DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bt and Hmcn2

DIOPT Version :9

Sequence 1:	NP_001162825.1	Gene:	bt / 43814	FlyBaseID:	FBgn0005666	Length:	8933	Species:	Drosophila melanogaster
Sequence 2:	XP_006498564.1	Gene:	Hmcn2 / 665700	MGIID:	2677838	Length:	5092	Species:	Mus musculus

Alignment Length:	5969	Identity:	1112/5969 - (18%)
Similarity:	1843/5969 - (30%)	Gaps:	2177/5969 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 APSFVKKPQLHQEDDGNRLIFECQLLSSPKPDIEWFRSDNKVVEDVRTKFKIQPVGENKYTVVLE 72
            ||......:..:...|..:...|.....|.|.|.|.|....:.||.|.....|.      |::::
Mouse   608 APQVSINARSQRFSQGVEVRVSCSASGYPTPHISWSREGLALPEDSRIHVDAQG------TLIIQ 666

  Fly    73 LDDVVETDAGLYKVKAKNKSGEVSASINLNFTPADEPKEKQIDGFAPTFAKKPAIRQEEDGKRLL 137
              .:...|||.|..:|.|:.|....::.|.:|  |.|....::....|..          |:..:
Mouse   667 --GLAPEDAGNYSCQATNEVGTDEETVTLYYT--DPPSVSAVNAVVLTAV----------GEEAV 717

  Fly   138 FECRVNADPIPAIIWFHNGAAVKESERHKITVDKDVHSYFATLEILNVTVEDAGKYKVNAKNELG 202
            ..|..:..|.|.:||:..|..|       |....|..|  .||.|......|||.|...|.||||
Mouse   718 LLCAASGVPPPRVIWYRGGLEV-------ILAPGDSRS--GTLRIPEAQERDAGLYTCKAVNELG 773

  Fly   203 ESNATISLNFDSDEAPVPESAEGIKPTFTERPVIRQSEDGGNVTFECRCVGDPTPTVTWSHGETE 267
            :::|.|.|            ..|..|..|:.|.....|.|.:|...||..|.|.|.|||..|:.:
Mouse   774 DASAEIQL------------VVGNAPRLTDPPQDVTVELGKSVFLTCRATGRPPPIVTWRRGDGQ 826

  Fly   268 LNESNRYKMSLTMDQKLYHIACLEISSVVSSDQGEYRAQAKNKHGSGVATINLNFESGSKKIPDG 332
            ..|..|...:...|.     ..|....|...||..|..:|:|..|...|...|        :..|
Mouse   827 ALEPGRGSRTGQRDS-----GVLVFERVSLEDQAPYVCEARNVFGKAQAEARL--------VVTG 878

  Fly   333 KSPRFPKKPTIRQEEDLL-IME-------CV-LEAHPVPDIVWYCSEKEICNNQRTKMTRKAITK 388
            .:|     |.|.....:: ::|       || |...|:|:..|..:...:     ....|.|:..
Mouse   879 HAP-----PQIANSASVVRVLEGQPVSLTCVILAGRPLPERRWLKAGSPL-----PPGNRHAVRA 933

  Fly   389 DSYILTLEIQNPTKEDGGNYRCNAINMYGESNANIALNFQGASDANGFAPSFIEKPRIIPNES-- 451
            |.   :|.:....:||.|.|.|.|.|:.|..:.::.|..|        .|     |||.|..:
Mouse   934 DG---SLHLDRALQEDAGRYSCVATNVAGSQHRDVELVVQ--------VP-----PRIHPTSTHH 982

  Fly   452 ----GTLITMKCKCKAKPEPTVTWYRGQDLVEKSKKIKINTTVIAEDTYELTLEIKDPGATDGGT 512
                |...::.|.....|.|.:||.:..:.:..|....::...        ||.|..|...|.|.
Mouse   983 VTNEGVPASLPCIASGVPTPKITWTKETNALTTSGHYSVSRNG--------TLVIVQPSPQDAGA 1039

  Fly   513 YRCNVKNEYGESNANLNLNIEAEPEPEGEGPTFIEKPRIVSENNGKLVIMECKVKADPKPDVIWF 577
            |.|...|..|.|:..:.|::..:|..:..|...::.|..|:...|:.|.::|:.:..|.|.:.|
Mouse  1040 YVCTATNSVGFSSQEMWLSVNTKPMIKMNGSQAVDVPLRVTVKAGEEVTLDCEAQGSPTPLLTW- 1103

  Fly   578 RNGEVIKESNKIKTFIEQRGDQYYI----KLELLDPQLEDSGLYKCNIKNTLGELNANLTLNIEI 638
                 .|::|.:....    ::|.:    .|.|...|:.|:|||.|...|..|..:....|.:::
Mouse  1104 -----TKDANPLLPVT----NRYELLPSGSLRLAQAQVGDNGLYGCTASNPAGATSRRYVLRVQV 1159

  Fly   639 VPVIKDKPKIIKIIKKRTVVIECTVASKFEPKCTWYKETSTVKESKRHVYQVEQTKEGEFAV-KL 702
            .|.::..|:::|::....:.:.|......:|:..|:|:...:.              ||.|. .:
Mouse  1160 PPQVQPGPRVLKVLAGEALDLNCVAEGNPQPQLNWFKDGMALM--------------GEGAQGSV 1210

  Fly   703 EINDVEESDKGAYKLVASNEKGEAVSQIVNLVDIP----EEERKPCKPEISRKLADQKVAESKTF 763
            ....|:.||.|.|:..|||..|....::..||..|    .:|.|        .|.::...|:.:
Mouse  1211 HFAAVKTSDAGLYRCEASNSAGTDTWKLELLVLEPPHWGTDETK--------SLLERVAGENAS- 1266

  Fly   764 ELLVSLSQTDRKCKVEWYKG--STVIRETKDITTTFDGTTARLTFSSARTEHTSNYKVIVTNEVG 826
              |...:|...|.::.|.:|  |..:....|:....:|:   |..||.....:..|:...|||||
Mouse  1267 --LPCPAQGTPKPRITWRRGPSSEPLNGRPDVAVLDEGS---LFLSSVSLADSGEYECQATNEVG 1326

  Fly   827 KDESSCKITVEKVAKKKEEKPKEKEKTKNEKEVEQKEMEEDKNESGQSVAQTEGRI-NIEQISEG 890
            ......|:.|......:|                                  ||.| |:..:: |
Mouse  1327 SASRRAKLVVYVPPSIRE----------------------------------EGHITNVSGLA-G 1356

  Fly   891 DPKEELTVK--------EEILDKRDTQEVKESSVELQDSAGHEVPEPKKATSDSKLDQSNQKNLD 947
            .|   ||::        .|:...:|.|.:.|:|       ||.:           ||.|...:..
Mouse  1357 QP---LTLECDINGFPAPEVAWLKDGQLIPEAS-------GHRL-----------LDGSRSLHFP 1400

  Fly   948 KKHKTDQSESKTNKNVSLAEPIKSNKQESEEQQATEQIGLKKVDRKASIVSVKEEISSDVRRKST 1012
            :                    |:.:.......||..|.|..:.|...::......:.:.
Mouse  1401 R--------------------IQESHSGLYSCQAENQAGSAQRDFNLAVFIPPSLLGAG------ 1439

  Fly  1013 IKAKEEITVDDKKASSRRSSLAVEESNTESRRSSIIDKKPLEQVDNKPIDANKNPQPLKEEIPRL 1077
              |.:|:.           .||..:...|.:.|.:    |..||     :..|:.||:....|.:
Mouse  1440 --AAQEVL-----------GLAGADVTLECQTSGV----PTPQV-----EWTKDGQPILPGDPHI 1482

  Fly  1078 KPAEKRRTSKVIEEPKPDEGLPKLRKASIAQVKEEAKPAAPKLKAKAKAKPKYEELPEIPDYERP 1142
            ...|..:..::|.....|||  :.:..:.:...::||.....:                 .|..|
Mouse  1483 LLQEDGQVLRIISSHLGDEG--QYQCVAFSPAGQQAKDFQLSI-----------------HYGDP 1528

  Fly  1143 QLEKYEKS---DFTPSDFARDLEIPNKMEKPIIDSGKKEPAVLAQKNGIPKKTDIIEQYADEPKG 1204
            :.::.|::   .:||.......|..   |..:::....:  :|.:..|:|  :..|..|
Mouse  1529 EAQRGERTYPRSYTPPTIWGSNETG---EVTVLEGHTAQ--LLCEARGMP--SPAITWY------ 1580

  Fly  1205 LKVGKGKLPDEGDGRDGAVLKPVIIEPEKEILDLGNKKNNQHADKPTVLDIIKQRRRSSIRNLMT 1269
                          :||.:|
Mouse  1581 --------------KDGTLL--------------------------------------------- 1586

  Fly  1270 KEPIQNESFLGVVLKPVIKDTREQAAPQQAIQLTKANATEQFSPTKAVKAQVADLKKPETLATLE 1334
                                     ||...:..:|.....|.     ||||.:|    ..|.|.:
Mouse  1587 -------------------------APSSEVVYSKGGRQLQL-----VKAQPSD----AGLYTCQ 1617

  Fly  1335 DNYERPVLEKYDPFSIDKTKSEKSTPSIITPDIRGPEVKLPVQETKEEKQKVPKMQPPAPGDPPK 1399
            .:         :|..|  ||...|....:.|.|.|.:             ..|.:.....|.|..
Mouse  1618 AS---------NPAGI--TKKSTSLEVYVPPTIEGAD-------------GGPYLVQAVAGRPVA 1658

  Fly  1400 IEVIREKRPSLAPEPPSRRGSLIPPADTGRRPSLIINDEKK--LRPGEVMDTRLLRPGEVGEGQR 1462
            :|.:....|              ||..:.:...|.:.|...  |..|..:  :|..|||...|
Mouse  1659 LECVARGHP--------------PPTISWQHEGLPVVDSNGTWLEAGGAL--QLENPGEASGG-- 1705

  Fly  1463 RRPSIDVRRPSVQDLEDLINKPSTPLRD------VGDGGPPSIVDVQESYSVVEDSTAYLTVG-- 1519
                          |...:  .|:|..:      |....||.:: |.|....|   ||  |||
Mouse  1706 --------------LYSCV--ASSPAGEAVLQYSVEMQVPPQLL-VAEGMGQV---TA--TVGQS 1748

  Fly  1520 ------VEGSPAPTFKFYKGVSEILEGGR-------FKFLTDGQTNTITLCMRKCKPNDESKYKI 1571
                  ..|||.||.::       |:.||       .:..:.|   || |.:...:.|....:..
Mouse  1749 LDLPCQASGSPVPTIQW-------LQNGRPAEELAGVQLASQG---TI-LHISHVELNHSGLFAC 1802

  Fly  1572 VVSNIHGEDSAEMQLYVSDSSGMDFRAMLKKRRYQKWDKDEQDPNWGDLKETEKPLPALKKVERK 1636
            ..:|..|...||:::.|.:                                    ||::.
Mouse  1803 QATNEAGTAGAEVEVSVHE------------------------------------LPSVH----- 1826

  Fly  1637 VESFLSPLIDQFAKEGKDKKVVFEARFSKPNCKPKWLFRKDEVFTGSKFKFKQENDTYQLIITTP 1701

Mouse  1827 ----------------------------------------------------------------- 1826

  Fly  1702 KVEDTGKYTIEIGGVSSTAFLNVEEADPTYTFTKPLKKKLEGFTQHETTLEC-SVSSSMANVHWF 1765
                      .|||.:.||           .|.:|:            ||:| .:.....::.|:
Mouse  1827 ----------IIGGENLTA-----------PFLQPV------------TLQCVGIGVPTPSLRWW 1858

  Fly  1766 KNNTKLESDDPRYLISKDINGNLKLIIKDSVLDDAGLYRCQLDK--QPDKTECNLKV----TEYP 1824
            |:...:.:.          .|||:  |:.:.|.|.|:|.|....  ...|.:..|||    ...|
Mouse  1859 KDGVAVATS----------GGNLQ--IEKADLRDEGVYTCSATNLAGESKKDVTLKVLVPPNIEP 1911

  Fly  1825 YKFVKVLKSQQCIEKDTVTLACEIDDAMG----EVQWLRNGEEIKPDKRIQIVKDGRKRKLVIKD 1885
            ....||:     :|..:|||.|.   |.|    :|.|.:..:.|...:|:.:..||  |.|.|:.
Mouse  1912 GPVNKVV-----LENASVTLECL---ASGVPPPDVSWFKGRQPISTQRRVIVSADG--RVLHIER 1966

  Fly  1886 CKVTDAGQFKCTTNADTTESEIIINYQNRFNKKLKDTEAVEREKLILDIELQDQTAPCDWKFNGE 1950
            .:::|||.::|.  |........:.|..|.|
Mouse  1967 VQLSDAGSYRCV--ATNVAGSAGLKYGLRVN---------------------------------- 1995

  Fly  1951 PIVPSESIEIKNMGGGKHQLIFSSLDMSNEGEITCESGQLSSKCKLSIRKGESRPNIDCPDKFSG 2015
              ||                                                  |.|..|....|
Mouse  1996 --VP--------------------------------------------------PRITLPPNLPG 2008

  Fly  2016 PISAPVLLEVPFKVS-GTKQTPVEAKLF-KDGKPLP---VKDVEVAVTDDKVTFKIKKPSRDLSG 2075
                ||||..||::: ....||....:: |||.|:.   :..::|......:|....:.|.  ||
Mouse  2009 ----PVLLGTPFRLTCNATGTPRPTLIWLKDGNPVSPEGIPGLKVFPGGQVLTVASARASD--SG 2067

  Fly  2076 PYQIKISNGQGEDTKDVQIICQDVPQPP----QDVDITDVYQTS----CVVSFNPPSDDGGTPIT 2132
            .|.....:..|||.:||.:   .|..||    ::::::.|...|    |.....||      |:.
Mouse  2068 SYSCVAVSAVGEDRRDVIL---QVHMPPSILGEELNMSVVVNESVTLECQSHAVPP------PVL 2123

  Fly  2133 KYVIERQDLSKKHGWESVAEVLPSEPCLKKIDDLIPKKQYRFRIRAVNAIGQSDPATFKNTILAK 2197
            :             |:.....|...|.:              |:.|..|:.:.|.|..
Mouse  2124 R-------------WQKDGRPLEPHPGI--------------RLSADKALLEVDRAAV------- 2154

  Fly  2198 DPWDEPGKPKAVDLTDWDKDHADLKWEAPETDGGDPITAYIVEYKEKFSNDWVSGKEVDGDARTA 2262
                            ||..|
Mouse  2155 ----------------WDAGH-------------------------------------------- 2159

  Fly  2263 TVDGLKEGQQYEFRVRAVNRAGPGEPSDKTKSIIAKCRFVKPFIVGEGLKNVTVKKGQTIRFDIK 2327
                        :...|:|:||   .|:|..::..   :|.|....:....:||.:|||.|....
Mouse  2160 ------------YTCEAINQAG---RSEKHFNLHV---WVPPAFPSKEPYTLTVTEGQTARLSCD 2206

  Fly  2328 YDGEPEPAATWVKGTDNLKFDNQRICLDQLER----NSSITIKKSVRKDTGKYKLVLSNSSGTIE 2388
            ..|.|.|..:|.|....|..:.     |.||:    ...:.:.::.....|.|....||::||..
Mouse  2207 CQGIPFPKISWRKDGQPLPGEG-----DSLEQVLAVGRLLYLGQAQSAQEGTYTCECSNAAGTSS 2266

  Fly  2389 SEAQVVVLDRPLPPGGPFEPEEIRASHIKMKWKRPDDDGGCEISGYALERMDEETGRWIPAGEVG 2453
            .|..:.||   :||                                      :.||.|
Mouse  2267 QEQSLEVL---VPP--------------------------------------QVTGLW------- 2283

  Fly  2454 PNETSFDFKGLTPNKKYKFRVKAINKEGESEPLETFDAI------VARNPYDPPSPPSQPVIDDY 2512
                                          |||.|...|      :|.|....|.|
Mouse  2284 ------------------------------EPLTTVSVIQDGNTTLACNATGKPLP--------- 2309

  Fly  2513 DNKSVLLKWKRPPSDGGRPITHYIVEIKDKFAPSWSEVAKTDDPNPECNVEGLKEKMVYQFRVRA 2577
                 ::.|:|    .|:|::   ||      |.    .:..:.|...:||          |.:|
Mouse  2310 -----VVTWQR----DGQPVS---VE------PG----LRLQNQNHSLHVE----------RAQA 2342

  Fly  2578 VNKAGPSEPSQPTDNHLCKHKNLKPQIDRSTFKRVTIKSGRTHKWSVDVLGEPIPELHWSWRDDI 2642
            .:..|.|          |..:|...:.:|              ::::.||..|    |.:...|
Mouse  2343 SHAGGYS----------CVAENTAGRAER--------------RFALSVLAPP----HLTGDSD- 2378

  Fly  2643 PLTNGDRIKIENVDYHTDFSITNVLRKDSGFYTLKAENRNGIDRETVELVVLGKPSSPKGPLAVS 2707
                               |:|||.....|.:||..| ..|:...||:....|:|.||:   ..:
Mouse  2379 -------------------SLTNVTATLHGSFTLLCE-AAGVPAPTVQWFQEGQPISPR---EGT 2420

  Fly  2708 DVTASGCKLQWKKPED------------DGGVPIKEYVVEKMDTATGKWVRVGRSPGEKEPPSFD 2760
            .:.|.|..|:..:.::            :.|...:.:.||.:                 .|||.:
Mouse  2421 YLLAGGWMLKMTQAQEQDRGLYSCLASNEAGEARRNFSVEVL-----------------VPPSIE 2468

  Fly  2761 VTGLSLGSEYMFRVSAVNEEGESEPLTTLVGVVAKDPFDEPNKPG--TPEVTDY-DNQSISLKWA 2822
            ...|    |.:.:|    .||::..|             |.|..|  .|:||.: |.||::::..
Mouse  2469 NEDL----EEVIKV----PEGQTAQL-------------ECNATGHPPPKVTWFKDGQSLTVEDP 2512

  Fly  2823 APNNDGGAPIQKYIIEKKNKNKTEWEKALEIPGDQLEATVAGLQEYGEYQFRVIAVNKAG----- 2882
            ...:..||.:              |     ||       .|.|...|.|.  .||.|..|
Mouse  2513 YEMSPDGAFL--------------W-----IP-------QANLSNAGHYS--CIASNAVGEKTKH 2549

  Fly  2883 -----LSPPSDASVPQIVKYKKLKPRIDRSNLKPLLIRAGKPIRYDVNVRGEPAPVITWYQNDKE 2942
                 |..|:...||            :::..:.:.:....||.........|:|.|||.   |:
Mouse  2550 TQLSVLVVPTILGVP------------EKNANEEVTVTINNPISLICEALAFPSPNITWM---KD 2599

  Fly  2943 LKPEELPSSSEIKNIPYNTKISIIETVRKHTGIYKIIAVNEHGQDEATVEVNILAPPS----KPR 3003
            ..|.|  :|..|:.:|....:.|:...::..|.|..:..||.|:......|.:|.|||    .|.
Mouse  2600 GSPFE--ASKNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEATKNYHVEVLIPPSISKDDPL 2662

  Fly  3004 GPLDVKDV-TKDSCKLK-----WKKPEDD-----GGKPIS-AYQVEKFDKKQGRWVPLGRTSAND 3056
            |.:.||:| ||.:..|.     |..|...     .|:|:: ::::....  :||.:.:..|..:|
Mouse  2663 GEVSVKEVKTKVNSSLTLECECWATPPPSISWYKDGRPVTPSHRLSVLG--EGRLLQIQPTQVSD 2725

  Fly  3057 TEFDVKGLQEGHEYQFRVKAINEEGESDPLDSDDSIIAKNPYDAASKPGTPNIVDYNEHMVKLKW 3121
            :.            ::...|.|..||.   |.|.:::.:.|      |....:.|.
Mouse  2726 SG------------RYLCVATNVAGED---DQDFNVLIQVP------PMFQKMGDV--------- 2760

  Fly  3122 EAPRSDGGAPISGYIIEKKDKFSPIWDEILSTNTSVPEATVEGLVEGNIYQFRVRAVNKAGFSDP 3186
                 |.|             |.|:..|        .||      :|.:.::|
Mouse  2761 -----DAG-------------FEPLPHE--------EEA------QGRVTEYR------------ 2781

  Fly  3187 SDATEPHLAKPRNLKPYINRDKMKPIKVRAGQPVKFDVDVKGEPAPSLTWFLKETELTSTGQVRL 3251
                                      ::....|.....|....|.|.|||:.:...|::...|.:
Mouse  2782 --------------------------EIVENNPAYLYCDTNAIPPPELTWYREGQPLSAADGVSV 2820

  Fly  3252 ENIDYNTKLTLLDTDRKQSGQYKLRAENINGVDEAVVEVIILDKPSKPEGPIEVSDIHKEGCKLK 3316
            .......:|.|:..:  .:|:|..:|.|..|.|....|:::|..|..|
Mouse  2821 LQGGRILQLPLVQAE--DAGRYSCKAANEVGEDWLHYELLVLTPPVIP----------------- 2866

  Fly  3317 WRKPKDDGGIPITGYVIEKMDTATGKWVPAGSVDPEKYDIEIKGLDPNHRYQFRVKAVNEEGESE 3381
                                                                         |:::
Mouse  2867 -------------------------------------------------------------GDTQ 2870

  Fly  3382 PLETESAITAKNPFDVSAPP-GLP-ELEDWDEHHVKLKWEPPIRDGGSPITNYIIEVMDKDSGEF 3444
            .|..|..:.|.:...:..|. |.| ....|.::             |.|:
Mouse  2871 ELVEEVTVNASSAVSLECPALGNPAPAVSWFQN-------------GLPV--------------- 2907

  Fly  3445 VKAVETDSPVCKGVVKKLEEGQQYK-----------FRVRAVNKAGPSD---------PSEQTNW 3489
                 :.||    .::.|||||..|           :...|.|:||.::         |.:.::|
Mouse  2908 -----SPSP----RLQVLEEGQVLKVATAEVADAASYMCVAENQAGSAEKLFTLKVQVPPQISDW 2963

  Fly  3490 HVAKPRFLKPHIDRVNLKPVIVKTGLSISLDINIRGEPAPKVEWFFNNSSVTSDE--------HS 3546
            ..::               :......|:||...:...|.|:|.|:.:...::..:        |:
Mouse  2964 TTSQ---------------LTATLNSSVSLPCEVYAHPNPEVTWYKDGQPLSLGQEAFLLPGTHT 3013

  Fly  3547 VKIDNVDYNTKFFVMRAQRSQSGKYIIKATNEVGEDEAELEVTVL------GKPGKPKGPLQV-- 3603
            :::           .|||.:.||.|:.:|.|..|.|:..:::.||      ..||.|:..:||
Mouse  3014 LRL-----------ARAQPADSGTYLCEALNAAGRDQKMVQLNVLVPPSFKQAPGGPQEAIQVRA 3067

  Fly  3604 NDITKHSCKLKWEKPDDDGGSPIDYYEIEKLDPHTGQWLPCGKSTEPEA---KVIGLHEGKAYK- 3664
            .|....||                  |.:.|......|.   |..:|.|   ::.||..|:..:
Mouse  3068 GDKAILSC------------------ETDSLPEPAVTWF---KDQQPLALGQRIQGLQGGQTLEI 3111

  Fly  3665 ----------FRVRAVNKEGESEDLETEKPIIAKNP-YDEPDR-----------------PGKPE 3701
                      :..:..|..||:  :.|....|...| :::|:|                 .|.|.
Mouse  3112 LDSQASDKGVYSCKVSNTAGEA--IRTFVLAIQVPPTFEKPERETVNQVAGRTLVLACDVSGIPA 3174

  Fly  3702 PT-NWDKDFVDLAWDPPKNDGGAPIQKYVIQ-MRDKSGRAWVDSATVPGDKCNGTVTGVEEGHEY 3764
            || .|.||.:             |::..|:. :..:.||..: |...|...  ||.|.|.|..:.
Mouse  3175 PTVTWLKDRL-------------PVESSVVHGVVSRGGRLQL-SHLQPAQA--GTYTCVAENAQA 3223

  Fly  3765 EFRIVAVNKAGPSDPSDVSKSVIAKPRFLKPHIDRKN--LQKKIMRSGQMLHIDALIKAEPPAKV 3827
            |.|            .|...||:..|:.....:.:::  |:|:.:|    ||.:|  :.:||..:
Mouse  3224 EAR------------KDFVVSVLVPPQIQDSGMAQEHNVLEKQEIR----LHCEA--EGQPPPDI 3270

  Fly  3828 TWTYN--KTEIKTSDHIKIENEDYKTTFIMPKVKRADRGIYIVTAKNDSGSDTVEVELEVLCKPS 3890
            ||..:  ..:.....|::...:.  :|.::..::.||.|.|...|.|.:|.|.....:.||..|:
Mouse  3271 TWLKDGGLLDQHVGPHLRFYLDG--STLVLKGLRTADSGAYTCVAHNPAGEDARLHTVNVLVPPT 3333

  Fly  3891 KPKGPLAVSNVTAET---------------LHLKWEKPEDDGGD-PIEQYLVERMDTETGRWVPV 3939
            ..:.......:.:.|               :|:.|.|   ||.. |:.|   ..:...:||.:.:
Mouse  3334 IKQQAGDTGTLVSRTGELVTMVCPVQGSPPIHVSWLK---DGLPLPLSQ---RTLLHSSGRTLRI 3392

  Fly  3940 LTTKTPEADVTGLTEGKEYLFRVKAVNSEGESE------PLVTDI--PTKAKNPFDAA------- 3989
            ...:..::.|          |...|.:..|.::      .||..|  |.:.:|...||
Mouse  3393 SQVQLADSGV----------FTCVAASPAGVADRNFTLLVLVPPILEPVEFQNNVMAAQGSEVVL 3447

  Fly  3990 --DTPGKP-QIVDWSGNHCDLKWRAPEDDGGASITGYIVERKDPNTGKWQKALETSTPDCKARVN 4051
              :..|.| .:|.|.            .||...:               .::||.. |..|  :.
Mouse  3448 PCEARGSPLPLVSWM------------KDGEPLL---------------PQSLEQG-PGLK--LE 3482

  Fly  4052 DLIAGNKYQFRIMAVNKAGKSKPSEPSDQMTAKDRFAPPKIDRT-NIKDITIKAGQHIRFDIKVS 4115
            .:..|:...:...|.::||:::   ...|:|..|   ||.|:.: ...::::..|.|:....:..
Mouse  3483 SVSVGDAGTYSCTAASEAGEAR---RHFQLTVMD---PPHIEESGETSELSLTPGAHLELLCEAR 3541

  Fly  4116 GEPPATKVWLHNKA----RLENDDSNYNIDMESYRTKLTVPISKRFHSGKYTLKAENESGRDEAS 4176
            |.||....| |...    |.|||.....:        |.|...:..::|.||..||:.:|..|.|
Mouse  3542 GIPPPNITW-HKDGQALRRTENDSQAGRV--------LRVRDVQVDNAGLYTCLAESPAGEVEKS 3597

  Fly  4177 FEVIVLDKPG--PPEGPLRVT-----------DVHKEGC-KLKWNAPLDDGGLPID-----HYII 4222
            |.|.|...|.  .|.||..|.           .|..|.. :::|:.    ||:.:.     |:
Mouse  3598 FRVRVQAPPNVVGPRGPRSVVGLAPGQLILECSVEAEPAPEIEWHR----GGVLLQADAHTHF-- 3656

  Fly  4223 EKMDVESGRWL--------PSGRFKESFAELNNLEPSHEYKFRVLAVNTEG--ESEPLTGEQSVI 4277
                .|.||:|        ..|.:.   ....|...|....||| .::|..  :|.|.|...||.
Mouse  3657 ----PEQGRFLKLQALSTADGGDYS---CTARNRAGSTSVAFRV-EIHTAPTIQSGPNTVNVSVN 3713

  Fly  4278 AKN--PFDEPGKPGTPEAVDWDKDHVDLVWRPPINDGGSPITGYVVEKREKGTDKWIKGTEITIP 4340
            ...  |....|.| || .|.|.||.:.|  .|     |||...::.|           |:....|
Mouse  3714 RTTLLPCQTHGVP-TP-LVSWRKDGIPL--HP-----GSPRLEFLPE-----------GSLRIHP 3758

  Fly  4341 CLGEECKATVPTLNENCEYEFRVKAINAAGPGEPSDASKPI---ITKPRKLAPKIDRKNIRTYNF 4402
            .|.::..            .:...|.|:||    || .|.:   :.:|..:||......:..|:
Mouse  3759 VLAQDAG------------HYLCLASNSAG----SD-RKGLDLRVFEPPAIAPGPSNLTLTAYS- 3805

  Fly  4403 KSGEPIFLDINISGEPAPDVTWNQNNKS----VQTTSFSHIENLPYNTKYINNNPERKDTGLYKI 4463
                |..|.....|.|.|.|||.::.:.    :|..::   ..||.|..:: ..|..:|:..::.
Mouse  3806 ----PASLPCEARGSPKPLVTWWKDGQKLDLRLQQGAY---RLLPSNALFL-TAPSPQDSAQFEC 3862

  Fly  4464 SAHNFYGQDQVEFQINIITKPGKPE----------GPLEVSEVHKDGC---KLKWKKPKDDGGEP 4515
            ...|..|:.:..:|:.:...|...:          .|: :...|..|.   .:.|.|.....|..
Mouse  3863 VVSNEVGESRRRYQVTVHVPPTIADDQTHFTVTRMAPV-ILTCHSTGSPTPAVSWSKAGTQLGAR 3926

  Fly  4516 VESYLVEKFDPDTGIWLPVGRSDGPEYNVDGLVPGHDYKFRVKAVNKEGES-------------- 4566
            ...|.:          ||.|..:     ::..:|.|..::...|.|..|.:
Mouse  3927 GSGYRI----------LPSGALE-----IERALPLHAGRYTCTARNSAGVARKHMVLTVQASPVV 3976

  Fly  4567 EPLETLGSIIAKDPFSVPTK-PGVPEPTDWTANKVELAWPEPASDGGSPIQGYIVEVKDKYSPLW 4630
            :||.::..::|.:...:|.: .|:|:|                                  ..:|
Mouse  3977 KPLPSVVQVVASEEVLLPCEASGIPQP----------------------------------MVIW 4007

  Fly  4631 EKALETNSPTPTATVQGLIEGNEYQFRVVALNKGGLSEPSDPSKIF----------TAKPRYL-- 4683
            :|  |..|....|.:|.|..|   |.|::.      :.|.|....|          .||.|.:
Mouse  4008 QK--EGLSIPEGAHMQVLPSG---QLRIMH------ASPEDAGNYFCIAQNSVGSAMAKTRLVVQ 4061

  Fly  4684 APKIDRRNLRNITLSSGTALKLDANITGEPAPKVEWKLSNYHLQSGK--NVTIETPDYYTKLVIR 4746
            .|.:....|.:::...|:...|.....|.|.|.:.|: .:.||.||.  ..|::...   :|:::
Mouse  4062 VPPVIENGLPDLSTIEGSHALLPCTAKGSPEPAITWE-KDGHLVSGAEGKFTLQPSG---ELLVK 4122

  Fly  4747 PTQRSDSGEYLVTATNTSGKDSVLVNVVITDKP----SPPNGPLQISDVHKEGC--------HLK 4799
            .::..|:|.|:.||.|..|:....|::.|...|    .|.:..|::.|.....|        .:.
Mouse  4123 NSEGQDAGTYICTAENAVGRARRRVHLTILTLPVLTTLPGDRSLRLGDRLWLRCVARGSPTPRIG 4187

  Fly  4800 W---KRP------SDDGGTPIEYFQIDKLEPET-GCWIPSCRSTEPQVDVTGLSPGNEYKFRVSA 4854
            |   .:|      ..|||:.::...:.:.:..| .||      .|.:|.            ||.|
Mouse  4188 WTINDQPVTEGVSEQDGGSTLQRAAVTREDSGTYTCW------AENRVG------------RVQA 4234

  Fly  4855 VN---------AEGES-----QPLVGDESI--VARNPFDEPGKPENLKATD--WDKDHVDLAWTP 4901
            |:         .:||:     :|:.|...:  |.|      |.|    |.|  |.||.:.|
Mouse  4235 VSFVHVKEAPVLQGEAFSYLVEPVGGSIQLHCVVR------GDP----APDIHWTKDGLPL---- 4285

  Fly  4902 PLIDGGSPIS-----------CYIIEKQDKYGKWERALDVPADQCKATIPDLVEGQTYKFRVSAV 4955
                   |||           ..:..|.|..|::         ||                 .||
Mouse  4286 -------PISRLHFQLQNGSLTILRTKMDDAGRY---------QC-----------------LAV 4317

  Fly  4956 NAAGTGEPSDSTPPIIAKARNKPPIIDRSSLVE---VRIKAGQSFTFDCKVSGEPAPQTKWLLKK 5017
            |..||      ...::.......|:..    ||   |.:::|......|:.:|||.|..:||...
Mouse  4318 NEMGT------VKKVVTVVLQSAPVFQ----VEPQDVTVRSGVDVELRCRATGEPVPTIEWLRAG 4372

  Fly  5018 KEVYSKDNVKVTNVDYNTKLKVNSATRSDSGIYTVFAENANGEDSADVKVTVIDKPAPPNGPLK- 5081
            :.:.:...::...   :..|.:......|:|:|...|.|..|..:|...:.|..:|....|.:.
Mouse  4373 RPLQAGRKLRALP---DGSLWLEHVEAGDAGVYECVAHNHLGSVTAKALLAVRGEPRGSRGSMTG 4434

  Fly  5082 ----------------VDEINSESCTLHWNP----PDDDGGQPIDNYVVEKLDETTGRWIPAGET 5126
                            :.:.:||:.|: |:.    |...|  |:...:|..:...  .|..|.|:
Mouse  4435 VINGQEFGMATLNISVLQQGSSEAPTI-WSSISQVPASVG--PLMRVLVVTIAPI--YWALARES 4494

  Fly  5127 DGPVTALKVGGLTPGHKYKFRVRAKNRQGTSEPLTTAQAIIAKNPFD-----------VPTK--P 5178
            .   .||....||.|   .|:..::....|.|.||..|.....:|..           :|..  .
Mouse  4495 G---EALNGYSLTGG---SFQQESQMEFSTGELLTMTQVARGLDPDGLLLVDMKINGMIPESLAD 4553

  Fly  5179 GTPTIKDFDKEFVDLEWTRPEADGGSPITGYVVEKRDKFSPDWEKC-AEISDDITNAHVPDLIEG 5242
            |...::||.:.:|.   |.|    |....|..........|...:| ..|..|.|....|.|::.
Mouse  4554 GDLRVQDFQEHYVQ---TGP----GQLFAGSTQRFLHDSLPASLRCNHSIQYDETRGLQPQLVQH 4611

  Fly  5243 LKYEFRVRAVNKA-GPGSPS---------DATETHVARPKNTPPKIDRNFMSDIKIKAGNVFEFD 5297
            |    |..:::.| .|.:.:         ...|..|..|:...|.:...|..|           .
Mouse  4612 L----RASSISSAFDPEAEALNFQLTTALQTEENEVGCPEGFEPDVQGAFCVD-----------K 4661

  Fly  5298 VPVTGEPLPSKDWTHEGNMIINTDRVKISNFD-----------DRTKIRILDAKRSDTGVYTLTA 5351
            ...:|.|.|..          :|.|....:|.           |....|.:|....:|.:.....
Mouse  4662 DECSGGPSPCS----------HTCRNAPGHFSCSCPTGFSLAWDHRNCRDVDECAGNTHLCQEEQ 4716

  Fly  5352 RNINGTDRHNVKVTILDAPSVPEGPLRNGDVSKNSIVLRWRPPKDDGGSEITHYVVEKMDNEAMR 5416
            |.:|....:|...:           .|.|          :|...|....|.....:|::|
Mouse  4717 RCVNLLGSYNCLAS-----------CRPG----------FRVTADGSNCEDVDECLEQLD----- 4755

  Fly  5417 WVPVGDCTDTEIRADNLIENHDYSFRV---RAVNKQGQSQP-LTTSQPITAKDP----------- 5466
                      |...:.|.||.......   |...:||.|.| |..::.:....|
Mouse  4756 ----------ECHYNQLCENTPGGHHCGCPRGYRQQGHSLPCLDINECLQLPTPCVYQCQNLQGS 4810

  Fly  5467 YSHPDKPGQPQATDWGKHFVDLEWSTPKRDGGAPISSYIIEKRPKFGQWERAAV 5520
            |.....|||....| |:..:.||.:..        :..|:..|..||.|.|:.|
Mouse  4811 YRCLCPPGQTLLRD-GRTCIPLERNRQ--------NITIVSHRSPFGPWLRSRV 4855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bt	NP_001162825.1	I-set	9..101	CDD:254352	20/91 (22%)
		Ig	26..100	CDD:143165	18/73 (25%)
		I-set	119..210	CDD:254352	26/90 (29%)
		Ig	136..209	CDD:143165	23/72 (32%)
		I-set	228..320	CDD:254352	27/91 (30%)
		IGc2	242..312	CDD:197706	21/69 (30%)
		I-set	335..425	CDD:254352	22/98 (22%)
		Ig	350..423	CDD:143165	19/81 (23%)
		Ig	436..530	CDD:299845	23/99 (23%)
		I-set	438..532	CDD:254352	24/99 (24%)
		I-set	545..636	CDD:254352	22/94 (23%)
		Ig	560..633	CDD:143165	18/76 (24%)
		Ig	657..731	CDD:143165	16/74 (22%)
		I-set	746..835	CDD:254352	20/90 (22%)
		Ig	1496..1586	CDD:299845	27/104 (26%)
		IG_like	1503..1588	CDD:214653	24/99 (24%)
		I-set	1639..1724	CDD:254352	5/84 (6%)
		IG	1750..1821	CDD:214652	18/77 (23%)
		IGc2	1750..1806	CDD:197706	13/56 (23%)
		I-set	1826..1909	CDD:254352	23/86 (27%)
		Ig	1831..1897	CDD:299845	19/69 (28%)
		I-set	1914..1998	CDD:254352	4/83 (5%)
		Ig	2020..2095	CDD:299845	23/79 (29%)
		FN3	2100..2194	CDD:238020	16/101 (16%)
		FN3	2203..2292	CDD:238020	8/88 (9%)
		I-set	2311..2395	CDD:254352	22/87 (25%)
		Ig	2321..2395	CDD:299845	18/77 (23%)
		FN3	2399..2493	CDD:238020	10/99 (10%)
		FN3	2501..2590	CDD:238020	16/88 (18%)
		I-set	2602..2693	CDD:254352	17/90 (19%)
		Ig	2619..2693	CDD:299845	16/73 (22%)
		FN3	2697..2793	CDD:238020	18/107 (17%)
		FN3	2801..2893	CDD:238020	24/104 (23%)
		I-set	2902..2995	CDD:254352	20/92 (22%)
		Ig	2919..2993	CDD:299845	19/73 (26%)
		FN3	2999..3088	CDD:238020	22/104 (21%)
		FN3	3102..3191	CDD:238020	11/88 (13%)
		I-set	3208..3292	CDD:254352	18/83 (22%)
		Ig	3219..3292	CDD:299845	18/72 (25%)
		FN3	3296..3390	CDD:238020	5/93 (5%)
		FN3	3400..3489	CDD:238020	19/110 (17%)
		I-set	3494..3590	CDD:254352	18/103 (17%)
		Ig	3516..3590	CDD:299845	18/81 (22%)
		FN3	3594..3682	CDD:238020	20/103 (19%)
		FN3	3694..3781	CDD:238020	22/105 (21%)
		I-set	3795..3885	CDD:254352	20/93 (22%)
		Ig	3813..3885	CDD:299845	17/73 (23%)
		FN3	3889..3980	CDD:238020	18/114 (16%)
		FN3	3990..4082	CDD:238020	15/92 (16%)
		I-set	4090..4181	CDD:254352	25/95 (26%)
		Ig	4108..4181	CDD:299845	21/76 (28%)
		FN3	4185..4271	CDD:238020	24/114 (21%)
		FN3	4285..4383	CDD:238020	24/100 (24%)
		Ig	4404..4480	CDD:299845	17/79 (22%)
		FN3	4484..4571	CDD:238020	18/113 (16%)
		FN3	4584..4677	CDD:238020	17/103 (17%)
		I-set	4685..4775	CDD:254352	22/91 (24%)
		Ig	4703..4775	CDD:299845	19/73 (26%)
		FN3	4779..4863	CDD:238020	21/119 (18%)
		FN3	4879..4970	CDD:238020	21/103 (20%)
		IG	4989..5069	CDD:214652	17/79 (22%)
		Ig	4996..5069	CDD:299845	15/72 (21%)
		FN3	5073..5166	CDD:238020	24/113 (21%)
		FN3	5175..5265	CDD:238020	20/102 (20%)
I-set	5276..5366	CDD:254352	16/100 (16%)
Ig	5293..5366	CDD:299845	13/83 (16%)
FN3	5370..5462	CDD:238020	17/95 (18%)
FN3	5470..5561	CDD:238020	14/51 (27%)
Ig	5559..5654	CDD:299845
I-set	5570..5660	CDD:254352
FN3	5664..5755	CDD:238020
FN3	5764..5853	CDD:238020
I-set	5865..5954	CDD:254352
Ig	5882..5954	CDD:299845
FN3	5958..6049	CDD:238020
FN3	6062..6153	CDD:238020
I-set	6173..6255	CDD:254352
Ig_Titin_like	6182..6255	CDD:143225
FN3	6259..6350	CDD:238020
FN3	6359..6451	CDD:238020
FN3	6470..6552	CDD:238020
I-set	6564..6650	CDD:254352
Ig_Titin_like	6577..6650	CDD:143225
FN3	6654..6745	CDD:238020
FN3	6754..6840	CDD:238020
I-set	6855..6946	CDD:254352
Ig	6874..6946	CDD:299845
FN3	6950..7042	CDD:238020
FN3	7050..7139	CDD:238020
FN3	7151..7237	CDD:238020
I-set	7254..7334	CDD:254352
Ig	7272..7339	CDD:143165
IG_like	7354..7440	CDD:214653
Ig	7366..7440	CDD:299845
FN3	7444..7531	CDD:238020
FN3	7545..7637	CDD:238020
I-set	7648..7737	CDD:254352
Ig	7665..7734	CDD:143165
Ig	7760..7833	CDD:299845
FN3	7837..7927	CDD:238020
STKc_Twitchin_like	7986..8244	CDD:271016
S_TKc	7989..8244	CDD:214567
Ig	8311..8394	CDD:299845
I-set	8312..8401	CDD:254352
I-set	8437..8525	CDD:254352
Ig	8455..8519	CDD:143165
I-set	8632..8721	CDD:254352
IGc2	8646..8711	CDD:197706
I-set	8740..8831	CDD:254352
Ig	8757..8826	CDD:143165
I-set	8839..8922	CDD:254352
Ig	8845..>8909	CDD:299845
Hmcn2	XP_006498564.1	vWFA	38..196	CDD:238119
		Ig	445..511	CDD:319273
		IG	525..605	CDD:214652
		I-set	609..693	CDD:369462	20/91 (22%)
		IG	707..783	CDD:214652	27/106 (25%)
		IG_like	793..876	CDD:214653	26/95 (27%)
		I-set	889..969	CDD:369462	20/87 (23%)
		Ig	992..1058	CDD:386229	17/73 (23%)
		IG	1076..1157	CDD:214652	22/90 (24%)
		Ig	1161..1242	CDD:386229	19/94 (20%)
		Ig	1262..1336	CDD:386229	19/79 (24%)
		I-set	1345..1429	CDD:369462	24/125 (19%)
		I-set	1449..1523	CDD:369462	16/84 (19%)
		IG	1553..1633	CDD:214652	25/196 (13%)
		IGc2	1654..1716	CDD:197706	18/95 (19%)
		Ig	1741..1819	CDD:386229	23/93 (25%)
		Ig	1839..1903	CDD:386229	17/87 (20%)
		I-set	1907..1986	CDD:369462	24/90 (27%)
		Ig_3	1998..2073	CDD:372822	22/80 (28%)
		Ig	2092..2179	CDD:386229	24/201 (12%)
		Ig	2183..2273	CDD:386229	23/94 (24%)
		Ig	2291..2367	CDD:386229	22/140 (16%)
		IGc2	2389..2451	CDD:197706	14/65 (22%)
		I-set	2476..2554	CDD:369462	26/122 (21%)
		I-set	2558..2650	CDD:369462	23/108 (21%)
		I-set	2668..2740	CDD:369462	16/85 (19%)
		Ig	2782..2859	CDD:386229	18/78 (23%)
		I-set	2876..2954	CDD:369462	19/114 (17%)
		I-set	2966..3046	CDD:369462	18/105 (17%)
		I-set	3050..3141	CDD:369462	21/113 (19%)
		Ig	3145..3233	CDD:386229	24/115 (21%)
		Ig	3256..3320	CDD:319273	17/71 (24%)
		Ig	3347..3422	CDD:386229	14/90 (16%)
		IG_like	3436..3511	CDD:214653	17/107 (16%)
		IGc2	3530..3592	CDD:197706	18/70 (26%)
		Ig	3614..3695	CDD:386229	18/94 (19%)
		I-set	3699..3786	CDD:369462	30/123 (24%)
		Ig	3789..3874	CDD:386229	20/93 (22%)
		Ig	3900..3967	CDD:319273	14/82 (17%)
		I-set	3974..4060	CDD:369462	23/130 (18%)
		Ig	4064..4151	CDD:386229	21/90 (23%)
		I-set	4155..4240	CDD:369462	19/102 (19%)
		IGc2	4259..4321	CDD:197706	22/108 (20%)
		I-set	4335..4421	CDD:369462	20/92 (22%)
		G2F	4423..4605	CDD:369383	39/199 (20%)
		FXa_inhibition	4664..4699	CDD:373209	7/44 (16%)
		EGF_CA	4701..4744	CDD:311536	9/63 (14%)
		EGF_CA	4746..4783	CDD:214542	8/51 (16%)
		EGF_CA	4789..4829	CDD:214542	7/40 (18%)
		EGF_CA	4896..4935	CDD:214542
		EGF_CA	4936..4974	CDD:214542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4475
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100287
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.710