DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bt and CNTN5

DIOPT Version :9

Sequence 1:	NP_001162825.1	Gene:	bt / 43814	FlyBaseID:	FBgn0005666	Length:	8933	Species:	Drosophila melanogaster
Sequence 2:	NP_001230199.1	Gene:	CNTN5 / 53942	HGNCID:	2175	Length:	1100	Species:	Homo sapiens

Alignment Length:	1044	Identity:	224/1044 - (21%)
Similarity:	375/1044 - (35%)	Gaps:	290/1044 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 AGLYKVKAKNKS----------------GEVSAS--------------INLNFTPADEPKEKQID 115
            |.|.::|..:.|                |.:|||              ||| :..:|..|:.:..
Human    32 AALLRIKKSSSSSLFGSKTRPRYSSPSLGTLSASSPSWLGAAQNYYSPINL-YHSSDAFKQDESV 95

  Fly   116 GFAPTFAKKP---AIRQEEDGKRLLFECRVNADPIPAIIWFHNGAAVK-ESERHKITVDKDVHSY 176
            .:.|.|.::|   ....:.|.|::...|.|..:|:|:..|..||..:. ||:.....:|
Human    96 DYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLID------ 154

  Fly   177 FATLEILNVT-VEDAGKYKVNAKNELG---ESNATISLNFDSDEAPVPESAEGIKPTFTERPVIR 237
             .|..|.|.: .:|:|.|:..|.|.:|   ...||:...:..:.:....||..::
Human   155 -GTFIISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVR---------- 208

  Fly   238 QSEDGGNVTFECRCVGDPTP-----TVTWSHGETE---LNESNRYKMSLTMDQKLYHIACLEISS 294
               :|..|...|    .|.|     ..:|...|..   ..:|.|:....|.:        |.||.
Human   209 ---EGQGVVLMC----SPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGN--------LYISK 258

  Fly   295 VVSSDQGEYRAQAKNKHGSGVATINLNFESGSKKIP-----DG----KSPR----FP------KK 340
            |.:||.|.|....||       |:. |....|...|     ||    ..|:    ||      |.
Human   259 VQTSDVGSYICLVKN-------TVT-NARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKG 315

  Fly   341 PTIRQEEDLLIMECVLEAHPVPDIVWYCSEKEICNNQRTKMTRKAITKDSYILTLEIQNPTKEDG 405
            .|::       |||....:|||.|.|......|.:..|.:.::         ..|||.|...:|.
Human   316 TTVK-------MECFALGNPVPTITWMKVNGYIPSKARLRKSQ---------AVLEIPNVQLDDA 364

  Fly   406 GNYRCNAINMYGESNANIALNFQGASDANGFAPSFIEKPRIIPNESGTLITMKCKCKAKPEPTVT 470
            |.|.|.|.|..|::      :|:|......: |.::||......:||:.:..:||...||.||..
Human   365 GIYECRAENSRGKN------SFRGQLQVYTY-PHWVEKLNDTQLDSGSPLRWECKATGKPRPTYR 422

  Fly   471 WYR-GQDLVEKSKKIKINTTVIAEDTYELTLEIKDPGATDGGTYRCNVKNEYGESNANLNLNIEA 534
            |.: |..|..:|:...:|.          .|.|.:...:|.|.|:|..:|:||...|:..|.|.|
Human   423 WLKNGVPLSPQSRVEMVNG----------VLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILA 477

  Fly   535 EPEPEGEGPTF----IEKPRIVSENNGKLVIMECKVKADPKPDVIWFRNGEVIKESNKIKTFIEQ 595
                  ..|||    ::|..||:::  :.|::|||.:..|||.:.|.:....::|:.:|....:.
Human   478 ------SAPTFALNQLKKTIIVTKD--QEVVIECKPQGSPKPTISWKKGDRAVRENKRIAILPDG 534

  Fly   596 RGDQYYIKLELLDPQLEDSGLYKCNIKNTLGELNANLTLNIEIVPVIKDKPKIIKIIKKRTVVIE 660
                   .|.:|:....|.|.|.|..:|..|......:|:::....|:..||..::....::|:.
Human   535 -------SLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLN 592

  Fly   661 CTVASKFEPKCTWYKETSTVKESKRHVYQVEQTKEGEFAVKLEINDVEESDKGAYKLVASNEKGE 725
            |..........|:|                       :.:|.:..|.|| :.|.::.:.: :...
Human   593 CKAIHDASLDVTFY-----------------------WTLKGQPIDFEE-EGGHFESIRA-QASS 632

  Fly   726 AVSQIVNLVDIPEEERKPCKPEISRKLADQKVAESKTFELLVSLSQTDRKCKVEWYKGSTVIRET 790
            |...|.|:: :....|..|:.:.:   ||....|:   |||           |....|...|...
Human   633 ADLMIRNIL-LMHAGRYGCRVQTT---ADSVSDEA---ELL-----------VRGPPGPPGIVIV 679

  Fly   791 KDITTTFDGTTARLTFSSARTEHT--SNY------------------------------------ 817
            ::||.    :||.|::|.|...|:  |:|
Human   680 EEITE----STATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNP 740

  Fly   818 ------KVIVTNEVGKDESSCKITVEKVAKKKEEKPKEKEKTKNEKEVEQKEM--------EEDK 868
                  :|:.||.:|..:.|   |..::.:..|..||......:.:...:.|:        ||.:
Human   741 WVEYEFRVVATNPIGTGDPS---TPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQ 802

  Fly   869 NESG-----------------QSVAQTEGRINIEQISEGDPKEELTVKEEILDKRD----TQEVK 912
            |..|                 :.|..:|....|.:.....|.....||..:.:.:.    :|.|.
Human   803 NGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVV 867

  Fly   913 ESSVELQDSAGHEVPEPKKATSDSKLD-----QSNQKNLDKKHKTDQSESKTNKNVSLAEPIKSN 972
            ..|.|.:.||   .|...||||.|..:     :..:::|.:....:....|..:....||.:|:.
Human   868 ICSAEGEPSA---APTDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKDMEQEDTAETVKTR 929

  Fly   973 KQES 976
            ..||
Human   930 GNES 933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bt	NP_001162825.1	I-set	9..101	CDD:254352	9/49 (18%)
		Ig	26..100	CDD:143165	8/48 (17%)
		I-set	119..210	CDD:254352	26/98 (27%)
		Ig	136..209	CDD:143165	21/77 (27%)
		I-set	228..320	CDD:254352	21/99 (21%)
		IGc2	242..312	CDD:197706	20/77 (26%)
		I-set	335..425	CDD:254352	26/99 (26%)
		Ig	350..423	CDD:143165	21/72 (29%)
		Ig	436..530	CDD:299845	26/94 (28%)
		I-set	438..532	CDD:254352	27/94 (29%)
		I-set	545..636	CDD:254352	23/94 (24%)
		Ig	560..633	CDD:143165	18/72 (25%)
		Ig	657..731	CDD:143165	10/73 (14%)
		I-set	746..835	CDD:254352	24/132 (18%)
		Ig	1496..1586	CDD:299845
		IG_like	1503..1588	CDD:214653
		I-set	1639..1724	CDD:254352
		IG	1750..1821	CDD:214652
		IGc2	1750..1806	CDD:197706
		I-set	1826..1909	CDD:254352
		Ig	1831..1897	CDD:299845
		I-set	1914..1998	CDD:254352
		Ig	2020..2095	CDD:299845
		FN3	2100..2194	CDD:238020
		FN3	2203..2292	CDD:238020
		I-set	2311..2395	CDD:254352
		Ig	2321..2395	CDD:299845
		FN3	2399..2493	CDD:238020
		FN3	2501..2590	CDD:238020
		I-set	2602..2693	CDD:254352
		Ig	2619..2693	CDD:299845
		FN3	2697..2793	CDD:238020
		FN3	2801..2893	CDD:238020
		I-set	2902..2995	CDD:254352
		Ig	2919..2993	CDD:299845
		FN3	2999..3088	CDD:238020
		FN3	3102..3191	CDD:238020
		I-set	3208..3292	CDD:254352
		Ig	3219..3292	CDD:299845
		FN3	3296..3390	CDD:238020
		FN3	3400..3489	CDD:238020
		I-set	3494..3590	CDD:254352
		Ig	3516..3590	CDD:299845
		FN3	3594..3682	CDD:238020
		FN3	3694..3781	CDD:238020
		I-set	3795..3885	CDD:254352
		Ig	3813..3885	CDD:299845
		FN3	3889..3980	CDD:238020
		FN3	3990..4082	CDD:238020
		I-set	4090..4181	CDD:254352
		Ig	4108..4181	CDD:299845
		FN3	4185..4271	CDD:238020
		FN3	4285..4383	CDD:238020
		Ig	4404..4480	CDD:299845
		FN3	4484..4571	CDD:238020
		FN3	4584..4677	CDD:238020
		I-set	4685..4775	CDD:254352
		Ig	4703..4775	CDD:299845
		FN3	4779..4863	CDD:238020
		FN3	4879..4970	CDD:238020
		IG	4989..5069	CDD:214652
		Ig	4996..5069	CDD:299845
		FN3	5073..5166	CDD:238020
		FN3	5175..5265	CDD:238020
I-set	5276..5366	CDD:254352
Ig	5293..5366	CDD:299845
FN3	5370..5462	CDD:238020
FN3	5470..5561	CDD:238020
Ig	5559..5654	CDD:299845
I-set	5570..5660	CDD:254352
FN3	5664..5755	CDD:238020
FN3	5764..5853	CDD:238020
I-set	5865..5954	CDD:254352
Ig	5882..5954	CDD:299845
FN3	5958..6049	CDD:238020
FN3	6062..6153	CDD:238020
I-set	6173..6255	CDD:254352
Ig_Titin_like	6182..6255	CDD:143225
FN3	6259..6350	CDD:238020
FN3	6359..6451	CDD:238020
FN3	6470..6552	CDD:238020
I-set	6564..6650	CDD:254352
Ig_Titin_like	6577..6650	CDD:143225
FN3	6654..6745	CDD:238020
FN3	6754..6840	CDD:238020
I-set	6855..6946	CDD:254352
Ig	6874..6946	CDD:299845
FN3	6950..7042	CDD:238020
FN3	7050..7139	CDD:238020
FN3	7151..7237	CDD:238020
I-set	7254..7334	CDD:254352
Ig	7272..7339	CDD:143165
IG_like	7354..7440	CDD:214653
Ig	7366..7440	CDD:299845
FN3	7444..7531	CDD:238020
FN3	7545..7637	CDD:238020
I-set	7648..7737	CDD:254352
Ig	7665..7734	CDD:143165
Ig	7760..7833	CDD:299845
FN3	7837..7927	CDD:238020
STKc_Twitchin_like	7986..8244	CDD:271016
S_TKc	7989..8244	CDD:214567
Ig	8311..8394	CDD:299845
I-set	8312..8401	CDD:254352
I-set	8437..8525	CDD:254352
Ig	8455..8519	CDD:143165
I-set	8632..8721	CDD:254352
IGc2	8646..8711	CDD:197706
I-set	8740..8831	CDD:254352
Ig	8757..8826	CDD:143165
I-set	8839..8922	CDD:254352
Ig	8845..>8909	CDD:299845
CNTN5	NP_001230199.1	Ig1_Contactin-5	98..191	CDD:143256	26/99 (26%)
		I-set	99..190	CDD:254352	26/97 (27%)
		Ig	193..287	CDD:299845	25/126 (20%)
		IG_like	205..278	CDD:214653	21/105 (20%)
		Ig	300..387	CDD:299845	28/108 (26%)
		I-set	300..386	CDD:254352	28/107 (26%)
		I-set	390..475	CDD:254352	27/94 (29%)
		Ig	392..475	CDD:299845	26/92 (28%)
		I-set	489..568	CDD:254352	22/87 (25%)
		Ig5_Contactin_like	496..568	CDD:143170	19/80 (24%)
		I-set	573..667	CDD:254352	23/136 (17%)
		Ig	587..671	CDD:299845	21/126 (17%)
		FN3	671..768	CDD:238020	18/103 (17%)
		FN3	776..868	CDD:238020	13/91 (14%)
		FN3	878..969	CDD:238020	13/56 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	959..982
		FN3	977..1062	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910