DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment bt and PTK7

DIOPT Version :9

Sequence 1:NP_001162825.1 Gene:bt / 43814 FlyBaseID:FBgn0005666 Length:8933 Species:Drosophila melanogaster
Sequence 2:NP_001257327.1 Gene:PTK7 / 5754 HGNCID:9618 Length:1078 Species:Homo sapiens


Alignment Length:1105 Identity:224/1105 - (20%)
Similarity:398/1105 - (36%) Gaps:277/1105 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MGVAEDFAPSFVKKPQLHQEDDGNRLIFECQLLSSPKPDIEWFRSDNKVVEDVRTKFKIQPVGEN 65
            :|.....|..|:|:|.......|.|.:..|: :.:|.|...::..|...|:|...:|   ..|.:
Human    32 VGPGTQTAIVFIKQPSSQDALQGRRALLRCE-VEAPGPVHVYWLLDGAPVQDTERRF---AQGSS 92

  Fly    66 -KYTVVLELDDVVETDAGLYKVKAKNK-SGEVSASINLNFTPADEPKEKQIDGFAPTFAKKPAIR 128
             .:..|..|.     |:|.::..|::. :||.:.|.|.:|      ..|.|:. .|...|.||..
Human    93 LSFAAVDRLQ-----DSGTFQCVARDDVTGEEARSANASF------NIKWIEA-GPVVLKHPASE 145

  Fly   129 QE-EDGKRLLFECRVNADPIPAIIWFHNGAAVKESERHKITVDKDVHSYFATLEILNVTV----- 187
            .| :...::...|.::..|.|...||.:|..:.:.:.:.....|:          .|:|:     
Human   146 AEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKE----------RNLTLRPAGP 200

  Fly   188 EDAGKYKVNAKNELGES----NATISLNFDSDEAPVPESAEGIKPTFTERPVIRQSEDGGNVTFE 248
            |.:|.|...|.:..|::    |.|:|: .|...|.|..:.:.:        |:.:.|:   ..|.
Human   201 EHSGLYSCCAHSAFGQACSSQNFTLSI-ADESFARVVLAPQDV--------VVARYEE---AMFH 253

  Fly   249 CRCVGDPTPTVTWSHGETELNESNRYKMSLTMDQKLYHIACLEISSVVSSDQGEYRAQAKNKHGS 313
            |:....|.|::.|.. |.|...:||.:........::....|.::.|...:.|.||...:.:.|.
Human   254 CQFSAQPPPSLQWLF-EDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGP 317

  Fly   314 GV---ATINLNFESGSKKIPDGKSPRF-PKKPTIRQEEDLLIMECVLEAHPVPDIVWYCSEKEIC 374
            .:   ||::|      .:|.|  .|.| |:..|...||.:..:.  .:..|.|.:.|..:...:.
Human   318 PIILEATLHL------AEIED--MPLFEPRVFTAGSEERVTCLP--PKGLPEPSVWWEHAGVRLP 372

  Fly   375 NNQRTKMTRKAITKDSYILTLEIQNPTKEDGGNYRCNAINMYGESNANIALNFQGASDANGFAPS 439
            .:.|       :.:..:.|.|  .|..:.|.|.|.|:|.|:.|:...::  |...|:     .||
Human   373 THGR-------VYQKGHELVL--ANIAESDAGVYTCHAANLAGQRRQDV--NITVAT-----VPS 421

  Fly   440 FIEKPRIIPNESGTLITMKCKCKAKPEPTVTWYRGQDLVEKSKKIKINTTVIAEDTYELTLEIKD 504
            :::||:....|.|....:.|..:|.|:|||.|||.|.|:.:..:.::....        ||.|..
Human   422 WLKKPQDSQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNG--------TLRINS 478

  Fly   505 PGATDGGTYRCNVKNEYGESNANLNLNI----EAEPEPEGEGPTFIEKPRIVSENNGKLVIMECK 565
            ....||..|||......|...|...:.:    :..|.|:.:.....:|...|          .|.
Human   479 VEVYDGTWYRCMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATV----------PCS 533

  Fly   566 VKADPKPDVIWFR-NGEVIKESNKIKTFIEQRGDQYYIKLELLDPQLEDSGLYKCNIKN-TLGEL 628
            .....||.:.|.| :|..:.|     ...:..|..::.::     ..:|:|.|.|...| ..|::
Human   534 ATGREKPTIKWERADGSSLPE-----WVTDNAGTLHFARV-----TRDDAGNYTCIASNGPQGQI 588

  Fly   629 NANLTLNIEIVPVIKDKPKIIKIIKKRTVVIECTVASKFEPKCTWYKETSTVKESK----RHVYQ 689
            .|::.|.:.:....|.:|:...:.:..|.:::|......:|...|..:...:..:|    .|::|
Human   589 RAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQ 653

  Fly   690 VEQTKEGEFAVKLEINDVEESDKGAYKLVASN----EKGEAVSQIVNLVDIPEEERKPCKPEISR 750
                 .|    .|.|:||...|.|.|..:|.|    :..||...:|: ..:|||...|..|...:
Human   654 -----NG----SLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVD-KPVPEESEGPGSPPPYK 708

  Fly   751 KLADQKVAESKTFELLVSLSQTDRKCKVEWYKGSTVIRETKDITTTFDGTTARLTFSSARTEHTS 815
            .:        :|..|.|               |:.|.                            
Human   709 MI--------QTIGLSV---------------GAAVA---------------------------- 722

  Fly   816 NYKVIVTNEVGKDESSCKITVEKVAKKKEEKPKEKEKTKNEKEVEQKEMEEDKNESGQSVAQTEG 880
             |.:.|...:...:..||      ||:.:::|          |.|:.|||               
Human   723 -YIIAVLGLMFYCKKRCK------AKRLQKQP----------EGEEPEME--------------- 755

  Fly   881 RINIEQISEGDPKEELTVKEEILDKRDTQEVKESSVELQDSAGHEVPEPKKATSDS-KLDQSNQK 944
            .:|...:..|.|..|:           .:||..:|:    .:|......:.:|||. ...:|:.:
Human   756 CLNGGPLQNGQPSAEI-----------QEEVALTSL----GSGPAATNKRHSTSDKMHFPRSSLQ 805

  Fly   945 NLDKKHKTDQSESKTNKNVSLAEPIKSNKQESEEQQATEQIGLKKVDRKASIVSVKEEISSDVRR 1009
            .:....|::..|      |.||      |.:..|:...|.:.|.|     |:.|..|:...|.||
Human   806 PITTLGKSEFGE------VFLA------KAQGLEEGVAETLVLVK-----SLQSKDEQQQLDFRR 853

  Fly  1010 KSTIKAK-----------------------EEITVDDKKASSRRSSLAVEESNTESRRSSIIDKK 1051
            :..:..|                       |.:.:.|.|     ..|.:.:|..|..:|..:..|
Human   854 ELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLK-----QFLRISKSKDEKLKSQPLSTK 913

  Fly  1052  1051
            Human   914  913

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
btNP_001162825.1 I-set 9..101 CDD:254352 21/93 (23%)
Ig 26..100 CDD:143165 16/75 (21%)
I-set 119..210 CDD:254352 21/100 (21%)
Ig 136..209 CDD:143165 16/81 (20%)
I-set 228..320 CDD:254352 19/94 (20%)
IGc2 242..312 CDD:197706 14/69 (20%)
I-set 335..425 CDD:254352 20/90 (22%)
Ig 350..423 CDD:143165 14/72 (19%)
Ig 436..530 CDD:299845 27/93 (29%)
I-set 438..532 CDD:254352 27/93 (29%)
I-set 545..636 CDD:254352 18/92 (20%)
Ig 560..633 CDD:143165 15/74 (20%)
Ig 657..731 CDD:143165 18/81 (22%)
I-set 746..835 CDD:254352 10/88 (11%)
Ig 1496..1586 CDD:299845
IG_like 1503..1588 CDD:214653
I-set 1639..1724 CDD:254352
IG 1750..1821 CDD:214652
IGc2 1750..1806 CDD:197706
I-set 1826..1909 CDD:254352
Ig 1831..1897 CDD:299845
I-set 1914..1998 CDD:254352
Ig 2020..2095 CDD:299845
FN3 2100..2194 CDD:238020
FN3 2203..2292 CDD:238020
I-set 2311..2395 CDD:254352
Ig 2321..2395 CDD:299845
FN3 2399..2493 CDD:238020
FN3 2501..2590 CDD:238020
I-set 2602..2693 CDD:254352
Ig 2619..2693 CDD:299845
FN3 2697..2793 CDD:238020
FN3 2801..2893 CDD:238020
I-set 2902..2995 CDD:254352
Ig 2919..2993 CDD:299845
FN3 2999..3088 CDD:238020
FN3 3102..3191 CDD:238020
I-set 3208..3292 CDD:254352
Ig 3219..3292 CDD:299845
FN3 3296..3390 CDD:238020
FN3 3400..3489 CDD:238020
I-set 3494..3590 CDD:254352
Ig 3516..3590 CDD:299845
FN3 3594..3682 CDD:238020
FN3 3694..3781 CDD:238020
I-set 3795..3885 CDD:254352
Ig 3813..3885 CDD:299845
FN3 3889..3980 CDD:238020
FN3 3990..4082 CDD:238020
I-set 4090..4181 CDD:254352
Ig 4108..4181 CDD:299845
FN3 4185..4271 CDD:238020
FN3 4285..4383 CDD:238020
Ig 4404..4480 CDD:299845
FN3 4484..4571 CDD:238020
FN3 4584..4677 CDD:238020
I-set 4685..4775 CDD:254352
Ig 4703..4775 CDD:299845
FN3 4779..4863 CDD:238020
FN3 4879..4970 CDD:238020
IG 4989..5069 CDD:214652
Ig 4996..5069 CDD:299845
FN3 5073..5166 CDD:238020
FN3 5175..5265 CDD:238020
I-set 5276..5366 CDD:254352
Ig 5293..5366 CDD:299845
FN3 5370..5462 CDD:238020
FN3 5470..5561 CDD:238020
Ig 5559..5654 CDD:299845
I-set 5570..5660 CDD:254352
FN3 5664..5755 CDD:238020
FN3 5764..5853 CDD:238020
I-set 5865..5954 CDD:254352
Ig 5882..5954 CDD:299845
FN3 5958..6049 CDD:238020
FN3 6062..6153 CDD:238020
I-set 6173..6255 CDD:254352
Ig_Titin_like 6182..6255 CDD:143225
FN3 6259..6350 CDD:238020
FN3 6359..6451 CDD:238020
FN3 6470..6552 CDD:238020
I-set 6564..6650 CDD:254352
Ig_Titin_like 6577..6650 CDD:143225
FN3 6654..6745 CDD:238020
FN3 6754..6840 CDD:238020
I-set 6855..6946 CDD:254352
Ig 6874..6946 CDD:299845
FN3 6950..7042 CDD:238020
FN3 7050..7139 CDD:238020
FN3 7151..7237 CDD:238020
I-set 7254..7334 CDD:254352
Ig 7272..7339 CDD:143165
IG_like 7354..7440 CDD:214653
Ig 7366..7440 CDD:299845
FN3 7444..7531 CDD:238020
FN3 7545..7637 CDD:238020
I-set 7648..7737 CDD:254352
Ig 7665..7734 CDD:143165
Ig 7760..7833 CDD:299845
FN3 7837..7927 CDD:238020
STKc_Twitchin_like 7986..8244 CDD:271016
S_TKc 7989..8244 CDD:214567
Ig 8311..8394 CDD:299845
I-set 8312..8401 CDD:254352
I-set 8437..8525 CDD:254352
Ig 8455..8519 CDD:143165
I-set 8632..8721 CDD:254352
IGc2 8646..8711 CDD:197706
I-set 8740..8831 CDD:254352
Ig 8757..8826 CDD:143165
I-set 8839..8922 CDD:254352
Ig 8845..>8909 CDD:299845
PTK7NP_001257327.1 IG_like 46..120 CDD:214653 18/82 (22%)
IGc2 53..113 CDD:197706 15/68 (22%)
Ig2_PTK7 154..230 CDD:143237 17/86 (20%)
IG_like 239..>309 CDD:214653 15/81 (19%)
Ig 250..310 CDD:143165 14/60 (23%)
IG 348..416 CDD:214652 15/80 (19%)
IGc2 348..406 CDD:197706 13/68 (19%)
I-set 420..506 CDD:254352 27/93 (29%)
Ig 422..506 CDD:299845 25/91 (27%)
I-set 511..596 CDD:254352 20/104 (19%)
IGc2 528..582 CDD:197706 13/73 (18%)
IG_like 606..689 CDD:214653 20/91 (22%)
IGc2 613..677 CDD:197706 16/72 (22%)
PTK_CCK4 798..1071 CDD:133178 26/138 (19%)
STYKc 809..1069 CDD:214568 25/127 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4475
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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