DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bt and mybpc1

DIOPT Version :9

Sequence 1:	NP_001162825.1	Gene:	bt / 43814	FlyBaseID:	FBgn0005666	Length:	8933	Species:	Drosophila melanogaster
Sequence 2:	XP_009298541.1	Gene:	mybpc1 / 492356	ZFINID:	ZDB-GENE-041114-196	Length:	1294	Species:	Danio rerio

Alignment Length:	1668	Identity:	360/1668 - (21%)
Similarity:	579/1668 - (34%)	Gaps:	515/1668 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  5369 APSVPEGPLRNGDVSKNSIVLRWRPPKDDGGSEITHYVVEKMDNEAMRWVPV------------- 5420
            ||...:.|..|...||.:.|    ..||      |...|.:.:.||....|.
Zfish    15 APDSSDVPSENSVTSKEAKV----ATKD------TEAKVTEAEAEAAVPTPAAEPPQPQPVVIVV 69

  Fly  5421 -------GDCTDTEIRADNLIEN-HDYSFRVRAVNKQGQSQPLTTSQPITAKDPYSHPDKPGQPQ 5477
                   |:.||.:......:|| |         ::..|:||..:.|.|..|:     ::|...:
Zfish    70 TELEPVEGEVTDPQPIVTEPVENGH---------SEPEQTQPERSVQVIEVKE-----EEPSSSK 120

  Fly  5478 ATDWGKHFVDLEWSTPK-----RDGGAPISSYIIEKRPKFGQWERAAVVLGDNCKAHVPELTNGG 5537
            ..|...   |:..|||.     .||..|               ::.::.|.::..   ||.|.|.
Zfish   121 THDKDD---DVTASTPSPPPPAEDGSTP---------------KKLSIDLPNDSD---PESTRGR 164

  Fly  5538 EYEFRVIAVNRGGPSDPSD------PSSTIICKPRFLAPFFDKSLLNDITVHAGKRLGWTLPIEA 5596
            :..  |.::..|.|.:..|      |.||::         .:|.....|||  |..:.:...:||
Zfish   165 KDS--VWSLGDGQPPEEIDKQTENPPLSTLL---------IEKPQSGSITV--GGDITFIAKVEA 216

  Fly  5597 SP---RPLITWLYNGKEIGSNSRGESGLFQNELTFEIVSSLRSDEGRYTLILKNEHGSFDASAHA 5658
            ..   :|.:.| :.||.:...|:....| |.:.:||.:|.:.:.|.......:|..|::
Zfish   217 KDLLRKPTVKW-FKGKWMDLASKTGKHL-QLKESFERLSKIHTFEMHIIKAKENYAGNY------ 273

  Fly  5659 TVLDRPSPPKGPLDITKITRDGCHLTWNVPDDDGGSPILHYIIEKMDLSRSTWSDAGMSTHIVHD 5723
                                 .|.:|:.               :|.|..
Zfish   274 ---------------------RCEVTYK---------------DKFDSC---------------- 286

  Fly  5724 VTRLVHRKEYLFRVKAVNAIGESDPLEAVNTIIAKNEFDEPDAPGKPIITDWDRDHIDLQWAVPK 5788
                    .:...||.|..:.:|                                 ||::.|..:
Zfish   287 --------SFDLEVKEVPEVSQS---------------------------------IDIRSAFKR 310

  Fly  5789 SDGGAPISEYIIQKKEKGSPYWTNV---RHVPSNKNTTTIPE------LTEGQEYEFRVIA---- 5840
            |..|         :.:.|...::.:   ||....|...| ||      |...:..|:..||
Zfish   311 SSEG---------QDDAGELDFSGLLKHRHGREVKQEET-PEVDVWEILKNARPDEYEKIAFTYG 365

  Fly  5841 -------VNQAGQSEPSEPSDMIMAKPRYLPPKIITPLNEVRIKCGLIFHTDIHFIGEPAPEATW 5898
                   :.:..:::..|......|| |..|...:....::|:         |..:.:|..|..|
Zfish   366 ITDLRGLLKRLKKTKKEEKKSEAFAK-RLEPAYQVDKGGKIRL---------IVDLADPTVELKW 420

  Fly  5899 TLNS---NPLLSNDRSTITSIGHHSVVHTVNCQRSDSGIYHLLLRNSSGIDEGSFELVVLDRPGP 5960
            ..|.   .|..:|.:......|...::...|||.||...|.:    ::|.::.:.||.|.:.|..
Zfish   421 YKNGQEIRPTPNNRKFIFEHKGTQRIMVINNCQMSDDAAYSV----TAGEEKCTTELFVKELPVN 481

  Fly  5961 PEGPMEYEEITANS-VTISWKPPKDNGGSEISSYVIEKRDLTHGGGWVPAVNYVSAKYNHAVVPR 6024
            ....:|..:.|.|. :.:.         .|:|....:.:.:.:|   |.....|.::|...
Zfish   482 IVKELEPVKTTVNERIELE---------CEVSEEGAKVKWMKNG---VEVPTGVRSRYRVK---- 530

  Fly  6025 LLEGTMYELRVMAENLQGRSDPLTSDQPVVAKSQYTVPGAPG----------KPELTDSDKNHIT 6079
             .|||.:.|.:         |..:.|.    ...|::....|          ||.....|...:|
Zfish   531 -SEGTKHWLII---------DDASKDD----TGTYSLMATGGTSQAHVQVDLKPLKVLMDLQSVT 581

  Fly  6080 IKWKQPISNGGSPIIGYDIERRDVNTGRWIKINGQPVPTAEYQDDRV-----TSNHQYQYRISAV 6139
            :...||:.      :..:|...:| .|||.| |||.|    ..:||:     |.||......|.:
Zfish   582 VLLGQPLK------LNCEIYPGNV-PGRWYK-NGQLV----QPNDRISITHKTKNHSLDVESSTI 634

  Fly  6140 NAAGN------GKTSEPSAIFNARPLREKPRFYFDGL--IGKRIKVRAGEPVNLNIPISGAPTPT 6196
            :.||:      |.|...||..:   :.:.||.:.:.|  ....:.:.||..:.|.|||||.|.|.
Zfish   635 HDAGDYTFVPEGYTQTLSAKVH---IIDPPRVHLEALNVQDNTVTIVAGNKLRLEIPISGEPAPR 696

  Fly  6197 IEWKRGD-LKLEEGKRISYETNSERTLFRIDDSNRRDSGKYTVTAANEFGKDTADIEVIVVDKPS 6260
            :.|.:|: :.|:.|.|:..||.::.|...||.:.|.|:|.|.:...||.|:|||.::|.|||.|.
Zfish   697 VVWMKGERVILDTGSRVHAETFADHTCLTIDITEREDTGNYKIVLQNEAGEDTASVKVKVVDIPD 761

  Fly  6261 PPEGPLSYTETAPDHISLHWYSPKDDGGSDITGYIIEFTEFGVDDWKPVP-GTCPNTNFTVKNLV 6324
            |||.|| .||...|..::.|..|:.||||.|.||.||..:.....|..:. ..|..|.|..|.::
Zfish   762 PPEAPL-VTEVGGDWCTMTWEPPRYDGGSPILGYFIERKKKQSSRWMRLNFDLCKETTFEPKKMI 825

  Fly  6325 EGKKYVFRIRAENIYGASEALEGKPVLAKSPFDPPGAPSQPT---ISAYTPNSANLEWHPPDDCG 6386
            ||..|..||.|.|..|.|     ||.....||.|....|:||   :...|..:..::|.|||..|
Zfish   826 EGVPYEVRIFAVNAIGVS-----KPSEPSKPFIPLAVTSEPTMLVVDDVTDTTVTMKWRPPDTIG 885

  Fly  6387 GKPITGYIVERRERG-GEWIKCNNYPTPNTSYTVSNLRDGARYEFRVLAVNEAGPGHPSKPSDPM 6450
            ...:.||.:|....| .:||..|...|..|.||::.|...|:...||.|:|.||      .|.|.
Zfish   886 AAGLDGYQIEYCIEGTDDWIVANKELTEKTKYTITGLPVEAKILVRVKAINAAG------ASQPR 944

  Fly  6451 TAEHQRYRPDPPEPPKPDRITRNGVTLSWRPPRTDGKSRIKGYYVEMRPKNGKDWKTVNDIPINS 6515
            |.:|.....:..||||            .|.||     .:|..|:.
Zfish   945 TTQHSILVKEVIEPPK------------IRIPR-----HLKQTYIR------------------- 973

  Fly  6516 TVYTVPSLKEGEEYSFRVVAENEVGRSDPSKPSQPITIEEQPNKPCMELGKVRDIVCRAGDDFSI 6580
                                                           ::|:|.::|
Zfish   974 -----------------------------------------------KVGEVVNLV--------- 982

  Fly  6581 HVPYLAFPKPNAFWYSNDNMLDDNNRVHKHLTDDAASVV-VKNSKRADSGQYRLQLKNTSGFDTA 6644
             ||::..|:|...|......:|....:.   ..|..|:: ::.::|..||:|.|.::..:..|||
Zfish   983 -VPFVGKPRPKVTWLKEGQPIDPTISIR---NSDCDSIMFIRKAERKHSGKYELSVQVENHIDTA 1043

  Fly  6645 TINVRVLDRPSPPTRLRADEFSGDSLTLYWNPPNDDGGSAIQNYIIEKKEARSSTWSKVSSFCTV 6709
            .::::::|.|.||..::.:|..|:::.|.|:||.|.|.:.|..|.|:|.:.::..|.........
Zfish  1044 MLDIQIVDLPGPPQAVKIEEIWGNNVALDWSPPKDSGNAPITGYTIQKADKKTMEWYTCVEHYHR 1108

  Fly  6710 PFVRIRNLVLNKEYDFRVIAENKYGQSDPANTSEPILARHPFDIPNTPGIPHGIDSTEDSITIAW 6774
            ..:.|.:||:..||.||:.:||..|.|:.|.                        :|:||..|.
Zfish  1109 TCITISDLVVGNEYFFRIYSENMVGLSEDAT------------------------ATKDSALIV- 1148

  Fly  6775 TKPKHDGGSPITGYIIEKRLLSDDKWTKAVHALCPDLSCKIPNLIENAEYEFRVAAVNAAGQSAY 6839
                                      .:.:|             ::|.||
Zfish  1149 --------------------------KEGLH-------------LKNPEY--------------- 1159

  Fly  6840 SGSSDLIFCRRPPHAPKITSDLSIRDMTVIAGDEFRITVPYHASPRPTASWSLNGLEVIPGERIK 6904
               :|..|    ...|:.|..|.  :...|||....:.....|:|||...|..|.:.:|...|.:
Zfish  1160 ---NDRDF----TEPPRFTQPLI--NTFAIAGYNATLNCSVRANPRPKVVWMKNKITIIDDPRYR 1215

  Fly  6905 -FDSNDYASMYYNKSAKRDETGSYTITLTNNKGSDTASCHVTV 6946
             |.:....::...|.:..| .|.||....|:.|.....|.:.|
Zfish  1216 MFHNQGVCTLEIRKPSPFD-GGVYTCKAVNDLGEAQVDCKLEV 1257

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bt	NP_001162825.1	I-set	9..101	CDD:254352
		Ig	26..100	CDD:143165
		I-set	119..210	CDD:254352
		Ig	136..209	CDD:143165
		I-set	228..320	CDD:254352
		IGc2	242..312	CDD:197706
		I-set	335..425	CDD:254352
		Ig	350..423	CDD:143165
		Ig	436..530	CDD:299845
		I-set	438..532	CDD:254352
		I-set	545..636	CDD:254352
		Ig	560..633	CDD:143165
		Ig	657..731	CDD:143165
		I-set	746..835	CDD:254352
		Ig	1496..1586	CDD:299845
		IG_like	1503..1588	CDD:214653
		I-set	1639..1724	CDD:254352
		IG	1750..1821	CDD:214652
		IGc2	1750..1806	CDD:197706
		I-set	1826..1909	CDD:254352
		Ig	1831..1897	CDD:299845
		I-set	1914..1998	CDD:254352
		Ig	2020..2095	CDD:299845
		FN3	2100..2194	CDD:238020
		FN3	2203..2292	CDD:238020
		I-set	2311..2395	CDD:254352
		Ig	2321..2395	CDD:299845
		FN3	2399..2493	CDD:238020
		FN3	2501..2590	CDD:238020
		I-set	2602..2693	CDD:254352
		Ig	2619..2693	CDD:299845
		FN3	2697..2793	CDD:238020
		FN3	2801..2893	CDD:238020
		I-set	2902..2995	CDD:254352
		Ig	2919..2993	CDD:299845
		FN3	2999..3088	CDD:238020
		FN3	3102..3191	CDD:238020
		I-set	3208..3292	CDD:254352
		Ig	3219..3292	CDD:299845
		FN3	3296..3390	CDD:238020
		FN3	3400..3489	CDD:238020
		I-set	3494..3590	CDD:254352
		Ig	3516..3590	CDD:299845
		FN3	3594..3682	CDD:238020
		FN3	3694..3781	CDD:238020
		I-set	3795..3885	CDD:254352
		Ig	3813..3885	CDD:299845
		FN3	3889..3980	CDD:238020
		FN3	3990..4082	CDD:238020
		I-set	4090..4181	CDD:254352
		Ig	4108..4181	CDD:299845
		FN3	4185..4271	CDD:238020
		FN3	4285..4383	CDD:238020
		Ig	4404..4480	CDD:299845
		FN3	4484..4571	CDD:238020
		FN3	4584..4677	CDD:238020
		I-set	4685..4775	CDD:254352
		Ig	4703..4775	CDD:299845
		FN3	4779..4863	CDD:238020
		FN3	4879..4970	CDD:238020
		IG	4989..5069	CDD:214652
		Ig	4996..5069	CDD:299845
		FN3	5073..5166	CDD:238020
		FN3	5175..5265	CDD:238020
I-set	5276..5366	CDD:254352
Ig	5293..5366	CDD:299845
FN3	5370..5462	CDD:238020	23/112 (21%)
FN3	5470..5561	CDD:238020	20/101 (20%)
Ig	5559..5654	CDD:299845	22/97 (23%)
I-set	5570..5660	CDD:254352	20/92 (22%)
FN3	5664..5755	CDD:238020	8/90 (9%)
FN3	5764..5853	CDD:238020	17/108 (16%)
I-set	5865..5954	CDD:254352	18/91 (20%)
Ig	5882..5954	CDD:299845	17/74 (23%)
FN3	5958..6049	CDD:238020	15/91 (16%)
FN3	6062..6153	CDD:238020	28/111 (25%)
I-set	6173..6255	CDD:254352	31/82 (38%)
Ig_Titin_like	6182..6255	CDD:143225	29/73 (40%)
FN3	6259..6350	CDD:238020	35/91 (38%)
FN3	6359..6451	CDD:238020	30/95 (32%)
FN3	6470..6552	CDD:238020	5/81 (6%)
I-set	6564..6650	CDD:254352	19/86 (22%)
Ig_Titin_like	6577..6650	CDD:143225	16/73 (22%)
FN3	6654..6745	CDD:238020	28/90 (31%)
FN3	6754..6840	CDD:238020	8/85 (9%)
I-set	6855..6946	CDD:254352	23/91 (25%)
Ig	6874..6946	CDD:299845	17/72 (24%)
FN3	6950..7042	CDD:238020
FN3	7050..7139	CDD:238020
FN3	7151..7237	CDD:238020
I-set	7254..7334	CDD:254352
Ig	7272..7339	CDD:143165
IG_like	7354..7440	CDD:214653
Ig	7366..7440	CDD:299845
FN3	7444..7531	CDD:238020
FN3	7545..7637	CDD:238020
I-set	7648..7737	CDD:254352
Ig	7665..7734	CDD:143165
Ig	7760..7833	CDD:299845
FN3	7837..7927	CDD:238020
STKc_Twitchin_like	7986..8244	CDD:271016
S_TKc	7989..8244	CDD:214567
Ig	8311..8394	CDD:299845
I-set	8312..8401	CDD:254352
I-set	8437..8525	CDD:254352
Ig	8455..8519	CDD:143165
I-set	8632..8721	CDD:254352
IGc2	8646..8711	CDD:197706
I-set	8740..8831	CDD:254352
Ig	8757..8826	CDD:143165
I-set	8839..8922	CDD:254352
Ig	8845..>8909	CDD:299845
mybpc1	XP_009298541.1	IG_like	197..292	CDD:214653	23/164 (14%)
		Ig	222..288	CDD:143165	17/133 (13%)
		IG_like	395..475	CDD:214653	19/92 (21%)
		Ig	413..464	CDD:143165	13/54 (24%)
		I-set	482..566	CDD:254352	17/113 (15%)
		Ig	497..565	CDD:143165	14/97 (14%)
		Ig	570..645	CDD:299845	23/86 (27%)
		IG_like	578..658	CDD:214653	25/94 (27%)
		Ig	672..756	CDD:299845	31/83 (37%)
		IG_like	674..756	CDD:214653	31/81 (38%)
		FN3	760..849	CDD:238020	36/94 (38%)
		FN3	<877..943	CDD:238020	25/71 (35%)
		IG_like	969..1043	CDD:214653	18/152 (12%)
		Ig	978..1049	CDD:299845	18/83 (22%)
		FN3	1053..1136	CDD:238020	26/82 (32%)
		I-set	1168..1257	CDD:254352	23/91 (25%)
		Ig	1185..1251	CDD:143165	16/66 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	63	1.000	Domainoid score	I10220
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13817
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.100