DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bt and MYBPC2

DIOPT Version :9

Sequence 1:	NP_001162825.1	Gene:	bt / 43814	FlyBaseID:	FBgn0005666	Length:	8933	Species:	Drosophila melanogaster
Sequence 2:	NP_004524.3	Gene:	MYBPC2 / 4606	HGNCID:	7550	Length:	1141	Species:	Homo sapiens

Alignment Length:	1505	Identity:	344/1505 - (22%)
Similarity:	515/1505 - (34%)	Gaps:	516/1505 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  5551 PSDPS----DPSSTIICKPRFLAPFFDKSLLNDITVHAGKRL-------GWTLPIEASPRPLITW 5604
            |.|.|    :|:...:.||            :.::|..||..       |..||    .:|.|.|
Human    40 PEDQSPTAEEPTGVFLKKP------------DSVSVETGKDAVVVAKVNGKELP----DKPTIKW 88

  Fly  5605 LYNGK--EIGSNS----------RGESGLFQNELTFEIVSSLRSDEGRYTLILKN---------- 5647
             :.||  |:||.|          ...|.::..||  .|...:..|.|.|.|.:|.
Human    89 -FKGKWLELGSKSGARFSFKESHNSASNVYTVEL--HIGKVVLGDRGYYRLEVKAKDTCDSCGFN 150

  Fly  5648 ---EHGSFDASAHA-----TVLDRPSPPKGPLDIT--------------KITRDGCHLTWNVPDD 5690
               |....|||..:     ...::.|...|.||.:              |..:|         ||
Human   151 IDVEAPRQDASGQSLESFKRTSEKKSDTAGELDFSGLLKKREVVEEEKKKKKKD---------DD 206

  Fly  5691 DGGSPILHYIIEKMDLSRSTWSDAGMSTHIVHDVTRLVHR-KEYLFRVKAVNAIGES-DPLEAV- 5752
            |.|.|  ..|.|.:..::.:..:.....:.:.|:..::.| |:....||...|..:. ||...|
Human   207 DLGIP--PEIWELLKGAKKSEYEKIAFQYGITDLRGMLKRLKKAKVEVKKSAAFTKKLDPAYQVD 269

  Fly  5753 --NTIIAKNEFDEPDAPGKPIITDWDRDHIDLQWAVPKSDGGAPISEYIIQKKEKGSPYWTNVRH 5815
              |.|....|..:||     :...|.::..:::          |.|:|:.:...|
Human   270 RGNKIKLMVEISDPD-----LTLKWFKNGQEIK----------PSSKYVFENVGK---------- 309

  Fly  5816 VPSNKNTTTIPELTEGQEYEFRVIAVNQAGQSEPSEPSDMIMAKPRYLPPKIITPLNEVRIKCGL 5880
                |...||.:.|...:..:.|...::...:|      :.:.:|   |..|:|||.:.::..|.
Human   310 ----KRILTINKCTLADDAAYEVAVKDEKCFTE------LFVKEP---PVLIVTPLEDQQVFVGD 361

  Fly  5881 IFHTDIHFIGEPAPEATWTLNSNPLLSNDRSTITSIGHHSVVHTVNCQRSDS----------GIY 5935
            .....:. :.|...:..|..:.                      |...|.||          |..
Human   362 RVEMAVE-VSEEGAQVMWMKDG----------------------VELTREDSFKARYRFKKDGKR 403

  Fly  5936 HLLLRNSSGIDEGSFELVVLDRPGPPEGPMEYEEITANSVTISWKPPKDNGGSEISSYVIEKRDL 6000
            |:|:          |..||.:..|      .|:.||             |||...:..::|::.|
Human   404 HILI----------FSDVVQEDRG------RYQVIT-------------NGGQCEAELIVEEKQL 439

  Fly  6001 THGGGWVPAVNYVSAKYNHAVVPRLLEGTMYELRVMAENLQGRSDPLTSDQPVVAKSQYTVPGAP 6065
                                                 |.||..:| ||    |.|..|     |.
Human   440 -------------------------------------EVLQDIAD-LT----VKASEQ-----AV 457

  Fly  6066 GKPELTDSDKNHITIKWKQPISNGGSPIIGYDIERRDVNTGRWIKINGQPVPTAEYQDDRVTSNH 6130
            .|.|::|                             :..||:|.| ||..|..::    |:|.:|
Human   458 FKCEVSD-----------------------------EKVTGKWYK-NGVEVRPSK----RITISH 488

  Fly  6131 QYQYR---ISAVNAAGNGK-TSEP-------SAIFNAR-------PLREKPRFYFDGLIGK---- 6173
            ..::.   |..|.....|. |..|       ||..|..       |.:|.|:.:.| ..||
Human   489 VGRFHKLVIDDVRPEDEGDYTFVPDGYALSLSAKLNFLEIKVEYVPKQEPPKIHLD-CSGKTSEN 552

  Fly  6174 RIKVRAGEPVNLNIPISGAPTPTIEWKRGD--LKLEEGKRISYETNSERTLFRIDDSNRRDSGKY 6236
            .|.|.||..:.|::.|:|.|.|...|.:||  ....|| |...|...:.:.|.|:.:.|.|.|:|
Human   553 AIVVVAGNKLRLDVSITGEPPPVATWLKGDEVFTTTEG-RTRIEKRVDCSSFVIESAQREDEGRY 616

  Fly  6237 TVTAANEFGKDTADIEVIVVDKPSPPEGPLSYTETAPDHISLHWYSPKDDGGSDITGYIIEFTEF 6301
            |:...|..|:|.|.|.:.|||.|.|||.                               :..|..
Human   617 TIKVTNPVGEDVASIFLQVVDVPDPPEA-------------------------------VRITSV 650

  Fly  6302 GVDDWKPVPGTCPNTNFTVKNLVEGKKYVFRIRAENIYGASEALEGKPVLAKSPFDPPGAPSQPT 6366
            | :||
Human   651 G-EDW------------------------------------------------------------ 654

  Fly  6367 ISAYTPNSANLEWHPPDDCGGKPITGYIVERRERGGE-WIKCNNYPTPNTSYTVSNLRDGARYEF 6430
                    |.|.|.||...||||:|||:|||:::|.: |:|.|......|:|..:.:.:|..||.
Human   655 --------AILVWEPPMYDGGKPVTGYLVERKKKGSQRWMKLNFEVFTETTYESTKMIEGILYEM 711

  Fly  6431 RVLAVNEAGPGHPSKPSDPMTAEHQRYRPDPP--EPPK--PDRITRNGVTLSWRPPRTDGKSRIK 6491
            ||.|||..|...||..:.|       :.|..|  ||..  .:.:|....||.||||...|...|.
Human   712 RVFAVNAIGVSQPSMNTKP-------FMPIAPTSEPLHLIVEDVTDTTTTLKWRPPNRIGAGGID 769

  Fly  6492 GYYVEMRPKNGKDWKTVNDIPINSTVYTVPSLKEGEEYSFRVVAENEVGRSDPSKPSQPITIEEQ 6556
            ||.||...:..::|...|..|:....:||.:|..|....||||..|..|||:|:..:||:||.|.
Human   770 GYLVEYCLEGSEEWVPANTEPVERCGFTVKNLPTGARILFRVVGVNIAGRSEPATLAQPVTIREI 834

  Fly  6557 PNKPCMELGK-VRDIVCR-AGDDFSIHVPYLAFPKPNAFWYSNDNMLDDNNRVHKHLTDDAASVV 6619
            ...|.:.|.: :|....| .|:..::.||:...|:|...|......| |.:|||...:|......
Human   835 AEPPKIRLPRHLRQTYIRKVGEQLNLVVPFQGKPRPQVVWTKGGAPL-DTSRVHVRTSDFDTVFF 898

  Fly  6620 VKNSKRADSGQYRLQLKNTSGFDTATINVRVLDRPSPPTRLRADEFSGDSLTLYWNPPNDDGGSA 6684
            |:.:.|:|||:|.|.::..:..|||||.:||:::..||..:...|..|.:..:.|..|.|||.|.
Human   899 VRQAARSDSGEYELSVQIENMKDTATIRIRVVEKAGPPINVMVKEVWGTNALVEWQAPKDDGNSE 963

  Fly  6685 IQNYIIEKKEARSSTWSKV-----SSFCTVPFVRIRNLVLNKEYDFRVIAENKYGQSDPANTSEP 6744
            |..|.::|.:.::..|..|     .:.|||     .:|::..||.|||..||..|.||....|:
Human   964 IMGYFVQKADKKTMEWFNVYERNRHTSCTV-----SDLIVGNEYYFRVYTENICGLSDSPGVSK- 1022

  Fly  6745 ILARHPFDIPNTPGIPHGIDSTEDSITIAWTKPKHDGGSPITGYIIEKRLLSDDKWTKAVHALCP 6809
                      ||..|      .:..||.   ||
Human  1023 ----------NTARI------LKTGITF---KP-------------------------------- 1036

  Fly  6810 DLSCKIPNLIENAEYEFRVAAVNAAGQSAYSGSSDLIFCRRPPHAPKITSDLSIRDMTVIAGDEF 6874
                     .|..|::||:                         |||..:.|.  |..|:||...
Human  1037 ---------FEYKEHDFRM-------------------------APKFLTPLI--DRVVVAGYSA 1065

  Fly  6875 RITVPYHASPRPTASWSLNGLEVIPGERIKFDSNDYASMYYNKSAKRD---ETGSYTITLTNNKG 6936
            .:.......|:|...|..|.:|:  .|..||...:|..: ...:.:|.   :.|:||....|..|
Human  1066 ALNCAVRGHPKPKVVWMKNKMEI--REDPKFLITNYQGV-LTLNIRRPSPFDAGTYTCRAVNELG 1127

  Fly  6937 SDTASCHVTV 6946
            ...|.|.:.|
Human  1128 EALAECKLEV 1137

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bt	NP_001162825.1	I-set	9..101	CDD:254352
		Ig	26..100	CDD:143165
		I-set	119..210	CDD:254352
		Ig	136..209	CDD:143165
		I-set	228..320	CDD:254352
		IGc2	242..312	CDD:197706
		I-set	335..425	CDD:254352
		Ig	350..423	CDD:143165
		Ig	436..530	CDD:299845
		I-set	438..532	CDD:254352
		I-set	545..636	CDD:254352
		Ig	560..633	CDD:143165
		Ig	657..731	CDD:143165
		I-set	746..835	CDD:254352
		Ig	1496..1586	CDD:299845
		IG_like	1503..1588	CDD:214653
		I-set	1639..1724	CDD:254352
		IG	1750..1821	CDD:214652
		IGc2	1750..1806	CDD:197706
		I-set	1826..1909	CDD:254352
		Ig	1831..1897	CDD:299845
		I-set	1914..1998	CDD:254352
		Ig	2020..2095	CDD:299845
		FN3	2100..2194	CDD:238020
		FN3	2203..2292	CDD:238020
		I-set	2311..2395	CDD:254352
		Ig	2321..2395	CDD:299845
		FN3	2399..2493	CDD:238020
		FN3	2501..2590	CDD:238020
		I-set	2602..2693	CDD:254352
		Ig	2619..2693	CDD:299845
		FN3	2697..2793	CDD:238020
		FN3	2801..2893	CDD:238020
		I-set	2902..2995	CDD:254352
		Ig	2919..2993	CDD:299845
		FN3	2999..3088	CDD:238020
		FN3	3102..3191	CDD:238020
		I-set	3208..3292	CDD:254352
		Ig	3219..3292	CDD:299845
		FN3	3296..3390	CDD:238020
		FN3	3400..3489	CDD:238020
		I-set	3494..3590	CDD:254352
		Ig	3516..3590	CDD:299845
		FN3	3594..3682	CDD:238020
		FN3	3694..3781	CDD:238020
		I-set	3795..3885	CDD:254352
		Ig	3813..3885	CDD:299845
		FN3	3889..3980	CDD:238020
		FN3	3990..4082	CDD:238020
		I-set	4090..4181	CDD:254352
		Ig	4108..4181	CDD:299845
		FN3	4185..4271	CDD:238020
		FN3	4285..4383	CDD:238020
		Ig	4404..4480	CDD:299845
		FN3	4484..4571	CDD:238020
		FN3	4584..4677	CDD:238020
		I-set	4685..4775	CDD:254352
		Ig	4703..4775	CDD:299845
		FN3	4779..4863	CDD:238020
		FN3	4879..4970	CDD:238020
		IG	4989..5069	CDD:214652
		Ig	4996..5069	CDD:299845
		FN3	5073..5166	CDD:238020
		FN3	5175..5265	CDD:238020
I-set	5276..5366	CDD:254352
Ig	5293..5366	CDD:299845
FN3	5370..5462	CDD:238020
FN3	5470..5561	CDD:238020	4/13 (31%)
Ig	5559..5654	CDD:299845	27/126 (21%)
I-set	5570..5660	CDD:254352	28/126 (22%)
FN3	5664..5755	CDD:238020	23/109 (21%)
FN3	5764..5853	CDD:238020	13/88 (15%)
I-set	5865..5954	CDD:254352	15/98 (15%)
Ig	5882..5954	CDD:299845	10/81 (12%)
FN3	5958..6049	CDD:238020	14/90 (16%)
FN3	6062..6153	CDD:238020	20/101 (20%)
I-set	6173..6255	CDD:254352	29/87 (33%)
Ig_Titin_like	6182..6255	CDD:143225	24/74 (32%)
FN3	6259..6350	CDD:238020	8/90 (9%)
FN3	6359..6451	CDD:238020	33/92 (36%)
FN3	6470..6552	CDD:238020	31/81 (38%)
I-set	6564..6650	CDD:254352	27/87 (31%)
Ig_Titin_like	6577..6650	CDD:143225	23/72 (32%)
FN3	6654..6745	CDD:238020	30/95 (32%)
FN3	6754..6840	CDD:238020	11/85 (13%)
I-set	6855..6946	CDD:254352	24/93 (26%)
Ig	6874..6946	CDD:299845	17/74 (23%)
FN3	6950..7042	CDD:238020
FN3	7050..7139	CDD:238020
FN3	7151..7237	CDD:238020
I-set	7254..7334	CDD:254352
Ig	7272..7339	CDD:143165
IG_like	7354..7440	CDD:214653
Ig	7366..7440	CDD:299845
FN3	7444..7531	CDD:238020
FN3	7545..7637	CDD:238020
I-set	7648..7737	CDD:254352
Ig	7665..7734	CDD:143165
Ig	7760..7833	CDD:299845
FN3	7837..7927	CDD:238020
STKc_Twitchin_like	7986..8244	CDD:271016
S_TKc	7989..8244	CDD:214567
Ig	8311..8394	CDD:299845
I-set	8312..8401	CDD:254352
I-set	8437..8525	CDD:254352
Ig	8455..8519	CDD:143165
I-set	8632..8721	CDD:254352
IGc2	8646..8711	CDD:197706
I-set	8740..8831	CDD:254352
Ig	8757..8826	CDD:143165
I-set	8839..8922	CDD:254352
Ig	8845..>8909	CDD:299845
MYBPC2	NP_004524.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..62		6/33 (18%)
		IG_like	58..153	CDD:214653	25/113 (22%)
		I-set	258..342	CDD:254352	19/118 (16%)
		Ig	283..330	CDD:299845	12/75 (16%)
		I-set	348..434	CDD:254352	24/137 (18%)
		Ig	374..441	CDD:143165	20/154 (13%)
		IG_like	447..>509	CDD:214653	23/105 (22%)
		Ig	456..>509	CDD:143165	17/86 (20%)
		Ig_C5_MyBP-C	550..635	CDD:143302	28/85 (33%)
		IG_like	554..635	CDD:214653	28/81 (35%)
		FN3	639..725	CDD:238020	38/185 (21%)
		FN3	738..830	CDD:238020	33/91 (36%)
		IG_like	848..929	CDD:214653	25/81 (31%)
		Ig_Titin_like	857..929	CDD:143225	23/72 (32%)
		FN3	934..1016	CDD:238020	27/86 (31%)
		I-set	1048..1137	CDD:254352	24/93 (26%)
		Ig	1067..1132	CDD:143165	15/67 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	58	1.000	Domainoid score	I10772
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13817
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010