DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment bt and ROBO3

DIOPT Version :9

Sequence 1:NP_001162825.1 Gene:bt / 43814 FlyBaseID:FBgn0005666 Length:8933 Species:Drosophila melanogaster
Sequence 2:NP_071765.2 Gene:ROBO3 / 64221 HGNCID:13433 Length:1386 Species:Homo sapiens


Alignment Length:1685 Identity:338/1685 - (20%)
Similarity:539/1685 - (31%) Gaps:579/1685 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly  3476 NKAGPSDPSEQTNWHVAKPRFLKPHIDRVNLKPVIVKTGLSISLDINIRGEPAPKVEWFFNNSSV 3540
            ::.||.|         |.||.::...|      ::|..|...:|.....|.|.|.:||:.|.:.|
Human    55 SRVGPED---------AMPRIVEQPPD------LLVSRGEPATLPCRAEGRPRPNIEWYKNGARV 104

  Fly  3541 TSDEHSVKIDN--VDYNTKFFVM----RAQRSQSGKYIIKATNEVG---EDEAELEVTVL----- 3591
            .:.....:...  :.....||..    |..|...|.|...|.|.:|   ...|.|||.||     
Human   105 ATVREDPRAHRLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFR 169

  Fly  3592 ----------GKPG-----KPKG-PLQVNDITKHSCKLKWEKPDDDGGSPIDYYEIEKLDPHTGQ 3640
                      |:|.     .|:| |.......|...:||.|:                       
Human   170 QSPGNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEE----------------------- 211

  Fly  3641 WLPCGKSTEPEAKVIGLH--EGKAYKFRVRAVNKEGESED-----LETEKPIIAKNPYDE---PD 3695
                |:.|....|::..|  :..|..:...|.|..||.|.     :..|:|...:.|.::   .|
Human   212 ----GRITIRGGKLMMSHTLKSDAGMYVCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLAD 272

  Fly  3696 RP--------GKPEPTNWDKDFVDLAWDPPKNDGGAPIQKYVIQMRDKSGRAWVDSATVPGDKCN 3752
            .|        |.|.|.        |.|  .|.||..|..:|.|: .|.|  .|:           
Human   273 APVTFLCEVKGDPPPR--------LRW--RKEDGELPTGRYEIR-SDHS--LWI----------- 313

  Fly  3753 GTVTGVEEGHEYEFRIVAVNKAGPSDPSDVSKSVIAKPRFL-KPHIDRKNLQKKIMRSGQMLHID 3816
            |.|:..:||   .:..||.|..|.::.|. |.||...|:.: :|       |.::...|:.:...
Human   314 GHVSAEDEG---TYTCVAENSVGRAEASG-SLSVHVPPQLVTQP-------QDQMAAPGESVAFQ 367

  Fly  3817 ALIKAEPPAKVTWTYNKTEIKTSDHIKIENEDYKTT---FIMPK-------VKRADRGIYIVTAK 3871
            ...|..||..:.|....:::     :...::..:.|   .:.|:       |:|.|.|.|:..|.
Human   368 CETKGNPPPAIFWQKEGSQV-----LLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAV 427

  Fly  3872 NDSGSDTVEVELEVLCKPSKPKG--PLAVSNVTAETLHL------------------KWEKPEDD 3916
            :.:||...:..||:  |.:...|  |:.:.....:||.|                  :|:|   |
Human   428 SVAGSILAKALLEI--KGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQPSVRWKK---D 487

  Fly  3917 G----GDPIE--------QYLVERMDTETGRWVPVLTTKTPEADVTGLTEGKEYLFRVKAVNSEG 3969
            |    ||.::        .|:....:.:.|.:..|..:.|.||..:|..:.:|         ..|
Human   488 GQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEATWSGWLKMRE---------DWG 543

  Fly  3970 ESEPLVTDIPTKAKNPFDAADTPGKPQIVDWSGNHCDLKWRAPEDDGGASITGYIVERKDPNTGK 4034
            .|    .|.||:..:|..|   |.:|.:.:.:.|...|.|: |....||::|.|::|...|..|.
Human   544 VS----PDPPTEPSSPPGA---PSQPVVTEITKNSITLTWK-PNPQTGAAVTSYVIEAFSPAAGN 600

  Fly  4035 -WQKA-----LETSTPDCKARVNDLIAGNKYQFRIMAVNKAGKSKPSEPSDQMTAKDRFAPPKID 4093
             |:..     |||.|      |:.|.....|.|.:.||...|.|:||..|:.:..:|.       
Human   601 TWRTVADGVQLETHT------VSGLQPNTIYLFLVRAVGAWGLSEPSPVSEPVRTQDS------- 652

  Fly  4094 RTNIKDITIKAGQHIRFDIKVSGEPPATKVWLHNKARLENDDSNYNIDMESYRTKLTVPISKRFH 4158
                                 |...|....|...:...|                :.|.:.:...
Human   653 ---------------------SPSRPVEDPWRGQQGLAE----------------VAVRLQEPIV 680

  Fly  4159 SGKYTLKAENESGRDEASFEVIVLDKPGPPEGPLRVTDVHKEGCKLKWNAPLDDGGLPIDHYIIE 4223
            .|..||         :.|:.|         :||:::.    :|.::.|.....:||      ...
Human   681 LGPRTL---------QVSWTV---------DGPVQLV----QGFRVSWRVAGPEGG------SWT 717

  Fly  4224 KMDVESGRWLPSGRFKESFAELNNLEPSHEYKFRVLAVNTEG-ESEPLTGEQSVIAKNPFDEPGK 4287
            .:|::|    ||    :....|..|.|..:.:.:|.|...|| .:|.|:..:|:    |.:.|..
Human   718 MLDLQS----PS----QQSTVLRGLPPGTQIQIKVQAQGQEGLGAESLSVTRSI----PEEAPSG 770

  Fly  4288 P--GTPEAVDWD-KDHVDLVWRPPINDGGSPITGYVVEKREKGTDKWIKGTEITIPCLGEECK-- 4347
            |  |...|:..| ...:.:.|.||:   .|...|.:              ||..|.|||.|.:  
Human   771 PPQGVAVALGGDGNSSITVSWEPPL---PSQQNGVI--------------TEYQIWCLGNESRFH 818

  Fly  4348 -----------ATVPTLNENCEYEFRVKAINAAGPGEPSDASKPIITK---PRKLAPKID----- 4393
                       |.:..|.....|...|.|..:||.|.|   |.|::.:   |..|.|.::     
Human   819 LNRSAAGWARSAMLRGLVPGLLYRTLVAAATSAGVGVP---SAPVLVQLPSPPDLEPGLEVGAGL 880

  Fly  4394 ----RKNIRTYNFKSGEPIFLDINISGEPA----------PDVTWNQNNK---SVQTTSFSHIEN 4441
                .:.:|       ||.||    :|..|          ..:.|.:..:   |..|.||::...
Human   881 AVRLARVLR-------EPAFL----AGSGAACGALLLGLCAALYWRRKQRKELSHYTASFAYTPA 934

  Fly  4442 LPY-NTKYINNNPERKDTGLYKISAHNFYGQDQVEFQINIITKPGKPEGPLEVSEVHKDGCKLKW 4505
            :.: :::.::....|...||                            ||...|.:..     .|
Human   935 VSFPHSEGLSGASSRPPMGL----------------------------GPAPYSWLAD-----SW 966

  Fly  4506 KKP--KDDGGEPVESYLVEKFDPD------TGIWLPVGRS--------DGPEYNVDGLVPGHDYK 4554
            ..|  .....||..|......|||      .||.|.:.::        :||.|:           
Human   967 PHPSRSPSAQEPRGSCCPSNPDPDDRYYNEAGISLYLAQTARGTAAPGEGPVYS----------- 1020

  Fly  4555 FRVKAVNKEGESEPLETLGSIIAKDPFSVPTKPGVPE-------------PTDWT-------ANK 4599
                .::..||.  |:|...             |.|:             |.:|:       ..|
Human  1021 ----TIDPAGEE--LQTFHG-------------GFPQHPSGDLGPWSQYAPPEWSQGDSGAKGGK 1066

  Fly  4600 VELAWPEPASDGGSPIQGYIVEVKDKYSPLWEKALETNSPTPTATVQGLIEGNEYQFRVVALNKG 4664
            |:|.        |.|:|        ..|..|.:||   .|.|.:.....:||.|.:..       
Human  1067 VKLL--------GKPVQ--------MPSLNWPEAL---PPPPPSCELSCLEGPEEELE------- 1105

  Fly  4665 GLSEPSDPSKIFTAKPRYLAPKIDRRNLRNITLSSGTALKLDANITGEPAPKVEWKLSNYHLQSG 4729
            |.|||.:          :..|..:|.:|...:.|.|..:......|..|.|       :|..||.
Human  1106 GSSEPEE----------WCPPMPERSHLTEPSSSGGCLVTPSRRETPSPTP-------SYGQQST 1153

  Fly  4730 KNVTIETPDYYTKLVIRPTQRSDSGEYLVTATNTSGKDSVLVNVVITDKPSPPNGPLQISDVHKE 4794
            ..:|...||        |.|......:|              :.:....|..|:.||.:|   :.
Human  1154 ATLTPSPPD--------PPQPPTDMPHL--------------HQMPRRVPLGPSSPLSVS---QP 1193

  Fly  4795 GCHLKWKRPSDDGGTPIEYFQIDKLEPETGCWIPSCRSTEPQVDVTGLSPGNEYKFRVSAVNAEG 4859
            ...::..||:..|..|       ...|..        |..|.......:||..::       ..|
Human  1194 MLGIREARPAGLGAGP-------AASPHL--------SPSPAPSTASSAPGRTWQ-------GNG 1236

  Fly  4860 E-SQPLVGDESIVARNPFDEPGKPEN----LKATDWDKDHVDLAWTPPLIDGGSPISCYIIEKQD 4919
            | :.||.|..:...:.|...|.:.||    |..........:.:|...|...||..|.    :::
Human  1237 EMTPPLQGPRARFRKKPKALPYRRENSPGDLPPPPLPPPEEEASWALELRAAGSMSSL----ERE 1297

  Fly  4920 KYGKWERALDVPADQCKATIPD------------LVEGQTYKFRVSAVNAAGTGEPSDST 4967
            :.|:.:....||....:...||            |..||    ..|..:.||:.....|:
Human  1298 RSGERKAVQAVPLAAQRVLHPDEEAWLPYSRPSFLSRGQ----GTSTCSTAGSNSSRGSS 1353

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
btNP_001162825.1 I-set 9..101 CDD:254352
Ig 26..100 CDD:143165
I-set 119..210 CDD:254352
Ig 136..209 CDD:143165
I-set 228..320 CDD:254352
IGc2 242..312 CDD:197706
I-set 335..425 CDD:254352
Ig 350..423 CDD:143165
Ig 436..530 CDD:299845
I-set 438..532 CDD:254352
I-set 545..636 CDD:254352
Ig 560..633 CDD:143165
Ig 657..731 CDD:143165
I-set 746..835 CDD:254352
Ig 1496..1586 CDD:299845
IG_like 1503..1588 CDD:214653
I-set 1639..1724 CDD:254352
IG 1750..1821 CDD:214652
IGc2 1750..1806 CDD:197706
I-set 1826..1909 CDD:254352
Ig 1831..1897 CDD:299845
I-set 1914..1998 CDD:254352
Ig 2020..2095 CDD:299845
FN3 2100..2194 CDD:238020
FN3 2203..2292 CDD:238020
I-set 2311..2395 CDD:254352
Ig 2321..2395 CDD:299845
FN3 2399..2493 CDD:238020
FN3 2501..2590 CDD:238020
I-set 2602..2693 CDD:254352
Ig 2619..2693 CDD:299845
FN3 2697..2793 CDD:238020
FN3 2801..2893 CDD:238020
I-set 2902..2995 CDD:254352
Ig 2919..2993 CDD:299845
FN3 2999..3088 CDD:238020
FN3 3102..3191 CDD:238020
I-set 3208..3292 CDD:254352
Ig 3219..3292 CDD:299845
FN3 3296..3390 CDD:238020
FN3 3400..3489 CDD:238020 3/12 (25%)
I-set 3494..3590 CDD:254352 26/104 (25%)
Ig 3516..3590 CDD:299845 21/82 (26%)
FN3 3594..3682 CDD:238020 18/100 (18%)
FN3 3694..3781 CDD:238020 24/94 (26%)
I-set 3795..3885 CDD:254352 18/99 (18%)
Ig 3813..3885 CDD:299845 15/81 (19%)
FN3 3889..3980 CDD:238020 22/122 (18%)
FN3 3990..4082 CDD:238020 29/97 (30%)
I-set 4090..4181 CDD:254352 10/90 (11%)
Ig 4108..4181 CDD:299845 10/72 (14%)
FN3 4185..4271 CDD:238020 18/86 (21%)
FN3 4285..4383 CDD:238020 28/113 (25%)
Ig 4404..4480 CDD:299845 14/89 (16%)
FN3 4484..4571 CDD:238020 20/102 (20%)
FN3 4584..4677 CDD:238020 23/112 (21%)
I-set 4685..4775 CDD:254352 17/89 (19%)
Ig 4703..4775 CDD:299845 12/71 (17%)
FN3 4779..4863 CDD:238020 16/84 (19%)
FN3 4879..4970 CDD:238020 21/105 (20%)
IG 4989..5069 CDD:214652
Ig 4996..5069 CDD:299845
FN3 5073..5166 CDD:238020
FN3 5175..5265 CDD:238020
I-set 5276..5366 CDD:254352
Ig 5293..5366 CDD:299845
FN3 5370..5462 CDD:238020
FN3 5470..5561 CDD:238020
Ig 5559..5654 CDD:299845
I-set 5570..5660 CDD:254352
FN3 5664..5755 CDD:238020
FN3 5764..5853 CDD:238020
I-set 5865..5954 CDD:254352
Ig 5882..5954 CDD:299845
FN3 5958..6049 CDD:238020
FN3 6062..6153 CDD:238020
I-set 6173..6255 CDD:254352
Ig_Titin_like 6182..6255 CDD:143225
FN3 6259..6350 CDD:238020
FN3 6359..6451 CDD:238020
FN3 6470..6552 CDD:238020
I-set 6564..6650 CDD:254352
Ig_Titin_like 6577..6650 CDD:143225
FN3 6654..6745 CDD:238020
FN3 6754..6840 CDD:238020
I-set 6855..6946 CDD:254352
Ig 6874..6946 CDD:299845
FN3 6950..7042 CDD:238020
FN3 7050..7139 CDD:238020
FN3 7151..7237 CDD:238020
I-set 7254..7334 CDD:254352
Ig 7272..7339 CDD:143165
IG_like 7354..7440 CDD:214653
Ig 7366..7440 CDD:299845
FN3 7444..7531 CDD:238020
FN3 7545..7637 CDD:238020
I-set 7648..7737 CDD:254352
Ig 7665..7734 CDD:143165
Ig 7760..7833 CDD:299845
FN3 7837..7927 CDD:238020
STKc_Twitchin_like 7986..8244 CDD:271016
S_TKc 7989..8244 CDD:214567
Ig 8311..8394 CDD:299845
I-set 8312..8401 CDD:254352
I-set 8437..8525 CDD:254352
Ig 8455..8519 CDD:143165
I-set 8632..8721 CDD:254352
IGc2 8646..8711 CDD:197706
I-set 8740..8831 CDD:254352
Ig 8757..8826 CDD:143165
I-set 8839..8922 CDD:254352
Ig 8845..>8909 CDD:299845
ROBO3NP_071765.2 Ig 64..162 CDD:299845 25/103 (24%)
I-set 64..161 CDD:254352 24/102 (24%)
I-set 168..249 CDD:254352 19/107 (18%)
Ig 170..254 CDD:299845 19/110 (17%)
I-set 258..343 CDD:254352 28/112 (25%)
Ig 275..343 CDD:299845 24/95 (25%)
I-set 347..441 CDD:254352 19/105 (18%)
Ig 361..450 CDD:299845 19/95 (20%)
I-set 451..531 CDD:254352 15/82 (18%)
IGc2 465..528 CDD:197706 9/65 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 541..563 8/28 (29%)
FN3 556..649 CDD:238020 30/102 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 639..662 6/50 (12%)
FN3 680..760 CDD:238020 24/115 (21%)
FN3 770..863 CDD:238020 27/112 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 965..989 5/23 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1028..1310 73/390 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1327..1386 7/31 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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