DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bt and MYLK

DIOPT Version :9

Sequence 1:	NP_001162825.1	Gene:	bt / 43814	FlyBaseID:	FBgn0005666	Length:	8933	Species:	Drosophila melanogaster
Sequence 2:	XP_024309300.1	Gene:	MYLK / 4638	HGNCID:	7590	Length:	1924	Species:	Homo sapiens

Alignment Length:	2163	Identity:	518/2163 - (23%)
Similarity:	794/2163 - (36%)	Gaps:	609/2163 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  6724 DFRVIAENKYGQS----DPANTSEPILARHPFDI--PNTPGIPHGIDSTEDSITIAWTKPK---H 6779
            |.:::|.:...::    ||:......|...|..|  |....|..|..:..:.....:.:|:   |
Human    13 DVKLVASSHISKTSLSVDPSRVDSMPLTEAPAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWH 77

  Fly  6780 DGGSPITGYIIEKRLLSD----DKWTKAVHALCPD----LSCKIPN-------LIE-NAEYEFRV 6828
            ..|.|||.   ..|.|.|    ..::..:||:..:    .:|:..|       .:| ..|..|
Human    78 RNGQPITS---GGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVELTVEGSF-- 137

  Fly  6829 AAVNAAGQSAYSGSSDLIFC-----RRP------PHAPKITSDLSIRDMTVIAGDEFRITVPYHA 6882
              ....||...|.:....|.     .||      |  ||..:.|.  .:.|..|...|.:.....
Human   138 --AKQLGQPVVSKTLGDRFSAPAVETRPSIWGECP--PKFATKLG--RVVVKEGQMGRFSCKITG 196

  Fly  6883 SPRPTASWSLNGLEVIPGERIKFDSNDYASMYYNKSAKRDETGSYTITLTNNKGSDTASCHVTVV 6947
            .|:|..:|....:.:.|..|:.....:...:.......:|:.|.||..:.|..|..:.|..:::
Human   197 RPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSI- 260

  Fly  6948 DRPLPPQGPLNAYDITPDTCTLAWKTPLDDGGSPITNYVVE--KLDNSGSWVKISSFVRNTHYDV 7010
                  ||    .|....:.....|....|....:||.:.:  |||:    ::.::..:|.....
Human   261 ------QG----LDSANRSFVRETKATNSDVRKEVTNVISKESKLDS----LEAAAKSKNCSSPQ 311

  Fly  7011 MGLEPHYKYNFRVRAENQYGLSDPLDIIEPIVAKHQFTVPDEPGQPKVIDWDSGNVTL----IWT 7071
            .|..|.:..|.:.:...:..|....|        ...|.|..|    |:...|.::||    :..
Human   312 RGGSPPWAANSQPQPPRESKLESCKD--------SPRTAPQTP----VLQKTSSSITLQAARVQP 364

  Fly  7072 RP-------LSDGG---------------SRIQGYQIEYRDILN-------------DSSWNAYD 7101
            .|       ||..|               :|..|  :..:|:::             ||::..:
Human   365 EPRAPGLGVLSPSGEERKRPAPPRPATFPTRQPG--LGSQDVVSKAANRRIPMEGQRDSAFPKF- 426

  Fly  7102 YIIKDTKYQLYNLINGSEYEFRIKAKNAAGLSKPSSPSLRFKLKGKFTVPSPPGAPQVTRVGKNY 7166
                ::|.|...:......:||.:   .:|:.|   |.:.:.|:|. .|....|:.:|
Human   427 ----ESKPQSQEVKENQTVKFRCE---VSGIPK---PEVAWFLEGT-PVRRQEGSIEV------- 473

  Fly  7167 VDLKWEKPLRDGGSRITGYIIER-RDIGGAVWVKCNDYNVLDTEYTVMNLIEMGDYEFRVFAVNS 7230
                    ..|.||.....:..| ||.|.......|....|...:|:.  :|.
Human   474 --------YEDAGSHYLCLLKARTRDSGTYSCTASNAQGQLSCSWTLQ--VER------------ 516

  Fly  7231 AGRSEPSLCTMPIKVCEVLGGKKPDWITRLQDKVAPFGKDYTLQCAASGKPSPTARWLRNGKEIQ 7295
                        :.|.||    .|.:.:.|:|.....|:|:.|||:..|.|.|...||.||:.||
Human   517 ------------LAVMEV----APSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPIQ 565

  Fly  7296 MNGGRMTCDSKDGVFRLHISNVQTGDDGDYTCEAMNSLGFVNTSGYLKI---------------- 7344
            .  .|.||::  ||..|||.:....|.|.|||.|.|:||.|:.|.::.:
Human   566 Y--ARSTCEA--GVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVA 626

  Fly  7345 ---GSPPIINRCPSELKLPEGDNSKIKIFYSGDQPLTVI-LKKNNEVICDSNDDTHVKVNIFDDY 7405
               .:.||..:..|:||:.:|....:.:..||:.|..|| |...||:  ..::|.|.:..  ...
Human   627 PSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEI--QESEDFHFEQR--GTQ 687

  Fly  7406 VAIYIRNIVKSDGGPYQIEFTNESGSATGEFYVHITGMPSAPTGPMGISYINKNSCMLNWRPPSY 7470
            .::.|:.:...|.|.|..|..|.:|....:..:.:. .|...|.|..||           :|.|.
Human   688 HSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQ-EPHDGTQPWFIS-----------KPRSV 740

  Fly  7471 DGGLKVSHYV---IERKDVSSPHWI-TVSSTCKDTA-FNVQGLIENQEYIFRV------------ 7518
            ...|..|..:   |......:.||: ...:.||||. |.|   ::|::....|
Human   741 TASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEV---LQNEDVFTLVLKKVQPWHAGQY 802

  Fly  7519 -----------------MAVNENGMGPPLEGLNPIRAKDPIDPPSPPGSPQITEIGGD----FVH 7562
                             |..|.:....|       |.::|.......|.....:.||.    .:.
Human   803 EILLKNRVGECSCQVSLMLQNSSARALP-------RGREPASCEDLCGGGVGADGGGSDRYGSLR 860

  Fly  7563 LEWEKP-----ESDGGAHIQGYWIDKREVGSNTWQRVNATI--CAANQINCINL----------- 7609
            ..|...     |.:.|..::|  :.||.|  .|.|.....|  ....|::..:|
Human   861 PGWPARGQGWLEEEDGEDVRG--VLKRRV--ETRQHTEEAIRQQEVEQLDFRDLLGKKVSTKTLS 921

  Fly  7610 ------IEGRQYEFRIFAQNVAGLSTESSASQAV------------------------KIIDPQA 7644
                  |...|.:||...|......|.|...:.|                        |:..|:.
Human   922 EDDLKEIPAEQMDFRANLQRQVKPKTVSEEERKVHSPQQVDFRSVLAKKGTSKTPVPEKVPPPKP 986

  Fly  7645 ASP------------------------------------------PL------------------ 7649
            |:|                                          ||
Human   987 ATPDFRSVLGGKKKLPAENGSSSAETLNAKAVESSKPLSNAQPSGPLKPVGNAKPAETLKPMGNA 1051

  Fly  7650 ----IVKPL----------------------RDANCIQNH----------NAQFT---------- 7668
                .:||:                      .|.||.:.|          .:|.|
Human  1052 KPAETLKPMGNAKPDENLKSASKEELKKDVKNDVNCKRGHAGTTDNEKRSESQGTAPAFKQKLQD 1116

  Fly  7669 ------------CTINGVPKPTISWYKGAREISNGARYHMYSEGDNHFLNINDVFGEDADEYVCR 7721
                        |.::..|..||.|....:.:.......:..||....::|.....||...|.|.
Human  1117 VHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDRGLYKCV 1181

  Fly  7722 AVNKAG-----------------------AKSTR--------------ATL----AIMTAPKLNV 7745
            |.|.||                       .||.|              ||:    |..|.||..:
Human  1182 AKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPKSSLPPVLGTESDATVKKKPAPKTPPKAAM 1246

  Fly  7746 PP---RFRDTAYFDKGENVVIKIPFTGFPKPRIHWVRDGENIESGGHYTVEVKERHAVLIIRDGS 7807
            ||   :|.:......||:|.:....||.......|::..:.|:...|..||..|..:.|.|....
Human  1247 PPQIIQFPEDQKVRAGESVELFGKVTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLTILAAR 1311

  Fly  7808 HLDSGPYRITAENELGSDTAIIQVQISDRPDPPR-FPLIESIGTESLSLSWKAPVWDGCSDITNY 7871
            ....|.|.:..||:|||..|.:.:.:.|:||||. .|....|.:.||:|||....:||.|.:.:|
Human  1312 QEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSY 1376

  Fly  7872 YVERREHPLSSWIRVGNTRFTSMAVSGLTPGKEYDFRIFADNVYGRSDASDTSTLIKTKESVKKK 7936
            .:|..:....:|..:...|.||..|..|.|..||.||:.|.||||.|:.|..|.|    .:|.:|
Human  1377 SIEIWDSANKTWKELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESEL----TTVGEK 1437

  Fly  7937 PIERKWEIDANGRKLRGKADGPVKDYDSYVFDIYSKFVPQPVEISQQSVYDRYDILEEIGTGAFG 8001
            |.|.|.|::.:.    .....|..||.:...:            ::|.|.|.|||.|.:|:|.||
Human  1438 PEEPKDEVEVSD----DDEKEPEVDYRTVTIN------------TEQKVSDFYDIEERLGSGKFG 1486

  Fly  8002 VVHRCRERSTGNIFAAKFIPVSHSVEKDLIRREIDIMNQLHHQKLINLHDAFEDDDEMILILEFL 8066
            .|.|..|:.|..::|.||.....:.||:.||:||.|||.|||.||:...||||:...::::||.:
Human  1487 QVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLEIV 1551

  Fly  8067 SGGELFERITAEGYVMTEAEVINYMRQICEGIRHMHEQNIIHLDIKPENIMCQTRSSTNVKLIDF 8131
            |||||||||..|.:.:||.|.|.|||||.||:.::|:|.|:|||:|||||||..::.|.:|||||
Human  1552 SGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDF 1616

  Fly  8132 GLATRLDPNEVVKITTGTAEFAAPEIVNREPVGFYTDMWATGVLSYVLLSGLSPFAGDNDVQTLK 8196
            |||.||:....:|:..||.||.|||::|.||:|:.||||:.||:.|:|:||||||.||||.:||.
Human  1617 GLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLA 1681

  Fly  8197 NVKACDWDFDVESFKYISEEAKDFIRKLLVRNKEKRMTAHECLLHPWLTGDHSAMK-QEINRDRY 8260
            ||.:..||||.|:|..||::|||||..||.::.:.|:...:||.||||..|...|: :::::||.
Human  1682 NVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQCLQHPWLMKDTKNMEAKKLSKDRM 1746

  Fly  8261 LAYREKLRRKYEDFERFLLPIGRLSEYSSLRKLLMEKYKIHDAVFDRRQAAPRFVIRPSSQFCYE 8325
            ..|  ..|||::.....:..|||||..:.:..|...|
Human  1747 KKY--MARRKWQKTGNAVRAIGRLSSMAMISGLSGRK---------------------------- 1781

  Fly  8326 GQSVKFYCRCIAIATPTLTWSHNNIELRQSVKFMKRYVGDDYYFIINRVKLDDRGEYIIRAENHY 8390
                      .:..:||..                          :|..||:
Human  1782 ----------SSTGSPTSP--------------------------LNAEKLE------------- 1797

  Fly  8391 GSREEVVFLNVQPLPKEQPRYRTESTPVRRREPLPYTFWQEESETAPSFTFLLRPRVMQARDTCK 8455
             |.|:|....::.:.:|:|..:                        |.|:..:|...:......:
Human  1798 -SEEDVSQAFLEAVAEEKPHVK------------------------PYFSKTIRDLEVVEGSAAR 1837

  Fly  8456 LLCCLSGKPVPNVRWYKDGREL--SKYEYAMTHSDGVVTMEIIDCKPSDSGKYSCKATNCHGTDE 8518
            ..|.:.|.|.|.|.|:||.:.:  |::.......||..::.|.|....|..||:|||.|..|...
Human  1838 FDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEAT 1902

  Fly  8519 TDCVVIVEGEWVTPEQAQ 8536
            ....:|||    |.|:.:
Human  1903 CTAELIVE----TMEEGE 1916

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bt	NP_001162825.1	I-set	9..101	CDD:254352
		Ig	26..100	CDD:143165
		I-set	119..210	CDD:254352
		Ig	136..209	CDD:143165
		I-set	228..320	CDD:254352
		IGc2	242..312	CDD:197706
		I-set	335..425	CDD:254352
		Ig	350..423	CDD:143165
		Ig	436..530	CDD:299845
		I-set	438..532	CDD:254352
		I-set	545..636	CDD:254352
		Ig	560..633	CDD:143165
		Ig	657..731	CDD:143165
		I-set	746..835	CDD:254352
		Ig	1496..1586	CDD:299845
		IG_like	1503..1588	CDD:214653
		I-set	1639..1724	CDD:254352
		IG	1750..1821	CDD:214652
		IGc2	1750..1806	CDD:197706
		I-set	1826..1909	CDD:254352
		Ig	1831..1897	CDD:299845
		I-set	1914..1998	CDD:254352
		Ig	2020..2095	CDD:299845
		FN3	2100..2194	CDD:238020
		FN3	2203..2292	CDD:238020
		I-set	2311..2395	CDD:254352
		Ig	2321..2395	CDD:299845
		FN3	2399..2493	CDD:238020
		FN3	2501..2590	CDD:238020
		I-set	2602..2693	CDD:254352
		Ig	2619..2693	CDD:299845
		FN3	2697..2793	CDD:238020
		FN3	2801..2893	CDD:238020
		I-set	2902..2995	CDD:254352
		Ig	2919..2993	CDD:299845
		FN3	2999..3088	CDD:238020
		FN3	3102..3191	CDD:238020
		I-set	3208..3292	CDD:254352
		Ig	3219..3292	CDD:299845
		FN3	3296..3390	CDD:238020
		FN3	3400..3489	CDD:238020
		I-set	3494..3590	CDD:254352
		Ig	3516..3590	CDD:299845
		FN3	3594..3682	CDD:238020
		FN3	3694..3781	CDD:238020
		I-set	3795..3885	CDD:254352
		Ig	3813..3885	CDD:299845
		FN3	3889..3980	CDD:238020
		FN3	3990..4082	CDD:238020
		I-set	4090..4181	CDD:254352
		Ig	4108..4181	CDD:299845
		FN3	4185..4271	CDD:238020
		FN3	4285..4383	CDD:238020
		Ig	4404..4480	CDD:299845
		FN3	4484..4571	CDD:238020
		FN3	4584..4677	CDD:238020
		I-set	4685..4775	CDD:254352
		Ig	4703..4775	CDD:299845
		FN3	4779..4863	CDD:238020
		FN3	4879..4970	CDD:238020
		IG	4989..5069	CDD:214652
		Ig	4996..5069	CDD:299845
		FN3	5073..5166	CDD:238020
		FN3	5175..5265	CDD:238020
I-set	5276..5366	CDD:254352
Ig	5293..5366	CDD:299845
FN3	5370..5462	CDD:238020
FN3	5470..5561	CDD:238020
Ig	5559..5654	CDD:299845
I-set	5570..5660	CDD:254352
FN3	5664..5755	CDD:238020
FN3	5764..5853	CDD:238020
I-set	5865..5954	CDD:254352
Ig	5882..5954	CDD:299845
FN3	5958..6049	CDD:238020
FN3	6062..6153	CDD:238020
I-set	6173..6255	CDD:254352
Ig_Titin_like	6182..6255	CDD:143225
FN3	6259..6350	CDD:238020
FN3	6359..6451	CDD:238020
FN3	6470..6552	CDD:238020
I-set	6564..6650	CDD:254352
Ig_Titin_like	6577..6650	CDD:143225
FN3	6654..6745	CDD:238020	4/24 (17%)
FN3	6754..6840	CDD:238020	21/104 (20%)
I-set	6855..6946	CDD:254352	18/90 (20%)
Ig	6874..6946	CDD:299845	13/71 (18%)
FN3	6950..7042	CDD:238020	16/93 (17%)
FN3	7050..7139	CDD:238020	21/127 (17%)
FN3	7151..7237	CDD:238020	13/86 (15%)
I-set	7254..7334	CDD:254352	32/79 (41%)
Ig	7272..7339	CDD:143165	30/66 (45%)
IG_like	7354..7440	CDD:214653	21/86 (24%)
Ig	7366..7440	CDD:299845	17/74 (23%)
FN3	7444..7531	CDD:238020	23/120 (19%)
FN3	7545..7637	CDD:238020	22/119 (18%)
I-set	7648..7737	CDD:254352	31/205 (15%)
Ig	7665..7734	CDD:143165	21/127 (17%)
Ig	7760..7833	CDD:299845	19/72 (26%)
FN3	7837..7927	CDD:238020	35/90 (39%)
STKc_Twitchin_like	7986..8244	CDD:271016	135/257 (53%)
S_TKc	7989..8244	CDD:214567	134/254 (53%)
Ig	8311..8394	CDD:299845	6/82 (7%)
I-set	8312..8401	CDD:254352	8/88 (9%)
I-set	8437..8525	CDD:254352	24/89 (27%)
Ig	8455..8519	CDD:143165	21/65 (32%)
I-set	8632..8721	CDD:254352
IGc2	8646..8711	CDD:197706
I-set	8740..8831	CDD:254352
Ig	8757..8826	CDD:143165
I-set	8839..8922	CDD:254352
Ig	8845..>8909	CDD:299845
MYLK	XP_024309300.1	I-set	43..133	CDD:254352	19/92 (21%)
		I-set	171..260	CDD:254352	18/90 (20%)
		23ISL	261..422	CDD:318761	31/182 (17%)
		I-set	424..514	CDD:254352	22/118 (19%)
		I-set	524..610	CDD:254352	36/89 (40%)
		I-set	633..722	CDD:254352	23/92 (25%)
		I-set	731..819	CDD:254352	18/101 (18%)
		I-set	1108..1197	CDD:254352	16/88 (18%)
		Ig8_hMLCK_like	1248..1345	CDD:143239	27/96 (28%)
		FN3	1341..1433	CDD:238020	36/95 (38%)
		STKc_MLCK1	1471..1729	CDD:271093	135/257 (53%)
		I-set	1819..1909	CDD:254352	24/89 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I9222
eggNOG	1	0.900	-	-		E1_KOG0613
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810