DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bt and ALPK3

DIOPT Version :9

Sequence 1:	NP_001162825.1	Gene:	bt / 43814	FlyBaseID:	FBgn0005666	Length:	8933	Species:	Drosophila melanogaster
Sequence 2:	NP_065829.4	Gene:	ALPK3 / 57538	HGNCID:	17574	Length:	1705	Species:	Homo sapiens

Alignment Length:	2061	Identity:	380/2061 - (18%)
Similarity:	613/2061 - (29%)	Gaps:	723/2061 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VAEDFAPSF---VKKPQLHQEDDGNRLIFECQLLSSPKPDIEWFRSDNKVVEDV-RTKFKIQPVG 63
            :.|:..|.|   :|...:.::.|   :.|.|.:...|:|::.|::.|.::.... ..|::|...|
Human    71 LTEETQPLFETTLKSRSVSEDSD---VRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQG 132

  Fly    64 ENKYTVVLELDDVVETDAGLYKVKAKNKSGEVSASINLNFTPADEPKEKQIDGFAPTFAK---KP 125
             |::|  |:|....|.||.:|:..|:|..|.||.|..|......|.|..|     ..|||   |.
Human   133 -NRHT--LQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTMTEYKIHQ-----RWFAKLKRKA 189

  Fly   126 AIRQEEDGKRLLFECRVNADPIPAIIWFHNGAAVKESERHKITVDKDVHSYFATLEILNVTVEDA 190
            |.:..|                           :::|.:|:..|..:|.           |:...
Human   190 AAKLRE---------------------------IEQSWKHEKAVPGEVD-----------TLRKL 216

  Fly   191 GKYKVNAKNELGESNATISLNFDSDEAPVPESAEGIKPTFTERPVIRQSEDGGNVTFECRCVGDP 255
            ...:...|..|..:           :||.|.     .||        :..:||.:
Human   217 SPDRFQRKRRLSGA-----------QAPGPS-----VPT--------REPEGGTL---------- 247

  Fly   256 TPTVTWSHGETELNESNRYKMSLTMDQKLYHIACLEISSVVSSDQGEYRAQAKNKHGSGVATINL 320
               ..|..||||..:               |.....|:|..|.:                  :..
Human   248 ---AAWQEGETETAQ---------------HSGLGLINSFASGE------------------VTT 276

  Fly   321 NFESGSKKIPDGKSPRFPKKPTIRQEEDLLIMEC-VLEAHPVPDIVWYCSEKEICNNQRTKMTRK 384
            |.|:..:...||             |..||...| .:|..|...:......|:...::.:|.
Human   277 NGEAAPENGEDG-------------EHGLLTYICDAMELGPQRALKEESGAKKKKKDEESKQ--- 325

  Fly   385 AITKDSYILTLEIQNPTKEDGGNYRCNAINMYGESNANIALNFQGASDANGFAPSFIE----KPR 445
                       .::.|..|.....|.::.|....|:...:...||        |..:|    :||
Human   326 -----------GLRKPELEKAAQSRRSSENCIPSSDEPDSCGTQG--------PVGVEQVQTQPR 371

  Fly   446 ----IIPNESGTLITMK--------CKCKAKPEPTVTWYRGQDLVEKSKKIKINTTVIAEDTYE- 497
                ..|..|||..|.|        .|.:..|.|.    .||::....|.:.:..|.......|
Human   372 GRAARGPGSSGTDSTRKPASAVGTPDKAQKAPGPG----PGQEVYFSLKDMYLENTQAVRPLGEE 432

  Fly   498 --LTLEIKDPGATDGGTYRCNVKNEYGESNANLNLNIEAEPEPEGEGPTFIEKPRIVSENNGKLV 560
              .||.::.||.:..|             .|.|....|..|...|: ||....|:.....|.|..
Human   433 GPQTLSVRAPGESPKG-------------KAPLRARSEGVPGAPGQ-PTHSLTPQPTRPFNRKRF 483

  Fly   561 IMECKVKADPKPDVIWFRNGEVIKESNKIKTFIEQRGDQYYIKLELLDPQLEDSGLYKCNIKNTL 625
                   |.|||      .||...:|..|.:.                .|..:.|      ..:|
Human   484 -------APPKP------KGEATTDSKPISSL----------------SQAPECG------AQSL 513

  Fly   626 GELNANLTLNIEIVPVIKDKPKIIKIIK----KRT--VVIECTVASKFEPKCTWYKETSTVKESK 684
            |:.....::.:...|..:........::    .||  .|:||              :|:|..
Human   514 GKAPPQASVQVPTPPARRRHGTRDSTLQGQAGHRTPGEVLEC--------------QTTTAP--- 561

  Fly   685 RHVYQVEQTKEGEFAVKLEINDVEESDKGAYKLVASNEKGEAVSQIVNLVDIPEEERKPCKPEIS 749
                              .::....||..:..:..|..:|     |:..:|:..:|.       .
Human   562 ------------------TMSASSSSDVASIGVSTSGSQG-----IIEPMDMETQED-------G 596

  Fly   750 RKLADQKVAESKTFELLVSLSQTDRKCKVEWYKGSTVIRETKDITTTFDGT-TARLTFSSARTE- 812
            |..|:|:....|..       |.|.|.:|             |..|..||| ||:.|.:..:|:
Human   597 RTSANQRTGSKKNV-------QADGKIQV-------------DGRTRGDGTQTAQRTRADRKTQV 641

  Fly   813 ------------HTSNYKVIVTNEVGKDESSCKITVEKVAKKKEEKPKEKEKTKNEKEV-EQKEM 864
                        ..|..|.::|.  |:.|:..:.|      :..||.:|..|.:.:|.. |.:.|
Human   642 DAGTQESKRPQSDRSAQKGMMTQ--GRAETQLETT------QAGEKIQEDRKAQADKGTQEDRRM 698

  Fly   865 EEDKNESGQSVAQTEGRINIEQISEGDPKEELTVKEEILDKRDTQEVKESSVELQDSAGHEVP-- 927
            :.:|...|:...|:||  :.....||..::|:..         :......:.:|..:||...|
Human   699 QGEKGMQGEKGTQSEG--SAPTAMEGQSEQEVAT---------SLGPPSRTPKLPPTAGPRAPLN 752

  Fly   928 -EPKKATSDSKLDQSNQKNLDKKHKTDQSESKTNKNVSLAEPIKSN---KQESEEQQATEQIGLK 988
             |....|.:..........|.:..:...:.|:.::...|. |:..|   ..:...:.:.||:|.:
Human   753 IECFVQTPEGSCFPKKPGCLPRSEEAVVTASRNHEQTVLG-PLSGNLMLPAQPPHEGSVEQVGGE 816

  Fly   989 KV--DRKASIVSVKEE---------------------------ISSDVRRKSTIKAKEEITVDDK 1024
            :.  .:.:..|..|:|                           :|.:|....::.. ..:|...|
Human   817 RCRGPQSSGPVEAKQEDSPFQCPKEERPGGVPCMDQGGCPLAGLSQEVPTMPSLPG-TGLTASPK 880

  Fly  1025 KASSRRSSLAVEESNTESRRSSIIDKKPLEQVDNKPIDANKNPQPLKEEIPRL----------KP 1079
            ....         |...|:..|.....|.|.            |.|....|.|          .|
Human   881 AGPC---------STPTSQHGSTATFLPSED------------QVLMSSAPTLHLGLGTPTQSHP 924

  Fly  1080 AEKRRTSKV--------IEEPKP-----DEGLPK--------LRKASIAQV-----KEEAKPAAP 1118
            .|...||..        :|...|     |.||..        |.|.|..:.     :.:...|..
Human   925 PETMATSSEGACAQVPDVEGRTPGPRSCDPGLIDSLKNYLLLLLKLSSTETSGAGGESQVGAATG 989

  Fly  1119 KLKAKAKAKPKYEELPEIPDYERPQLEKYEKSD---------FTPSDFAR-----DLEI------ 1163
            .|...|...|..|.....|...|..||:.|.:.         .:|....|     |.|:
Human   990 GLVPSATLTPTVEVAGLSPRTSRRILERVENNHLVQSAQTLLLSPCTSRRLTGLLDREVQAGRQA 1054

  Fly  1164 -----------PNKMEKPIIDSGKKEPAVLAQKNGIPKKTDIIEQYADEPKGLKVGKGKLPDEGD 1217
                       |:.:..|.|...:::|.:.::                   |...|:|::..||.
Human  1055 LAAARGSWGPGPSSLTVPAIVVDEEDPGLASE-------------------GASEGEGEVSPEGP 1100

  Fly  1218 GRDGAVLKPVIIEPEKEILDLGNKKNNQHA--DKPTVLDIIKQRRRSSIRNLMTKEPIQNESFLG 1280
            |..||       ..|..:.....:...|.|  ..|:...|             .:||.|.|.|.|
Human  1101 GLLGA-------SQESSMAGRLGEAGGQAAPGQGPSAESI-------------AQEPSQEEKFPG 1145

  Fly  1281 VVLKPVIKDTREQAAPQQAIQLTKANATEQFSPTKAVKAQVADLKKPETLATLEDNYERPVLEKY 1345
            ..|..:...|.|        :|......::|.|    |.:.|.    :..||..:..|.|.:...
Human  1146 EALTGLPAATPE--------ELALGARRKRFLP----KVRAAG----DGEATTPEERESPTVSPR 1194

  Fly  1346 DPFSIDKTKSEKS-TPSIITPDIRGPEVKLPVQETKEEKQKVPKMQPP-APGDPPKIEVIREKRP 1408
            .|        .|| .|.  :|...|.|.:.|.|..|....:||:.:.. |.||
Human  1195 GP--------RKSLVPG--SPGTPGRERRSPTQGRKASMLEVPRAEEELAAGD------------ 1237

  Fly  1409 SLAPEPPSRRGSLIPPA--DTGRRPSLIINDEKKLRPGEVMDTRLLRPGEVGEGQRRRPSIDVRR 1471
             |.|.|  :.|.|....  |.|::.:|       .:|.:..|  ||:..:|           :|:
Human  1238 -LGPSP--KAGGLDTEVALDEGKQETL-------AKPRKAKD--LLKAPQV-----------IRK 1279

  Fly  1472 PSVQDLEDLINKPSTPLRDVGDGGPPSIVDVQESYSVVEDSTAYLTVGVEGSPAPTFKFYKGVSE 1536
            ..|:...|               ...|:....:.::::.||.  ||...:..|         |.|
Human  1280 IRVEQFPD---------------ASGSLKLWCQFFNILSDSV--LTWAKDQRP---------VGE 1318

  Fly  1537 ILEGGRFKFLTDGQTNTITLCMRKCKPNDESKYKIVVSNIHGEDSAEMQLYVSDSSGMDFRAMLK 1601
            :   ||    :.|......|.:.:..|.|...|:..:.|.||..|.:..|.....||     .:.
Human  1319 V---GR----SAGDEGPAALAIVQASPVDCGVYRCTIHNEHGSASTDFCLSPEVLSG-----FIS 1371

  Fly  1602 KRRYQKWDKDEQDPN-----------WGDLKETEKPLPALKKVERKVESFLSPLIDQFAKEGKDK 1655
            :...:..::.|..|.           |||     |....|...|.:...:...|     ::....
Human  1372 REEGEVGEEIEMTPMVFAKGLADSGCWGD-----KLFGRLVSEELRGGGYGCGL-----RKASQA 1426

  Fly  1656 KVVF--EARF-SKPNCKPKWLFRKDEVFTGSKFKFKQENDT------YQLIITTPKVEDTGKYTI 1711
            ||::  |..| |...|..|         ..|...|...::|      |.:.|...|:::..:...
Human  1427 KVIYGLEPIFESGRTCIIK---------VSSLLVFGPSSETSLVGRNYDVTIQGCKIQNMSREYC 1482

  Fly  1712 EIGGVSSTA---FLNVEEADPTYTFTKP------------LKKKLEGFTQH-------------- 1747
            :|....:.|   |..|.|..|.|...:|            |.|.||.:...
Human  1483 KIFAAEARAAPGFGEVPEIIPLYLIYRPANNIPYATLEEDLGKPLESYCSREWGCAEAPTASGSS 1547

  Fly  1748 ETTLECS--------------VSSSMANVHWFKNN----TKL-------ESDDP----RYLISKD 1783
            |...:|.              :.:.:|.|.|...:    |||       ||..|    |:..|..
Human  1548 EAMQKCQTFQHWLYQWTNGSFLVTDLAGVDWKMTDVQIATKLRGYQGLKESCFPALLDRFASSHQ 1612

  Fly  1784 INGNLKLI----------------IKDSVLDDAGLYRCQLDKQPDK 1813
            .|...:|:                .|.|....||....||..||.|
Human  1613 CNAYCELLGLTPLKGPEAAHPQAKAKGSKSPSAGRKGSQLSPQPQK 1658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bt	NP_001162825.1	I-set	9..101	CDD:254352	27/95 (28%)
		Ig	26..100	CDD:143165	23/74 (31%)
		I-set	119..210	CDD:254352	13/93 (14%)
		Ig	136..209	CDD:143165	7/72 (10%)
		I-set	228..320	CDD:254352	13/91 (14%)
		IGc2	242..312	CDD:197706	11/69 (16%)
		I-set	335..425	CDD:254352	13/90 (14%)
		Ig	350..423	CDD:143165	11/73 (15%)
		Ig	436..530	CDD:299845	25/112 (22%)
		I-set	438..532	CDD:254352	25/112 (22%)
		I-set	545..636	CDD:254352	15/90 (17%)
		Ig	560..633	CDD:143165	12/72 (17%)
		Ig	657..731	CDD:143165	9/73 (12%)
		I-set	746..835	CDD:254352	22/102 (22%)
		Ig	1496..1586	CDD:299845	19/89 (21%)
		IG_like	1503..1588	CDD:214653	19/84 (23%)
		I-set	1639..1724	CDD:254352	17/96 (18%)
		IG	1750..1821	CDD:214652	23/109 (21%)
		IGc2	1750..1806	CDD:197706	18/100 (18%)
		I-set	1826..1909	CDD:254352
		Ig	1831..1897	CDD:299845
		I-set	1914..1998	CDD:254352
		Ig	2020..2095	CDD:299845
		FN3	2100..2194	CDD:238020
		FN3	2203..2292	CDD:238020
		I-set	2311..2395	CDD:254352
		Ig	2321..2395	CDD:299845
		FN3	2399..2493	CDD:238020
		FN3	2501..2590	CDD:238020
		I-set	2602..2693	CDD:254352
		Ig	2619..2693	CDD:299845
		FN3	2697..2793	CDD:238020
		FN3	2801..2893	CDD:238020
		I-set	2902..2995	CDD:254352
		Ig	2919..2993	CDD:299845
		FN3	2999..3088	CDD:238020
		FN3	3102..3191	CDD:238020
		I-set	3208..3292	CDD:254352
		Ig	3219..3292	CDD:299845
		FN3	3296..3390	CDD:238020
		FN3	3400..3489	CDD:238020
		I-set	3494..3590	CDD:254352
		Ig	3516..3590	CDD:299845
		FN3	3594..3682	CDD:238020
		FN3	3694..3781	CDD:238020
		I-set	3795..3885	CDD:254352
		Ig	3813..3885	CDD:299845
		FN3	3889..3980	CDD:238020
		FN3	3990..4082	CDD:238020
		I-set	4090..4181	CDD:254352
		Ig	4108..4181	CDD:299845
		FN3	4185..4271	CDD:238020
		FN3	4285..4383	CDD:238020
		Ig	4404..4480	CDD:299845
		FN3	4484..4571	CDD:238020
		FN3	4584..4677	CDD:238020
		I-set	4685..4775	CDD:254352
		Ig	4703..4775	CDD:299845
		FN3	4779..4863	CDD:238020
		FN3	4879..4970	CDD:238020
		IG	4989..5069	CDD:214652
		Ig	4996..5069	CDD:299845
		FN3	5073..5166	CDD:238020
		FN3	5175..5265	CDD:238020
I-set	5276..5366	CDD:254352
Ig	5293..5366	CDD:299845
FN3	5370..5462	CDD:238020
FN3	5470..5561	CDD:238020
Ig	5559..5654	CDD:299845
I-set	5570..5660	CDD:254352
FN3	5664..5755	CDD:238020
FN3	5764..5853	CDD:238020
I-set	5865..5954	CDD:254352
Ig	5882..5954	CDD:299845
FN3	5958..6049	CDD:238020
FN3	6062..6153	CDD:238020
I-set	6173..6255	CDD:254352
Ig_Titin_like	6182..6255	CDD:143225
FN3	6259..6350	CDD:238020
FN3	6359..6451	CDD:238020
FN3	6470..6552	CDD:238020
I-set	6564..6650	CDD:254352
Ig_Titin_like	6577..6650	CDD:143225
FN3	6654..6745	CDD:238020
FN3	6754..6840	CDD:238020
I-set	6855..6946	CDD:254352
Ig	6874..6946	CDD:299845
FN3	6950..7042	CDD:238020
FN3	7050..7139	CDD:238020
FN3	7151..7237	CDD:238020
I-set	7254..7334	CDD:254352
Ig	7272..7339	CDD:143165
IG_like	7354..7440	CDD:214653
Ig	7366..7440	CDD:299845
FN3	7444..7531	CDD:238020
FN3	7545..7637	CDD:238020
I-set	7648..7737	CDD:254352
Ig	7665..7734	CDD:143165
Ig	7760..7833	CDD:299845
FN3	7837..7927	CDD:238020
STKc_Twitchin_like	7986..8244	CDD:271016
S_TKc	7989..8244	CDD:214567
Ig	8311..8394	CDD:299845
I-set	8312..8401	CDD:254352
I-set	8437..8525	CDD:254352
Ig	8455..8519	CDD:143165
I-set	8632..8721	CDD:254352
IGc2	8646..8711	CDD:197706
I-set	8740..8831	CDD:254352
Ig	8757..8826	CDD:143165
I-set	8839..8922	CDD:254352
Ig	8845..>8909	CDD:299845
ALPK3	NP_065829.4	I-set	77..169	CDD:369462	28/97 (29%)
		Atrophin-1	578..>950	CDD:367360	79/445 (18%)
		Ig	1306..1359	CDD:319273	16/70 (23%)
		Alpha_kinase	1383..1617	CDD:355793	47/252 (19%)
		PHA03378	<1624..1705	CDD:223065	9/35 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157007
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930