DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bt and Obsl1

DIOPT Version :9

Sequence 1:	NP_001162825.1	Gene:	bt / 43814	FlyBaseID:	FBgn0005666	Length:	8933	Species:	Drosophila melanogaster
Sequence 2:	XP_017452317.1	Gene:	Obsl1 / 363259	RGDID:	1306073	Length:	1897	Species:	Rattus norvegicus

Alignment Length:	2496	Identity:	462/2496 - (18%)
Similarity:	800/2496 - (32%)	Gaps:	834/2496 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   428 QGASDANGFAPSFIEKPRIIPNESGTLITMKCKCKAKPEPTVTWYRGQDLVEKSKKIKINTTVIA 492
            :.:|...|..|.|:..||.:...||....:||....:|.|||.|.:|...:..|:::.     ..
  Rat     2 KASSGDQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPTVLWEKGGQQLVASERLS-----FP 61

  Fly   493 EDTYELTLEIKDPGATDGGTYRCNVKNEYGESNANLNLNI----EAEPEPE-----------GEG 542
            ||..|..|.:.....||.|.|.|..:|..||:.|...:.:    ..||||:           |||
  Rat    62 EDGAEHGLLLSGALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPAPEPEPQSSECPPPPPGTGEG 126

  Fly   543 -PTFIEKPRIVSENNGKLVIMECKVKADPKPDVIWFRNGEVIKE--SNKIKTFIEQRGDQ---YY 601
             |.|:..|:......|..|::.|:|...|:|.:.|.::|..:.|  .:...|....||..   ..
  Rat   127 APVFLTGPQSQWVLRGAEVVLTCQVGGLPEPKLYWEKDGMALDEVWDSSHYTLEPDRGASDGGAS 191

  Fly   602 IKLELLDPQLEDSGLYKCNIKNTLGELNANLTLN----------------IEIVPVIKDKPKIIK 650
            :.|.:|..:|.|||:|.|:.:|..|...|...|.                :.::..:|..||...
  Rat   192 LTLRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPHENPPQDPDEPPVRVIEPLKCAPKTFW 256

  Fly   651 IIKKRTVVIECTVASKFEPKCTWYKETSTVKESKRHVYQVEQTKEGEFAVKLEINDVEESDKGAY 715
            :.:.:.....|.|..|.||:..|:.|...:...:|.:  :.:.::|.|.:|  :...:..|:|.|
  Rat   257 VNEGKHAKFRCYVMGKPEPEIEWHLEGRPLLPDRRRL--MYRDRDGGFVLK--VLYCQAKDRGLY 317

  Fly   716 KLVASNEKGEAVSQIVNLVDIPEEERKPCKPEISRKLADQKVAESKTFELLVSLSQTDRKCKV-- 778
            ...|.|..|:.:|.:...|..|       :...:|.|.|   .|.:...::|      .:|||
  Rat   318 VCAARNSAGQTLSAVQLHVKEP-------RLRFTRPLQD---VEGREHGIVV------LECKVPN 366

  Fly   779 -----EWYKGSTVIRETKDITTTFDGTTARLTFSSARTEHTSNYKVIVTNEVGKDESSCKITVEK 838
                 .|::....:...:......:||..||.....:.:....|   :....|:..:...:||:.
  Rat   367 SRIPTAWFREDQRLLPCRKYEQIEEGTVRRLVIHRLKADDDGVY---LCEMRGRVRTVANVTVKG 428

  Fly   839 VAKKKEEKPKEKEKTKNEKEVEQKEMEEDKNESGQSVAQTEGRINIEQISEGDPKEELTVKEEIL 903
            ...|:  .|::.:..:.|..|...|.:|         |..:|                      .
  Rat   429 PILKR--LPRKLDVLEGENAVLLVETQE---------AGVQG----------------------C 460

  Fly   904 DKRDTQEVKESSVELQDSAGHEVPEPKKATSDSKLDQSNQKNLDKKHKTDQSESKTNKNVSLAEP 968
            ..||.:|:..:   .|.|.||                        .|             :|..|
  Rat   461 WSRDGEELPAT---CQSSCGH------------------------MH-------------ALVLP 485

  Fly   969 IKSNKQESEEQQATEQIGLKKVDRKASIVSVKEEISSDVRRKSTIKAKEEITVDDKKASSRRSSL 1033
                             |:.:.|......|:....::.:.|...:|            .|.....
  Rat   486 -----------------GVTREDAGEVTFSLGNSRTTTLLRVKCVK------------HSPPGPP 521

  Fly  1034 AVEESNTESRRSSIIDKKPLEQVDNKPIDANKNPQPLKEEIPRLK-------------PAEKRRT 1085
            .:.|.....:.:.::..||.|            |.|....|.||:             ..||...
  Rat   522 VLVEMFKGQKNTVLLTWKPPE------------PPPETSFIYRLERQEVGSEDWIQCFSIEKAGA 574

  Fly  1086 SKVIEEPKPDEGLPKLRKASIAQVKEEAKPAAPKLKAKAKAKPKYEELPEIPDYERPQLEKYEKS 1150
            .:|..:..|.||..:.|   |..|.|..:.........|...|....:..:.|     ::.|:..
  Rat   575 VEVPGDCVPTEGDYRFR---ICTVSEHGRSPHVVFNGSAHLVPTARLVSGLED-----VQVYDGE 631

  Fly  1151 DFTPSDFARDLE--------IPNKMEKPIIDSGKKEPAVLAQKNGIPKKTDIIEQYADEPKGLKV 1207
            |   :.|:.||.        :..::.|.....|:.||..|              :|..|.|||
  Rat   632 D---AVFSLDLSTIIQGSWFLNGELLKNDEAEGQVEPGAL--------------RYRIEQKGL-- 677

  Fly  1208 GKGKLPDEGDGRDGAVLKPVIIEPEKEILDLGNKKNNQHADKPTVLDIIKQRRRSSIRNLMTKEP 1272
                                                 ||.   .:|..:|.:
  Rat   678 -------------------------------------QHR---LILQTVKHQ------------- 689

  Fly  1273 IQNESFLGVVLKPVIKDTREQAAPQQAIQLTKANATEQFSPTKAVKAQVADLKKPETLATLEDNY 1337
             .|.:.:|.:. |.::|:              |..:.|.||..
  Rat   690 -DNGALVGFIC-PGVQDS--------------AALSIQESPVH---------------------- 716

  Fly  1338 ERPVLEKYDPFSIDKTKSEKSTPSIITPDIRGPEVKLPVQETKEEKQKVPKMQPPAPGDPPKIEV 1402
               :|...|...:..|.||:   .::|.::  ..|..|....| :.|||
  Rat   717 ---ILSPQDKVLLTFTTSER---VVLTCEL--SRVDFPATWYK-DGQKV---------------- 756

  Fly  1403 IREKRPSLAPEPPSRRGSLIPPADTGRRPSLIINDEKKLRPGEVMDTRLLRPGEVGEGQRRRPSI 1467
              |:..||..:...|:..||.|             |.::|.....:.|.       ||.....|:
  Rat   757 --EESESLVVKMDGRKHRLILP-------------EAQVRDSGEFECRT-------EGISAFFSV 799

  Fly  1468 DVRRPSVQDLEDLINKPSTPLRDVGDGGPPSIVDVQESYSV--VEDSTAYLTVGVEGSPAPTFKF 1530
            .|:.|                       |..|||.||...|  :...:..||..|:...| ...:
  Rat   800 TVQDP-----------------------PVHIVDPQEHVFVHAITSESVMLTCEVDREDA-AVHW 840

  Fly  1531 YKGVSEILEGGRFKFLTDGQTNTITLCMRKCKPNDESKYKIVVSNIHGEDSAEMQLYVSD-SSGM 1594
            ||...|:.|........:|..:.:.|  ...:|:|..:::.||    |::.|...:.::| ||.:
  Rat   841 YKDGQEVEESAVIVLEKEGPRHRLVL--PAAQPSDGGEFQCVV----GDERAYFTVTITDVSSWI 899

  Fly  1595 DFRAMLKKRRYQKWDKDEQDPNWGDLKETEKPLPALKKVERKVESFLSPLIDQFAKEGKDKKVVF 1659
            .:                  ||       .|...|..::||                     ||.
  Rat   900 VY------------------PN-------GKVYVAAVRLER---------------------VVL 918

  Fly  1660 EARFSKPNCKPKWLFRKDEVFTGSKFKFKQENDTYQLIITTPKVEDTGKYTIEIGGVSSTAFLNV 1724
            .....:|..:.:|....:||........::|:...:|::.:.::||:|:|..||         :.
  Rat   919 TCELCRPWAEVRWTKDGEEVLESPALLLEKEDTIRRLVLPSVQLEDSGEYLCEI---------HD 974

  Fly  1725 EEADPTYTFTKPLKKKL---EGFTQHETTLECSV-----SSSMANVHWFKNNTK--------LES 1773
            |.|..|.|.|:|..:.:   :..|.|..:|||.|     |...|.|.|:|:..:        |:|
  Rat   975 ESASFTITVTEPPVRIIYPQDEVTLHAVSLECVVLTCELSRVDAPVRWYKDGLEVEETEALVLQS 1039

  Fly  1774 DDPRYLISKDINGNLKLIIKDSVLDDAGLYRCQLDKQPDKTECNLKVTEYPYKFVKVLKSQQCIE 1838
            |.||          .:|::..:..:|.|.:.|  |...|.....:.||..|.:.|..:.....::
  Rat  1040 DGPR----------RRLVLPAAQPEDGGEFVC--DAGDDSAFFTVTVTAPPERIVHPVARSLDLQ 1092

  Fly  1839 ---KDTVTLACEIDDAMGEVQWLRNGEEIKPDKRIQIVKDGRKRKLVIKDCKVTDAGQFKCTTNA 1900
               ...|.|.||:..|..:|:|.::|.|::....:|:..:|..|.|.:...:..|||::.|.|..
  Rat  1093 FGAPGHVELRCEVAPAGSQVRWYKDGLEVEVSDALQLGAEGPARTLTLPHAQPEDAGEYVCETRD 1157

  Fly  1901 DTTESEIIINYQNRFNKKLKD-------TEAVER-------EKLILDIELQDQTAPCDWKFNGEP 1951
            :..          .||..|.:       .|||..       |.::|..||...:|...|..||.|
  Rat  1158 EAV----------TFNVSLAELPVQFLAPEAVPNPLCVVPGEPVMLSCELSRASAHVSWSHNGNP 1212

  Fly  1952 IVPSESIEIKNMGGGKHQLIFSSLDMSNEGEITCESGQLSSKCKLSIRKGESRPNIDCPDKFSGP 2016
            :...|.:|:: ..|.:..|...:.|:::.|..||:||.......||.....:.|    |.:...|
  Rat  1213 VKQGEGLELR-AEGPRRILCIQAADLAHTGVYTCQSGTAPGAPSLSFNVQVAEP----PVRVVAP 1272

  Fly  2017 ISAPVLLEVPFKVSGTKQTPVE-----------AKLFKDGKPLPVKD-VEVAVTDDKVTFKIKKP 2069
            .:|..      :|..|....:|           .:.:|||:.|..:. |::....::...:::..
  Rat  1273 EAAQT------RVRSTPGGDLELVVHLSRPGGPVRWYKDGERLASQGRVQLEQAGERQVLRVRGA 1331

  Fly  2070 SRDLSGPYQIKISNGQGEDTKDVQIICQDVPQP-------------------------PQDVDIT 2109
            .|..:|.|....|    :|:: :.|:..:.|.|                         |.|.::|
  Rat  1332 RRGDAGEYLCDAS----QDSR-IFIVSVEEPPPVKLVSELTPLTVHEGDDATFQCEVSPPDAEVT 1391

  Fly  2110 DVYQTSCVVSFNPPSD------------------DGGTPITK------------------YVIER 2138
            .: :...:|:..|..:                  |.||...:                  ::...
  Rat  1392 WL-RNGAIVTPGPQLEMVHSGSSRTLIIRGCQLKDAGTVTARAGATDTSARLHVRETELLFLRRL 1455

  Fly  2139 QDLSKKHGWESVAEVLPSEPCLKKIDDLIPKKQYRFRIRAVNAIGQSDPATFKNTILAKDPWDEP 2203
            ||:..:.|.:...||...                  |:.|..|:                .|...
  Rat  1456 QDVRAEEGQDVYLEVETG------------------RVGAPGAV----------------RWLRG 1486

  Fly  2204 GKPKAVD--------------------LTDWD----KDHAD------------LKWEAPETD--- 2229
            |:|..:|                    |||..    :.|.|            |:...|..|
  Rat  1487 GEPLPLDSRLTTAQDGHVHRLSIHGVLLTDQGTYGCESHHDRTLARLSVRPRQLRELRPLEDVTV 1551

  Fly  2230 --GGDPITAYIVEYKEKFSNDWVSGKEVDGDARTATVDGLK-----EGQQYEFRVRAVNRAGPGE 2287
              ||.      ..::.:.|.:.|:|:...|..|..  .|.|     ||:.:...:..:..|..|.
  Rat  1552 HEGGS------ATFQLELSQEGVTGEWAQGGVRLH--PGPKCHIHSEGRTHCLVLSGLGLADSGC 1608

  Fly  2288 PSDKTKSIIAKCRFV---KPFIVGEGLKNVTVKKGQTIRFDIKYDGEPEPAATWVKGTDNLKFDN 2349
            .|....::....|..   .|..:.:|.:::.|.:|.|..|:.:. .:......|.|....|.. :
  Rat  1609 ISFTADTLRCAARLTVREVPVTIVQGPQDLEVTEGDTATFECEL-SQTLADVIWEKDGQALSL-S 1671

  Fly  2350 QRICLDQLERNSSITIKKSVRKDTGKYKLVLSNSSGTIES-EAQVVVLDRPLPPGGPFEPEEIRA 2413
            .|:.|..|.....:.:::....|.|.|...:    ||..| .|::.|.:|.:...|     |:|:
  Rat  1672 PRLRLQSLGTRRLLLLRRCSSSDAGTYCCAV----GTARSGPARLTVREREVSVLG-----ELRS 1727

  Fly  2414 SHIKMKWKRPDDDGG---CEISGYALERMDEETGRWIPAGEVGPNETSFDFKGLTPNKKYKFRVK 2475
            ...:      :.|..   |.:|      ..|.||||    |:|.       :.|.|..:.:.|
  Rat  1728 LSAR------EGDSATFECTVS------ESETTGRW----ELGG-------RALRPGGRVRIR-- 1767

  Fly  2476 AINKEGESEPLETFDAIVARNPYDPPSPPSQPVIDDYDNKSVLLKWKRPPSDGGRPITHYIVEIK 2540
               :||:.                                                  |.:|
  Rat  1768 ---QEGKK--------------------------------------------------HILV--- 1776

  Fly  2541 DKFAPSWSEVAKTDDPNPECNVEGLKEKMVYQFRVRAVNKAGPSEPSQPTDNHLCKH--KNLKPQ 2603
                  .||: :|:|....|...|..:.:. :..|.|:       |.|     :|:.  :.....
  Rat  1777 ------LSEL-RTEDTGEVCFQAGPAQSLA-RLEVEAL-------PLQ-----MCRRPPREKTVL 1821

  Fly  2604 IDRSTFKRVTIKSGRTHKWSVDVLGEPIPELHWSW-RDDIPLTNGDRIKIENVDYHTDFSITNVL 2667
            :||.....||:..               |..|..| |:.:.|..|.:.::.:........|.:|.
  Rat  1822 VDRRAVLEVTVSR---------------PGGHVCWMREGVELCPGSKYEMRSHGTTHSLVIHDVR 1871

  Fly  2668 RKDSGFYTLKAENRNGIDRETVELVV 2693
            .:|.|.|:.:|    |.|....:|:|
  Rat  1872 PEDQGTYSCQA----GQDSADTQLLV 1893

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bt	NP_001162825.1	I-set	9..101	CDD:254352
		Ig	26..100	CDD:143165
		I-set	119..210	CDD:254352
		Ig	136..209	CDD:143165
		I-set	228..320	CDD:254352
		IGc2	242..312	CDD:197706
		I-set	335..425	CDD:254352
		Ig	350..423	CDD:143165
		Ig	436..530	CDD:299845	28/93 (30%)
		I-set	438..532	CDD:254352	28/93 (30%)
		I-set	545..636	CDD:254352	26/111 (23%)
		Ig	560..633	CDD:143165	22/77 (29%)
		Ig	657..731	CDD:143165	18/73 (25%)
		I-set	746..835	CDD:254352	15/95 (16%)
		Ig	1496..1586	CDD:299845	23/91 (25%)
		IG_like	1503..1588	CDD:214653	19/86 (22%)
		I-set	1639..1724	CDD:254352	14/84 (17%)
		IG	1750..1821	CDD:214652	20/83 (24%)
		IGc2	1750..1806	CDD:197706	17/68 (25%)
		I-set	1826..1909	CDD:254352	19/85 (22%)
		Ig	1831..1897	CDD:299845	16/68 (24%)
		I-set	1914..1998	CDD:254352	26/97 (27%)
		Ig	2020..2095	CDD:299845	13/86 (15%)
		FN3	2100..2194	CDD:238020	18/154 (12%)
		FN3	2203..2292	CDD:238020	25/134 (19%)
		I-set	2311..2395	CDD:254352	17/84 (20%)
		Ig	2321..2395	CDD:299845	15/74 (20%)
		FN3	2399..2493	CDD:238020	18/96 (19%)
		FN3	2501..2590	CDD:238020	12/88 (14%)
		I-set	2602..2693	CDD:254352	19/91 (21%)
		Ig	2619..2693	CDD:299845	15/74 (20%)
		FN3	2697..2793	CDD:238020
		FN3	2801..2893	CDD:238020
		I-set	2902..2995	CDD:254352
		Ig	2919..2993	CDD:299845
		FN3	2999..3088	CDD:238020
		FN3	3102..3191	CDD:238020
		I-set	3208..3292	CDD:254352
		Ig	3219..3292	CDD:299845
		FN3	3296..3390	CDD:238020
		FN3	3400..3489	CDD:238020
		I-set	3494..3590	CDD:254352
		Ig	3516..3590	CDD:299845
		FN3	3594..3682	CDD:238020
		FN3	3694..3781	CDD:238020
		I-set	3795..3885	CDD:254352
		Ig	3813..3885	CDD:299845
		FN3	3889..3980	CDD:238020
		FN3	3990..4082	CDD:238020
		I-set	4090..4181	CDD:254352
		Ig	4108..4181	CDD:299845
		FN3	4185..4271	CDD:238020
		FN3	4285..4383	CDD:238020
		Ig	4404..4480	CDD:299845
		FN3	4484..4571	CDD:238020
		FN3	4584..4677	CDD:238020
		I-set	4685..4775	CDD:254352
		Ig	4703..4775	CDD:299845
		FN3	4779..4863	CDD:238020
		FN3	4879..4970	CDD:238020
		IG	4989..5069	CDD:214652
		Ig	4996..5069	CDD:299845
		FN3	5073..5166	CDD:238020
		FN3	5175..5265	CDD:238020
I-set	5276..5366	CDD:254352
Ig	5293..5366	CDD:299845
FN3	5370..5462	CDD:238020
FN3	5470..5561	CDD:238020
Ig	5559..5654	CDD:299845
I-set	5570..5660	CDD:254352
FN3	5664..5755	CDD:238020
FN3	5764..5853	CDD:238020
I-set	5865..5954	CDD:254352
Ig	5882..5954	CDD:299845
FN3	5958..6049	CDD:238020
FN3	6062..6153	CDD:238020
I-set	6173..6255	CDD:254352
Ig_Titin_like	6182..6255	CDD:143225
FN3	6259..6350	CDD:238020
FN3	6359..6451	CDD:238020
FN3	6470..6552	CDD:238020
I-set	6564..6650	CDD:254352
Ig_Titin_like	6577..6650	CDD:143225
FN3	6654..6745	CDD:238020
FN3	6754..6840	CDD:238020
I-set	6855..6946	CDD:254352
Ig	6874..6946	CDD:299845
FN3	6950..7042	CDD:238020
FN3	7050..7139	CDD:238020
FN3	7151..7237	CDD:238020
I-set	7254..7334	CDD:254352
Ig	7272..7339	CDD:143165
IG_like	7354..7440	CDD:214653
Ig	7366..7440	CDD:299845
FN3	7444..7531	CDD:238020
FN3	7545..7637	CDD:238020
I-set	7648..7737	CDD:254352
Ig	7665..7734	CDD:143165
Ig	7760..7833	CDD:299845
FN3	7837..7927	CDD:238020
STKc_Twitchin_like	7986..8244	CDD:271016
S_TKc	7989..8244	CDD:214567
Ig	8311..8394	CDD:299845
I-set	8312..8401	CDD:254352
I-set	8437..8525	CDD:254352
Ig	8455..8519	CDD:143165
I-set	8632..8721	CDD:254352
IGc2	8646..8711	CDD:197706
I-set	8740..8831	CDD:254352
Ig	8757..8826	CDD:143165
I-set	8839..8922	CDD:254352
Ig	8845..>8909	CDD:299845
Obsl1	XP_017452317.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I11138
eggNOG	1	0.900	-	-		E1_KOG0613
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100287
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.800