DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bt and mylka

DIOPT Version :9

Sequence 1:	NP_001162825.1	Gene:	bt / 43814	FlyBaseID:	FBgn0005666	Length:	8933	Species:	Drosophila melanogaster
Sequence 2:	XP_009302720.1	Gene:	mylka / 569510	ZFINID:	ZDB-GENE-030131-8207	Length:	1857	Species:	Danio rerio

Alignment Length:	2071	Identity:	498/2071 - (24%)
Similarity:	794/2071 - (38%)	Gaps:	493/2071 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  6539 VGRSDPSKPSQPITIEEQPNKPC------MELGKVRDIVCRAGDDFSIHVPYLAFPKPNAFWYSN 6597
            :||..|||.....|:..:..:.|      :| ||||                 .||:|...|:.|
Zfish    75 LGRGSPSKEPPVFTLPPRNTRVCQGGTARLE-GKVR-----------------GFPEPQVCWFRN 121

  Fly  6598 DNML--DDNNRVHKHLTDDAASVVVKNSKRADSGQYRLQLKNTSGFDTATINVRVLDRPSPPTRL 6660
            ..:|  .|:..:.:.:. ...|:||:..:.||.|:|..:..|.:|....|:.:.|.........|
Zfish   122 GKLLIAGDHYSMEQSVR-GTFSLVVQEVEDADGGRYTCEAVNDAGSCQVTVEIIVEGNTGKKYSL 185

  Fly  6661 RADEFSGDSLTLYWNPPNDDGGSAIQNYIIEKKEARSSTWSKVSSFCTVPFVRIRNLVLNKEYDF 6725
            .:...:|.|:          |..|::|        |:|.|
Zfish   186 PSTNRTGRSM----------GAPAVEN--------RASIW------------------------- 207

  Fly  6726 RVIAENKYGQSDPANTSEPILARHPFDIPNTPGIPHGIDSTEDSITIAWTKPKHDGGSPITGYII 6790
                    |:|.|...::|  :|....:..|......|......: :.|.|.
Zfish   208 --------GESPPKFVAKP--SRLYLKVGQTGKFSAKITGRPQPL-VQWYKG------------- 248

  Fly  6791 EKRLLSDDKWT----KAVHALCPDLSCKIPNLIENAEYEFRVAAVNAAGQSA-------YSGSSD 6844
            |:.:...|.:.    ..:|.|      :|.|:.......:.....|:||:::       ..|.::
Zfish   249 EEMIQQSDHYNMFERSGMHFL------EIRNVFSEDAGMYTCLVANSAGKASAAAELIMQDGDTE 307

  Fly  6845 LIFCRRPPHAP------KITSD-LSIRDMTVIAGDEFRIT---VPYHASPRPTASWSLNGLEVIP 6899
            .:...:|.|.|      |.||: |:....|.....|..||   .|...:..||.. |:|     .
Zfish   308 TVIMAKPSHNPSKSFMLKDTSNTLANEQKTSSTSIETIITETPTPLSTTTVPTVP-SMN-----R 366

  Fly  6900 GERIKFDSNDYASMYYNKSAKRDETGSYTITLTNNKGSDTASCHVTVVDRPL-----PPQGPLNA 6959
            ||.....|:.::......:..|..||..|..|.|.:..::.........|.|     |.|.|.::
Zfish   367 GETTIVTSSLHSQPISRSTDGRSATGQNTSNLVNLRSQNSVKNETHGTKRVLGMFRAPGQMPQSS 431

  Fly  6960 Y------DITPDTCTLAWKTPLDDGGSPITNYVVE------KLDNSG------SWVKISSFVRNT 7006
            .      ..|.:|.....:||......|.:..|::      |...||      ||:|..:.:|.
Zfish   432 QIESSTRQQTKETRMDVLETPPSFDSQPQSQEVLQGEKVTFKCQVSGSPVPAVSWLKDGAPLRQ- 495

  Fly  7007 HYDV-----MGLEPHYKYNFRVRAENQYGLSDPLDIIEPIVAKHQFTVPDEPGQPKVIDWDSGNV 7066
            ..||     .||......|..:....|||.:         .|..:                 ||.
Zfish   496 RSDVSTRQEAGLHVLCLDNAHITDTGQYGCT---------AANRR-----------------GNT 534

  Fly  7067 TLIWTRPLSDGGSRIQGYQIEYRDILNDSSWNAYDYIIKDTKYQLYNLINGSEYEFRIKAKNAAG 7131
            ...|:              :..:.:..|:....:...:||.     ::..|.|:
Zfish   535 AAHWS--------------LTVKRVRVDAKPPVFSSALKDC-----SVCEGQEF----------- 569

  Fly  7132 LSKPSSPSLRFKLKGKFTVPSPPGAPQVTRVGKNYVDLKW---EKPLRDGGSRITGYIIERRDIG 7193
                   :|:..::||   |.|              :|.|   :||:....:.......:.| :.
Zfish   570 -------TLQCSVEGK---PQP--------------ELSWLHNDKPIPFSHTMFDNSKAQLR-VQ 609

  Fly  7194 GAVWVKCNDYNVLDTEYTVMNLIEMGDYEFRVFAVNSAGRSEPSLCTMPI--------------K 7244
            .||                  |.:.|.|.  ..|||..||   ::||..:              .
Zfish   610 AAV------------------LEDAGVYS--CVAVNEHGR---AVCTAHVLVKARPRVKRSAAPP 651

  Fly  7245 VCEVLGGKKPDWITRLQDKVAPFGKDYTLQCAASGKPSPTARWLRNGKEIQMNGGRMTCDSKDGV 7309
            |.::.....|.::..|||.....|....:....:|.|:|...||.|||||| .......:.|.|.
Zfish   652 VTDLRRTSAPLFLKGLQDLRVMDGSQVIMTVEVTGNPAPEVVWLHNGKEIQ-ESEDFHFEKKGGQ 715

  Fly  7310 FRLHISNVQTGDDGDYTCEAMNSLGFVNTSGYLKIGSPP-------IINRCPSELKLPEGDNSKI 7367
            :.|.|..|...|.|.||||..|..|...|...|.:..|.       |.....|...|  |.::.:
Zfish   716 YTLFIQEVFPEDTGTYTCEVWNEAGNARTQASLTVQEPQDGVQPWFITKTKSSTASL--GQHALL 778

  Fly  7368 KIFYSGDQPLTVILKKNNEVICDSNDDTHVKVNIFDDYVAIYIRNIVKSDGGPYQIEFTNESGSA 7432
            ....:||.....:..|:.:||....|   .::...:|.|::.||.:.....|.|:|...|:.|..
Zfish   779 SCAIAGDPFPEFLWMKDGQVISGDGD---FEILQKEDVVSLLIRKVAMHHAGNYEIHLKNKVGEC 840

  Fly  7433 TGEFYVHIT------------------------GMPSAPTGPMGISYINKNSC------------ 7461
            .....:|::                        |.|..|: |....:..::|.
Zfish   841 RSVATLHVSEDPMLSADDANKRRGVEKTALGRGGQPKTPS-PAASLHSEEHSSGTDQQEEEGGST 904

  Fly  7462 --MLNWRPPSYDG-------------------GLKVSHYVIERKDVSSPHWITVSSTCKDTAFNV 7505
              :|..|..:.:.                   |.||:...:..:|:..     :::...|...|:
Zfish   905 RGLLKRRVETKEHREDQIRQQEAEQIDFRTVLGRKVTTKSVSEEDLKE-----ITAEQMDFRGNL 964

  Fly  7506 QGLIENQEYIFRVMAVNENGMGPPLEGLNPIRAKDPIDPPSP-PGS----PQITEIGGDFVHLEW 7565
            |..|:.:........||.    |.......:..|.....|.| |||    |...| ..||..:..
Zfish   965 QRQIKPKTQTEEQRKVNT----PQQVDFRAVLGKKASQGPKPAPGSLKTQPSKNE-AVDFRSVLG 1024

  Fly  7566 EK---PESDGGAHIQGYWIDKREVGSNTWQRVNATICAANQINCINLIEGRQYEFRIFAQNVAGL 7627
            .|   |..|.....||   |.|  |..            |.:||::                 |.
Zfish  1025 NKKKPPTQDRNGESQG---DPR--GKE------------NDVNCVD-----------------GE 1055

  Fly  7628 STESSASQAVKIIDPQAASPPLIVKPLRDANCIQNHNAQFTCTINGVPKPTISWYKGAREISNGA 7692
            ..|::.:...|        .|:.|:.|.|...:........|.::......::|....:.|....
Zfish  1056 IKETTKAAGKK--------EPVFVEKLSDVTVLDGERLHLQCQLSSESPAKVTWMLDGKVIRPSK 1112

  Fly  7693 RYHMYSEGDNHFLNINDVFGEDADEYVCRAVNKAGAKSTRATLAIM------------------- 7738
            ...:.:|||.:.|:|:....||..:|||||....|  .|..:..::
Zfish  1113 FIIITNEGDRYSLSIDKALPEDEGQYVCRAETDEG--KTECSCVVLVNDPSVSTPDDKRSRKPST 1175

  Fly  7739 ---------------TAPKLNVPP---RFRDTAYFDKGENVVIKIPFTGFPKPRIHWVRDGENIE 7785
                           |.||...||   :|.|......|:.|:::..|||.......|::..:.|:
Zfish  1176 PTTENEAKIKKPPPKTLPKQGAPPQIQQFPDDMKIMAGQEVILQCKFTGALPISCTWLKFRKPIQ 1240

  Fly  7786 SGGHYTVEVKERHAVLIIRDGSHLDSGPYRITAENELGSDTAIIQVQISDRPDPP-RFPLIESIG 7849
            .|...::...:..:.|.|.:|.....|.|.|..:|..|...|.:.:.|.|:|||| |.|....|.
Zfish  1241 EGQGISIVSTDSSSQLTITEGQQEHCGCYTIEIKNSFGVRQAALNLTIVDKPDPPARVPAASDIR 1305

  Fly  7850 TESLSLSWKAPVWDGCSDITNYYVERREHPLSSWIRVGNTRFTSMAVSGLTPGKEYDFRIFADNV 7914
            ..||:|||..|.:||.|.:.:|.:|........|..|.:...||..|..|.|.::|.||:.|.|:
Zfish  1306 KSSLTLSWYGPTYDGGSAVQSYNLEAWNSLDMKWTDVASCNSTSYNVQDLLPDRQYKFRVRAVNI 1370

  Fly  7915 YGRSDASDTSTLIKTKESVKKKPIERKWEIDANGRKLRGKADGPVKDYDSYVFDIYSKFVPQPVE 7979
            ||..:           .|.:.:|::...|           |:|..|:.:....|..|:.||....
Zfish  1371 YGVGE-----------PSAESEPVQVGLE-----------AEGENKEDEVEPSDDESEKVPDYRN 1413

  Fly  7980 ISQQS---VYDRYDILEEIGTGAFGVVHRCRERSTGNIFAAKFIPVSHSVEKDLIRREIDIMNQL 8041
            ::.::   |.|.||:.:.:|||.||.|.:..|:||..::|.|||....:.||:.:|:||.|||.|
Zfish  1414 VTIKTDVKVKDFYDVEDRLGTGKFGTVFKLIEKSTKKVWAGKFIKAYSAKEKENVRQEIAIMNDL 1478

  Fly  8042 HHQKLINLHDAFEDDDEMILILEFLSGGELFERITAEGYVMTEAEVINYMRQICEGIRHMHEQNI 8106
            ||.||:...||||...:::::||.:||||||:||..|.:.:||.|||.||.||.:|:..:|::.|
Zfish  1479 HHPKLVQCIDAFEGKTDIVMVLEMISGGELFDRIIDEDFELTEREVIKYMLQIVDGVNFIHKKGI 1543

  Fly  8107 IHLDIKPENIMCQTRSSTNVKLIDFGLATRLDPNEVVKITTGTAEFAAPEIVNREPVGFYTDMWA 8171
            :|||:|||||||..::.:.:||||||||.||:....:|:..||.||.|||::|.|.:.:.||||:
Zfish  1544 VHLDLKPENIMCVNKTGSKIKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEAISYATDMWS 1608

  Fly  8172 TGVLSYVLLSGLSPFAGDNDVQTLKNVKACDWDFDVESFKYISEEAKDFIRKLLVRNKEKRMTAH 8236
            .||:.|:|:||||||.||||.:||.||.:..|||:.|:|..|||||||||..||.::.:.|:|..
Zfish  1609 IGVICYILVSGLSPFMGDNDNETLSNVTSATWDFEDEAFDEISEEAKDFISNLLKKDMKARLTCD 1673

  Fly  8237 ECLLHPWLTGDHSAMK-QEINRDRYLAYREKLRRKYEDFERFLLPIGRLSEYSSLRKLLMEKYKI 8300
            :|..||||..|.:.|: ::::::|...|  .||||::.....:..|||||..:.:..:..:|...
Zfish  1674 QCFQHPWLKQDTTNMEAKKLSKERMKKY--ILRRKWQKTGHAVRAIGRLSNMALMAGVHAKKSSP 1736

  Fly  8301 HDAVFDRRQAA----------PRF--VIRPSSQFCYEGQSVKFYCRCIAIATPTLTWSHNNIELR 8353
            .:|  |.:|.|          |.|  ||:...  ..||.:.:|.|:......|.:.|..::..::
Zfish  1737 TEA--DAKQFAAELEAKTLMKPTFSSVIKDVE--VVEGSAARFDCKIEGYPDPEVVWYKDDQPIK 1797

  Fly  8354 QSVKFMKRYVGD-DYYFIINRVKLDDRGEYIIRAENHYGSREEVVFLNVQPLPKEQ 8408
            ::..|...|..| :...:|:.|..||..:|..:|.|..|.......|.|:.:.:|:
Zfish  1798 ETRHFQIDYDEDGNCSLVISEVNGDDDAKYTCKAMNSLGETTCTAELIVEVMGEEE 1853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bt	NP_001162825.1	I-set	9..101	CDD:254352
		Ig	26..100	CDD:143165
		I-set	119..210	CDD:254352
		Ig	136..209	CDD:143165
		I-set	228..320	CDD:254352
		IGc2	242..312	CDD:197706
		I-set	335..425	CDD:254352
		Ig	350..423	CDD:143165
		Ig	436..530	CDD:299845
		I-set	438..532	CDD:254352
		I-set	545..636	CDD:254352
		Ig	560..633	CDD:143165
		Ig	657..731	CDD:143165
		I-set	746..835	CDD:254352
		Ig	1496..1586	CDD:299845
		IG_like	1503..1588	CDD:214653
		I-set	1639..1724	CDD:254352
		IG	1750..1821	CDD:214652
		IGc2	1750..1806	CDD:197706
		I-set	1826..1909	CDD:254352
		Ig	1831..1897	CDD:299845
		I-set	1914..1998	CDD:254352
		Ig	2020..2095	CDD:299845
		FN3	2100..2194	CDD:238020
		FN3	2203..2292	CDD:238020
		I-set	2311..2395	CDD:254352
		Ig	2321..2395	CDD:299845
		FN3	2399..2493	CDD:238020
		FN3	2501..2590	CDD:238020
		I-set	2602..2693	CDD:254352
		Ig	2619..2693	CDD:299845
		FN3	2697..2793	CDD:238020
		FN3	2801..2893	CDD:238020
		I-set	2902..2995	CDD:254352
		Ig	2919..2993	CDD:299845
		FN3	2999..3088	CDD:238020
		FN3	3102..3191	CDD:238020
		I-set	3208..3292	CDD:254352
		Ig	3219..3292	CDD:299845
		FN3	3296..3390	CDD:238020
		FN3	3400..3489	CDD:238020
		I-set	3494..3590	CDD:254352
		Ig	3516..3590	CDD:299845
		FN3	3594..3682	CDD:238020
		FN3	3694..3781	CDD:238020
		I-set	3795..3885	CDD:254352
		Ig	3813..3885	CDD:299845
		FN3	3889..3980	CDD:238020
		FN3	3990..4082	CDD:238020
		I-set	4090..4181	CDD:254352
		Ig	4108..4181	CDD:299845
		FN3	4185..4271	CDD:238020
		FN3	4285..4383	CDD:238020
		Ig	4404..4480	CDD:299845
		FN3	4484..4571	CDD:238020
		FN3	4584..4677	CDD:238020
		I-set	4685..4775	CDD:254352
		Ig	4703..4775	CDD:299845
		FN3	4779..4863	CDD:238020
		FN3	4879..4970	CDD:238020
		IG	4989..5069	CDD:214652
		Ig	4996..5069	CDD:299845
		FN3	5073..5166	CDD:238020
		FN3	5175..5265	CDD:238020
I-set	5276..5366	CDD:254352
Ig	5293..5366	CDD:299845
FN3	5370..5462	CDD:238020
FN3	5470..5561	CDD:238020
Ig	5559..5654	CDD:299845
I-set	5570..5660	CDD:254352
FN3	5664..5755	CDD:238020
FN3	5764..5853	CDD:238020
I-set	5865..5954	CDD:254352
Ig	5882..5954	CDD:299845
FN3	5958..6049	CDD:238020
FN3	6062..6153	CDD:238020
I-set	6173..6255	CDD:254352
Ig_Titin_like	6182..6255	CDD:143225
FN3	6259..6350	CDD:238020
FN3	6359..6451	CDD:238020
FN3	6470..6552	CDD:238020	5/12 (42%)
I-set	6564..6650	CDD:254352	21/87 (24%)
Ig_Titin_like	6577..6650	CDD:143225	17/74 (23%)
FN3	6654..6745	CDD:238020	12/90 (13%)
FN3	6754..6840	CDD:238020	13/96 (14%)
I-set	6855..6946	CDD:254352	23/100 (23%)
Ig	6874..6946	CDD:299845	16/74 (22%)
FN3	6950..7042	CDD:238020	25/119 (21%)
FN3	7050..7139	CDD:238020	8/88 (9%)
FN3	7151..7237	CDD:238020	17/88 (19%)
I-set	7254..7334	CDD:254352	28/79 (35%)
Ig	7272..7339	CDD:143165	24/66 (36%)
IG_like	7354..7440	CDD:214653	18/85 (21%)
Ig	7366..7440	CDD:299845	15/73 (21%)
FN3	7444..7531	CDD:238020	17/119 (14%)
FN3	7545..7637	CDD:238020	22/99 (22%)
I-set	7648..7737	CDD:254352	21/88 (24%)
Ig	7665..7734	CDD:143165	17/68 (25%)
Ig	7760..7833	CDD:299845	16/72 (22%)
FN3	7837..7927	CDD:238020	32/90 (36%)
STKc_Twitchin_like	7986..8244	CDD:271016	129/257 (50%)
S_TKc	7989..8244	CDD:214567	128/254 (50%)
Ig	8311..8394	CDD:299845	22/95 (23%)
I-set	8312..8401	CDD:254352	22/91 (24%)
I-set	8437..8525	CDD:254352
Ig	8455..8519	CDD:143165
I-set	8632..8721	CDD:254352
IGc2	8646..8711	CDD:197706
I-set	8740..8831	CDD:254352
Ig	8757..8826	CDD:143165
I-set	8839..8922	CDD:254352
Ig	8845..>8909	CDD:299845
mylka	XP_009302720.1	I-set	85..175	CDD:254352	24/108 (22%)
		Ig	91..165	CDD:299845	21/92 (23%)
		I-set	212..300	CDD:254352	16/109 (15%)
		Ig	231..301	CDD:299845	12/89 (13%)
		PHA03255	283..>461	CDD:165513	39/183 (21%)
		Ig	452..541	CDD:299845	22/129 (17%)
		I-set	453..542	CDD:254352	21/129 (16%)
		I-set	552..638	CDD:254352	26/149 (17%)
		IGc2	565..628	CDD:197706	20/118 (17%)
		I-set	661..750	CDD:254352	31/89 (35%)
		Ig	678..747	CDD:143165	25/69 (36%)
		I-set	759..848	CDD:254352	19/93 (20%)
		Ig	762..846	CDD:299845	19/88 (22%)
		I-set	1068..1157	CDD:254352	21/90 (23%)
		Ig	1087..1152	CDD:143165	17/66 (26%)
		Ig8_MLCK	1199..1296	CDD:143239	25/96 (26%)
		I-set	1199..1288	CDD:254352	20/88 (23%)
		FN3	1292..1381	CDD:238020	33/99 (33%)
		STKc_MLCK1	1423..1681	CDD:271093	129/257 (50%)
		Pkinase	1426..1681	CDD:278497	128/254 (50%)
		I-set	1756..1846	CDD:254352	22/91 (24%)
		IGc2	1769..1836	CDD:197706	16/66 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I8905
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13817
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.010