:238020
FN3 5764..5853 CDD:238020
I-set 5865..5954 CDD:254352
Ig 5882..5954 CDD:299845
FN3 5958..6049 CDD:238020
FN3 6062..6153 CDD:238020
I-set 6173..6255 CDD:254352
Ig_Titin_like 6182..6255 CDD:143225
FN3 6259..6350 CDD:238020
FN3 6359..6451 CDD:238020
FN3 6470..6552 CDD:238020
I-set 6564..6650 CDD:254352
Ig_Titin_like 6577..6650 CDD:143225
FN3 6654..6745 CDD:238020
FN3 6754..6840 CDD:238020
I-set 6855..6946 CDD:254352
Ig 6874..6946 CDD:299845
FN3 6950..7042 CDD:238020
FN3 7050..7139 CDD:238020
FN3 7151..7237 CDD:238020
I-set 7254..7334 CDD:254352
Ig 7272..7339 CDD:143165
IG_like 7354..7440 CDD:214653
Ig 7366..7440 CDD:299845
FN3 7444..7531 CDD:238020
FN3 7545..7637 CDD:238020
I-set 7648..7737 CDD:254352
Ig 7665..7734 CDD:143165
Ig 7760..7833 CDD:299845
FN3 7837..7927 CDD:238020
STKc_Twitchin_like 7986..8244 CDD:271016
S_TKc 7989..8244 CDD:214567
Ig 8311..8394 CDD:299845
I-set 8312..8401 CDD:254352
I-set 8437..8525 CDD:254352
Ig 8455..8519 CDD:143165
I-set 8632..8721 CDD:254352
IGc2 8646..8711 CDD:197706
I-set 8740..8831 CDD:254352
Ig 8757..8826 CDD:143165
I-set 8839..8922 CDD:254352
Ig 8845..>8909 CDD:299845
Fndc3bNP_001343882.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 184..213
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 230..265 5/21 (24%)
FN3 283..377 CDD:238020 26/113 (23%)
FN3 382..473 CDD:238020 28/98 (29%)
FN3 481..570 CDD:238020 21/101 (21%)
FN3 575..669 CDD:238020 33/98 (34%)
FN3 691..765 CDD:238020 27/181 (15%)
FN3 770..859 CDD:238020 21/92 (23%)
fn3 878..950 CDD:394996 23/93 (25%)
FN3 973..1052 CDD:238020 18/88 (20%)
FN3 1057..1130 CDD:238020 19/86 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0613
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.