DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bt and hmcn2

DIOPT Version :9

Sequence 1:	NP_001162825.1	Gene:	bt / 43814	FlyBaseID:	FBgn0005666	Length:	8933	Species:	Drosophila melanogaster
Sequence 2:	XP_001920501.5	Gene:	hmcn2 / 565032	ZFINID:	ZDB-GENE-030131-9765	Length:	4212	Species:	Danio rerio

Alignment Length:	5564	Identity:	989/5564 - (17%)
Similarity:	1594/5564 - (28%)	Gaps:	2287/5564 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly  3778 DPSDVSKSVIAKPRFLKPHIDRKNLQKKIMRSG---QMLHIDALIKA-EPPAKVTWTYNKTEIKT 3838
            ||.....|:...|:..     :|:||:..::.|   ..:.|.|:.|| |.....::.|..|:.:.
Zfish    84 DPDIGPVSITTDPKKF-----QKDLQELFVQGGGDCPEMSIGAIKKALEVSLPGSFIYVFTDARA 143

  Fly  3839 SDHIKIENEDYKTTFIMPKVK-RADRGIYIVTAKNDSGSDTVEVELEVLCKPSKPKGPLAVSNVT 3902
            .|: :::.:      ::..|: |..:.::::|..               |......|..|...:.
Zfish   144 KDY-RLKRD------VLQLVQLRQSQVVFVLTGD---------------CGDRSQPGYRAYEEIA 186

  Fly  3903 A----ETLHLKWEKPEDDGGDPIEQYLVERMDTETGRWVPVLTTKTPEADVTGLTEGKEYLFRVK 3963
            |    :..||.                 ::...|..:||.. |.:|               .:|.
Zfish   187 ATSSGQIFHLD-----------------KQQVNEVLKWVEE-TIQT---------------MKVH 218

  Fly  3964 AVNSEGESEPLVTDIPTKAKNPFDAADTPGKPQI-VDWSGNHCDLKWRAP------EDDGGASI- 4020
            .::|:.|     |...::.:.|||    |...:: |..||....::.|.|      |..|...:
Zfish   219 LLSSDHE-----TAQESQWEVPFD----PSLKEVTVSLSGPAPQIELRDPLGRTVGERQGLRELL 274

  Fly  4021 ----TGYIVERKDPNTGKWQKALETSTPDCKARVNDLIAGNKYQFRIMAVN----KAG------- 4070
                :..:|..|:|..|.|     |....|..|         :..|:..|:    :||
Zfish   275 NIPNSARVVNLKNPRPGPW-----TLKVGCSGR---------HTLRVTGVSNLDFRAGFSSIPVS 325

  Fly  4071 -----KSKPSE--PSDQMTAKDRFAPPKIDRTNIKDITIKAGQHIR-FDIKVSGEPPATKVWLHN 4127
                 :.:|.:  |:..|.......||.: .||::.::: .|:.:| ..:.:.|:..:..:|...
Zfish   326 EFTRTRERPIKGVPAHVMLKCSGLKPPGL-VTNMELVSL-GGRSLRTIPVPLPGDGGSGGIWSIP 388

  Fly  4128 KARLE----------NDDSNYN---IDMESY----------------------------RTKLTV 4151
            :.|..          ||...||   :...||                            ..:..:
Zfish   389 EFRTPSQSFFLRVSGNDGDGYNFQRLSSVSYTNIIPEPPVVVMPTVVRGFYMQPAVIDCSVESDL 453

  Fly  4152 PISKRFHSGKYTLKAEN--------------ESGRDEASFEVIVLDKPG-------------PP- 4188
            |...||..|..||..|.              .||.||.::|.:.....|             ||
Zfish   454 PYKLRFIRGGDTLGEERTYEASGKASWEIPYASGDDEGAYECVARSTAGMGRALTQLTVREPPPV 518

  Fly  4189 -EGPLRVTD----VHKEGCKLKWNAPLDDGGLPIDHYIIEKMDVESGRWLP--SGRFK---ESFA 4243
             ..|:.||.    |....|:::.:         :.|.:..   ..:|..||  |||.:   .|..
Zfish   519 LRPPVNVTSSPGTVAVLSCQIQGS---------VRHNLTW---YRTGSALPSRSGRVRVLANSSL 571

  Fly  4244 ELNNLEPSHEYKFRVLAVNTEGESE----------------PLTGEQSVIAKNPFDEPGKPGTPE 4292
            |::.:.......::..|.|..|||:                |.|...|:.|:...........|.
Zfish   572 EISWVRSQDAGPYQCRASNAHGESQAVVWLVVLEAPSVVVSPQTQSFSLGAEVHISCSASGSPPP 636

  Fly  4293 AVDWDKDHVDLV--WRPPINDGGS-PITGYVVEKREKGTDKWIKGTEITIPCLGEECKAT--VPT 4352
            .|.|...::.|.  .|..|::.|. .|.|...|.....|                 |.||  |.|
Zfish   637 KVFWSHGNIFLSNHHRMSISESGMLTIRGAAPEDSGNYT-----------------CLATNEVGT 684

  Fly  4353 LNENCEYEFRVKAINAAGPGEPSDASKPIITKPRKLAPKIDRKNIRTYNFKSGEPIFLDINISGE 4417
            .:::..       :|.|.|        |.|:..:::...:           :||...|:...||.
Zfish   685 ASQSVN-------VNYAEP--------PSISVVQQMVMVV-----------AGEDASLECQASGT 723

  Fly  4418 PAPDVTWNQNNKSVQTTSFSHIENLPYNTKYINNNPERKDTGLYKISAHNFYGQDQVEFQINIIT 4482
            |:|.|.|.:.:..:.|..|:. :::...|..|....| .|:|.|...|.|..|.......:.:..
Zfish   724 PSPIVKWQKGDLDLGTAPFAE-QDVHRGTLQIRGVQE-LDSGDYTCVASNIAGSSSAVVVLQVGA 786

  Fly  4483 KPGKPEGPLEVSEVHKDGCKLK------------WKKPKDDGGEPVESYLVEKFDPDTGIWLPVG 4535
            .|...|.|::::....|...|.            |::   ..|.|:       |...:|   .||
Zfish   787 APTFSESPVDITASVGDNITLPCIARGFPTPSLIWRR---QDGRPI-------FGKSSG---HVG 838

  Fly  4536 RSDGPE--YNVDGLVPGHDYKFRVKAVNKEGESEPL-----------------ETLGSIIAKDPF 4581
            .|..|.  ..:..:....:..:..:|.|:.|..:.|                 .::.::||: |.
Zfish   839 TSQLPSGALQIQSVWVDDEGVYLCEAKNQFGSIKALARVTVTGLEPPLLVQGAPSITTMIAQ-PL 902

  Fly  4582 SVPTK--PGVPEPTD-WTAN--------KVELAWPEPASDGGSPIQGYIVEVKDKYSPLWEKALE 4635
            ::|.:  .|:|.|.. ||.|        :|.|     .|||...:               ::|:.
Zfish   903 NLPCRLLDGIPLPERIWTHNGKQVRVGGRVFL-----RSDGSLHV---------------DRAVP 947

  Fly  4636 TNSPTPTATVQGLIEGNEYQFRVVALNKGGLSEPSDPSKIFTAKPRYLAPKIDRRNLRNITLSSG 4700
            .::.|...|               |:|..|       |...|......||...:....:.|.|.|
Zfish   948 EDAGTYVCT---------------AVNVAG-------SANITVTVEVHAPPDIKAGPLHYTASEG 990

  Fly  4701 TALKLDANITGEPAPKVEWKLSNYHLQSGKNVTIETPDYYTKLVIRPTQRSDSGEYLVTATNTSG 4765
            |.:.|.....|.|.|.:.|......|....:...|..|  ..|.|......|:|.|:.|||:..|
Zfish   991 TPISLSCEARGVPKPTISWSKGRDPLNRPVSAPFEAAD--GSLYISSPTEEDAGVYICTATSAVG 1053

  Fly  4766 KDSVLVNVVITDKPSPPNGPLQISDVHKEGCHLKWKRPSDDGGTPIEYFQIDKLEPETGCWIPSC 4830
            ..|..:::::..||.
Zfish  1054 YTSREMHLIVNSKPR-------------------------------------------------- 1068

  Fly  4831 RSTEPQVDVTGLSPGNEYKFRVSAVNAEGESQPLVGDESIVARNPFDEPGKPENLKATDWDKDHV 4895
                    :.| :.|::...:::|.         ||.|.|:   |.:..|.|..|  ..|.::..
Zfish  1069 --------IVG-ADGSQVTVKMAAE---------VGSEVIL---PCEVQGSPTPL--VTWSRNGQ 1110

  Fly  4896 DL----AWTPPLIDGGSPISCYIIEKQDKYGKWERALDVPADQCKATIPDLVEGQTYKFRVSAVN 4956
            .:    ||...|..|...||..            |.:|.....|.|..|......||..:|.|
Zfish  1111 TIPPVTAWFTMLPSGSLKISDV------------RVVDSKLYTCSAVNPAGNVSLTYNLQVQA-- 1161

  Fly  4957 AAGTGEPSDSTPPIIAKARNKPPIIDRSSLVEVRIKAGQSFTFDCKVSGEPAPQTKWLLKKKEVY 5021
                                ||.|....|.::..|  ||:....|.|.|||:||..||.....|.
Zfish  1162 --------------------KPRIHPAPSTLKALI--GQTVVLPCVVQGEPSPQVSWLHNGLPVA 1204

  Fly  5022 SKDNVKVTNVDYNTKLKVNSATRSDSGIYTVFAENANGEDSADVKVTVIDKP-APPNGPLKVDEI 5085
            |           :..||:.:...||||.|...|.|:.|||:..:.:.|::.| ...||...::.:
Zfish  1205 S-----------DRMLKIQAVQHSDSGTYRCVARNSAGEDTIQIVLDVLEGPYFETNGETVIESV 1258

  Fly  5086 NSESCTLHWNPPDDDGGQPIDNYVVEKLDETTGRWIPAG--------------ETDGPVTALKVG 5136
            .:....:    |....|.|....          ||...|              ..||   ||.:|
Zfish  1259 ANSKVLI----PCPARGSPAPQV----------RWFKNGLEVHMERSEHGVSLAEDG---ALVIG 1306

  Fly  5137 GLTPGHKYKFRVRAKNRQGTSEPLTTAQ----------------AIIAKNP-------FDVPTKP 5178
            ..:..|...|:..|.|..|:.|..|..:                .:..|.|       |.:|
Zfish  1307 SASASHSGDFKCVATNEAGSVERKTRLKVNVPPEIQDDGQLLNLTVTLKQPLTLGCDAFGIP--- 1368

  Fly  5179 GTPTIKDFDKEFVDLEWT---RPEADGGSPITGYVVEKRDKFSPDWEKCAEISDDITNAHVPDLI 5240
             ||||          .||   ||           |:|....:..:.::..:|. .:.:.|..
Zfish  1369 -TPTI----------SWTKDNRP-----------VLETPGVYLQNGKRLLKIY-RVQHDHAG--- 1407

  Fly  5241 EGLKYEFRVRAVNKAGPGSPSDATETHVARPKNTPPKID-RNFMSDIKIKAGNVFEFDVPVTGEP 5304
                 .|...|.|.||........|.      ..||.|. .:.:.::.|.||...:....|:|.|
Zfish  1408 -----RFSCTAQNSAGEAKREYTIEV------QAPPVISGTSGVQEVTIMAGQEVDMQCRVSGRP 1461

  Fly  5305 LPSKDWTHEGNMIINTDRVKISNFDDRTKIRILDAKRSDTGVYTLTARNINGTDRHNVKVTILDA 5369
            |||.:|||:|.::.......:...:....:|:...:..|.|:|...|.|..||.....::||..|
Zfish  1462 LPSVEWTHDGEVLSPNGDPHVEFLEKGQVLRVKSVRPRDRGLYQCVATNNAGTQTRQFRLTIQAA 1526

  Fly  5370 PSVPEGPLRNGDVSKNSIVLRWRPPKDDGGSEITHYVVEKMDNEAMRWVPVGDCTDTEIRADNLI 5434
            |.:.:    :|:.|:.::||        |...:.|..||.:....:.|:           .||
Zfish  1527 PLIRD----SGEDSEVTVVL--------GFPAVLHCEVEGIPLPTITWL-----------KDN-- 1566

  Fly  5435 ENHDYSFRVRAVNKQGQSQPLTTSQPITAKDPYSHPDKPGQPQATDWGKHFVDLEWSTPKRDGGA 5499
                              ||:.:|                 ||.|
Zfish  1567 ------------------QPIVSS-----------------PQLT-------------------- 1576

  Fly  5500 PISSYIIEKRPKFGQWERAAVVLGDN-----CKAHVPELTNGGEYEFRVIAVNRGGPSDPSDPSS 5559
                     ..:.||..|.|...|::     |:|..|..|....|..|::.    .|....|  |
Zfish  1577 ---------YTQGGQSLRVAAARGEDAGAYTCRATNPAGTAHRHYTLRIMV----PPQIEGD--S 1626

  Fly  5560 TIICKPRFLAPFFDKSLLNDITVHAGKRLGWTLPIEASPRPLITWLYNGKEIGSNSRGESGLFQN 5624
            ||:...|           .:..|.....|..:...:..|.|:..|..:|:.:..|:  .|||..|
Zfish  1627 TILSFGR-----------REEKVRINGTLTLSCLAKGFPEPVTQWFKDGQLLNGNT--HSGLSVN 1678

  Fly  5625 ELTFEIVSSLRSDEGRYTLILKNEHGSFDASAHATVLDRPSPP------KGPLDITKITRDGCHL 5683
            .....:.:::.|.||:||.::.|..|......|.|:   ..||      .|..|.|...|:|
Zfish  1679 SHMLHVDNAMLSHEGQYTCVVSNSAGEDKRDFHLTI---QVPPVFHRVINGAADFTLGEREG--- 1737

  Fly  5684 TWNVPDDDGGSPILHYIIEKMDLSRSTWSDAGMSTHIVHDVTRLVHRKEYLFRVKAVNAIGESDP 5748
                .::|..||                  .||           |.|:|.|        :|.|..
Zfish  1738 ----DEEDPDSP------------------DGM-----------VERREVL--------LGHSIS 1761

  Fly  5749 LEAVNTIIAKNEFDEPDAPGKPIITDWDRDHIDLQWAVPKSDGG--APISEYIIQKKEKGSPYWT 5811
            |...:..|            .|....|.|....|    ..|||.  || ..:|:|
Zfish  1762 LSCESNAI------------PPPRLSWYRQGRQL----TSSDGVVLAP-GGHILQ---------- 1799

  Fly  5812 NVRHVPSNKNTTTIPELTEGQEYEFRVIAVNQAGQSEPSEPSDMIMAKPRYLPPKIITPLNE--- 5873
                         ||.:......::...|||:||:.:.....:::      :||.|....:|
Zfish  1800 -------------IPRVQLEDAGKYTCQAVNEAGEDKMHYDLEVL------VPPVISGQTDEFMQ 1845

  Fly  5874 ---------VRIKCGLIFHTDIHFIGEPAPEATWTLNSNPLLSNDRSTITSIGHHSVVHTVNCQR 5929
                     |.::|      |:.  |.|:|..:|..:..||.|:.|..|...|  .::..||.|.
Zfish  1846 DVDTVVNSTVSLRC------DVS--GHPSPSVSWIKDGLPLYSDSRHNILEDG--KLLEIVNVQV 1900

  Fly  5930 SDSGIYHLLLRNSSGIDEGSFELVVLDRPGPPEGPMEYEEITANSVTISWKPPKDNGGSEISSYV 5994
            ||...|..:..|.:|..|..:.|                     |:.:   ||:..|..|....|
Zfish  1901 SDGASYQCVAENKAGAVERLYSL---------------------SIQV---PPRIVGRREEEMSV 1941

  Fly  5995 IEKRDLTHGGGWVPAVNYVSAKYNHAVVPRLLEGTMYELRVMAENLQGRSDPLTSDQPVVAKSQY 6059
            :|       |..:..:..|.| |..|.:....:|.|.|.
Zfish  1942 VE-------GHMISLLCDVQA-YPPADIIWTKDGQMLEF-------------------------- 1972

  Fly  6060 TVPGAPGKPELTDSDKNHITIKWKQPISNGGSPIIGYDIERRDVNTGRWIKINGQ--PVPTAEYQ 6122
                                                        .||..|...||  .:|.|..|
Zfish  1973 --------------------------------------------TTGIHILPGGQMLQIPRAGQQ 1993

  Fly  6123 DDRVTSNHQYQYRISAVNAAGNGKTSEPSAIFNARPLREKPRFYFDGLIGKRIKVR---AGEPVN 6184
            |       ..||..:|.|:||..:.|....|:....|  .||      :....:||   .|..:.
Zfish  1994 D-------AGQYVCTATNSAGQDQKSILLTIYALPAL--VPR------LESESEVRTPLVGSTLI 2043

  Fly  6185 LNIPISGAPTPTIEWKRGDLKLEEGKRISYETNSERTLFRIDDSNRRDSGKYTVTAANEFGKDTA 6249
            |....:|.|.|.:.|.|..|:|..|..:    ..||....|......|.|.||...:|..|:...
Zfish  2044 LRCEANGIPKPEVTWYRNGLQLAAGNGL----RIERQQLEIVGVQVADGGVYTCKVSNIAGQVDR 2104

  Fly  6250 DIEVIVVDKPSPPEGPL--SYTETAPDHISLHWYSPKDDGGSDITGYIIEFTEFGVDDWKPVPGT 6312
            ...| .|..|...||||  :.|:....||:|                                 .
Zfish  2105 TFRV-TVHVPPVMEGPLHETLTQNLGSHITL---------------------------------I 2135

  Fly  6313 CPNTNFTVKNLVEGKKYVFRIRAENIYGASEALEGKPVLAKSPFDPPGAPSQPTISAYTPNSANL 6377
            |..:...|.|:...|                  :|.|:                       .::|
Zfish  2136 CEASGIPVPNIAWLK------------------DGSPI-----------------------ESSL 2159

  Fly  6378 EWHPPDDCGGKPITGYIVERRERGGEWIKCNNYPTPNTSYTVSNLRDGARYEFRVLAVNEAGPGH 6442
            :|:                       |....|                 |.|...|.::.||
Zfish  2160 QWN-----------------------WSTRAN-----------------RLELGPLQLSHAG--- 2181

  Fly  6443 PSKPSDPMTAEHQRYRPDPPEPPKPDRITRNGVTLSWRPPRTDGKSRIKGYYVEMRPKNGKDWKT 6507
                                             |.:.....|:|:::             ||:
Zfish  2182 ---------------------------------TYTCIAKNTEGQTQ-------------KDY-- 2198

  Fly  6508 VNDIPINSTVYTVPSLKEGEEYSFRVVAENEVGRSDPSKPSQPITIEEQPNKPCMELGKVRDIVC 6572
                  :.|:|..||:               :....||:.|.|:             |:...:.|
Zfish  2199 ------SLTIYAPPSI---------------IDSGHPSEVSAPV-------------GEELALEC 2229

  Fly  6573 RAGDDFSIHVPYLAFPKPNAFWYSNDNMLDDNNRVHKHLTDDAASVVVKNSKRADSGQYRLQLKN 6637
            ||          :..|.|...|..|...|.:.|..|.:::.|.:::...:.|..|||.|.....:
Zfish  2230 RA----------MGSPAPKVSWLRNGKTLVNGNTEHINISPDGSTLTFLSVKPEDSGTYTCLAVS 2284

  Fly  6638 TSGFDTATINVRVLDRPSPPTRLRADEFSGDSLTLYWNPPNDDGGSAIQNYIIEKKEARSSTWSK 6702
            ::|.:|....:..|..||         .||::
Zfish  2285 SAGQETKIYTLFALVPPS---------ISGET--------------------------------- 2307

  Fly  6703 VSSFCTVPFVRIRNLVLNKEYDFRVIAENKYGQSDPANTSEPILARHPFDIPNTPGIPHGIDSTE 6767
                                                                   .:|..:.:|:
Zfish  2308 -------------------------------------------------------SVPREVHTTQ 2317

  Fly  6768 DSITIAWTKPKHDGGSPITGYIIEKRLLSDDKWTKAVHALCPDLSCKIPNLIENAEYEFRVAAVN 6832
            .|:.....|.|   |:|      :.::    .|.:..|.|.  ||.:|..|  :|:...|::.|:
Zfish  2318 HSVVTLECKAK---GTP------QPQI----SWLRDGHPLL--LSPRIRLL--SADSTLRISPVH 2365

  Fly  6833 AAGQSAY-------SGSSDLIFCRRPPHAPKITSDLSIRDMTVIAGDEFRITVPYHASPRPTASW 6890
            .:....|       :|.::|.|..:....|.:........:.|:.|....:|......|.||.||
Zfish  2366 LSDSGIYTCVARSRAGLAELNFDLQVQAPPAVERTEPTEQVAVVQGSSVTLTCEARGVPPPTLSW 2430

  Fly  6891 -------SLNGLEVIPGERIKFDSNDYASMYYNKSAKRDETGSYTITLTNNKGSDTASCHVTVVD 6948
                   ||:...::.|:..:|..:|...         .:.|.|:...:|..||.|.:.::||::
Zfish  2431 LKDGQPLSLHRNLLLDGQETRFLLSDVGP---------SDAGLYSCVASNQAGSSTKTFNLTVLE 2486

  Fly  6949 RP-----LPPQGPLNAYD-----------ITPDTCTLAWKTPLDDGGSPITN--YVVEK------ 6989
            .|     |.|:..|.|.|           :.|.  ||:|   |.| |.||.:  .::|:
Zfish  2487 PPKITGSLSPEEQLIAVDSLLELECIATGLPPP--TLSW---LKD-GRPIQDNMAIIERDGQLLR 2545

  Fly  6990 -----LDNSGSWVKISSFV-----RNTHYDVMGLEPHYKYNFRVRAENQYGLSDPLDIIEPIVAK 7044
                 ::::|.:..::|..     || |:..:.|.|           ...|.:|...:..|  ||
Zfish  2546 INKVQVEDAGLYTCLASSPAGEDGRN-HWVRVQLPP-----------TLLGSNDIRTVSVP--AK 2596

  Fly  7045 HQFTV--PDEPGQPKVIDWDSGNVTLIWTRPLSDGGSRIQ----GYQIEYRDI-LNDSSWNAYDY 7102
            ...|:  ..:...|..|:|...||.:       ..|.|||    |..:|.:|: ::||.
Zfish  2597 GHLTLECQTDSDPPPEIEWYKDNVKV-------QLGGRIQSIASGQFLEIQDVRMHDSG------ 2648

  Fly  7103 IIKDTKYQLYNLINGSEYEFRIKAKNAAGLSKPSSPSLRFKLKGKFTVPSPPGAPQVTRVGKNYV 7167
                              ::.....|.||     |.||.|.::    :..||
Zfish  2649 ------------------QYSCVVTNIAG-----STSLFFTVE----ILLPP------------- 2673

  Fly  7168 DLKWEKPLRDGGSRITGYIIERRDIGGAVWVKCNDYNVLDTEYTVMNLIEMGDYEFRVFAVNSAG 7232
                  .:|:|.|.|
Zfish  2674 ------VIREGSSLI-------------------------------------------------- 2682

  Fly  7233 RSEPSLCTMPIKVCEVLGGKKPDWITRLQDKVAPFGKDYTLQCAASGKPSPTARWLRNGKEIQMN 7297
                                           :|..|:|..|.|...|.||.:..|.::|..:.::
Zfish  2683 -------------------------------IAHVGQDAVLPCEVEGAPSSSVMWRKDGGPVPLH 2716

  Fly  7298 GGRMTCDSKDGVFRLHISNVQTGDDGDYTCEAMNSLGFVNTSGYLKIGSPPIINRCPSELKLPEG 7362
            ..|.|..|:..   |.||.||..|.|.|.|...|..|..:....||:...|.|:..|..
Zfish  2717 NNRFTLLSEGS---LRISTVQLSDVGRYYCSVSNQAGSDHRGMDLKVYVGPSISPGPFN------ 2772

  Fly  7363 DNSKIKIFYSGDQPLTVILKKNNEVICDSNDDTHVKVNIFDDYVAIYIRNIVKSDGGPYQIEFTN 7427
                          :||:..:...:.|:|
Zfish  2773 --------------VTVVTGQRAVLSCES------------------------------------ 2787

  Fly  7428 ESGSATGEFYVHITGMPSAPTGPMGISYINKNSCMLNWR----PPSYDGGLKVSHYVIERKDVSS 7488
                         ||:| ||              .::||    |.|.|   :.|.|.:    :||
Zfish  2788 -------------TGIP-AP--------------QVSWRRNGSPISVD---QSSAYRL----MSS 2817

  Fly  7489 PHWITVSSTCKDTAFNVQGLIENQEYIFRVMAVNENG----------MGPP-----LEGLNPIRA 7538
            ...:..|.|.:|..:            |.....||.|          ..||     :..:..::.
Zfish  2818 GSLVITSPTAEDEGY------------FECTVTNEVGEERRVIEVILQVPPVIKDDVSSVTAVKM 2870

  Fly  7539 KDPIDPPSPPGSPQITEIGGDFVHLEWEKPESDGGAHIQGYWIDKREVGSNTWQRVNATICAANQ 7603
            ...:.|....|.|:..        :.|.|.....||....|    |.:.:...:.:.||...|.:
Zfish  2871 SPVVLPCHATGRPEPV--------ISWNKNWMQLGARGGSY----RVLPTGALEILAATPSHAGK 2923

  Fly  7604 INCINLIEGRQYEFRIFAQNVAGLSTESSASQAVKIIDPQAASPPLIVKPLRDANCIQNHNAQFT 7668
            ..|             .|:|..|:        |.|.:......||.|.....:...:.:|:....
Zfish  2924 YTC-------------SARNPVGV--------AYKHVTLTVQEPPEIRPMAEEVQVVLHHSVVLP 2967

  Fly  7669 CTINGVPKPTISWYKGAREISNGARYHMYSEGDNHFLNINDVFGEDADEYVCRAVNKAGAKSTRA 7733
            |.:.|.|:|||:|.:....::.|.|..:.|.|...|..:  ..| ||..|.|.|.|:||....:.
Zfish  2968 CEVQGFPRPTITWQREGVPVATGHRLAVLSNGALKFSRV--TLG-DAGTYQCLAQNEAGTALAQT 3029

  Fly  7734 TLAIMTAPKLNVPPRFRDTAYFDKGENVVIKIPFTGFPKPRIHWVRDGENIESGGHYTVEVKERH 7798
            .|.:...|.|:| ||.......  |:.|.:.....|.|||.:.|.||...:....|
Zfish  3030 QLILQVPPVLSV-PRLEYVVVL--GQPVSLDCVADGQPKPEVTWHRDRRPVVDSSH--------- 3082

  Fly  7799 AVLIIRDGS-HL------DSGPYRITAENELGSDTAIIQVQISDRPDPPRFPLIESIGTESLSLS 7856
             :.:..:|| |:      |:|.|..:|.|.:|..:..:::.:.   .||:.    .:|...:|:.
Zfish  3083 -LRLFSNGSLHITATQRGDAGIYTCSARNSVGRASHDVRLILH---TPPQI----FVGQSEISVM 3139

  Fly  7857 WKAPVWDGCSDITNYYVERREHPLSSWIRVGNTRFTSMAVSGLTPGKEYDFRIFADNVYGRSDAS 7921
            ....|...|:      .:....|..||.:.|      ::||.: |||
Zfish  3140 QGLRVMLPCA------AQGVPEPRMSWEKKG------VSVSNM-PGK------------------ 3173

  Fly  7922 DTSTLIKTKESVKKKPIERKWEIDANGRKLRGKADGPVKDYDSYVFDIYSKFVPQPVEISQQSVY 7986
                                                         |.:
Zfish  3174 ---------------------------------------------FTL----------------- 3176

  Fly  7987 DRYDILEEIGTGAFGVVHRCRERSTGNIFAAKFIPVSHSVEKDLIRREIDIMNQLHHQKLINLHD 8051
                                                          ||
Zfish  3177 ----------------------------------------------RE----------------- 3178

  Fly  8052 AFEDDDEMILILEFLSGGELFERITAEGYVMTEAEVINYMRQICEGIRHMHEQNIIHLDIKPENI 8116
                           |||.:.||..|.
Zfish  3179 ---------------SGGLIIERAEAG-------------------------------------- 3190

  Fly  8117 MCQTRSSTNVKLIDFGLATRLDPNEVVKITTGTAEFAAPEIVNREPVGFYTDMWATGVLSYVLLS 8181
                         |.||.|.:..|     |.|:|.
Zfish  3191 -------------DAGLFTCVATN-----TAGSAR------------------------------ 3207

  Fly  8182 GLSPFAGDNDVQTLKNVKACDWDFDVESFKYISEEAKDFIRKLLVRNKEKRMTAHECLLHPWLTG 8246
                                 ||.                          |:|.:
Zfish  3208 ---------------------WDI--------------------------RLTVN---------- 3215

  Fly  8247 DHSAMKQEINRDRYLAYREKLRRKYEDFERFLLPIGRLSEYSSLRKLLMEKYKIHDAVFDRRQAA 8311
                                                                           ..
Zfish  3216 ---------------------------------------------------------------MR 3217

  Fly  8312 PRFVIRPSSQFCYEGQSVKFYCRCIAIATPTLTWSHNNIELRQSVKFMKRYVGDDY------YFI 8370
            |.|...|......:|||:...|......|||:||:.||          :.|.|...      ..|
Zfish  3218 PAFKELPGDVTLNKGQSLSLSCHAEGTPTPTITWTANN----------RPYTGASVDETGRSSVI 3272

  Fly  8371 INRVKLDDRGEYIIRAENHYGSREEVVFLNVQPLPKEQPRYRTESTPVRRREPLPYTFWQEESET 8435
            .:.|.:.|.|.|...|||..|....:.|:.|    :|.|..|.|:               ..|:|
Zfish  3273 FDNVTVSDGGTYACIAENTVGLIRALSFVRV----REPPVLRGEA---------------HTSQT 3318

  Fly  8436 APSFTFLLRPRVMQARDTCKLLCCLSGKPVPNVRWYKDGREL--SKYEYAMTHSDGVVTMEIIDC 8498
                       |:|.: :..|.|.:||.|||::||:|||:.|  |...:.:.:....:...||
Zfish  3319 -----------VIQGK-SAMLDCAVSGDPVPSLRWHKDGQPLLGSLRFHPLRNGSLALYSAII-- 3369

  Fly  8499 KPSDSGKYSCKATNCHGTDETDCVVIVE--------GEW----VT-----PEQAQLAHNFLYSGD 8546
              .|||:|.|.|.:..|..|....:.|:        .||    ||     .|:.:..:|
Zfish  3370 --GDSGEYRCVAESEAGAAERTISLKVQVPGGYSNWEEWGPCSVTCGQGIQERIRFCNN------ 3426

  Fly  8547 RKYIEQPIKPAPL---PIVTSRQYTSSSVQNTS--EPQGDKVNVSNSNSSGISN-KKKYASNSLQ 8605
                ..|....||   |.|.||:..:|.....|  ..:|..:.:.|....|::. :.....|.|:
Zfish  3427 ----PPPAYGGPLCEGPNVDSRKCQASLCPGESPRRARGSLIGMVNEKEFGVAYLEANITENDLE 3487

  Fly  8606 APGSPSRSRSATKELILPPDDSLM-CKPEFTKPLHDLTIHDGEQLILTCYVKGDPEPQISWSKNG 8669
            .    :.:..|..|.|.|....|: .......|::..|::..::                 ::||
Zfish  3488 G----TSTLEAHVENIPPSVGPLLRVLVSVFAPVYWTTVYQTQE-----------------TQNG 3531

  Fly  8670 KSLSSSDI---LDLRYKNG-IATLTINEVFPEDEGV--ITCTATNSVGAVETKCKLTIQPLDKNI 8728
            .|::....   ..|.::.| |..||......:.|||  :.......|..:.....|.:|..|::.
Zfish  3532 FSITEGQFRQESQLEFETGEILKLTHVARGLDGEGVLLVDIVINGFVPPMLLSSNLNLQEFDESY 3596

  Fly  8729 NKRKVNAGDNAPKIVSHLESRFVRDGDAVNLACRIIGAQHFDVVWLHNNKEIKPSKDFQYTNEAN 8793
                |..|..  ::.|......:|||..:.|.|     .|   ..:....|.:.....|......
Zfish  3597 ----VQTGSG--QLYSWSTQNHIRDGAPLTLRC-----NH---TMVFEGPESRQGPLLQLLRLTG 3647

  Fly  8794 I------------YRLQIAEIFPE-DGGT--------------------------YTCEAFNDIG 8819
            |            :::..:.:.|| ||.|                          ::|.  |::|
Zfish  3648 ISGTYSLYTLSLDFKMTASLLIPEGDGETCPKGFILDTASYCADEDECAVDSPCSHSCN--NNMG 3710

  Fly  8820 ESFSTCTINVTVPG--------DETKQPSFVKFPTSVSVLEGEGTTFECEIDSELLNLVWLKDGK 8876
            .....|....|:..        ||..|.|.:..|....|  ....|:.|:....|
Zfish  3711 GFSCACPSGFTISTESNSCQDIDECSQGSHLCHPNQQCV--NTVGTYRCQAKCGL---------- 3763

  Fly  8877 PIDETLPRYSFTKDGHRYSFAVAKCNMDDVGQYQAKAVS 8915
                          |.:.|.....|  :||.:.|..|||
Zfish  3764 --------------GFKPSLVGTSC--EDVDECQESAVS 3786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bt	NP_001162825.1	I-set	9..101	CDD:254352
		Ig	26..100	CDD:143165
		I-set	119..210	CDD:254352
		Ig	136..209	CDD:143165
		I-set	228..320	CDD:254352
		IGc2	242..312	CDD:197706
		I-set	335..425	CDD:254352
		Ig	350..423	CDD:143165
		Ig	436..530	CDD:299845
		I-set	438..532	CDD:254352
		I-set	545..636	CDD:254352
		Ig	560..633	CDD:143165
		Ig	657..731	CDD:143165
		I-set	746..835	CDD:254352
		Ig	1496..1586	CDD:299845
		IG_like	1503..1588	CDD:214653
		I-set	1639..1724	CDD:254352
		IG	1750..1821	CDD:214652
		IGc2	1750..1806	CDD:197706
		I-set	1826..1909	CDD:254352
		Ig	1831..1897	CDD:299845
		I-set	1914..1998	CDD:254352
		Ig	2020..2095	CDD:299845
		FN3	2100..2194	CDD:238020
		FN3	2203..2292	CDD:238020
		I-set	2311..2395	CDD:254352
		Ig	2321..2395	CDD:299845
		FN3	2399..2493	CDD:238020
		FN3	2501..2590	CDD:238020
		I-set	2602..2693	CDD:254352
		Ig	2619..2693	CDD:299845
		FN3	2697..2793	CDD:238020
		FN3	2801..2893	CDD:238020
		I-set	2902..2995	CDD:254352
		Ig	2919..2993	CDD:299845
		FN3	2999..3088	CDD:238020
		FN3	3102..3191	CDD:238020
		I-set	3208..3292	CDD:254352
		Ig	3219..3292	CDD:299845
		FN3	3296..3390	CDD:238020
		FN3	3400..3489	CDD:238020
		I-set	3494..3590	CDD:254352
		Ig	3516..3590	CDD:299845
		FN3	3594..3682	CDD:238020
		FN3	3694..3781	CDD:238020	2/2 (100%)
		I-set	3795..3885	CDD:254352	15/94 (16%)
		Ig	3813..3885	CDD:299845	11/73 (15%)
		FN3	3889..3980	CDD:238020	14/94 (15%)
		FN3	3990..4082	CDD:238020	22/121 (18%)
		I-set	4090..4181	CDD:254352	26/146 (18%)
		Ig	4108..4181	CDD:299845	22/128 (17%)
		FN3	4185..4271	CDD:238020	23/125 (18%)
		FN3	4285..4383	CDD:238020	20/102 (20%)
		Ig	4404..4480	CDD:299845	20/75 (27%)
		FN3	4484..4571	CDD:238020	18/117 (15%)
		FN3	4584..4677	CDD:238020	19/103 (18%)
		I-set	4685..4775	CDD:254352	23/89 (26%)
		Ig	4703..4775	CDD:299845	18/71 (25%)
		FN3	4779..4863	CDD:238020	4/83 (5%)
		FN3	4879..4970	CDD:238020	19/94 (20%)
		IG	4989..5069	CDD:214652	26/79 (33%)
		Ig	4996..5069	CDD:299845	23/72 (32%)
		FN3	5073..5166	CDD:238020	21/123 (17%)
		FN3	5175..5265	CDD:238020	18/92 (20%)
I-set	5276..5366	CDD:254352	23/90 (26%)
Ig	5293..5366	CDD:299845	18/72 (25%)
FN3	5370..5462	CDD:238020	15/91 (16%)
FN3	5470..5561	CDD:238020	17/95 (18%)
Ig	5559..5654	CDD:299845	22/94 (23%)
I-set	5570..5660	CDD:254352	19/89 (21%)
FN3	5664..5755	CDD:238020	19/96 (20%)
FN3	5764..5853	CDD:238020	18/90 (20%)
I-set	5865..5954	CDD:254352	26/100 (26%)
Ig	5882..5954	CDD:299845	21/71 (30%)
FN3	5958..6049	CDD:238020	15/90 (17%)
FN3	6062..6153	CDD:238020	16/92 (17%)
I-set	6173..6255	CDD:254352	22/84 (26%)
Ig_Titin_like	6182..6255	CDD:143225	19/72 (26%)
FN3	6259..6350	CDD:238020	14/92 (15%)
FN3	6359..6451	CDD:238020	9/91 (10%)
FN3	6470..6552	CDD:238020	13/81 (16%)
I-set	6564..6650	CDD:254352	19/85 (22%)
Ig_Titin_like	6577..6650	CDD:143225	15/72 (21%)
FN3	6654..6745	CDD:238020	4/90 (4%)
FN3	6754..6840	CDD:238020	18/92 (20%)
I-set	6855..6946	CDD:254352	20/97 (21%)
Ig	6874..6946	CDD:299845	17/78 (22%)
FN3	6950..7042	CDD:238020	26/125 (21%)
FN3	7050..7139	CDD:238020	18/93 (19%)
FN3	7151..7237	CDD:238020	6/85 (7%)
I-set	7254..7334	CDD:254352	23/79 (29%)
Ig	7272..7339	CDD:143165	21/66 (32%)
IG_like	7354..7440	CDD:214653	5/85 (6%)
Ig	7366..7440	CDD:299845	4/73 (5%)
FN3	7444..7531	CDD:238020	21/105 (20%)
FN3	7545..7637	CDD:238020	15/91 (16%)
I-set	7648..7737	CDD:254352	25/88 (28%)
Ig	7665..7734	CDD:143165	21/68 (31%)
Ig	7760..7833	CDD:299845	18/79 (23%)
FN3	7837..7927	CDD:238020	15/89 (17%)
STKc_Twitchin_like	7986..8244	CDD:271016	20/257 (8%)
S_TKc	7989..8244	CDD:214567	20/254 (8%)
Ig	8311..8394	CDD:299845	25/88 (28%)
I-set	8312..8401	CDD:254352	26/94 (28%)
I-set	8437..8525	CDD:254352	26/89 (29%)
Ig	8455..8519	CDD:143165	23/65 (35%)
I-set	8632..8721	CDD:254352	15/94 (16%)
IGc2	8646..8711	CDD:197706	11/70 (16%)
I-set	8740..8831	CDD:254352	19/129 (15%)
Ig	8757..8826	CDD:143165	14/107 (13%)
I-set	8839..8922	CDD:254352	15/77 (19%)
Ig	8845..>8909	CDD:299845	10/63 (16%)
hmcn2	XP_001920501.5	VWA_2	38..208	CDD:290253	26/167 (16%)
		IG	441..512	CDD:214652	13/70 (19%)
		Ig	441..502	CDD:299845	12/60 (20%)
		I-set	516..603	CDD:254352	21/98 (21%)
		Ig	533..600	CDD:143165	15/78 (19%)
		IG	613..691	CDD:214652	20/101 (20%)
		Ig	624..690	CDD:143165	16/82 (20%)
		IG	710..784	CDD:214652	20/75 (27%)
		Ig	714..781	CDD:143165	18/68 (26%)
		IG	794..879	CDD:214652	16/97 (16%)
		Ig	794..879	CDD:299845	16/97 (16%)
		I-set	885..972	CDD:254352	23/129 (18%)
		Ig	904..972	CDD:299845	20/109 (18%)
		IG_like	982..1063	CDD:214653	22/82 (27%)
		IGc2	989..1053	CDD:197706	18/65 (28%)
		IG_like	1083..1159	CDD:214653	23/101 (23%)
		Ig	1089..1156	CDD:143165	18/83 (22%)
		I-set	1163..1241	CDD:254352	29/90 (32%)
		IGc2	1176..1231	CDD:197706	23/67 (34%)
		Ig	1244..1327	CDD:299845	19/99 (19%)
		IG_like	1258..1335	CDD:214653	18/93 (19%)
		Ig	1338..1430	CDD:299845	22/131 (17%)
		I-set	1344..1428	CDD:254352	21/117 (18%)
		IG_like	1441..1523	CDD:214653	21/81 (26%)
		IGc2	1448..1513	CDD:197706	17/64 (27%)
		IG_like	1536..1616	CDD:214653	26/164 (16%)
		IGc2	1545..1606	CDD:197706	20/137 (15%)
		IG_like	1638..1714	CDD:214653	19/77 (25%)
		Ig	1644..1711	CDD:143165	17/68 (25%)
		IG_like	1753..1830	CDD:214653	24/124 (19%)
		Ig	1760..1822	CDD:143165	20/101 (20%)
		I-set	1834..1918	CDD:254352	24/93 (26%)
		Ig	1851..1925	CDD:299845	23/104 (22%)
		IG_like	1937..2017	CDD:214653	26/164 (16%)
		IGc2	1943..2007	CDD:197706	22/148 (15%)
		IG_like	2031..2110	CDD:214653	22/83 (27%)
		IGc2	2039..2100	CDD:197706	18/64 (28%)
		I-set	2114..2202	CDD:254352	28/258 (11%)
		IGc2	2129..2192	CDD:197706	20/212 (9%)
		IG	2214..2295	CDD:214652	23/103 (22%)
		IGc2	2222..2287	CDD:197706	17/74 (23%)
		I-set	2307..2391	CDD:254352	21/188 (11%)
		IGc2	2321..2381	CDD:197706	15/76 (20%)
		I-set	2400..2484	CDD:254352	19/92 (21%)
		IGc2	2410..2474	CDD:197706	15/72 (21%)
		IG_like	2496..2576	CDD:214653	19/86 (22%)
		IGc2	2507..2566	CDD:197706	12/64 (19%)
		IG	2589..2669	CDD:214652	25/121 (21%)
		IGc2	2597..2659	CDD:197706	16/92 (17%)
		IG	2679..2760	CDD:214652	27/164 (16%)
		IGc2	2687..2750	CDD:197706	22/65 (34%)
		I-set	2764..2851	CDD:254352	28/189 (15%)
		Ig	2770..2845	CDD:299845	26/177 (15%)
		IG	2863..2943	CDD:214652	18/112 (16%)
		Ig	2873..2942	CDD:299845	18/101 (18%)
		IG_like	2954..3032	CDD:214653	22/80 (28%)
		IGc2	2963..3023	CDD:197706	19/62 (31%)
		IG_like	3046..3122	CDD:214653	19/87 (22%)
		IGc2	3051..3113	CDD:197706	18/71 (25%)
		IG_like	3133..3214	CDD:214653	32/384 (8%)
		Ig	3144..3213	CDD:299845	31/372 (8%)
		IG	3224..3303	CDD:214652	24/88 (27%)
		IGc2	3232..3293	CDD:197706	21/70 (30%)
		IG_like	3316..3394	CDD:214653	28/93 (30%)
IGc2	3321..3384	CDD:197706	23/67 (34%)
TSP1	3401..3452	CDD:214559	14/60 (23%)
G2F	3455..3636	CDD:284812	38/215 (18%)
EGF_CA	3691..3721	CDD:214542	4/31 (13%)
Furin-like	3728..3857	CDD:279142	18/87 (21%)
EGF_CA	3731..3774	CDD:284955	11/68 (16%)
EGF_CA	3776..3814	CDD:214542	6/11 (55%)
EGF_CA	3816..3849	CDD:238011
EGF_CA	3858..3899	CDD:284955
EGF_CA	3901..3940	CDD:214542
EGF_CA	4005..4044	CDD:214542
EGF_CA	4045..4085	CDD:214542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592671
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4475
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100287
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.730