DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment bt and MUSK

DIOPT Version :9

Sequence 1:NP_001162825.1 Gene:bt / 43814 FlyBaseID:FBgn0005666 Length:8933 Species:Drosophila melanogaster
Sequence 2:XP_005252051.1 Gene:MUSK / 4593 HGNCID:7525 Length:879 Species:Homo sapiens


Alignment Length:795 Identity:160/795 - (20%)
Similarity:264/795 - (33%) Gaps:258/795 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly  7621 AQNVAGLSTESSASQAVKIIDPQAASPPLIVKPLRDANCIQNHNAQFTCTINGVPKPTISWYKGA 7685
            |.|..|.:.||..:..|| :.|:...||:.||      .|:...|...||..|.|||::||.||.
Human   101 ANNGVGGAVESCGALQVK-MKPKITRPPINVK------IIEGLKAVLPCTTMGNPKPSVSWIKGD 158

  Fly  7686 REISNGARYHMYSEGDNHFLNINDVFGEDADEYVCRAVNKAGAKSTRATLAIMTAPKLNVPPRF- 7749
            ..:...:|..:...|.   |.|::|..|||.:|.|.|.|..|...::..       ||.|.... 
Human   159 SPLRENSRIAVLESGS---LRIHNVQKEDAGQYRCVAKNSLGTAYSKVV-------KLEVEEESE 213

  Fly  7750 --RDTAYFDK------------GENVVIKIPFTGFPKPRIHWVRDGENIESGGHYTVEVKERHAV 7800
              :||..|.:            |..|.:....||.|.|.|.|:.:| |..|.|.....||:|   
Human   214 PEQDTKVFARILRAPESHNVTFGSFVTLHCTATGIPVPTITWIENG-NAVSSGSIQESVKDR--- 274

  Fly  7801 LIIRDGSHL---DSGPYRITAENELGSDTAIIQVQISDRPDPPRFPLIESIGTESLSLSWKAPVW 7862
             :|.....|   ..|.|...|.|:.|.                :|...::..|.|:: .|..|..
Human   275 -VIDSRLQLFITKPGLYTCIATNKHGE----------------KFSTAKAAATISIA-EWSKPQK 321

  Fly  7863 DG-----------CSDI----------TNYYVERREHPL---SSW--IRVGN------------- 7888
            |.           |:.:          |:|........|   ::|  ::|.:             
Human   322 DNKGYCAQYRGEVCNAVLAKDALVFLNTSYADPEEAQELLVHTAWNELKVVSPVCRPAAEALLCN 386

  Fly  7889 -----------------TRFTSMAVSGLTPGKEYDFRIFADNVYGRSDASDTSTLIKTKESVKKK 7936
                             .|...:||..|...||:   :..:....|........|:...|..|..
Human   387 HIFQECSPGVVPTPIPICREYCLAVKELFCAKEW---LVMEEKTHRGLYRSEMHLLSVPECSKLP 448

  Fly  7937 PIERKWE---------IDANGRKLR-------GKADGPVKDYDS---------------YVFDIY 7970
            .:.  |:         :|.|...|:       .|....:.:..|               .:..|.
Human   449 SMH--WDPTACARLPHLDYNKENLKTFPPMTSSKPSVDIPNLPSSSSSSFSVSPTYSMTVIISIM 511

  Fly  7971 SKFV--------------------------------------------PQPVE-----------I 7980
            |.|.                                            |.|:.           :
Human   512 SSFAIFVLLTITTLYCCRRRKQWKNKKRESAAVTLTTLPSELLLDRLHPNPMYQRMPLLLNPKLL 576

  Fly  7981 SQQSVYDRYDILEEIGTGAFGVVHRCRERSTG-------NIFAAKFIPVSHSVEKDL-IRREIDI 8037
            |.:...:..:.:.:||.||||.|.:.  |:.|       .:.|.|.:....|.:... .:||..:
Human   577 SLEYPRNNIEYVRDIGEGAFGRVFQA--RAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAAL 639

  Fly  8038 MNQLHHQKLINLHDAFEDDDEMILILEFLSGGELFE----------------------RITAEG- 8079
            |.:..:..::.|.........|.|:.|:::.|:|.|                      ::::.| 
Human   640 MAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQVSSPGP 704

  Fly  8080 YVMTEAEVINYMRQICEGIRHMHEQNIIHLDIKPENIMCQTRSSTNVKLIDFGLATRLDPNEVVK 8144
            ..::.||.:...||:..|:.::.|:..:|.|:...|  |....:..||:.||||:..:...:..|
Human   705 PPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRN--CLVGENMVVKIADFGLSRNIYSADYYK 767

  Fly  8145 ITTGTA---EFAAPEIV--NREPVGFYT---DMWATGVLSYVLLS-GLSPFAGDNDVQTL----- 8195
            .....|   .:..||.:  ||     ||   |:||.||:.:.:.| ||.|:.|....:.:     
Human   768 ANENDAIPIRWMPPESIFYNR-----YTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRD 827

  Fly  8196 KNVKACDWDFDVESF 8210
            .|:.:|..:..||.:
Human   828 GNILSCPENCPVELY 842

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
btNP_001162825.1 I-set 9..101 CDD:254352
Ig 26..100 CDD:143165
I-set 119..210 CDD:254352
Ig 136..209 CDD:143165
I-set 228..320 CDD:254352
IGc2 242..312 CDD:197706
I-set 335..425 CDD:254352
Ig 350..423 CDD:143165
Ig 436..530 CDD:299845
I-set 438..532 CDD:254352
I-set 545..636 CDD:254352
Ig 560..633 CDD:143165
Ig 657..731 CDD:143165
I-set 746..835 CDD:254352
Ig 1496..1586 CDD:299845
IG_like 1503..1588 CDD:214653
I-set 1639..1724 CDD:254352
IG 1750..1821 CDD:214652
IGc2 1750..1806 CDD:197706
I-set 1826..1909 CDD:254352
Ig 1831..1897 CDD:299845
I-set 1914..1998 CDD:254352
Ig 2020..2095 CDD:299845
FN3 2100..2194 CDD:238020
FN3 2203..2292 CDD:238020
I-set 2311..2395 CDD:254352
Ig 2321..2395 CDD:299845
FN3 2399..2493 CDD:238020
FN3 2501..2590 CDD:238020
I-set 2602..2693 CDD:254352
Ig 2619..2693 CDD:299845
FN3 2697..2793 CDD:238020
FN3 2801..2893 CDD:238020
I-set 2902..2995 CDD:254352
Ig 2919..2993 CDD:299845
FN3 2999..3088 CDD:238020
FN3 3102..3191 CDD:238020
I-set 3208..3292 CDD:254352
Ig 3219..3292 CDD:299845
FN3 3296..3390 CDD:238020
FN3 3400..3489 CDD:238020
I-set 3494..3590 CDD:254352
Ig 3516..3590 CDD:299845
FN3 3594..3682 CDD:238020
FN3 3694..3781 CDD:238020
I-set 3795..3885 CDD:254352
Ig 3813..3885 CDD:299845
FN3 3889..3980 CDD:238020
FN3 3990..4082 CDD:238020
I-set 4090..4181 CDD:254352
Ig 4108..4181 CDD:299845
FN3 4185..4271 CDD:238020
FN3 4285..4383 CDD:238020
Ig 4404..4480 CDD:299845
FN3 4484..4571 CDD:238020
FN3 4584..4677 CDD:238020
I-set 4685..4775 CDD:254352
Ig 4703..4775 CDD:299845
FN3 4779..4863 CDD:238020
FN3 4879..4970 CDD:238020
IG 4989..5069 CDD:214652
Ig 4996..5069 CDD:299845
FN3 5073..5166 CDD:238020
FN3 5175..5265 CDD:238020
I-set 5276..5366 CDD:254352
Ig 5293..5366 CDD:299845
FN3 5370..5462 CDD:238020
FN3 5470..5561 CDD:238020
Ig 5559..5654 CDD:299845
I-set 5570..5660 CDD:254352
FN3 5664..5755 CDD:238020
FN3 5764..5853 CDD:238020
I-set 5865..5954 CDD:254352
Ig 5882..5954 CDD:299845
FN3 5958..6049 CDD:238020
FN3 6062..6153 CDD:238020
I-set 6173..6255 CDD:254352
Ig_Titin_like 6182..6255 CDD:143225
FN3 6259..6350 CDD:238020
FN3 6359..6451 CDD:238020
FN3 6470..6552 CDD:238020
I-set 6564..6650 CDD:254352
Ig_Titin_like 6577..6650 CDD:143225
FN3 6654..6745 CDD:238020
FN3 6754..6840 CDD:238020
I-set 6855..6946 CDD:254352
Ig 6874..6946 CDD:299845
FN3 6950..7042 CDD:238020
FN3 7050..7139 CDD:238020
FN3 7151..7237 CDD:238020
I-set 7254..7334 CDD:254352
Ig 7272..7339 CDD:143165
IG_like 7354..7440 CDD:214653
Ig 7366..7440 CDD:299845
FN3 7444..7531 CDD:238020
FN3 7545..7637 CDD:238020 5/15 (33%)
I-set 7648..7737 CDD:254352 28/88 (32%)
Ig 7665..7734 CDD:143165 24/68 (35%)
Ig 7760..7833 CDD:299845 21/75 (28%)
FN3 7837..7927 CDD:238020 19/145 (13%)
STKc_Twitchin_like 7986..8244 CDD:271016 61/270 (23%)
S_TKc 7989..8244 CDD:214567 61/267 (23%)
Ig 8311..8394 CDD:299845
I-set 8312..8401 CDD:254352
I-set 8437..8525 CDD:254352
Ig 8455..8519 CDD:143165
I-set 8632..8721 CDD:254352
IGc2 8646..8711 CDD:197706
I-set 8740..8831 CDD:254352
Ig 8757..8826 CDD:143165
I-set 8839..8922 CDD:254352
Ig 8845..>8909 CDD:299845
MUSKXP_005252051.1 I-set 28..117 CDD:254352 5/15 (33%)
Ig 36..117 CDD:299845 5/15 (33%)
I-set 121..203 CDD:254352 30/90 (33%)
Ig 135..201 CDD:299845 24/68 (35%)
I-set 223..306 CDD:254352 23/103 (22%)
Ig 239..306 CDD:143165 22/87 (25%)
CRD_FZ 325..467 CDD:295308 18/146 (12%)
PTKc_Musk 579..868 CDD:133181 61/273 (22%)
Pkinase_Tyr 585..866 CDD:285015 61/267 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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