DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bt and LRRC4C

DIOPT Version :9

Sequence 1:	NP_001162825.1	Gene:	bt / 43814	FlyBaseID:	FBgn0005666	Length:	8933	Species:	Drosophila melanogaster
Sequence 2:	NP_001245348.1	Gene:	LRRC4C / 57689	HGNCID:	29317	Length:	640	Species:	Homo sapiens

Alignment Length:	276	Identity:	57/276 - (20%)
Similarity:	85/276 - (30%)	Gaps:	89/276 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   409 RCNAINMYGESNANIALNFQGASDANGF---APSFIEKPRIIPNESGTLITMKCKCKAKPEPTVT 470
            |||       :..|:...:.|..|.|.|   ||..:|.|..:....|....:||:.... ..:|:
Human   329 RCN-------TPPNLKGRYIGELDQNYFTCYAPVIVEPPADLNVTEGMAAELKCRASTS-LTSVS 385

  Fly   471 WYRGQDLVEKSKKIKINTTVIAEDTYELTLEIKDPGATDGGTYRCNVKNEYGESNANLNLNIEA- 534
            |......|......|:...|:::.|...|    :....|.|.|.|.|.|..|.:.|:..||:.|
Human   386 WITPNGTVMTHGAYKVRIAVLSDGTLNFT----NVTVQDTGMYTCMVSNSVGNTTASATLNVTAA 446

  Fly   535 ----------------EPEPEGEGPTFIEKPRIVSENNGKLVIMECKVKADPKPDVIWFRNGEVI 583
                            ||..        ::.|....|.|            |.|.|.|
Human   447 TTTPFSYFSTVTVETMEPSQ--------DEARTTDNNVG------------PTPVVDW------- 484

  Fly   584 KESNKIKTFIEQRGDQYYIKLELLDPQLEDSGLYKCNIKNTLGELNANLTLNIEIVPVIKDKPKI 648
             |:..:.|              .|.||...|               ...|..|.:..:....|.|
Human   485 -ETTNVTT--------------SLTPQSTRS---------------TEKTFTIPVTDINSGIPGI 519

  Fly   649 IKIIKKRTVVIECTVA 664
            .:::|...::|.|.||
Human   520 DEVMKTTKIIIGCFVA 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bt	NP_001162825.1	I-set	9..101	CDD:254352
		Ig	26..100	CDD:143165
		I-set	119..210	CDD:254352
		Ig	136..209	CDD:143165
		I-set	228..320	CDD:254352
		IGc2	242..312	CDD:197706
		I-set	335..425	CDD:254352	4/15 (27%)
		Ig	350..423	CDD:143165	3/13 (23%)
		Ig	436..530	CDD:299845	23/96 (24%)
		I-set	438..532	CDD:254352	22/93 (24%)
		I-set	545..636	CDD:254352	14/90 (16%)
		Ig	560..633	CDD:143165	10/72 (14%)
		Ig	657..731	CDD:143165	4/8 (50%)
		I-set	746..835	CDD:254352
		Ig	1496..1586	CDD:299845
		IG_like	1503..1588	CDD:214653
		I-set	1639..1724	CDD:254352
		IG	1750..1821	CDD:214652
		IGc2	1750..1806	CDD:197706
		I-set	1826..1909	CDD:254352
		Ig	1831..1897	CDD:299845
		I-set	1914..1998	CDD:254352
		Ig	2020..2095	CDD:299845
		FN3	2100..2194	CDD:238020
		FN3	2203..2292	CDD:238020
		I-set	2311..2395	CDD:254352
		Ig	2321..2395	CDD:299845
		FN3	2399..2493	CDD:238020
		FN3	2501..2590	CDD:238020
		I-set	2602..2693	CDD:254352
		Ig	2619..2693	CDD:299845
		FN3	2697..2793	CDD:238020
		FN3	2801..2893	CDD:238020
		I-set	2902..2995	CDD:254352
		Ig	2919..2993	CDD:299845
		FN3	2999..3088	CDD:238020
		FN3	3102..3191	CDD:238020
		I-set	3208..3292	CDD:254352
		Ig	3219..3292	CDD:299845
		FN3	3296..3390	CDD:238020
		FN3	3400..3489	CDD:238020
		I-set	3494..3590	CDD:254352
		Ig	3516..3590	CDD:299845
		FN3	3594..3682	CDD:238020
		FN3	3694..3781	CDD:238020
		I-set	3795..3885	CDD:254352
		Ig	3813..3885	CDD:299845
		FN3	3889..3980	CDD:238020
		FN3	3990..4082	CDD:238020
		I-set	4090..4181	CDD:254352
		Ig	4108..4181	CDD:299845
		FN3	4185..4271	CDD:238020
		FN3	4285..4383	CDD:238020
		Ig	4404..4480	CDD:299845
		FN3	4484..4571	CDD:238020
		FN3	4584..4677	CDD:238020
		I-set	4685..4775	CDD:254352
		Ig	4703..4775	CDD:299845
		FN3	4779..4863	CDD:238020
		FN3	4879..4970	CDD:238020
		IG	4989..5069	CDD:214652
		Ig	4996..5069	CDD:299845
		FN3	5073..5166	CDD:238020
		FN3	5175..5265	CDD:238020
I-set	5276..5366	CDD:254352
Ig	5293..5366	CDD:299845
FN3	5370..5462	CDD:238020
FN3	5470..5561	CDD:238020
Ig	5559..5654	CDD:299845
I-set	5570..5660	CDD:254352
FN3	5664..5755	CDD:238020
FN3	5764..5853	CDD:238020
I-set	5865..5954	CDD:254352
Ig	5882..5954	CDD:299845
FN3	5958..6049	CDD:238020
FN3	6062..6153	CDD:238020
I-set	6173..6255	CDD:254352
Ig_Titin_like	6182..6255	CDD:143225
FN3	6259..6350	CDD:238020
FN3	6359..6451	CDD:238020
FN3	6470..6552	CDD:238020
I-set	6564..6650	CDD:254352
Ig_Titin_like	6577..6650	CDD:143225
FN3	6654..6745	CDD:238020
FN3	6754..6840	CDD:238020
I-set	6855..6946	CDD:254352
Ig	6874..6946	CDD:299845
FN3	6950..7042	CDD:238020
FN3	7050..7139	CDD:238020
FN3	7151..7237	CDD:238020
I-set	7254..7334	CDD:254352
Ig	7272..7339	CDD:143165
IG_like	7354..7440	CDD:214653
Ig	7366..7440	CDD:299845
FN3	7444..7531	CDD:238020
FN3	7545..7637	CDD:238020
I-set	7648..7737	CDD:254352
Ig	7665..7734	CDD:143165
Ig	7760..7833	CDD:299845
FN3	7837..7927	CDD:238020
STKc_Twitchin_like	7986..8244	CDD:271016
S_TKc	7989..8244	CDD:214567
Ig	8311..8394	CDD:299845
I-set	8312..8401	CDD:254352
I-set	8437..8525	CDD:254352
Ig	8455..8519	CDD:143165
I-set	8632..8721	CDD:254352
IGc2	8646..8711	CDD:197706
I-set	8740..8831	CDD:254352
Ig	8757..8826	CDD:143165
I-set	8839..8922	CDD:254352
Ig	8845..>8909	CDD:299845
LRRC4C	NP_001245348.1	LRRNT	47..80	CDD:214470
		PPP1R42	65..235	CDD:411060
		LRR 1	77..98
		leucine-rich repeat	78..101	CDD:275380
		LRR 2	101..122
		leucine-rich repeat	102..125	CDD:275380
		LRR 3	125..146
		leucine-rich repeat	126..149	CDD:275380
		LRR 4	149..170
		leucine-rich repeat	150..173	CDD:275380
		LRR 5	173..195
		leucine-rich repeat	174..198	CDD:275380
		LRR 6	198..219
		leucine-rich repeat	199..220	CDD:275380
		LRR_8	220..279	CDD:404697
		LRR 7	220..241
		leucine-rich repeat	221..244	CDD:275380
		LRR 8	244..265
		leucine-rich repeat	245..268	CDD:275380
		LRR_8	267..>301	CDD:404697
		LRR 9	268..289
		leucine-rich repeat	269..290	CDD:275380
		LRRCT	301..>339	CDD:214507	4/16 (25%)
		IG	360..443	CDD:214652	20/87 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	463..483		7/39 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910