DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment bt and NPHS1

DIOPT Version :9

Sequence 1:NP_001162825.1 Gene:bt / 43814 FlyBaseID:FBgn0005666 Length:8933 Species:Drosophila melanogaster
Sequence 2:NP_004637.1 Gene:NPHS1 / 4868 HGNCID:7908 Length:1241 Species:Homo sapiens


Alignment Length:1542 Identity:299/1542 - (19%)
Similarity:467/1542 - (30%) Gaps:583/1542 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly  1751 LECSVSSSMANVHWFKNNTKLESDD-----PRYLISKD-INGNLKLIIKDSVLDDAGLYRCQLDK 1809
            |.|.||:..:.|.|.|:...|..|.     |||.:..| ..|...|.|:...|.|...|.||:.:
Human    51 LRCGVSTPGSAVQWAKDGLLLGPDPRIPGFPRYRLEGDPARGEFHLHIEACDLSDDAEYECQVGR 115

  Fly  1810 Q-----------------PDK-----TECNLKVT-----EY----------PYKFVKVLKSQQCI 1837
            .                 |.|     .|....||     ||          |...:.:|.|.|.|
Human   116 SEMGPELVSPRVILSILVPPKLLLLTPEAGTMVTWVAGQEYVVNCVSGDAKPAPDITILLSGQTI 180

  Fly  1838 EKDTVT----------------------------LACE--------------------------- 1847
            ...:..                            |.||                           
Human   181 SDISANVNEGSQQKLFTVEATARVTPRSSDNRQLLVCEASSPALEAPIKASFTVNVLFPPGPPVI 245

  Fly  1848 ----IDDA-------------------MGEVQWLRNGEEIKP---DKRIQIVKDGRKRKLVIKDC 1886
                :|:.                   :..:|||:||:.:..   .:..|.|    .|.:::...
Human   246 EWPGLDEGHVRAGQSLELPCVARGGNPLATLQWLKNGQPVSTAWGTEHTQAV----ARSVLVMTV 306

  Fly  1887 KVTDAG-QFKC----TTNADTTE-----------SEIII-----NYQNRFNKKLKDTEAVEREKL 1930
            :..|.| |..|    :.:|.|.|           |.|||     ..:|: |..|.......|.::
Human   307 RPEDHGAQLSCEAHNSVSAGTQEHGITLQVTFPPSAIIILGSASQTENK-NVTLSCVSKSSRPRV 370

  Fly  1931 ILDIELQDQTAPCDWKFNGEPIVPSESIEIKNMGGG---KHQLIFSSLDMSNEGEITCESGQLSS 1992
            :|           .|......::|.|...:..:.||   ...|.|.:....|...:|||:  .|.
Human   371 LL-----------RWWLGWRQLLPMEETVMDGLHGGHISMSNLTFLARREDNGLTLTCEA--FSE 422

  Fly  1993 KCKLSIRKGESRPNIDCPDK---FSGPISAPVLLE------VPFKVSGT----------KQTPVE 2038
            .......|.....|:..|.:   ..||.....|..      |...:.|.          .:|..|
Human   423 AFTKETFKKSLILNVKYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTE 487

  Fly  2039 AKLFKDGKPLPVKDVEVAVTDDKVTFKIKKPSRDL---SGP--YQIKISNGQGEDTKDVQIICQD 2098
            ::|.::.:.:.:..||.:.:    ||     ||:|   :||  .|.|.:...|:.:...|:..| 
Human   488 SRLPQESRRVHLGSVEKSGS----TF-----SRELVLVTGPSDNQAKFTCKAGQLSASTQLAVQ- 542

  Fly  2099 VPQPPQDVDIT---------DVYQTSCV-VSFNPPSDDGGTPITKYVIERQDLSKKHGWESVAEV 2153
              .||.:|.|.         |....:|| ||.|||               .:||    |:...| 
Human   543 --FPPTNVTILANASALRPGDALNLTCVSVSSNPP---------------VNLS----WDKEGE- 585

  Fly  2154 LPSEPCLKKIDDLIPKKQYRFRIRAVNAIGQSDPATFKNTILAKDPWDEPGKPKAVDLTDWDKDH 2218
                                 |:..|.|..:..|  ||.:..|          ::|.|....:||
Human   586 ---------------------RLEGVAAPPRRAP--FKGSAAA----------RSVLLQVSSRDH 617

  Fly  2219 ADLKWEAPETDGGDPIT--AYIVEYKEKFSNDWVSGKEVDGDARTATVDGLKEGQQYEFRVRAVN 2281
                        |..:|  |:..|.:|..|:                          .:|:..:.
Human   618 ------------GQRVTCRAHSAELRETVSS--------------------------FYRLNVLY 644

  Fly  2282 RAGPGEPSDKTKSIIAKCRFVKPFIVGEGLKNVT-VKKGQTIRFDIKYDGEPEPAATWVKGTDNL 2345
            |                     |..:||.:..|| |::|:.: ..:.....|.|.|.      |.
Human   645 R---------------------PEFLGEQVLVVTAVEQGEAL-LPVSVSANPAPEAF------NW 681

  Fly  2346 KFDNQRIC-----LDQLERNSSITIKKSVRKDTGKYKLVLSNSSGTIESEAQVVVLDRPLPPGGP 2405
            .|...|:.     ..::..:.::.:....|.|.|.|:|...||.||.|:..::.|...|      
Human   682 TFRGYRLSPAGGPRHRILSSGALHLWNVTRADDGLYQLHCQNSEGTAEARLRLDVHYAP------ 740

  Fly  2406 FEPEEIRASHIKMKWKRPDDDGGCEISGYALERMDEETGRWIPAGEVGPNETSFDFKGLTPNKKY 2470
                .|||..                                     .|.|              
Human   741 ----TIRALQ-------------------------------------DPTE-------------- 750

  Fly  2471 KFRVKAINKEGESEPLETFDAIVARNPYDPPSPPSQPVIDDYDNKSV--LLKWKRPPSDGGRPIT 2533
                  :|..|..:.:.|.||    ||..|.....:.:.:|.:::|:  :.|..|.|:  ||...
Human   751 ------VNVGGSVDIVCTVDA----NPILPGMFNWERLGEDEEDQSLDDMEKISRGPT--GRLRI 803

  Fly  2534 HYIVEIKDKFAPSWSEVAKTDDPNPECNVEGLKEKMVYQFRVRAVNKAGPSEPSQPTDNHLCKHK 2598
            |:               ||            |.:...||..|.  |...|     |....|....
Human   804 HH---------------AK------------LAQAGAYQCIVD--NGVAP-----PARRLLRLVV 834

  Fly  2599 NLKPQIDRST-FKRVTIKSGRTHKWSVDVLGEPIPELHWSW-RDDIPLTNGDRIKIENVDYHTD- 2660
            ...||::..| ..:|......|...::......:|.:.::| ::.:||...|....|:. ||.. 
Human   835 RFAPQVEHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHT-YHQGG 898

  Fly  2661 -----FSITNV-LRKDSGFYTLKAENRNGIDRETVELVVLGKPSSPKGPLAVSDVTASGCKLQWK 2719
                 .:|.|| ..:|...:|..|.|..|.|:..::||.:.:|..|.| |.|..:|.....|:| 
Human   899 VHSSLLTIANVSAAQDYALFTCTATNALGSDQTNIQLVSISRPDPPSG-LKVVSLTPHSVGLEW- 961

  Fly  2720 KPEDDGGVPIKEYV-VEKMDTATGKWVRVGRSPGEKEPP---SFDVTGLSLGSEYMFRVSAVNEE 2780
            ||..|||:|.:..: .|.:.|....:|.|       .||   :|.:|||...:.|...:.|.|..
Human   962 KPGFDGGLPQRFCIRYEALGTPGFHYVDV-------VPPQATTFTLTGLQPSTRYRVWLLASNAL 1019

  Fly  2781 GESE--------PLTTLVGVVAKDPFDEPNKPGTPEVTDYDNQSISLKWAAPNNDGGAPIQKYII 2837
            |:|.        |:||       ....:|:  |.||        ..|....|:...|.|:...:.
Human  1020 GDSGLADKGTQLPITT-------PGLHQPS--GEPE--------DQLPTEPPSGPSGLPLLPVLF 1067

  Fly  2838 ---------EKKNKNKTEWEKALEIPGDQL-EATVAGLQ------EYGEYQFRVIAVNKAGLSPP 2886
                     .........|::.|....:.: |.|.||.:      ||.|.|:       .|....
Human  1068 ALGGLLLLSNASCVGGVLWQRRLRRLAEGISEKTEAGSEEDRVRNEYEESQW-------TGERDT 1125

  Fly  2887 SDASVPQIVKYKKLKPRIDRSNLKPLLIRAGKPIRYDVNVRGEPAPVITWYQNDKELKPEELPSS 2951
            ..::|.                                ....||     :|::.::..|:..|:.
Human  1126 QSSTVS--------------------------------TTEAEP-----YYRSLRDFSPQLPPTQ 1153

  Fly  2952 SEIKNIPYNTKISIIETVRKHTGIYKIIAVNEHGQDEATVEVNILAPPSKPRGPLDVKDVTKDSC 3016
            .|:.   |:         |..||..:.:|...|..|    ||....|||...||| ..:|.....
Human  1154 EEVS---YS---------RGFTGEDEDMAFPGHLYD----EVERTYPPSGAWGPL-YDEVQMGPW 1201

  Fly  3017 KLKWKKPEDDGGKPISAYQVEKFDKKQGRWVPLGRTSANDTEFDVKG 3063
            .|.|  |||....|...|     |:..|   .|.....:...|:::|
Human  1202 DLHW--PEDTYQDPRGIY-----DQVAG---DLDTLEPDSLPFELRG 1238

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
btNP_001162825.1 I-set 9..101 CDD:254352
Ig 26..100 CDD:143165
I-set 119..210 CDD:254352
Ig 136..209 CDD:143165
I-set 228..320 CDD:254352
IGc2 242..312 CDD:197706
I-set 335..425 CDD:254352
Ig 350..423 CDD:143165
Ig 436..530 CDD:299845
I-set 438..532 CDD:254352
I-set 545..636 CDD:254352
Ig 560..633 CDD:143165
Ig 657..731 CDD:143165
I-set 746..835 CDD:254352
Ig 1496..1586 CDD:299845
IG_like 1503..1588 CDD:214653
I-set 1639..1724 CDD:254352
IG 1750..1821 CDD:214652 24/97 (25%)
IGc2 1750..1806 CDD:197706 19/60 (32%)
I-set 1826..1909 CDD:254352 25/179 (14%)
Ig 1831..1897 CDD:299845 20/151 (13%)
I-set 1914..1998 CDD:254352 16/86 (19%)
Ig 2020..2095 CDD:299845 19/95 (20%)
FN3 2100..2194 CDD:238020 22/103 (21%)
FN3 2203..2292 CDD:238020 12/90 (13%)
I-set 2311..2395 CDD:254352 20/89 (22%)
Ig 2321..2395 CDD:299845 16/78 (21%)
FN3 2399..2493 CDD:238020 11/93 (12%)
FN3 2501..2590 CDD:238020 16/90 (18%)
I-set 2602..2693 CDD:254352 23/99 (23%)
Ig 2619..2693 CDD:299845 19/81 (23%)
FN3 2697..2793 CDD:238020 32/107 (30%)
FN3 2801..2893 CDD:238020 20/107 (19%)
I-set 2902..2995 CDD:254352 15/92 (16%)
Ig 2919..2993 CDD:299845 13/73 (18%)
FN3 2999..3088 CDD:238020 18/65 (28%)
FN3 3102..3191 CDD:238020
I-set 3208..3292 CDD:254352
Ig 3219..3292 CDD:299845
FN3 3296..3390 CDD:238020
FN3 3400..3489 CDD:238020
I-set 3494..3590 CDD:254352
Ig 3516..3590 CDD:299845
FN3 3594..3682 CDD:238020
FN3 3694..3781 CDD:238020
I-set 3795..3885 CDD:254352
Ig 3813..3885 CDD:299845
FN3 3889..3980 CDD:238020
FN3 3990..4082 CDD:238020
I-set 4090..4181 CDD:254352
Ig 4108..4181 CDD:299845
FN3 4185..4271 CDD:238020
FN3 4285..4383 CDD:238020
Ig 4404..4480 CDD:299845
FN3 4484..4571 CDD:238020
FN3 4584..4677 CDD:238020
I-set 4685..4775 CDD:254352
Ig 4703..4775 CDD:299845
FN3 4779..4863 CDD:238020
FN3 4879..4970 CDD:238020
IG 4989..5069 CDD:214652
Ig 4996..5069 CDD:299845
FN3 5073..5166 CDD:238020
FN3 5175..5265 CDD:238020
I-set 5276..5366 CDD:254352
Ig 5293..5366 CDD:299845
FN3 5370..5462 CDD:238020
FN3 5470..5561 CDD:238020
Ig 5559..5654 CDD:299845
I-set 5570..5660 CDD:254352
FN3 5664..5755 CDD:238020
FN3 5764..5853 CDD:238020
I-set 5865..5954 CDD:254352
Ig 5882..5954 CDD:299845
FN3 5958..6049 CDD:238020
FN3 6062..6153 CDD:238020
I-set 6173..6255 CDD:254352
Ig_Titin_like 6182..6255 CDD:143225
FN3 6259..6350 CDD:238020
FN3 6359..6451 CDD:238020
FN3 6470..6552 CDD:238020
I-set 6564..6650 CDD:254352
Ig_Titin_like 6577..6650 CDD:143225
FN3 6654..6745 CDD:238020
FN3 6754..6840 CDD:238020
I-set 6855..6946 CDD:254352
Ig 6874..6946 CDD:299845
FN3 6950..7042 CDD:238020
FN3 7050..7139 CDD:238020
FN3 7151..7237 CDD:238020
I-set 7254..7334 CDD:254352
Ig 7272..7339 CDD:143165
IG_like 7354..7440 CDD:214653
Ig 7366..7440 CDD:299845
FN3 7444..7531 CDD:238020
FN3 7545..7637 CDD:238020
I-set 7648..7737 CDD:254352
Ig 7665..7734 CDD:143165
Ig 7760..7833 CDD:299845
FN3 7837..7927 CDD:238020
STKc_Twitchin_like 7986..8244 CDD:271016
S_TKc 7989..8244 CDD:214567
Ig 8311..8394 CDD:299845
I-set 8312..8401 CDD:254352
I-set 8437..8525 CDD:254352
Ig 8455..8519 CDD:143165
I-set 8632..8721 CDD:254352
IGc2 8646..8711 CDD:197706
I-set 8740..8831 CDD:254352
Ig 8757..8826 CDD:143165
I-set 8839..8922 CDD:254352
Ig 8845..>8909 CDD:299845
NPHS1NP_004637.1 V-set 38..119 CDD:284989 21/67 (31%)
IG_like 38..113 CDD:214653 20/61 (33%)
C2-set_2 141..228 CDD:285423 13/86 (15%)
Ig 240..321 CDD:299845 13/84 (15%)
IG_like 254..336 CDD:214653 15/85 (18%)
Ig 345..424 CDD:299845 18/92 (20%)
Ig 445..530 CDD:299845 19/93 (20%)
I-set 446..541 CDD:254352 21/103 (20%)
Ig 549..632 CDD:299845 28/147 (19%)
IG_like 558..642 CDD:214653 30/174 (17%)
I-set 646..736 CDD:254352 23/96 (24%)
Ig 662..736 CDD:299845 17/80 (21%)
Ig_3 739..820 CDD:290638 28/182 (15%)
IG_like 748..821 CDD:214653 24/127 (19%)
Ig8_hNephrin_like 834..942 CDD:143250 24/108 (22%)
IG_like 845..935 CDD:214653 19/90 (21%)
fn3 942..1023 CDD:278470 27/89 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1025..1057 9/48 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1099..1137 10/76 (13%)
Binds to NPHS2 1160..1241 27/94 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.