DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment bt and SIGLEC1

DIOPT Version :9

Sequence 1:NP_001162825.1 Gene:bt / 43814 FlyBaseID:FBgn0005666 Length:8933 Species:Drosophila melanogaster
Sequence 2:NP_075556.1 Gene:SIGLEC1 / 6614 HGNCID:11127 Length:1709 Species:Homo sapiens


Alignment Length:1150 Identity:210/1150 - (18%)
Similarity:359/1150 - (31%) Gaps:470/1150 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 AEDFAPSFVKKP-QLHQEDDGNRLIFECQLLSSPK-PDIE------WFRSDNKVVEDVR-TKFKI 59
            ||:...|.|..| .||        ||..::..||. |.:|      ...:.|:...|:| :.:|.
Human   307 AENGVGSLVSPPISLH--------IFMAEVQVSPAGPILENQTVTLVCNTPNEAPSDLRYSWYKN 363

  Fly    60 QPVGENKYTVVLELDDVVETDAGLYKVKAKN-----KSGEVSASINLNFTPADEPKEKQIDGFAP 119
            ..:.|:.::..|.|......|.|.|..:.:|     :||.||..:|      ..|....:..|..
Human   364 HVLLEDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVN------HPPLTPVLTAFLE 422

  Fly   120 TFAKKPAIRQEEDGKRLLFECRVNADPIPAIIWFHNGAAVKESERHKITVDKDVHSYFA------ 178
            |.|          |...:..|.|.::|:..::..|.|..:..:     :.|.|....|:      
Human   423 TQA----------GLVGILHCSVVSEPLATLVLSHGGHILAST-----SGDSDHSPRFSGTSGPN 472

  Fly   179 --TLEILNVTVEDAGKYKVNAKNELGESNATISLNFDSDEA-----PVPESAEGIKPTFTERPVI 236
              .|||.::...|:|:||.:|.|.||  |||.:|:|.::.|     |..|..||           
Human   473 SLRLEIRDLEETDSGEYKCSATNSLG--NATSTLDFHANAARLLISPAAEVVEG----------- 524

  Fly   237 RQSEDGGNVTFECRCVGDPTPTVTWSHGETELNESNRYKMSLTMDQKLYHI---ACLEISSVVSS 298
             |:     ||..||....|||..               :.|..::..|.|.   :.|.:.:..|:
Human   525 -QA-----VTLSCRSGLSPTPDA---------------RFSWYLNGALLHEGPGSSLLLPAASST 568

  Fly   299 DQGEYRAQAKNKHG----SGVATINLNFESGSKKIPDGKSPRFPKKPTIRQEEDL---------- 349
            |.|.|..:|::.|.    |..|.:.:.:.              |::||.....||          
Human   569 DAGSYHCRARDGHSASGPSSPAVLTVLYP--------------PRQPTFTTRLDLDAAGAGAGRR 619

  Fly   350 -LIMECVLEAHPVPDIVWYCSEKEI---------CNNQRTKMTRKAITKDSYILTLEIQNPTKED 404
             |:: |.:::.|...:.....::.:         |:.......|..:||...:|.:||.||..|:
Human   620 GLLL-CRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEE 683

  Fly   405 GGNYRCNAINMYGESNANIALNFQGASDANGFAPSF----------------------------- 440
            .|.|.|.|.|..|  ||:.:..|.|.:.....|||.                             
Human   684 EGLYLCEASNALG--NASTSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSPANFSWFR 746

  Fly   441 ---------IEKPRIIP--------------NESGTLITMK------------------------ 458
                     :|...::|              .|:|..::..                        
Human   747 NGVLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSALLDMGQGH 811

  Fly   459 -----CKCKAKPEPTVTWYRGQDLVEKSKKIKINTTVIAEDTYE-------LTLEIKDPGATDGG 511
                 |...::|...:..:.|:.|:..|    :...|.:...::       |.||:::.|..|.|
Human   812 MALFICTVDSRPLALLALFHGEHLLATS----LGPQVPSHGRFQAKAEANSLKLEVRELGLGDSG 872

  Fly   512 TYRCNVKNEYGESNANLNLN-----IEAEPEPEGEGPTFIEKPRIVSENNGKLVIMECKVKAD-P 570
            :|||...|..|.||.:|...     ::..|.||.:              .|:.|::.|:|... |
Human   873 SYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQ--------------EGQAVVLSCQVHTGVP 923

  Fly   571 K-PDVIWFRNGEVIKESNK---------------------------------------------- 588
            : ....|:|:|:.::||..                                              
Human   924 EGTSYRWYRDGQPLQESTSATLRFAAITLTQAGAYHCQAQAPGSATTSLAAPISLHVSYAPRHVT 988

  Fly   589 IKTFIEQ-----------------------RGDQYY-------------------------IKLE 605
            :.|.::.                       .||:..                         ::||
Human   989 LTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLE 1053

  Fly   606 LLDPQLEDSGLYKCNIKNTLGELNANL-----TLNIEIVPVIKDKPKIIKIIKKRTVVIECTVAS 665
            :....|||.|:|.|...||||:.:|:.     .:|:::.|.       ..:.:.:.|.:.|.|.:
Human  1054 IHGAMLEDEGVYICEASNTLGQASASADFDAQAVNVQVWPG-------ATVREGQLVNLTCLVWT 1111

  Fly   666 KFEPKC--TWYKE-------------TSTVKESK------------------------------R 685
            ....:.  |||::             ..||:::.                              |
Human  1112 THPAQLTYTWYQDGQQRLDAHSIPLPNVTVRDATSYRCGVGPPGRAPRLSRPITLDVLYAPRNLR 1176

  Fly   686 HVYQVEQTKEGEFA----------------------------------VKLEINDVEESDKGAYK 716
            ..|.:| :..|:.|                                  ::||:...:..|:|.|.
Human  1177 LTYLLE-SHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYS 1240

  Fly   717 LVASNEKGEAVSQI------VNLVDIPEEERKPCKPE---ISRKLADQKVAESKTFELLVSLSQT 772
            ..|.:..|:|.:.:      |.::..||    ...||   |:...|| ..|.:.|.         
Human  1241 CSARSPLGQANTSLELRLEGVRVILAPE----AAVPEGAPITVTCAD-PAAHAPTL--------- 1291

  Fly   773 DRKCKVEWYKGSTVIRETKDITTTFDGTTARLTFSSARTEHTSNY 817
                 ..||.....::|         |..|.|:|..|...|...|
Human  1292 -----YTWYHNGRWLQE---------GPAASLSFLVATRAHAGAY 1322

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
btNP_001162825.1 I-set 9..101 CDD:254352 26/105 (25%)
Ig 26..100 CDD:143165 21/86 (24%)
I-set 119..210 CDD:254352 25/98 (26%)
Ig 136..209 CDD:143165 22/80 (28%)
I-set 228..320 CDD:254352 20/98 (20%)
IGc2 242..312 CDD:197706 16/72 (22%)
I-set 335..425 CDD:254352 26/109 (24%)
Ig 350..423 CDD:143165 21/81 (26%)
Ig 436..530 CDD:299845 27/181 (15%)
I-set 438..532 CDD:254352 26/186 (14%)
I-set 545..636 CDD:254352 26/191 (14%)
Ig 560..633 CDD:143165 25/173 (14%)
Ig 657..731 CDD:143165 21/158 (13%)
I-set 746..835 CDD:254352 16/74 (22%)
Ig 1496..1586 CDD:299845
IG_like 1503..1588 CDD:214653
I-set 1639..1724 CDD:254352
IG 1750..1821 CDD:214652
IGc2 1750..1806 CDD:197706
I-set 1826..1909 CDD:254352
Ig 1831..1897 CDD:299845
I-set 1914..1998 CDD:254352
Ig 2020..2095 CDD:299845
FN3 2100..2194 CDD:238020
FN3 2203..2292 CDD:238020
I-set 2311..2395 CDD:254352
Ig 2321..2395 CDD:299845
FN3 2399..2493 CDD:238020
FN3 2501..2590 CDD:238020
I-set 2602..2693 CDD:254352
Ig 2619..2693 CDD:299845
FN3 2697..2793 CDD:238020
FN3 2801..2893 CDD:238020
I-set 2902..2995 CDD:254352
Ig 2919..2993 CDD:299845
FN3 2999..3088 CDD:238020
FN3 3102..3191 CDD:238020
I-set 3208..3292 CDD:254352
Ig 3219..3292 CDD:299845
FN3 3296..3390 CDD:238020
FN3 3400..3489 CDD:238020
I-set 3494..3590 CDD:254352
Ig 3516..3590 CDD:299845
FN3 3594..3682 CDD:238020
FN3 3694..3781 CDD:238020
I-set 3795..3885 CDD:254352
Ig 3813..3885 CDD:299845
FN3 3889..3980 CDD:238020
FN3 3990..4082 CDD:238020
I-set 4090..4181 CDD:254352
Ig 4108..4181 CDD:299845
FN3 4185..4271 CDD:238020
FN3 4285..4383 CDD:238020
Ig 4404..4480 CDD:299845
FN3 4484..4571 CDD:238020
FN3 4584..4677 CDD:238020
I-set 4685..4775 CDD:254352
Ig 4703..4775 CDD:299845
FN3 4779..4863 CDD:238020
FN3 4879..4970 CDD:238020
IG 4989..5069 CDD:214652
Ig 4996..5069 CDD:299845
FN3 5073..5166 CDD:238020
FN3 5175..5265 CDD:238020
I-set 5276..5366 CDD:254352
Ig 5293..5366 CDD:299845
FN3 5370..5462 CDD:238020
FN3 5470..5561 CDD:238020
Ig 5559..5654 CDD:299845
I-set 5570..5660 CDD:254352
FN3 5664..5755 CDD:238020
FN3 5764..5853 CDD:238020
I-set 5865..5954 CDD:254352
Ig 5882..5954 CDD:299845
FN3 5958..6049 CDD:238020
FN3 6062..6153 CDD:238020
I-set 6173..6255 CDD:254352
Ig_Titin_like 6182..6255 CDD:143225
FN3 6259..6350 CDD:238020
FN3 6359..6451 CDD:238020
FN3 6470..6552 CDD:238020
I-set 6564..6650 CDD:254352
Ig_Titin_like 6577..6650 CDD:143225
FN3 6654..6745 CDD:238020
FN3 6754..6840 CDD:238020
I-set 6855..6946 CDD:254352
Ig 6874..6946 CDD:299845
FN3 6950..7042 CDD:238020
FN3 7050..7139 CDD:238020
FN3 7151..7237 CDD:238020
I-set 7254..7334 CDD:254352
Ig 7272..7339 CDD:143165
IG_like 7354..7440 CDD:214653
Ig 7366..7440 CDD:299845
FN3 7444..7531 CDD:238020
FN3 7545..7637 CDD:238020
I-set 7648..7737 CDD:254352
Ig 7665..7734 CDD:143165
Ig 7760..7833 CDD:299845
FN3 7837..7927 CDD:238020
STKc_Twitchin_like 7986..8244 CDD:271016
S_TKc 7989..8244 CDD:214567
Ig 8311..8394 CDD:299845
I-set 8312..8401 CDD:254352
I-set 8437..8525 CDD:254352
Ig 8455..8519 CDD:143165
I-set 8632..8721 CDD:254352
IGc2 8646..8711 CDD:197706
I-set 8740..8831 CDD:254352
Ig 8757..8826 CDD:143165
I-set 8839..8922 CDD:254352
Ig 8845..>8909 CDD:299845
SIGLEC1NP_075556.1 Ig 21..136 CDD:299845
IG_like 26..135 CDD:214653
Sialic acid binding. /evidence=ECO:0000250 122..126
C2-set_2 142..228 CDD:285423
Ig_2 245..323 CDD:290606 7/23 (30%)
IG_like 247..323 CDD:214653 7/23 (30%)
Ig 336..408 CDD:299845 16/71 (23%)
IG_like 338..408 CDD:214653 16/69 (23%)
Ig 430..503 CDD:143165 22/79 (28%)
IG_like 431..503 CDD:214653 22/78 (28%)
Ig_2 514..594 CDD:290606 24/111 (22%)
IG 516..594 CDD:214652 24/109 (22%)
IG_like 624..703 CDD:214653 20/80 (25%)
IG_like 715..792 CDD:214653 6/76 (8%)
ig 715..788 CDD:278476 6/72 (8%)
Ig 809..893 CDD:299845 20/87 (23%)
I-set 898..980 CDD:254352 13/95 (14%)
Ig_2 900..980 CDD:290606 13/93 (14%)
Ig 1003..1080 CDD:143165 15/76 (20%)
Ig_2 1093..1168 CDD:290606 9/81 (11%)
IG_like 1093..1168 CDD:214653 9/81 (11%)
I-set 1186..1256 CDD:254352 10/69 (14%)
Ig_2 1263..1342 CDD:290606 18/87 (21%)
IG_like 1271..1342 CDD:214653 16/75 (21%)
Ig 1363..1442 CDD:299845
IG_like 1455..1529 CDD:214653
Ig 1457..1518 CDD:299845
Ig <1552..1630 CDD:299845
IG 1552..1627 CDD:214652
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4475
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.