DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment bt and DSCAML1

DIOPT Version :9

Sequence 1:NP_001162825.1 Gene:bt / 43814 FlyBaseID:FBgn0005666 Length:8933 Species:Drosophila melanogaster
Sequence 2:XP_011541219.1 Gene:DSCAML1 / 57453 HGNCID:14656 Length:2065 Species:Homo sapiens


Alignment Length:2285 Identity:464/2285 - (20%)
Similarity:752/2285 - (32%) Gaps:749/2285 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly  2209 VDLTDWDKDHADLKWEAPE------TDGG---------DPITAYIVEYKEKFSNDWVSGKEVDGD 2258
            |.:..|:||...:   .||      ..||         |.::.|....|.|:     ||:....:
Human   156 VSVVSWEKDTVSI---IPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKY-----SGETRQSN 212

  Fly  2259 ARTATVDGLKEGQQYEFRVRAVNRAGPGEPSDKTKSIIAKCRFVKPFIVGEGLKNVTVKKGQTIR 2323
            ....:|.||         .||.:.....:|::...:|:            :|..:..|..|.|:.
Human   213 GARLSVTGL---------ARAADPLCLPDPAESIPTIL------------DGFHSQEVWAGHTVE 256

  Fly  2324 FDIKYDGEPEPAATWVKGTDNLKFDNQRICLDQLERNSSITIKKSVRKDTGKYKLVLSNSSGTIE 2388
            ......|.|.||..|:|....|..|::     ..:|.:.:||.....:|:|.|...::|:.|:.|
Human   257 LPCTASGYPIPAIRWLKDGRPLPADSR-----WTKRITGLTISDLRTEDSGTYICEVTNTFGSAE 316

  Fly  2389 SEAQVVVLDRPLPPGGPFEPEEIRASHIKMKWKR-PDDDGGCEISGYALERMDEETGRWIPAGEV 2452
            :...::|:| ||              |:.:..|: ....|...|...||....|.|.||....|:
Human   317 ATGILMVID-PL--------------HVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTEL 366

  Fly  2453 GPNETSFDFKGL----------------------------------------TPNKKYKFRVKAI 2477
            ...:.:...:||                                        ||.....|..|.:
Human   367 VLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVV 431

  Fly  2478 NKEGESEPLETFDAIVARNPYDPPSP----PSQPVIDDYDNKSVLLKWKRPPSDGGRPITHYIV- 2537
            |      |.|.|..:.|.....||:.    ..:|::.|..:::     .:.....|..|:|..| 
Human   432 N------PGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRT-----NQYTMSDGTTISHMNVT 485

  Fly  2538 --EIKDKFAPSWSEVAKTDDPNPECNVEGLKEKMVYQFRVRAVNKAGPSEPSQPTDNHLCKHKNL 2600
              :|:|      ..|.:       |....|.....||.|   :|..||                 
Human   486 GPQIRD------GGVYR-------CTARNLVGSAEYQAR---INVRGP----------------- 517

  Fly  2601 KPQIDRSTFKRVTIKSGRTHKWSVDVLGEPIPELHWSWRDDIPLTNGDR-IKIENVDYHTDFSIT 2664
             |.|  ...:.:|..:||....:..|:|.|...:.| ::|.:.|.:..| :..||          
Human   518 -PSI--RAMRNITAVAGRDTLINCRVIGYPYYSIKW-YKDALLLPDNHRQVVFEN---------- 568

  Fly  2665 NVLRKDSGFYTLKAENRNGIDRETVELVVLGKPSSPKGPLAVSDVTASGCKLQWKKPEDDGGVPI 2729
                                                 |.|.::||         :|..|:|....
Human   569 -------------------------------------GTLKLTDV---------QKGMDEGEYLC 587

  Fly  2730 KEYVVEKMDTATGKWVRVGRSPGEKEPPSFDVTGLSLGSEYMFRVSAVNEEGESEPLTTLVGVVA 2794
            ...:..::..:....|.|      |.||..                                   
Human   588 SVLIQPQLSISQSVHVAV------KVPPLI----------------------------------- 611

  Fly  2795 KDPFDEPNKPGT-------PEVTDYDNQSISLKWAAPNNDGGAPI--QKYIIEKKNKNKTEWEKA 2850
             .||:.|  |.:       |.|....:..|.:.|   ..||...|  ....||.|     |:..:
Human   612 -QPFEFP--PASIGQLLYIPCVVSSGDMPIRITW---RKDGQVIISGSGVTIESK-----EFMSS 665

  Fly  2851 LEIPGDQLEATVAGLQEYGEYQFRVIAVNKAGLSPPSDASVP---QIVKYKKLKPR--IDRSNLK 2910
            |:|       :...|:..|.|  ..||.|.|       |:|.   |::  .::.||  :..:|..
Human   666 LQI-------SSVSLKHNGNY--TCIASNAA-------ATVSRERQLI--VRVPPRFVVQPNNQD 712

  Fly  2911 PLLIRAGKPIRYDVNVRGEPAPVITWYQNDKELKPEE---LPSSSEIKNIPYNTKISIIETVRKH 2972
            .:..:||.   .:.:|.|.|.|.:.|........|::   :|.:..|:.:| |:.:.|...:.:.
Human   713 GIYGKAGV---LNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILP-NSSLLIRHVLEED 773

  Fly  2973 TGIYKIIAVNEHGQDEA-----TVEVNILAPPSKPRGPLDVKDVTKD-SCK--------LKWKK- 3022
            .|.|...|.|..|.|.:     ||::..:. .|.|...:.:|...|: :|.        ::|:| 
Human   774 IGYYLCQASNGVGTDISKSMFLTVKIPAMI-TSHPNTTIAIKGHAKELNCTARGERPIIIRWEKG 837

  Fly  3023 ---------------PEDDGGKPISAYQVEKFDKKQGRWVPLGRTSANDTEFDVKGLQEGHEYQF 3072
                           .:|:|.:.:|..:::..|:             .|:.|            |
Human   838 DTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADR-------------GDSVF------------F 877

  Fly  3073 RVKAINEEGESDPLDSDDSIIAKNPYDAASKPGTPNIVDYNEHMVKLKWEAPRSDGGAPISGYII 3137
            ...|||..||...|   ..:..:.|.|    |....|.:.....:.|:| ..|.||.:.|:|:.|
Human   878 SCHAINSYGEDRGL---IQLTVQEPPD----PPELEIREVKARSMNLRW-TQRFDGNSIITGFDI 934

  Fly  3138 EKKDKFSPIWDEILSTNTSVP---EATVEGLVEGNIYQFRVRAVNKAGFSDPSDATEPHLAKPRN 3199
            |.|:| |..||...||....|   :|.:..|...::|..|:.:.||.|.|:||            
Human   935 EYKNK-SDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPS------------ 986

  Fly  3200 LKPYINRDKMKPIKVRAGQPVKFDVDVKGEPAPS----LTWFLKETELTSTGQVRLENIDY---- 3256
                    |...|......|....:||..:|..|    :||...:.|| ..|.:|...|.|    
Human   987 --------KELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKEL-QNGVIRGYQIGYRENS 1042

  Fly  3257 ----------------NTKLTLLDTDRKQSGQYKLRAENIN----GVDEAVVEVIIL-DKPSKPE 3300
                            ::::..|| :.|:..||.:..:..|    |...:.:....| |.||:|.
Human  1043 PGSNGQYSIVEMKATGDSEVYTLD-NLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPP 1106

  Fly  3301 GPIEVSDIHKEGCKLKWRKPKDD--GGIPITGY-VIEKMDTATGKWVPAGSVDPEKYDIEIKGLD 3362
            ..:....|..:...:.|.:|...  .|: :.|| ||.......|:|....::...:..:|::|::
Human  1107 ENVRALSITSDVAVISWSEPPRSTLNGV-LKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGME 1170

  Fly  3363 PNHRYQFRVKAVNEEGESEPLETESAITAKNPFDVSAPPGLPELEDWDEHHVKLKWEPPIRDGGS 3427
            ....|..:|.|..:.|:.   ...|.:..:...||..||...:........|.:.|.||.:..| 
Human  1171 KFTNYSVQVLAYTQAGDG---VRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNG- 1231

  Fly  3428 PITNYIIEVMDKDSGEFVKA-VETDSPVCKGVVKKLEEGQQYKFRVRAVNKAGPSDPSEQTNWHV 3491
            .|..|.|......||:...: .||........:..|..||||...|.||..||..:.||      
Human  1232 VIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSE------ 1290

  Fly  3492 AKPRFLKPHIDRVNLKPV------IVKTGLSIS--------LDINIRGEPAPKVEWFFNNSS--- 3539
                       :|.::|.      |:..|.:::        |..|..|:|||.|:|..::..   
Human  1291 -----------KVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAI 1344

  Fly  3540 -VTSDEHSVKIDNVDYNTKFFVMRAQRSQSGKYIIKATNEVGEDEAELEVTVLGKPGKPKGPLQV 3603
             |:.|.|.:    :..|....:...:...||.|...|||..|.|...:.:.|...|.:|:  |.|
Human  1345 PVSMDGHRL----IHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVPPDQPR--LTV 1403

  Fly  3604 NDITKHSCKLKWEKPDDDGGSPIDYYEIEKLDPHTGQWLPCG-KSTEPEAKVIGLHEGKAYKFRV 3667
            :..:..|..|.| .|.|:|||.|..:.::....::.:|.... .|:|...|:..|..|..||.::
Human  1404 SKTSASSITLTW-IPGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKL 1467

  Fly  3668 RAVNKEGE---SEDLETEKPIIAKNPYDEPDRPGKPEPTNWDKD---FVDL----------AWDP 3716
            .|.|..|.   ||.:|      ||....||         ::.||   |..:          .|  
Human  1468 AAKNSVGSGRISEIIE------AKTHGREP---------SFSKDQHLFTHINSTHARLNLQGW-- 1515

  Fly  3717 PKNDGGAPIQKYVIQMRDKSGRAWVDSATVPGDKCNGT----VTGVEEGHEYEFRIVAVNKAGPS 3777
              |:||.||...|::.|.|...||      .|.:.|.:    :|.:.|...||.|:.|.|.||..
Human  1516 --NNGGCPITAIVLEYRPKGTWAW------QGLRANSSGEVFLTELREATWYELRMRACNSAGCG 1572

  Fly  3778 DPSDVSKSVIAKPRFLKPHIDRKNLQKKIMRSGQMLHIDALIKAEPPAKVTWTYNKTEIKTSDHI 3842
            :                             .:.|...:|......||           ||::.. 
Human  1573 N-----------------------------ETAQFATLDYDGSTIPP-----------IKSAQG- 1596

  Fly  3843 KIENEDYKTTF----------------IMPKVKRADRGI----------YIVTAKNDSGSDTVEV 3881
              |.:|.|..|                .:.:.||.::.:          .::.:||:...||   
Human  1597 --EGDDVKKLFTIGCPVILATLGVALLFIVRKKRKEKRLKRLRDAKSLAEMLISKNNRSFDT--- 1656

  Fly  3882 ELEVLCKPSK--PKGPLAVSNVTAETLHLKWEKPEDDGGDPIEQYLVERM--------DTETGRW 3936
                   |.|  |:||         .||:         ..|..|.|:|..        |..|   
Human  1657 -------PVKGPPQGP---------RLHI---------DIPRVQLLIEDKEGIKQLGDDKAT--- 1693

  Fly  3937 VPVLTTK-----TPEADVTGLTEGKEYLFRVKAVNSEGESEPLV--TDI-----PTKAKNPFDAA 3989
            :||...:     .|::..||::     |.....:.|.|   ||:  :||     |...||...|.
Human  1694 IPVTDAEFSQAVNPQSFCTGVS-----LHHPTLIQSTG---PLIDMSDIRPGTNPVSRKNVKSAH 1750

  Fly  3990 DTPGKPQIVDWSGNHCDLK---------WRAPEDDGGASIT---GYIVERKDPNTGKWQKALETS 4042
            .|..: ....|:...|...         ||......|.::|   .|...... :|.|.:.:: .|
Human  1751 STRNR-YSSQWTLTKCQASTPARTLTSDWRTVGSQHGVTVTESDSYSASLSQ-DTDKGRNSM-VS 1812

  Fly  4043 TPDCK------------ARVNDLIAGNKYQFRIMAVNKAGKSK----PSEPSDQMTAKD------ 4085
            |....            |::.:.:...|::.....::.:...:    .:|.:|.||:..      
Human  1813 TESASSTYEELARAYEHAKLEEQLQHAKFEITECFISDSSSDQMTTGTNENADSMTSMSTPSEPG 1877

  Fly  4086 --RF--APPKID--------------RTNIKD-----ITIKAGQHIRFDIKVSG-EP----PATK 4122
              ||  :|||..              |.|..|     :..|:....|   |..| ||    |..:
Human  1878 ICRFTASPPKPQDADRGKNVAVPIPHRANKSDYCNLPLYAKSEAFFR---KADGREPCPVVPPRE 1939

  Fly  4123 VWLHNKARLENDDSNYNIDMESYRTK---LTV-PISKRF---HSGKYTLKAENESGRDEASFEVI 4180
            ..:.|.||             :|.|:   ||: |.||..   |.|.       .:....|:....
Human  1940 ASIRNLAR-------------TYHTQARHLTLDPASKSLGLPHPGA-------PAAASTATLPQR 1984

  Fly  4181 VLDKPGPPEG 4190
            .|..|.||.|
Human  1985 TLAMPAPPAG 1994

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
btNP_001162825.1 I-set 9..101 CDD:254352
Ig 26..100 CDD:143165
I-set 119..210 CDD:254352
Ig 136..209 CDD:143165
I-set 228..320 CDD:254352
IGc2 242..312 CDD:197706
I-set 335..425 CDD:254352
Ig 350..423 CDD:143165
Ig 436..530 CDD:299845
I-set 438..532 CDD:254352
I-set 545..636 CDD:254352
Ig 560..633 CDD:143165
Ig 657..731 CDD:143165
I-set 746..835 CDD:254352
Ig 1496..1586 CDD:299845
IG_like 1503..1588 CDD:214653
I-set 1639..1724 CDD:254352
IG 1750..1821 CDD:214652
IGc2 1750..1806 CDD:197706
I-set 1826..1909 CDD:254352
Ig 1831..1897 CDD:299845
I-set 1914..1998 CDD:254352
Ig 2020..2095 CDD:299845
FN3 2100..2194 CDD:238020
FN3 2203..2292 CDD:238020 20/97 (21%)
I-set 2311..2395 CDD:254352 20/83 (24%)
Ig 2321..2395 CDD:299845 18/73 (25%)
FN3 2399..2493 CDD:238020 23/134 (17%)
FN3 2501..2590 CDD:238020 18/95 (19%)
I-set 2602..2693 CDD:254352 14/91 (15%)
Ig 2619..2693 CDD:299845 9/74 (12%)
FN3 2697..2793 CDD:238020 12/95 (13%)
FN3 2801..2893 CDD:238020 24/103 (23%)
I-set 2902..2995 CDD:254352 24/102 (24%)
Ig 2919..2993 CDD:299845 19/81 (23%)
FN3 2999..3088 CDD:238020 20/113 (18%)
FN3 3102..3191 CDD:238020 29/91 (32%)
I-set 3208..3292 CDD:254352 22/111 (20%)
Ig 3219..3292 CDD:299845 20/100 (20%)
FN3 3296..3390 CDD:238020 20/96 (21%)
FN3 3400..3489 CDD:238020 26/89 (29%)
I-set 3494..3590 CDD:254352 24/113 (21%)
Ig 3516..3590 CDD:299845 20/85 (24%)
FN3 3594..3682 CDD:238020 27/91 (30%)
FN3 3694..3781 CDD:238020 26/103 (25%)
I-set 3795..3885 CDD:254352 16/115 (14%)
Ig 3813..3885 CDD:299845 15/97 (15%)
FN3 3889..3980 CDD:238020 25/112 (22%)
FN3 3990..4082 CDD:238020 16/119 (13%)
I-set 4090..4181 CDD:254352 25/121 (21%)
Ig 4108..4181 CDD:299845 19/84 (23%)
FN3 4185..4271 CDD:238020 4/6 (67%)
FN3 4285..4383 CDD:238020
Ig 4404..4480 CDD:299845
FN3 4484..4571 CDD:238020
FN3 4584..4677 CDD:238020
I-set 4685..4775 CDD:254352
Ig 4703..4775 CDD:299845
FN3 4779..4863 CDD:238020
FN3 4879..4970 CDD:238020
IG 4989..5069 CDD:214652
Ig 4996..5069 CDD:299845
FN3 5073..5166 CDD:238020
FN3 5175..5265 CDD:238020
I-set 5276..5366 CDD:254352
Ig 5293..5366 CDD:299845
FN3 5370..5462 CDD:238020
FN3 5470..5561 CDD:238020
Ig 5559..5654 CDD:299845
I-set 5570..5660 CDD:254352
FN3 5664..5755 CDD:238020
FN3 5764..5853 CDD:238020
I-set 5865..5954 CDD:254352
Ig 5882..5954 CDD:299845
FN3 5958..6049 CDD:238020
FN3 6062..6153 CDD:238020
I-set 6173..6255 CDD:254352
Ig_Titin_like 6182..6255 CDD:143225
FN3 6259..6350 CDD:238020
FN3 6359..6451 CDD:238020
FN3 6470..6552 CDD:238020
I-set 6564..6650 CDD:254352
Ig_Titin_like 6577..6650 CDD:143225
FN3 6654..6745 CDD:238020
FN3 6754..6840 CDD:238020
I-set 6855..6946 CDD:254352
Ig 6874..6946 CDD:299845
FN3 6950..7042 CDD:238020
FN3 7050..7139 CDD:238020
FN3 7151..7237 CDD:238020
I-set 7254..7334 CDD:254352
Ig 7272..7339 CDD:143165
IG_like 7354..7440 CDD:214653
Ig 7366..7440 CDD:299845
FN3 7444..7531 CDD:238020
FN3 7545..7637 CDD:238020
I-set 7648..7737 CDD:254352
Ig 7665..7734 CDD:143165
Ig 7760..7833 CDD:299845
FN3 7837..7927 CDD:238020
STKc_Twitchin_like 7986..8244 CDD:271016
S_TKc 7989..8244 CDD:214567
Ig 8311..8394 CDD:299845
I-set 8312..8401 CDD:254352
I-set 8437..8525 CDD:254352
Ig 8455..8519 CDD:143165
I-set 8632..8721 CDD:254352
IGc2 8646..8711 CDD:197706
I-set 8740..8831 CDD:254352
Ig 8757..8826 CDD:143165
I-set 8839..8922 CDD:254352
Ig 8845..>8909 CDD:299845
DSCAML1XP_011541219.1 IG_like 43..119 CDD:214653
IGc2 43..110 CDD:197706
Ig 125..218 CDD:299845 14/69 (20%)
IG_like 137..209 CDD:214653 14/60 (23%)
I-set 245..323 CDD:254352 20/82 (24%)
IGc2 252..313 CDD:197706 17/65 (26%)
IGc2 340..401 CDD:197706 11/60 (18%)
I-set 420..514 CDD:254352 24/120 (20%)
Ig 420..510 CDD:299845 22/113 (19%)
IGc2 531..589 CDD:197706 18/114 (16%)
IG_like 619..698 CDD:214653 23/104 (22%)
Ig 627..693 CDD:143165 22/89 (25%)
I-set 702..797 CDD:254352 22/98 (22%)
Ig7_DSCAM 719..797 CDD:143211 18/81 (22%)
I-set 803..896 CDD:254352 20/121 (17%)
Ig 815..903 CDD:299845 19/119 (16%)
FN3 899..993 CDD:238020 33/119 (28%)
FN3 1000..1097 CDD:238020 19/98 (19%)
fn3 1105..1191 CDD:278470 17/89 (19%)
FN3 1203..1294 CDD:238020 27/108 (25%)
IGc2 1318..1382 CDD:197706 18/67 (27%)
FN3 1396..1486 CDD:238020 28/98 (29%)
FN3 1500..1572 CDD:238020 23/81 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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