|
Fly 4680 PRYLAPKIDRRNLRNITLSSGTALKLDANITGEPAPKVEWKLSNYHLQSGKNVTIETPDYYTKLV 4744
|.:|.| |:|..:.:|:.::|...::|.|.|.:.| .:.|:.:....|: .:.|.
Rat 45 PVFLRP------LKNAAVCAGSDVRLRVVVSGTPEPSLSW------FRDGQLLPTPVPE-PSCLW 96
Fly 4745 IRPTQRSDSGEYLVTATNTSGK-----------------------DSVLVNVVITDKP------- 4779
:|.....|:|.|..:|.|..|| ||......|:|.|
Rat 97 LRNCGAQDAGVYSCSAQNERGKASCEAVLTVLEVRVFRSCRKQSYDSETAEDDISDVPGTQRLEL 161
Fly 4780 ------SPPNG-------------PLQISDVHKEGCHLKWKRPSDDGGTPIEYFQIDKLEPETGC 4825
|.|.| |..::...:| .:.| ...|.| .||.|.|
Rat 162 RDDRAFSTPTGGSDTLVGTSLDTPPTSVTGTSEE--QVSW---WGSGQT--------VLEQEAG- 212
Fly 4826 WIPSCRSTEP------QVDVTGLSP---GNEYKFRVSAVNAEGES----------QPLVGDE--- 4868
|...|.| |...||..| |.|...|.|..|..|.| ..|.|..
Rat 213 ---SGGGTRPLPGSPRQAQTTGAGPRHLGVEPLVRASRANLVGASWGSEDSLSVASDLYGSAFSL 274
Fly 4869 ------SIVARNPFDEPGKPENLKATDWDKDHVDL-------------AWTPP----LIDGGSPI 4910
||....| |..|: ::..|| |..|| |:...||
Rat 275 YRGRALSIHVSIP------PSGLR-----REEPDLQPQPASDALRPRPALPPPSKSALLPPPSP- 327
Fly 4911 SCYIIEKQDKYGKWERALDVPADQCKAT------------IPDLV----EGQTYKFRVSAVNAAG 4959
:.|| |||...:.|..|| :|:.: |.:..|.:.|..:.||
Rat 328 ---------RVGK--RALPGSSAQPPATPTSPHRCTQEPSLPEDITTTEEKRGKKPKSSGPSLAG 381
Fly 4960 TGEPSDSTP--------------PIIAKARNKPPIIDRSSLVEVRIKAGQSFTFDCKVSGEPAPQ 5010
|.|....|| |.:.:|.:: |:|:....|.|.::.: :....|||.
Rat 382 TVESRPQTPLSEASGRLSALGRSPRLVRAGSR--ILDKLQFFEERRRSLE------RSDSPPAPL 438
Fly 5011 TKWL-LKK----------------------KEVYS-KDNV---------KVTNVDYNTKLKVNSA 5042
..|: |:| :|:.| :.:| |..::|..|:.: ||
Rat 439 RPWVPLRKARSLEQPKSEGGAAWDTPGASQEELRSPRGSVAERRRLFQQKAASLDERTRQR--SA 501
Fly 5043 TRSDSGIYTVFAE-------NANGED----SADVKVTVIDKPAP-----------PNGPLKVDEI 5085
| |.:...||: :.:.|: ...::.|:...|:| |:.| |....
Rat 502 T---SDLELRFAQELGRIRRSTSREELVRSHESLRATLQRAPSPREPGEPPLFSRPSIP-KTSRA 562
Fly 5086 NSESCTLHWNPPDDDGGQPIDNYVVEKLDETTGRWIPAGETDGPVTALKVGGLTPGHKYKFRVRA 5150
.|.:.| .||...| ..|..:.||| ..:.|| ||...||...:..::.
Rat 563 VSPAAT---QPPPPSG--------AGKSGDETGR----PRSRGP-----VGRTEPGEGPQQEIKR 607
Fly 5151 KNRQGTSEPLTTAQAI-IAKNPFDVPTKPGTPTIKDFDKEFVDLEWTRPEADGGSPITGYVVEKR 5214
::: .|||.::|| ..::| ||.....| ||:...:| ...||
Rat 608 RDQ----FPLTRSRAIQECRSP--VPPFTADP----------------PESRTKAP----SARKR 646
Fly 5215 D------KFSPDWEKCAEISDDITNAHVPDLIE----GLKYEFRV-RAVNKAGPGSPSDATETHV 5268
: :|.| | .:..:.::.:|..:| |.:.|.|: |...:.||....|...|..
Rat 647 EPPAQAVRFLP-W-----ATPGVEDSVLPQTLEKNRAGPEAEKRLRRGPEEDGPWGAWDRRGTRS 705
Fly 5269 ------ARPKNTPPKIDRNFMSDIKIKAGN------VFEFDVP---------------VTGEPLP 5306
||| |.|:::.: .|..:.||. |||..:. :|..|.|
Rat 706 QGKGRRARP--TSPELESS--DDSYVSAGEEPLEAPVFEIPLQNMVVAPGADVLLKCIITANPPP 766
Fly 5307 SKDWTHEGNMIINTDRVKISNFDDRTKIRILDAKRSDTGVYTLTARNINGTDRHNVKVTILDAPS 5371
...|..:|:::.:..|:.|....:|..:.:.:|:.:|.|.||.||.|..|.
Rat 767 QVSWKKDGSVLHSEGRLLIRAEGERHTLLLREAQAADAGSYTATATNELGQ-------------- 817
Fly 5372 VPEGPLRNGDVSKNSIVLRWRPPKDDGGSEITHYVVEKMDNEAMRWVPVGDCTDTEIRADNLIEN 5436
..| |.:|
Rat 818 -------------------------------------------------ASC------ASSL--- 824
Fly 5437 HDYSFRVRAVNKQGQSQPLTTSQPITAKDPYSHPDKPGQPQATDWGKHFVDLEWSTPKRDGGAPI 5501
||.....:.|. |.|||:.:.|..|.
Rat 825 --------AVRPGASTSPF--SSPITSDEEYLSPP------------------------------ 849
Fly 5502 SSYIIEKRPKFGQ-WERAAVVLGDNCKAHVPELTNGGEYEFRVIAVNRGGPSDPSDPSSTIICKP 5565
|:.|:.|: |.|...: :..||...|.|.:....|
Rat 850 -----EEFPEPGETWSRTPTM--------------------------KPSPSQDRDSSDSSSKAP 883
Fly 5566 RFLAPFFDKSLLNDITVHAGKRLGWTLPIEASPRPLITWLYNGKEIGSNSR-----GESGLFQNE 5625
|.|..||: |.:|..|:.:..::.::..|:|:::||.|.:.:..:.| .|.||.:
Rat 884 ----PTFKVSLM-DQSVREGQDVIMSIRVQGEPKPVVSWLRNRQPVRPDQRRFAEEAEGGLCR-- 941
Fly 5626 LTFEIVSSLRSDEGRYTLILKNEHGSFDASAHATVLDRPSPPK---------------------- 5668
..|:::.|.|.|.||....||:|:....|...|...|....
Rat 942 --LRILAAERGDAGFYTCKAVNEYGARQCEARLEVRAHPESRSLAVLAPLQDVDVGAGEMALFEC 1004
Fly 5669 ---GPLDI-----------------TKITRDG--CH-LTWNVPDDDGG----------------- 5693
||.|: .|:..|| |. |..:|.:||.|
Rat 1005 LVAGPADVEVDWLCRGRLLQPALLKCKMHFDGRKCKLLLTSVHEDDSGVYTCKLSTVKDELTCSA 1069
Fly 5694 --------SPILHYIIEKMDLSRS-----------------TWS----------------DAGMS 5717
:|:...::|.:::... ||: |.|:
Rat 1070 RLTVRPSLAPLFTRLLEDVEVLEGRAARLDCKISGTPPPSVTWTHFGHPVNESENLRLRQDGGL- 1133
Fly 5718 THIVHDVTRLVHRKEYLFRVKAVNAIGESDPLEAVNTIIAKNEFDEPDAPGKPIITDWDRDHIDL 5782
|.:| :.|:....|.|:.|.|.|..|:: |...
Rat 1134 -HSLH-IARVGSEDEGLYEVSATNTHGQA--------------------------------HCSA 1164
Fly 5783 QWAV--PKSDGGAPISEYIIQKKEKGSPYWTNVRHVPSNKNTTTIPELTEGQEYEFRVIAVNQAG 5845
|..| |::....|.| |.|| :|| |||
Rat 1165 QLYVEEPRTAASGPSS-----KLEK----------MPS------IPE------------------ 1190
Fly 5846 QSEPSEPSDMIMAKPRYLPPKIITPLNEVRIKCGLIFHTDIHFIGEPAPEATWTLNSNPLLSNDR 5910
|| |..|: .|...|..:.||.::.:........:....|.|.|..:|..|.:.:.|:|.
Rat 1191 --EP-EHGDL----ERLSIPDFLRPLQDLEVGLAKEAMLECQVTGLPYPTISWFHNGHRIQSSDD 1248
Fly 5911 STITSIG--HHSVVHTVNCQRSDSGIYHLLLRNSSGIDEGSFELVVLD-RPGPPEGPMEYEEITA 5972
..:|... |..|...|..|. :|:|..::.|..|.......|.|.| .||||:|..:...:|.
Rat 1249 RRMTQYRDIHRLVFPAVGPQH--AGVYKSVIANKLGKAACYAHLYVTDVVPGPPDGAPQVVAVTG 1311
Fly 5973 NSVTISWKPPKDNGGSEISSYVIEKRDLTH--------GGGWVPAVNYVSAKYNHAVVPRLLEGT 6029
..||:||.||:. ....|:...||: ...|...| ...:........|.:|.
Rat 1312 RMVTLSWNPPRS------LDMAIDPDSLTYTVQHQVLGSDQWTALV--TGLREPEWAATGLKKGL 1368
Fly 6030 MYELRVMAENLQGRSDPLTSDQPV--------------VAKSQYTVPGAPGKPELTDSDKNHI-- 6078
.:..||::.:.:..|.|....:|| |...|..|....|:|.......||:
Rat 1369 HHIFRVLSSSGKSSSKPSAPSEPVQLLEHGPPLEEAPAVLDKQDIVYVVEGQPACVTVTFNHVEA 1433
Fly 6079 TIKWKQPISNGGSPIIG-YDIERRDVNTGRWIKINGQPVPTAEYQDDRVTSNHQYQYRISAVN-- 6140
.:.|:........|..| |::.:.| || ||..||..|:
Rat 1434 QVVWRSCRGALLEPRTGVYELSQPD--------------------DD------QYCLRICRVSRR 1472
Fly 6141 -------AAGNGKTSEPSAIFNARPLREKPRFYFDGLIGKRIKVRAGEPVNLNIPISGAPTPTIE 6198
:|.|...::..:| ...|.|.||| ..|.:.::|..||.....:.:.|.|.|.|.
Rat 1473 DLGPLTCSARNRHGTKACSI--TLELAEAPRF---ESIMEDVEVGPGETARFAVVVEGKPLPDIM 1532
Fly 6199 WKRGDLKLEEGKRISYETNSERTLFRIDDSNRRDSGKYTVTAANEFGKDT--ADIEVIVVDKPSP 6261
|.:.::.|.|...:|:..........:..:..:|.|.||.||.|..|:.: |::.|........
Rat 1533 WYKDEVLLAESNHVSFVYEENECSLVVLSAGSQDGGVYTCTARNLAGEVSCKAELSVHSAQTAME 1597
Fly 6262 PEGPLSYTETAPDHISLHWYSPKDDGGSDITGYI---------IEF-TEFGVDDWKP-------- 6308
.||.....|.....:| .:|....:.|.....|: :|| .:|.....||
Rat 1598 VEGVGEDEEHRGRRLS-DYYDIHQEIGRGAFSYLRRVVERSSGLEFAAKFIPSQAKPKASARREA 1661
Fly 6309 -----------------------------------------VPGTCPN-TNFTVKNLVEGKKYVF 6331
.|..|.: |...::.::||..|:.
Rat 1662 RLLARLQHDCVLYFHEAFERRRGLVIVTELCTEELLERMARKPTVCESETRTYMRQVLEGIGYLH 1726
Fly 6332 R-------IRAENI----------------YG-ASEALEGKPVLAKSPFDPPGAPS--QPTISAY 6370
: ::.||: :| |.|...|:|...:. |.|. .|.|...
Rat 1727 QSHVLHLDVKPENLLVWDGAGGEEQVRICDFGNAQELTPGEPQYCQF-----GTPEFVAPEIVNQ 1786
Fly 6371 TPNSANLEWHPPDDCGGKPITGY--IVERRERGGEWIKCNNYPTPNTSYTVSNL-RDGARYEFRV 6432
:|.|...:..|........:||. .|...:| ...:...||.......|..:| |:...:..:|
Rat 1787 SPVSGVTDIWPVGVVAFLCLTGISPFVGENDR-TTLMNIRNYNVAFEETTFLSLSREARGFLIKV 1850
Fly 6433 LAVNEAGP------GHPSKPSDPMTAE------------------------HQRYRPDPP---EP 6464
|..:...| .||...::...|| |...||.|. .|
Rat 1851 LVQDRLRPTAEETLEHPWFKTEAKGAEVSTDHLKLFLSRRRWQRSQISYKCHLVLRPIPELLRAP 1915
Fly 6465 PKPDRITRNGVTLSWRPPRTDGKSRIKGYYVE-----------MRPKNGKDWKTVNDIPINSTVY 6518
|: |..|.:..|.|.:.|.|.......| ::|:......::.|||......
Rat 1916 PE-----RVWVAMPRRQPPSGGLSSSSDSEEEELEELPSVPRPLQPEFSGSRVSLTDIPTEDEAL 1975
Fly 6519 TVPSLKEGEEYSFRVVAENEVGRSD------PSKPSQPITIEEQPNKPCMELGKVRDIVCRAGDD 6577
..|.........:: |.||:. ||..:.|...:|.|:.| ..|....|.|..
Rat 1976 GTPEAGAATPMDWQ-----EQGRAPSKDQEAPSPEALPSPGQESPDGP-----SPRRPELRRGSS 2030
Fly 6578 FSIHVPYLAFPKPNAFWYSNDNMLDDNNRVHKHLTDDAASVVVKNSKRADSGQYRLQLKNTSGFD 6642
....:|.:...:| ...:|| ||||.:...:....|..||........:
Rat 2031 AESALPRVGSREP-------------GRSLHK-----AASVELPQRRSPSPGATRLTRGGLGEGE 2077
Fly 6643 TA----TINVRVL---------------------DRPSPPTRLRADEFSGDSLTLYWNPPNDDGG 6682
.| .:..|:| .|...|...|| .|.::...:..||...|.
Rat 2078 YAQRLQALRQRLLRGGPEDGKVSGLRGPLLESLGGRARDPRMARA--ASSEAAPHHQPPPESRGL 2140
Fly 6683 SAIQNYIIEKKEARSSTWSKVSSFCTVPFVRIRNLVLNKEYDFRVIAENKYGQSDPANTSEPILA 6747
....::...:.|.| ....:..:...:|..|:....|.:......::|.:.......:..:|.:.
Rat 2141 QKSSSFSQGEAEPR-GRHRRAGAPLEIPVARLGARRLQESPSLSALSETQPPSPALPSAPKPSIT 2204
Fly 6748 RHP-------FDIPNTPG---IPHGIDSTEDSITIAWTKPKHDGGSPITGYIIEKRLLSDDKWTK 6802
:.| .|.|..|. :|..|...:.. .:...||.. .|:...:..:.|....:..:
Rat 2205 KSPEPSAATSRDSPQPPAPQPVPEKIPEPKPE-PVRAAKPAQ---PPLALQMPAQSLTPYAQIMQ 2265
Fly 6803 AVHALCPDLSCKIPNLIENAEYEFRVAAVNAAGQSAYSGSSDLIFCRRPPHAPKITSDLSIRDMT 6867
::....|.||.::|....... |||.|...|...|:|: :|.| |.|...
Rat 2266 SLQLSSPTLSPQVPPSEPKPH-----AAVFARVASPPPGASE----KRVP---------SARIPP 2312
Fly 6868 VIAGDEFRI-TVPYHASPRPTASWSLNGLEVIPGERIKFDSNDYASMYYNKSAKRDETGSYTITL 6931
|:| ::.|: ||| |||.:|.| ..:|.:..|.: |::. :.:| |:...|..:.|
Rat 2313 VLA-EKVRVPTVP----PRPGSSLS-GSIENLESEAV-FEAK------FKRS--RESPLSRGLRL 2362
Fly 6932 TNNKGSDTASCHVTVVDRPLPPQGPLNAYDITPDTCTLAWKTPLDDG-------GSPITNYVVEK 6989
.:...|: .:||....: ||| |:|:. :|.:
Rat 2363 LSRSRSE--------------ERGPFRGAE--------------DDGIYRPSPAGTPLE--LVRR 2397
Fly 6990 LDNSGSWVKISSFVRNTHYDVMGLEPHYKYNFRVRAENQYGLSDPLDIIEPIVAKHQFTVPDEPG 7054
.:.|.| |:: :|...:.||...|.: .:..|.:.| .||
Rat 2398 PERSRS-------VQD-----------------LRVAGEPGLVRRLSL--SLSQKLRRT---PPG 2433
Fly 7055 Q--PKVIDWDS---------------GNVTLIWTRPLSDG----GSRIQGYQIEYRDILNDSSWN 7098
| |. |:| |:..|...|.||.. .||:| |...::.|..
Rat 2434 QRHPA---WESRSGDGESSEGGSSARGSPVLAVRRRLSSTLERLSSRLQ------RSGSSEDSGG 2489
Fly 7099 AYDYIIKDTKY--QLYNLINGSEYEFRI-----KAKNAAGLSKPSSPSLRFKLKGKFTVPSPPGA 7156
|.. :.|.. :|....:..|...|: :..:..|.:.||:.||..:..| .|...|
Rat 2490 ASG---RSTPLFGRLRRATSEGESLRRLGVPHNQLASQTGATTPSAESLGSEASG----TSGSSA 2547
Fly 7157 PQVTRVGKNYVDLKWEKPLRDGGSRITGYIIERRDIGGAVWVKCNDYNVLDTEYTVMNLIEMGDY 7221
| |::....:| |.||: |:|
Rat 2548 P-----GESRSRHRW------GLSRL------RKD------------------------------ 2565
Fly 7222 EFRVFAVNSAGRSEPSLCTMPIKVCEVLGGK--------KPDWITRLQDKVAPFGKDYTLQCAAS 7278
.|.|:|:|.. .|.|.||.: .|.:..:|:|:|...|:..||.|..:
Rat 2566 ---------KGLSQPNLSA---SVQEDLGHQYVPSESDFPPVFHIKLKDQVLLEGEAATLLCLPA 2618
Fly 7279 GKPSPTARWLRNGKEIQMNGGRMTCDSKDGVFRLHISNVQTGDDGDYTCEAMNSLGFVNTSGYLK 7343
..|:|...|:::.:.::.....:....|||...|.|........|.|.|.|.|.||.:.:|..:.
Rat 2619 ACPTPRISWMKDKQSLRSEPSVVIVSCKDGRQLLSIPRASKRHAGLYECSATNVLGSITSSCTVA 2683
Fly 7344 IGSPPIINRCPSELKLPEGDNSKIKIFYSGDQPLTVILKKNNEVICDSNDDTHVKVNIFDDYVAI 7408
:. |.|.:|..|| .|.| .||
Rat 2684 VA------RTPGKLAPPE-------------VPQT---------YCD------------------ 2702
Fly 7409 YIRNIVKSDGGPYQIEFTNESGSATGEFYVHITGMPSAPTGPMGISYINKNSCMLNWRPPSYDGG 7473
:.::.|:| |.
Rat 2703 ---------------------------------------------------TALVLWKP----GD 2712
Fly 7474 LKV-SHYVIERKDVSSPHWITVSSTCKDTAFNVQGLIENQEYIFRVMAVNENGMGP---PLEGL- 7533
.:. ..|.:||:......|..|||...|..:||..|.......|||...|..|.|| |.|.:
Rat 2713 SRAPCTYTLERRVDGESVWHPVSSGIPDCYYNVTQLPVGVTVRFRVACSNRAGQGPFSNPSEKVF 2777
Fly 7534 ----------------------NPIRAKDPIDP----PSPPGSPQITEIGGDFVHLEWEKPESDG 7572
.|.||..|..| |:||.:||:::
Rat 2778 IRGTQDSPAQSAAAPRDAPVTSGPTRAPPPDSPTSLVPTPPLAPQVSQ----------------- 2825
Fly 7573 GAHIQGYWIDKREVGSNTWQRVNATICAANQINCINLIEGRQYEFRIFAQNVAGLSTESSASQA- 7636
|..::..::..||:||
Rat 2826 ------------------------------------------------ASTLSPSTSSMSANQAL 2842
Fly 7637 --VKIIDPQAASPPLIVKPLRDANCIQNHNAQFTCTINGVPKPTISWYKGAREISNGARYHMYSE 7699
:|.:.|..|:|| :.|.. ...|....|.|
Rat 2843 SSLKAVGPPPATPP------------RKHRG-LLATQQAEPSP---------------------- 2872
Fly 7700 GDNHFLNINDVFGEDADEYVCRAVNKAGAKSTRATLAIMTAPKLNVPPRFRDTAYFDKGENVVIK 7764
|.:.|.|....:...|.|......
Rat 2873 -----------------------------------------PSILVTPSEHKSFVPDTGTLTPTS 2896
Fly 7765 IPFTGFPKPRIHWVRDGENIESGGHYTVEVKERHAVLIIRDGSHLDSGPYRITAENELGSDTAII 7829
.|....|.|. .|..|.:|:
Rat 2897 SPQGVKPAPS-----------------------------------SSSLYMVTS----------- 2915
Fly 7830 QVQISDRPDP-PRFPLIESIGTESLSLSWKAPVWDGCSDITNYYVERREHPLSSWIRVGNTRFTS 7893
.:|..||| |..| |....| |.
Rat 2916 --FVSAPPDPQPPAP------------------------------EPPPEP------------TK 2936
Fly 7894 MAVSGLTPGKEYDFRIFADNVYGRSDASDTSTLIKTKESVKKKPIERKWEIDANGRKLRGKADGP 7958
:.|..|:|.||
Rat 2937 VTVRSLSPAKE------------------------------------------------------ 2947
Fly 7959 VKDYDSYVFDIYSKFVPQPVEISQQSVYDRYDILEEIGTGAFGVVHRCRERSTGNIFAAKFIPVS 8023
:.|...|:...:.|......|..|||...|.||||..|||.:||..|.||.:|
Rat 2948 ----------VVSSPTPESTTLRQGPPQKPYTFLEEKARGRFGVVRSCRENATGRTFVAKIVP-- 3000
Fly 8024 HSVE-KDLIRREIDIMNQLHHQKLINLHDAFEDDDEMILILEFLSGGELFERITAEGYVMTEAEV 8087
::.| |..:.:|.:::..|||::|::||:|:.....::||.|.....||...: ::.:..:|.:|
Rat 3001 YAAEGKRRVLQEYEVLRTLHHERLMSLHEAYITPRYLVLIAESCGNRELLCGL-SDRFRYSEDDV 3064
Fly 8088 INYMRQICEGIRHMHEQNIIHLDIKPENIMCQTRSSTNVKLIDFGLATRLDPNEVVKI--TTGTA 8150
..|:.|:.:|:.::|.::::||||||:|::....:: :|::|||.|...:|..:..: .|||.
Rat 3065 ATYVVQLLQGLDYLHGRHVLHLDIKPDNLLLAADNA--LKIVDFGSAQPYNPQALKPLGHRTGTL 3127
Fly 8151 EFAAPEIVNREPVGFYTDMWATGVLSYVLLSGLSPFAGDNDVQTLKNVKACDWDFDV-ESFKYIS 8214
||.|||:|..:|:|..||:|..|||:|::|||.|||...:..:| ..:.....||. :.:...|
Rat 3128 EFMAPEMVRGDPIGSATDIWGAGVLTYIMLSGYSPFYEPDPQET--EARIVGGRFDAFQLYPNTS 3190
Fly 8215 EEAKDFIRKLLVRNKEKRMTAHECLLHPWLTGDHSAMKQEINRDRYLAYREKLRRKYEDF----- 8274
:.|..|:||:|..:...|.:..:||.|||| :|.||. ||||:...|
Rat 3191 QSATLFLRKVLSVHPWSRPSLQDCLAHPWL------------QDAYLM---KLRRQTLTFTTNRL 3240
Fly 8275 ERFLLPIG----RLSEYSSLRKLLMEKY 8298
:.|| | |.:|.::..|:|:..|
Rat 3241 KEFL---GEQRRRRAEAATRHKVLLRSY 3265
| 
