DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bt and Ptprf

DIOPT Version :9

Sequence 1:	NP_001162825.1	Gene:	bt / 43814	FlyBaseID:	FBgn0005666	Length:	8933	Species:	Drosophila melanogaster
Sequence 2:	XP_038966081.1	Gene:	Ptprf / 360406	RGDID:	3453	Length:	1928	Species:	Rattus norvegicus

Alignment Length:	2278	Identity:	457/2278 - (20%)
Similarity:	754/2278 - (33%)	Gaps:	751/2278 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  5290 AGNVFEFDVPVTGEPLPSKDWTHEGNMIINTDRVKISNFDDRT----KIRILDAKRSDTGVYTLT 5350
            :|.|..|....||||.|...|..:|.. :::.|.::..|||..    :|:.|..:| |..:|..|
  Rat    46 SGGVASFVCQATGEPKPRITWMKKGKK-VSSQRFEVIEFDDGAGSVLRIQPLRVQR-DEAIYECT 108

  Fly  5351 ARNINGTDRHNVKVTILDAPSVPEGPLRNGDVSKNSIVLRWRPPKDDGGSEITHYVVEKMDNEAM 5415
            |.|..|....:.|:::|:...:|.|                 .|..|.|.::.  ||||.....|
  Rat   109 ATNSLGEINTSAKLSVLEEDQLPSG-----------------FPTIDMGPQLK--VVEKARTATM 154

  Fly  5416 RWVPVGDCTDTEIRADNLIENHDYSFRVRAVNKQGQSQPLTTSQPITAKDPYSHPDKPGQPQATD 5480
            .....|: .|.||                                                   .
  Rat   155 LCAAGGN-PDPEI---------------------------------------------------S 167

  Fly  5481 WGKHFVDLEWSTPK------RDGGAPISSYIIEKRPKFGQWERAAVVLGDNCKAHVPELTNGGEY 5539
            |.|.|:.::.::..      |.||:||               |.|:.:..:      |.::.|:|
  Rat   168 WFKDFLPVDPASSNGRIKQLRSGGSPI---------------RGALQIESS------EESDQGKY 211

  Fly  5540 EFRVIAVNRGGP--SDPS-----DPSSTIICKPRFLAPFFDKSLLNDITVHAGKRLGWTLPIEAS 5597
            |  .:|.|..|.  |.|:     |........|||..|...:.::      .|..:..|.....:
  Rat   212 E--CVATNSAGTRYSAPANLYVRDQREVRRVAPRFSIPPSSQEVM------PGGNVNLTCVAVGA 268

  Fly  5598 PRPLITWLYNGKEIGSNSRGESGLFQNELTFEIVSSLRSDEGRYTLILKNEHGSFDASAHATVLD 5662
            |.|.:.|:...:|:  ....|..:.:|.|  |:.:.:||  ..||.:..:..|..:|:|..||..
  Rat   269 PMPYVKWMMGAEEL--TKEDEMPVGRNVL--ELSNVMRS--ANYTCVAISSLGMIEATAQVTVKA 327

  Fly  5663 RPSPPKGPLDITKITRDGCHLTWNVPDDDGGSPILHYII-----------EKMDLSRST-WSDAG 5715
            .|.||. .|.:|:.|.....|||   |.....|:..|.|           :::|...|| :|..|
  Rat   328 LPKPPI-DLVVTETTATSVTLTW---DSGNTEPVSFYGIQYRAAGTDGPFQEVDGVASTRYSIGG 388

  Fly  5716 MSTHIVHDVTRLVHRKEYLFRVKAVNAIGESDPLEAVNTIIAKNEFDEPDAPGKPIITDW-DRDH 5779
            :|..           .||.|||.|||:||...|.|||.   |:.....|.:|.:.:.... ....
  Rat   389 LSPF-----------SEYAFRVLAVNSIGRGPPSEAVR---ARTGEQAPSSPPRRVQARMLSAST 439

  Fly  5780 IDLQWAVPKSDGGAPISEYIIQKKEKGSPYWTNVRHVPSNKNTTTIPELTEGQEYEFRVIAVNQA 5844
            :.:||..|:...|......:....:...|.....:|.......||:..|..|..|..||:|....
  Rat   440 MLVQWEPPEEPNGLVRGYRVYYTPDSRRPLSAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAV 504

  Fly  5845 G-------------QSEPSEPSDMIMAKPR---------YLPPKIITPLNEVRIKCGLIFHTDIH 5887
            |             |..|::|:| ..||..         .|||:      |..||..|::
  Rat   505 GDGPPSPTIQVKTQQGVPAQPAD-FQAKAESDTRIQLSWLLPPQ------ERIIKYELVY----- 557

  Fly  5888 FIGEPAPEATWTLNSNPLLSNDRSTITSIGHHSVV------HTVNCQRSDSGIYHLLLRNSSGID 5946
                      |.       :.|...     .|.|.      :|:...:.|: :||..|...|.:.
  Rat   558 ----------WA-------AEDEGQ-----QHKVTFDPTSSYTLEDLKPDT-LYHFQLAARSDLG 599

  Fly  5947 EGSFELVVLDRPG---PPEGPMEYEEITANSVT--ISW-KPPKDNGGSEISSYVI---------E 5996
            .|.|...|..|..   |...|.:...::..|.|  :|| .||.|:....|:.|.:         .
  Rat   600 VGVFTPTVEARTAQSTPSAPPQKVTCVSTGSTTVRVSWVPPPADSRNGIITQYSVAYEAVDGEDR 664

  Fly  5997 KRDLTHGGGWVPAVNYVSAKYNHAVVPRLLEGTMYELRVMAENLQGRSDPLTSDQPVVAKSQYTV 6061
            ||.:..|         :|.:::...:..|.:.|.|.:.|.|....|   |.....||:.::...|
  Rat   665 KRHVVDG---------ISREHSSWDLLGLEKWTEYRVWVRAHTDVG---PGPESSPVLVRTDEDV 717

  Fly  6062 P-GAPGKPELTDSDKNHITIKWKQPISN-GGSPIIGYDIERRDVNTGRWIKI-NGQPVPTAEYQD 6123
            | |.|.|.|:...:...:.:.||.|:.| ....|.||.:        .:::: ||:|
  Rat   718 PSGPPRKVEVEPLNSTAVHVSWKLPVPNKQHGQIRGYQV--------TYVRLENGEP-------- 766

  Fly  6124 DRVTSNHQYQYRISAVNAAGNGKTSEPSAIFNARPLREKPRFYFDGLIGKRIKVRAGEPVNLNIP 6188
                                                                   .|:|:..::.
  Rat   767 -------------------------------------------------------RGQPIIQDVM 776

  Fly  6189 ISGAPTPTIEWKRGDLKLEEGKRISYETN----SERTLFRIDDSNRRDSGKYTVTAANEFGKDTA 6249
            ::.|     :|:.     ||.:  .|||.    :..|.:.|           ||.|....|....
  Rat   777 LAEA-----QWRP-----EESE--DYETTISGLTPETTYSI-----------TVAAYTTKGDGAR 818

  Fly  6250 DIEVIVVDKPSPPEGPLSYTETAPDHIS-LHWYSPKDDGGSDITGYIIEF----------TEFGV 6303
            ....:|....:.|..|.....|...|.: |.|:.||:..| ::.||.:::          .:||.
  Rat   819 SKPKVVTTTGAVPGRPTMMVSTTAMHTALLQWHPPKELPG-ELLGYRLQYRRADEARPNTIDFGK 882

  Fly  6304 DDWKPVPGTCPNTNFTVKNLVEGKKYVFRIRAENIYGASEALEGKPVLAKSPFD-PPGAPSQPTI 6367
            ||          .:|||..|.:|..|:||:.|:|..|..|..|.:   ..:|.| |.|.|....:
  Rat   883 DD----------QHFTVTGLHKGATYIFRLAAKNRAGPGEEFEKE---ITTPEDAPSGFPQNLRV 934

  Fly  6368 SAYTPNSANLEWHPP--DDCGGKPITGYIVERRERGGEWIKCNNYPTPNTSYTVSNLRDGARYEF 6430
            :..|.::..|.|.||  .:..|: ||.|.|..|:...:....|  .|.:...|:..|:....|:.
  Rat   935 TGLTTSTTELAWDPPVLAERNGR-ITNYTVVYRDINSQHELQN--VTGDVHLTLLGLKPDTTYDI 996

  Fly  6431 RVLAVNE--AGPGHPSKPSDPMTAEH---QRYR---------------PDPPEPPKPDRITRNGV 6475
            :|.|...  |||..||..|..|..|.   :.:|               ||..:...|.:|..||.
  Rat   997 KVRAHTSKGAGPLSPSIQSQTMPMEQVFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYNGQ 1061

  Fly  6476 TLSWRPPRTDGKSRIKGYYVEMRPKNGKDWKTVNDIPINSTVYTVPSLKEGEEYSFRVVAENEVG 6540
            ::     ..||.|        ||       |.:.|:..|:            ||||.::......
  Rat  1062 SV-----EVDGHS--------MR-------KLIADLQPNT------------EYSFVLMNRGSSA 1094

  Fly  6541 ---------RSDPS-KPSQPITIEEQPNKPCMELGKVRDIVCRAGDDFSIHVPYLAFPKPNAFWY 6595
                     |:.|. .|.:|:     |....:|.|:           ||:.:|.:..|....::|
  Rat  1095 GGLQHLVSIRTAPDLLPQKPL-----PASAFIEDGR-----------FSLSMPQVQDPSLVRWFY 1143

  Fly  6596 --------SNDNMLDDNNRVHKHLTDDAASVVVKNSKRADSGQYRLQLKNTSGFDTATINVRVLD 6652
                    ...|:|.......:.|..|.   :::..::.:..|.|.:              |..:
  Rat  1144 IVVVPIDRVGGNLLAPRWSTPEELELDE---LLEAIEQGEEKQRRRR--------------RQAE 1191

  Fly  6653 RPSPPTRLRADEFSGDSLTL---------YWNPPNDDGGSAIQNYII-------EKKEARSSTWS 6701
            |..|....:.||.. ::.||         |..|.:.|  .:.|.:::       ::|...||.:|
  Rat  1192 RLKPYVAAQVDELP-ETFTLGDKKNYRGFYNRPLSPD--LSYQCFVLASLKEPMDQKRYASSPYS 1253

  Fly  6702 -----KVSS----------FCTVPFVRIRNLVLNKEYDFRVIA----------------ENKYGQ 6735
                 :|:.          :.|.|.:.:..::|      .|||                |...|.
  Rat  1254 DEIVVQVTPAQQQEEPEMLWVTGPVLAVILIIL------IVIAILLFKRKRTHSPSSKDEQSIGL 1312

  Fly  6736 SDP--ANTSEPI-LARHPFDIP--NTPGIPHGIDSTEDSITIAWTKPKHDGGSPITGYIIEKRLL 6795
            .|.  |::|:|: :.|..:..|  :.|..|: |.|..|...|           |||
  Rat  1313 KDSLLAHSSDPVEMRRLNYQTPGSSAPSCPN-ISSMRDHPPI-----------PIT--------- 1356

  Fly  6796 SDDKWTKAVHALCPDLSCKIPNLIEN------AEYEFRVAAVNAAGQSAYSGSSDLIFCRRPPHA 6854
                          ||:..|..|..|      .|||    :::...|..:..|:..:...:..:|
  Rat  1357 --------------DLADNIERLKANDGLKFSQEYE----SIDPGQQFTWENSNSEVNKPKNRYA 1403

  Fly  6855 PKITSDLSIRDMTVIAG------------DEFRITVPYHASPRPTAS---------WSLNGLEVI 6898
            ..|..|.|...:|.|.|            |.:|....|.|:..|...         |......|:
  Rat  1404 NVIAYDHSRVLLTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVV 1468

  Fly  6899 PGERIKFDSNDYASMYYNKSAKRDET-GSYTITLTNNKGSDTASCHVTVVDR------------- 6949
            ...|::..|......|:  .|:..|| |...:||.:.....|.:.....:.:
  Rat  1469 MMTRLEEKSRVKCDQYW--PARGTETYGLIQVTLVDTVELATYTMRTFALHKSGSSEKRELRQFQ 1531

  Fly  6950 --PLPPQG------PLNAYDITPDTCTLAWKTPLDDGGSPITNYVVEKLDNSGSWVKISSFV-RN 7005
              ..|..|      |:.|:......|     .|||.|  |:..:....:..:|.::.|.:.: |.
  Rat  1532 FMAWPDHGVPEYPTPILAFLRRVKAC-----NPLDAG--PMVVHCSAGVGRTGCFIVIDAMLERM 1589

  Fly  7006 THYDVMGLEPHY-----KYNFRVRAENQYGLSDPLDIIEPIVAKHQFTVPDEPGQPKVIDWDSGN 7065
            .|...:.:..|.     :.|:.|:.|:||            |..|:
  Rat  1590 KHEKTVDIYGHVTCMRSQRNYMVQTEDQY------------VFIHE------------------- 1623

  Fly  7066 VTLIWTRPLSDGGSRIQGYQIEYRDILNDSSWNAYDYIIKDTKYQLYNLINGSEYEFRIKAKNAA 7130
                         :.::.....:.::|   :.|.|.:|.|..:......:...|.||::.|.:.|
  Rat  1624 -------------ALLEAAMCGHTEVL---ARNLYAHIQKLGQVPPGESVTAMELEFKLLANSKA 1672

  Fly  7131 GLSKPSSPSL---RFKLKGKFTVPSPPGAPQVTRV---------GKNYVDLKW------------ 7171
            ..|:..|.:|   :||.:....:|.     ::|||         |.:|::..:
  Rat  1673 HTSRFISANLPCNKFKNRLVNIMPY-----ELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIA 1732

  Fly  7172 -EKPLRDG-----------GSRITGYIIERRDIGGAVWVKCNDYNVLDT----EYTVMNLI---E 7217
             :.||.:.           .|.|...:.:.|::|..   ||:.|...:.    :|.|::.:   .
  Rat  1733 TQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGRE---KCHQYWPAERSARYQYFVVDPMAEYN 1794

  Fly  7218 MGDYEFRVFAVNSA--GRSEP----SLCTMPIKVCEVLGGKKPDWITRLQDKVAPFGKD--YTLQ 7274
            |..|..|.|.|..|  |:|..    .....|.:.....|....|:|.::......||:|  .|:.
  Rat  1795 MPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVH 1859

  Fly  7275 CAA 7277
            |:|
  Rat  1860 CSA 1862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bt	NP_001162825.1	I-set	9..101	CDD:254352
		Ig	26..100	CDD:143165
		I-set	119..210	CDD:254352
		Ig	136..209	CDD:143165
		I-set	228..320	CDD:254352
		IGc2	242..312	CDD:197706
		I-set	335..425	CDD:254352
		Ig	350..423	CDD:143165
		Ig	436..530	CDD:299845
		I-set	438..532	CDD:254352
		I-set	545..636	CDD:254352
		Ig	560..633	CDD:143165
		Ig	657..731	CDD:143165
		I-set	746..835	CDD:254352
		Ig	1496..1586	CDD:299845
		IG_like	1503..1588	CDD:214653
		I-set	1639..1724	CDD:254352
		IG	1750..1821	CDD:214652
		IGc2	1750..1806	CDD:197706
		I-set	1826..1909	CDD:254352
		Ig	1831..1897	CDD:299845
		I-set	1914..1998	CDD:254352
		Ig	2020..2095	CDD:299845
		FN3	2100..2194	CDD:238020
		FN3	2203..2292	CDD:238020
		I-set	2311..2395	CDD:254352
		Ig	2321..2395	CDD:299845
		FN3	2399..2493	CDD:238020
		FN3	2501..2590	CDD:238020
		I-set	2602..2693	CDD:254352
		Ig	2619..2693	CDD:299845
		FN3	2697..2793	CDD:238020
		FN3	2801..2893	CDD:238020
		I-set	2902..2995	CDD:254352
		Ig	2919..2993	CDD:299845
		FN3	2999..3088	CDD:238020
		FN3	3102..3191	CDD:238020
		I-set	3208..3292	CDD:254352
		Ig	3219..3292	CDD:299845
		FN3	3296..3390	CDD:238020
		FN3	3400..3489	CDD:238020
		I-set	3494..3590	CDD:254352
		Ig	3516..3590	CDD:299845
		FN3	3594..3682	CDD:238020
		FN3	3694..3781	CDD:238020
		I-set	3795..3885	CDD:254352
		Ig	3813..3885	CDD:299845
		FN3	3889..3980	CDD:238020
		FN3	3990..4082	CDD:238020
		I-set	4090..4181	CDD:254352
		Ig	4108..4181	CDD:299845
		FN3	4185..4271	CDD:238020
		FN3	4285..4383	CDD:238020
		Ig	4404..4480	CDD:299845
		FN3	4484..4571	CDD:238020
		FN3	4584..4677	CDD:238020
		I-set	4685..4775	CDD:254352
		Ig	4703..4775	CDD:299845
		FN3	4779..4863	CDD:238020
		FN3	4879..4970	CDD:238020
		IG	4989..5069	CDD:214652
		Ig	4996..5069	CDD:299845
		FN3	5073..5166	CDD:238020
		FN3	5175..5265	CDD:238020
I-set	5276..5366	CDD:254352	24/79 (30%)
Ig	5293..5366	CDD:299845	23/76 (30%)
FN3	5370..5462	CDD:238020	14/91 (15%)
FN3	5470..5561	CDD:238020	20/103 (19%)
Ig	5559..5654	CDD:299845	19/94 (20%)
I-set	5570..5660	CDD:254352	18/89 (20%)
FN3	5664..5755	CDD:238020	33/102 (32%)
FN3	5764..5853	CDD:238020	19/102 (19%)
I-set	5865..5954	CDD:254352	17/94 (18%)
Ig	5882..5954	CDD:299845	12/77 (16%)
FN3	5958..6049	CDD:238020	22/105 (21%)
FN3	6062..6153	CDD:238020	15/93 (16%)
I-set	6173..6255	CDD:254352	15/85 (18%)
Ig_Titin_like	6182..6255	CDD:143225	14/76 (18%)
FN3	6259..6350	CDD:238020	28/101 (28%)
FN3	6359..6451	CDD:238020	26/95 (27%)
FN3	6470..6552	CDD:238020	19/91 (21%)
I-set	6564..6650	CDD:254352	12/93 (13%)
Ig_Titin_like	6577..6650	CDD:143225	11/80 (14%)
FN3	6654..6745	CDD:238020	25/139 (18%)
FN3	6754..6840	CDD:238020	19/93 (20%)
I-set	6855..6946	CDD:254352	23/112 (21%)
Ig	6874..6946	CDD:299845	16/81 (20%)
FN3	6950..7042	CDD:238020	20/103 (19%)
FN3	7050..7139	CDD:238020	12/88 (14%)
FN3	7151..7237	CDD:238020	25/131 (19%)
I-set	7254..7334	CDD:254352	8/26 (31%)
Ig	7272..7339	CDD:143165	3/6 (50%)
IG_like	7354..7440	CDD:214653
Ig	7366..7440	CDD:299845
FN3	7444..7531	CDD:238020
FN3	7545..7637	CDD:238020
I-set	7648..7737	CDD:254352
Ig	7665..7734	CDD:143165
Ig	7760..7833	CDD:299845
FN3	7837..7927	CDD:238020
STKc_Twitchin_like	7986..8244	CDD:271016
S_TKc	7989..8244	CDD:214567
Ig	8311..8394	CDD:299845
I-set	8312..8401	CDD:254352
I-set	8437..8525	CDD:254352
Ig	8455..8519	CDD:143165
I-set	8632..8721	CDD:254352
IGc2	8646..8711	CDD:197706
I-set	8740..8831	CDD:254352
Ig	8757..8826	CDD:143165
I-set	8839..8922	CDD:254352
Ig	8845..>8909	CDD:299845
Ptprf	XP_038966081.1	I-set	33..124	CDD:400151	24/79 (30%)
		Ig strand A	33..36	CDD:409353
		Ig strand A'	42..45	CDD:409353
		Ig strand B	50..57	CDD:409353	1/6 (17%)
		Ig strand C	63..68	CDD:409353	1/4 (25%)
		Ig strand C'	71..73	CDD:409353	0/2 (0%)
		Ig strand D	80..84	CDD:409353	0/3 (0%)
		Ig strand E	86..93	CDD:409353	0/6 (0%)
		Ig strand F	103..111	CDD:409353	3/7 (43%)
		Ig strand G	114..124	CDD:409353	2/9 (22%)
		IgI_2_RPTP_IIa_LAR_like	136..232	CDD:409400	30/172 (17%)
		Ig strand B	152..156	CDD:409400	1/3 (33%)
		Ig strand C	165..169	CDD:409400	2/54 (4%)
		Ig strand E	196..200	CDD:409400	1/3 (33%)
		Ig strand F	210..215	CDD:409400	2/6 (33%)
		Ig strand G	222..225	CDD:409400	0/2 (0%)
		IgI_3_RPTP_IIa_LAR_like	245..326	CDD:409401	19/92 (21%)
		Ig strand B	259..263	CDD:409401	0/3 (0%)
		Ig strand C	272..276	CDD:409401	0/3 (0%)
		Ig strand E	293..297	CDD:409401	2/5 (40%)
		Ig strand F	305..310	CDD:409401	2/4 (50%)
		Ig strand G	318..321	CDD:409401	1/2 (50%)
		FN3	329..418	CDD:238020	34/106 (32%)
		FN3	425..517	CDD:238020	16/91 (18%)
		FN3	522..611	CDD:238020	25/123 (20%)
		FN3	619..713	CDD:238020	23/105 (22%)
		FN3	720..826	CDD:238020	30/199 (15%)
		FN3	831..920	CDD:238020	28/102 (27%)
		FN3	929..1017	CDD:238020	25/90 (28%)
		FN3	1026..>1085	CDD:238020	17/90 (19%)
		PTP_DSP_cys	1356..1631	CDD:421693	57/354 (16%)
		R-PTP-F-2	1633..1923	CDD:350477	50/241 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910