DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment bt and dapk1

DIOPT Version :9

Sequence 1:NP_001162825.1 Gene:bt / 43814 FlyBaseID:FBgn0005666 Length:8933 Species:Drosophila melanogaster
Sequence 2:NP_001093460.1 Gene:dapk1 / 558314 ZFINID:ZDB-GENE-060526-177 Length:1439 Species:Danio rerio


Alignment Length:1042 Identity:253/1042 - (24%)
Similarity:397/1042 - (38%) Gaps:329/1042 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly  7981 SQQSVYDRYDILEEIGTGAFGVVHRCRERSTGNIFAAKFIPVSHS------VEKDLIRREIDIMN 8039
            :|::|.|.|:|..|:|:|.|.||.:||.:|||..:|||||....|      |.||.|.||:.|:.
Zfish     5 NQENVEDYYEIGGELGSGQFAVVKKCRHKSTGVEYAAKFIKKRRSKSSRRGVSKDDIEREVSILK 69

  Fly  8040 QLHHQKLINLHDAFEDDDEMILILEFLSGGELFERITAEGYVMTEAEVINYMRQICEGIRHMHEQ 8104
            ::.|..:|.|||.||:..|:|||||.::|||||: ..||...::|.|...:::||.:|:.::|.:
Zfish    70 EIQHPNVITLHDVFENKHEVILILELVAGGELFD-FLAEKESLSEEEATEFLKQILDGVSYLHSK 133

  Fly  8105 NIIHLDIKPENIMCQTRS--STNVKLIDFGLATRLDPNEVVKITTGTAEFAAPEIVNREPVGFYT 8167
            .|.|.|:||||||...|:  ...:||||||||.::|.....|...||.||.|||:||.||:|...
Zfish   134 RISHFDLKPENIMLLNRNVPHPRIKLIDFGLAHKIDFGNDFKNIFGTPEFVAPEVVNYEPLGLEA 198

  Fly  8168 DMWATGVLSYVLLSGLSPFAGDNDVQTLKNVKACDWDFDVESFKYISEEAKDFIRKLLVRNKEKR 8232
            |||:.||::|:||||.|||.|:|..:||.||.|.|::||.:.|.:.|..|||||.:||:::.:||
Zfish   199 DMWSIGVITYILLSGASPFLGENKQETLANVSAVDYEFDEDYFSHTSALAKDFIARLLIKDPKKR 263

  Fly  8233 MTAHECLLHPWLTGDHSAMKQEINRDRYLAYREKL-----RRKYEDFERFLLPIGRLSEYSSLRK 8292
            ||..:.|.|||:....:  :|.::|.......||.     |||::...|.:....|||. |.|.:
Zfish   264 MTILDSLQHPWIKPKDT--QQALSRKESAVNMEKFKKFAARRKWKQSVRLISLCNRLSR-SFLSR 325

  Fly  8293 LLMEKYKIHDAVFDRRQAAPRFVIRP-------------SSQFCYE-GQSVKFYCRCIAIATPTL 8343
            ..|...:..|.:.:......:.:|..             .|...|: .|..|.       .||.|
Zfish   326 SNMSVARSDDTLDEEDSFVMKAIIHAINDDNVPGLKHLLGSLTSYDINQPNKH-------GTPPL 383

  Fly  8344 TWSH--NNIEL------------------RQSVKFMKR--YVGDDYYFIINRVKLD--DR-GEYI 8383
            ..:.  .|:::                  ..::.:..|  :||...:....:..||  |: ||..
Zfish   384 LIAAGCGNVQIIDVLMKKGAEIQAFDKTGASAIYYAARHGHVGTLRFLHEKKCPLDIQDKSGETA 448

  Fly  8384 IRAENHYGSREEVVFL-----NVQPLPKEQPRYRTESTPVRRREPLPYTFWQEESETAPSFTFLL 8443
            :.....||:.:.|.:|     |...|.:||            ..||....|...|..        
Zfish   449 LHVAARYGNVDVVQYLCSIHANPDLLDREQ------------ETPLHCAAWHGYSAV-------- 493

  Fly  8444 RPRVMQARDTCKLLCCLSGK------PV--PNVRWYKDGRELSKYEYAMTHSDGVVTMEIIDCKP 8500
                  ||..|:..|.::.:      |:  .:.|.:||                     |::|..
Zfish   494 ------ARALCEAGCDVNARNREGESPLLTASARGFKD---------------------IVECLL 531

  Fly  8501 SDSGKYSCKATNCHGTD----ETD-----------CVVIVEGEWVTPEQAQLAHNFLYSGDRKYI 8550
            .            ||.|    :.|           |.|.|       .:..|:|:.......::.
Zfish   532 E------------HGADMDSADKDGHIALHLAVRRCQVEV-------VKCLLSHHCYVDHQDRHG 577

  Fly  8551 EQPI----KPAPLPIVTS-----------RQYTSSSVQNTSEPQGDKV----NVSNSNSSGISNK 8596
            ..|:    |.|.:|:||.           .::..:.:...:...|.:|    .:|.:|:..|:|.
Zfish   578 NTPLHIACKDANMPVVTQLCAAKANLDIPNKFGRTPLHLAASNGGLEVVRHLCLSGANTEAITND 642

  Fly  8597 KKYA------------------------------------------------------------- 8600
            .|.|                                                             
Zfish   643 GKTAEDLATAEQQEHVAVLLAKLKKDNHKSIYIQQLRPTQTLQHRLKLKLFGHSGAGKSTLVESL 707

  Fly  8601 ----------------SNSLQAPGSPSRSRSATK----------ELILPPDDSLMCKPEFTK--- 8636
                            :|.::.|.||..|:.|..          |.:.....|:|.:|..||   
Zfish   708 KCGILRSFFRRRRTRLTNPVRHPASPVTSKPAVSVSISNLYPGCENVSVRSRSMMFEPSLTKGVL 772

  Fly  8637 ----PLHDLTIHDGEQLILTCYVKGDPEPQISWSKNGKSLSSSD-----ILDLRYK--NGIATLT 8690
                |:|:                              :||::|     .:|::..  ||:...:
Zfish   773 EVFSPVHN------------------------------ALSTADDTATKAIDIQNANVNGVGDFS 807

  Fly  8691 INEVFPEDEGVITCT----ATNSVGAVETKCKLTIQPLDKNINKRKVNAGDNAPKIVSHLESRFV 8751
            |.|.  ....|..|:    |.|...|:........:|.:..:|  :|....|..|.::..|....
Zfish   808 IWEF--SGNPVYYCSYDYFAANDATAIHLVLFSLEEPYETQLN--QVTFWLNCLKALTLPEDNIA 868

  Fly  8752 RDGDAVNLACRIIGAQHFDVVWLHNNKEIKPSKDFQYTNEANIYR---------LQIAE-IFPED 8806
            ..|...|....::.|.|.|:|    |.......:|.|..|.::.:         |.|.| :|..|
Zfish   869 FGGKIRNPLRVVLVATHADIV----NLPRSFGGEFSYDKERSLLKEVRNRFGNDLLITEKLFVMD 929

  Fly  8807 GG 8808
            .|
Zfish   930 AG 931

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
btNP_001162825.1 I-set 9..101 CDD:254352
Ig 26..100 CDD:143165
I-set 119..210 CDD:254352
Ig 136..209 CDD:143165
I-set 228..320 CDD:254352
IGc2 242..312 CDD:197706
I-set 335..425 CDD:254352
Ig 350..423 CDD:143165
Ig 436..530 CDD:299845
I-set 438..532 CDD:254352
I-set 545..636 CDD:254352
Ig 560..633 CDD:143165
Ig 657..731 CDD:143165
I-set 746..835 CDD:254352
Ig 1496..1586 CDD:299845
IG_like 1503..1588 CDD:214653
I-set 1639..1724 CDD:254352
IG 1750..1821 CDD:214652
IGc2 1750..1806 CDD:197706
I-set 1826..1909 CDD:254352
Ig 1831..1897 CDD:299845
I-set 1914..1998 CDD:254352
Ig 2020..2095 CDD:299845
FN3 2100..2194 CDD:238020
FN3 2203..2292 CDD:238020
I-set 2311..2395 CDD:254352
Ig 2321..2395 CDD:299845
FN3 2399..2493 CDD:238020
FN3 2501..2590 CDD:238020
I-set 2602..2693 CDD:254352
Ig 2619..2693 CDD:299845
FN3 2697..2793 CDD:238020
FN3 2801..2893 CDD:238020
I-set 2902..2995 CDD:254352
Ig 2919..2993 CDD:299845
FN3 2999..3088 CDD:238020
FN3 3102..3191 CDD:238020
I-set 3208..3292 CDD:254352
Ig 3219..3292 CDD:299845
FN3 3296..3390 CDD:238020
FN3 3400..3489 CDD:238020
I-set 3494..3590 CDD:254352
Ig 3516..3590 CDD:299845
FN3 3594..3682 CDD:238020
FN3 3694..3781 CDD:238020
I-set 3795..3885 CDD:254352
Ig 3813..3885 CDD:299845
FN3 3889..3980 CDD:238020
FN3 3990..4082 CDD:238020
I-set 4090..4181 CDD:254352
Ig 4108..4181 CDD:299845
FN3 4185..4271 CDD:238020
FN3 4285..4383 CDD:238020
Ig 4404..4480 CDD:299845
FN3 4484..4571 CDD:238020
FN3 4584..4677 CDD:238020
I-set 4685..4775 CDD:254352
Ig 4703..4775 CDD:299845
FN3 4779..4863 CDD:238020
FN3 4879..4970 CDD:238020
IG 4989..5069 CDD:214652
Ig 4996..5069 CDD:299845
FN3 5073..5166 CDD:238020
FN3 5175..5265 CDD:238020
I-set 5276..5366 CDD:254352
Ig 5293..5366 CDD:299845
FN3 5370..5462 CDD:238020
FN3 5470..5561 CDD:238020
Ig 5559..5654 CDD:299845
I-set 5570..5660 CDD:254352
FN3 5664..5755 CDD:238020
FN3 5764..5853 CDD:238020
I-set 5865..5954 CDD:254352
Ig 5882..5954 CDD:299845
FN3 5958..6049 CDD:238020
FN3 6062..6153 CDD:238020
I-set 6173..6255 CDD:254352
Ig_Titin_like 6182..6255 CDD:143225
FN3 6259..6350 CDD:238020
FN3 6359..6451 CDD:238020
FN3 6470..6552 CDD:238020
I-set 6564..6650 CDD:254352
Ig_Titin_like 6577..6650 CDD:143225
FN3 6654..6745 CDD:238020
FN3 6754..6840 CDD:238020
I-set 6855..6946 CDD:254352
Ig 6874..6946 CDD:299845
FN3 6950..7042 CDD:238020
FN3 7050..7139 CDD:238020
FN3 7151..7237 CDD:238020
I-set 7254..7334 CDD:254352
Ig 7272..7339 CDD:143165
IG_like 7354..7440 CDD:214653
Ig 7366..7440 CDD:299845
FN3 7444..7531 CDD:238020
FN3 7545..7637 CDD:238020
I-set 7648..7737 CDD:254352
Ig 7665..7734 CDD:143165
Ig 7760..7833 CDD:299845
FN3 7837..7927 CDD:238020
STKc_Twitchin_like 7986..8244 CDD:271016 124/265 (47%)
S_TKc 7989..8244 CDD:214567 123/262 (47%)
Ig 8311..8394 CDD:299845 19/121 (16%)
I-set 8312..8401 CDD:254352 21/132 (16%)
I-set 8437..8525 CDD:254352 16/110 (15%)
Ig 8455..8519 CDD:143165 10/75 (13%)
I-set 8632..8721 CDD:254352 18/106 (17%)
IGc2 8646..8711 CDD:197706 12/75 (16%)
I-set 8740..8831 CDD:254352 18/79 (23%)
Ig 8757..8826 CDD:143165 15/62 (24%)
I-set 8839..8922 CDD:254352
Ig 8845..>8909 CDD:299845
dapk1NP_001093460.1 STKc_DAPK1 7..275 CDD:271096 125/268 (47%)
S_TKc 13..275 CDD:214567 123/262 (47%)
Ank_2 <337..409 CDD:289560 9/78 (12%)
ANK 373..497 CDD:238125 28/156 (18%)
ANK repeat 378..409 CDD:293786 4/37 (11%)
Ank_4 379..432 CDD:290365 7/52 (13%)
ANK repeat 412..442 CDD:293786 5/29 (17%)
Ank_2 416..508 CDD:289560 24/117 (21%)
ANK 439..564 CDD:238125 33/190 (17%)
ANK repeat 444..475 CDD:293786 7/30 (23%)
ANK repeat 477..508 CDD:293786 10/56 (18%)
ANK 505..629 CDD:238125 23/163 (14%)
ANK repeat 510..541 CDD:293786 9/63 (14%)
Ank_4 513..564 CDD:290365 13/90 (14%)
ANK repeat 543..574 CDD:293786 6/37 (16%)
Ank_2 548..635 CDD:289560 14/93 (15%)
ANK repeat 576..607 CDD:293786 6/30 (20%)
ANK 604..>671 CDD:238125 8/66 (12%)
ANK repeat 609..638 CDD:293786 4/28 (14%)
Ank_4 610..662 CDD:290365 8/51 (16%)
Death_DAPK1 1310..1399 CDD:260052
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.910

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