DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bt and Dscam1

DIOPT Version :9

Sequence 1:	NP_001162825.1	Gene:	bt / 43814	FlyBaseID:	FBgn0005666	Length:	8933	Species:	Drosophila melanogaster
Sequence 2:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster

Alignment Length:	2526	Identity:	504/2526 - (19%)
Similarity:	811/2526 - (32%)	Gaps:	797/2526 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  4656 FRVVALNKGGLSEPSDPSKIFTAKPRYLAPKIDRRN-------LRNITLSSGTALKLDANITGEP 4713
            |..|||...|       |:...|.|    |..|::.       ...|..|:.|..:::...:|.|
  Fly    14 FAAVALIACG-------SQTLAANP----PDADQKGPVFLKEPTNRIDFSNSTGAEIECKASGNP 67

  Fly  4714 APKVEWKLSNYHLQSGKNVTIETPDYYT-----KLVIRPTQRSDSGE------YLVTATNTSG-- 4765
            .|::.|      ::|......:.|....     |||..|.:..|..:      |...|.|..|
  Fly    68 MPEIIW------IRSDGTAVGDVPGLRQISSDGKLVFPPFRAEDYRQEVHAQVYACLARNQFGSI 126

  Fly  4766 -KDSVLVNVVITDKPSPPNGPLQISDVHK------EGCHLKWKRPSDDGGTPIEYFQIDKLEPET 4823
             ...|.|..|::....        .|:||      ....||...||         |..|.:.
  Fly   127 ISRDVHVRAVVSQHYE--------EDIHKAFVIRGNSAILKCDIPS---------FVADFVN--- 171

  Fly  4824 GCWIPSCRSTEPQVDVTGLSPGNEY----------KFRVSAVNAEG--------ESQPLVGDESI 4870
               :.|..|.|.:    ...||.||          :..:..|..|.        ....|.|:..:
  Fly   172 ---VISWHSDEKE----NFYPGTEYDGKYLVLPSGELHIREVGPEDGYKSYQCRTKHRLTGETRL 229

  Fly  4871 VA---RNPFDEP-GKPENLKATDWDKDHVDLAWTPPLIDGGSPISCYIIEKQDKYGKWERALD-- 4929
            .|   |....|| |......:.:.:::|:.|...|.:  |...:.|........:.:|.:.::
  Fly   230 SATKGRLVITEPVGSVSPQLSGNGNQEHITLTRVPKM--GSVTLMCPAQAYPVPFFRWYKFIEGT 292

  Fly  4930 ------VPADQCKAT-----IPDLVEGQTYKFRVSAVNAAGTGEPSDS----TPPIIAKARNKPP 4979
                  |..|:.|..     |.|.|...:.|:.....|:.| ||..::    |.|:.||.  .||
  Fly   293 TRKQAVVLNDRVKQVSGTLIIKDAVVEDSGKYLCVVNNSVG-GESVETVLTVTAPLSAKI--DPP 354

  Fly  4980 IIDRSSLVEVRIKAGQSFTFDCKVSGEPAPQTKWLLKKKEVYSKDNVKVTNVDYNTKLKVNSATR 5044
                    ...:..|:...|.|:.:|.|.....|:...|.:...:.|          |::.|..:
  Fly   355 --------TQTVDFGRPAVFTCQYTGNPIKTVSWMKDGKAIGHSEPV----------LRIESVKK 401

  Fly  5045 SDSGIYTVFAEN--ANGEDSADVKVTVIDKPAPPNGPLKVDEINSESCTLHWNPPDDDGGQPIDN 5107
            .|.|:|..|..|  .:.|.||::|:
  Fly   402 EDKGMYQCFVRNDQESAEASAELKL---------------------------------------- 426

  Fly  5108 YVVEKLDETTGRWIPAGETDGPVTALKVGGLTPGHKYKFRVRAKNRQGTSEPLTTA--QAIIAKN 5170
                           .|..|.||                 :|...::.|.||..:.  :.:...|
  Fly   427 ---------------GGRFDPPV-----------------IRQAFQEETMEPGPSVFLKCVAGGN 459

  Fly  5171 PFDVPTKPGTPTIKDFDKEFVDLEWTRPEADGGSPITGYVVEKRDKFSPDWEKCAEISDD----- 5230
            |        ||          ::.|   |.||..      :...|::...  :...::.|
  Fly   460 P--------TP----------EISW---ELDGKK------IANNDRYQVG--QYVTVNGDVVSYL 495

  Fly  5231 -ITNAHVPDLIEGLKYEFRVRAVNKAGPGSPSDATETHVARPKNTPPKIDRNFMSDIKIKAGNVF 5294
             ||:.|..|  .||   ::..|.:|.|....|.....:..      |.|.:  |....|.||...
  Fly   496 NITSVHAND--GGL---YKCIAKSKVGVAEHSAKLNVYGL------PYIRQ--MEKKAIVAGETL 547

  Fly  5295 EFDVPVTGEPLPSKDWTHEGNMIINTDRVKISNFDDRTKIRILDAKRSDTGVYTLTARNING-TD 5358
            ....||.|.|:.|..|..:...:....:.|:  |.:.|.|.....:.||...||..|:|..| :.
  Fly   548 IVTCPVAGYPIDSIVWERDNRALPINRKQKV--FPNGTLIIENVERNSDQATYTCVAKNQEGYSA 610

  Fly  5359 RHNVKVTILDAPSVPEGPLRNGDVSKNSIVLRWRPPKDDGGSEITHYVVEKMDNEAMRWVPVGDC 5423
            |.:::|.::..|                              :|..:..|.:.|       :||.
  Fly   611 RGSLEVQVMVLP------------------------------QIVPFAYEDLIN-------MGDS 638

  Fly  5424 TD--TEI-RADNLIENHDYSFRVRAVNKQG--QSQPLTTSQPITAKD-----PYSHPDKPGQPQA 5478
            .|  .:| :.|..|:.| :||. |:....|  |.||...:..|:.|.     |.:.|...|:...
  Fly   639 IDLFCQIQKGDRPIKVH-WSFE-RSAGDYGFDQVQPQMRTNRISEKTSMISIPSASPAHTGRDTC 701

  Fly  5479 TDWGK-----HFVDLEWSTPKRDGGAPISSYIIEKRPK-FGQWERAAVVLGDNCKAHVPELTNGG 5537
            ....|     :.|||..:.|.|        :|:|...| |.|...|.|    .|||
  Fly   702 IASNKAGTTTYSVDLTVNVPPR--------WILEPTDKAFAQGSDAKV----ECKA--------- 745

  Fly  5538 EYEFRVIAVNRGGPSDPSDPSSTIICKPRFLAPFFDKSLLNDITVHAGKRLGWTLPIEASPRPLI 5602
                                                                     :..|:|.:
  Fly   746 ---------------------------------------------------------DGFPKPQV 753

  Fly  5603 TWL---------YNGKEIGSNSRGESGLFQNELTFEIVSSLRSDEGRYTLILKNEHGSFDASAHA 5658
            ||.         |...:...|.|.|.|      |..:.:..:::||.|.....|..||  ..:..
  Fly   754 TWKKAVGDTPGEYKDLKKSDNIRVEEG------TLHVDNIQKTNEGYYLCEAINGIGS--GLSAV 810

  Fly  5659 TVLDRPSPPKGPLDITKIT-RDG------CH--------LTWNV------PDDDGGSPILHYIIE 5702
            .::...:||:....:...| |.|      |.        :.||:      |.:|.     .|.|.
  Fly   811 IMISVQAPPEFTEKLRNQTARRGEPAVLQCEAKGEKPIGILWNMNNMRLDPKNDN-----RYTIR 870

  Fly  5703 KMDLSRSTWSDAGMSTHIVHDVTRLVHRKEYLFRVKAVNAIGESDPLEAVNTIIAKNEFDEPDAP 5767
            :..||....|..        .:.|.......||...|.||.|..|  .::|.|:.    :.|:.|
  Fly   871 EEILSTGVMSSL--------SIKRTERSDSALFTCVATNAFGSDD--ASINMIVQ----EVPEMP 921

  Fly  5768 GKPIITDWDRDHIDLQWAVPKSDGGAPISEYIIQ-KKEKGSPYWTNVRH--VPSNKNTTTIPELT 5829
            ....:.|.....:.|.||.| .||.:|:..|||: |:.:.|  |:.:..  ||.:.....:.:|:
  Fly   922 YALKVLDKSGRSVQLSWAQP-YDGNSPLDRYIIEFKRSRAS--WSEIDRVIVPGHTTEAQVQKLS 983

  Fly  5830 EGQEYEFRVIAVNQAGQSEPSEPSDMIMAK--PRYLPPKI-ITPLNEVRIKCGLIFHTDIHFIGE 5891
            ....|..|::|.|..|.|:.||...:|.|:  |...|..| :.|:|:          |.:....:
  Fly   984 PATTYNIRIVAENAIGTSQSSEAVTIITAEEAPSGKPQNIKVEPVNQ----------TTMRVTWK 1038

  Fly  5892 PAPEATWTLNSNPL-------LSNDRSTITSIGHHSVVHTVNCQRSDSGIYHLLLRNSSGIDEGS 5949
            |.|...|  |...|       |||..|:.       |..|:|....:...::|.|:|.....:.|
  Fly  1039 PPPRTEW--NGEILGYYVGYKLSNTNSSY-------VFETINFITEEGKEHNLELQNLRVYTQYS 1094

  Fly  5950 FELVVLDRPGPPEGPMEYEE--------------------ITANSVTISW-KPPKDNGGSEISSY 5993
            ..:...::.|  .||:..||                    :|:.::.:.| .||.::....|.:|
  Fly  1095 VVIQAFNKIG--AGPLSEEEKQFTAEGTPSQPPSDTACTTLTSQTIRVGWVSPPLESANGVIKTY 1157

  Fly  5994 VI------EKRDLTHGGGWVPAVNYVSAKYNHAVVPRLLEGTMYELRVMAENLQGRSDPLTSDQP 6052
            .:      |..|.|..       :|.....:..|:..|.:.|.|.::|:|....|  |.:.| .|
  Fly  1158 KVVYAPSDEWYDETKR-------HYKKTASSDTVLHGLKKYTNYTMQVLATTAGG--DGVRS-VP 1212

  Fly  6053 VVAKSQYTVPGAPGKPELTDSDKNHITIKWKQPISNGGSPIIGYDIERRDVNTGRWIKINGQPVP 6117
            :..:::..||.||...:........|.:.|:.|....|. |..|.:..:........|....|..
  Fly  1213 IHCQTEPDVPEAPTDVKALVMGNAAILVSWRPPAQPNGI-ITQYTVYSKAEGAETETKTQKVPHY 1276

  Fly  6118 TAEYQDDRVTSNHQYQYRISAVNAAGNGKTSEPSAIFNARPLREKPR--FYFDGLIGKRIKVRAG 6180
            ...::...:..|..|::.::|....|.|:.|:...   |.|..:.|.  ..||.......|..|.
  Fly  1277 QMSFEATELEKNKPYEFWVTASTTIGEGQQSKSIV---AMPSDQVPAKIASFDDTFTATFKEDAK 1338

  Fly  6181 EPVNLNIPISGAPTPTIEWKRGDLKLEEGKRISYETNSE-RTL----FRIDDSNRRDSGKYTVTA 6240
            .|. |.:   |||.|.|.||.        |.:.:..|.. |.|    ..|...||:|:|.|:..|
  Fly  1339 MPC-LAV---GAPQPEITWKI--------KGVEFSANDRMRVLPDGSLLIKSVNRQDAGDYSCHA 1391

  Fly  6241 ANEFGKDTADIEVIVVDKPSPPEGPLSYTETAPDHISLHWYSPKDDGGSDITGYIIEF-TEFGVD 6304
            .|...||:...::||:..|..|...||.|.|....:.|   .|.:...:.:.||.:.: .|||
  Fly  1392 ENSIAKDSITHKLIVLAPPQSPHVTLSATTTDALTVKL---KPHEGDTAPLHGYTLHYKPEFG-- 1451

  Fly  6305 DWKPVPGTCPNTNFTVKNLVEGKKYVFRIRAENIYGASEALEGKPVL-AKSPFDPPGAPSQPTIS 6368
            :|:....:..:....::.|:.|.:|.......|..||.||.:   :| .::....|..|.:|...
  Fly  1452 EWETSEVSVDSQKHNIEGLLCGSRYQVYATGFNNIGAGEASD---ILNTRTKGQKPKLPEKPRFI 1513

  Fly  6369 AYTPNSANLEWHPPDDCGGKPITGYIVERRERGG-EWIKCNNYPTPNTSYTVSNLRDGARYEFRV 6432
            ..:.||.:|.:....| ||.|::.::||.::|.. ||.:.:|...|:.:|.|.:|.....|..|:
  Fly  1514 EVSSNSVSLHFKAWKD-GGCPMSHFVVESKKRDQIEWNQISNNVKPDNNYVVLDLEPATWYNLRI 1577

  Fly  6433 LAVNEAGPGHPSKPSDPMTAEHQRYRPDPPEPPKPDRITRNGVTLSWRPPRTDGK------SRIK 6491
            .|.|.||          .|.....:.          .:|..|.|::   |..||.      :||:
  Fly  1578 TAHNSAG----------FTVAEYDFA----------TLTVTGGTIA---PLDDGSGHGNVHTRIR 1619

  Fly  6492 GYYVEMRPKNGKDWKTVN-DIPINSTVYTVPSLKEGEEYSFRVVAENEVGRSDPSKPSQPITIEE 6555
                  .|....:|..:| .:|:.:||..|                 .||          |.:
  Fly  1620 ------LPAWMPEWLDLNFMVPLIATVVVV-----------------AVG----------ICV-- 1649

  Fly  6556 QPNKPCMELGKVRDIVCRAGD-DFSIHVPYLAFPKPNAFWYSNDNMLDDNNRVHKHLTDDAASVV 6619
                .|:.|.:.|....|.|. |....|.|.....|.|       .||   :....|.|:...:.
  Fly  1650 ----VCVALSRRRADDMRGGQKDVYYDVVYNQTMGPGA-------TLD---KRRPDLRDELGYIA 1700

  Fly  6620 VKNSK-------------RADSGQYRLQLKNTSGFDTATINVRVLDRPSPPTRLRADEFS---GD 6668
            ..|.|             |...|:..|: .|.|.:|.........:..:||..:..:.:.   |:
  Fly  1701 PPNRKLPPVPGSNYNTCDRIKRGRGGLR-SNHSTWDPRRNPNLYEELKAPPVPMHGNHYGHAHGN 1764

  Fly  6669 SLTLYWNPPNDDGGSAIQNY-IIEKKEARSSTWSKVSSFCTVPFVRIRNLVLNKEYDFRVIAENK 6732
            :...|.:|..:|.......: ::..:|....|  |..:|.|.|                    ::
  Fly  1765 AECHYRHPGMEDEICPYATFHLLGFREEMDPT--KAMNFQTFP--------------------HQ 1807

  Fly  6733 YGQSDP----ANTSEPILARHPFDIPNTPGIPHGIDSTEDSITI----AWTKPKHDGG-----SP 6784
            .|.:.|    |.|..|            ||.|..:.|...|.::    .:.:....||     :|
  Fly  1808 NGHAGPVPGHAGTMLP------------PGHPGHVHSRSGSQSMPRANRYQRKNSQGGQSSIYTP 1860

  Fly  6785 ITGYIIEKRLLSDDKWTKAVHALCPDLSCKIPNLIENAEYEFRVAAVNAAGQSAYSGSSDLIFCR 6849
            ...|        ||.                .|..|..:|. |...||:.|.|.|||
  Fly  1861 APEY--------DDP----------------ANCAEEDQYR-RYTRVNSQGGSLYSG-------- 1892

  Fly  6850 RPPHAPKITSDLSIRDMTVIAGDEFRITVPYHASPRPTASWSLNGLEVIPGERIKFDSNDYASMY 6914
                                .|.|:  ..|.:.:|                     :.:.|.|.|
  Fly  1893 --------------------PGPEY--DDPANCAP---------------------EEDQYGSQY 1914

  Fly  6915 -------YNKSAKRDETGSYTITLTNNKGSDTASCHVTVVDRPLPPQGPLNAYDIT 6963
                   |:....|...|..:|....|.|:.:          |.||..|...:|::
  Fly  1915 GGPYGQPYDHYGSRGSMGRRSIGSARNPGNGS----------PEPPPPPPRNHDMS 1960

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bt	NP_001162825.1	I-set	9..101	CDD:254352
		Ig	26..100	CDD:143165
		I-set	119..210	CDD:254352
		Ig	136..209	CDD:143165
		I-set	228..320	CDD:254352
		IGc2	242..312	CDD:197706
		I-set	335..425	CDD:254352
		Ig	350..423	CDD:143165
		Ig	436..530	CDD:299845
		I-set	438..532	CDD:254352
		I-set	545..636	CDD:254352
		Ig	560..633	CDD:143165
		Ig	657..731	CDD:143165
		I-set	746..835	CDD:254352
		Ig	1496..1586	CDD:299845
		IG_like	1503..1588	CDD:214653
		I-set	1639..1724	CDD:254352
		IG	1750..1821	CDD:214652
		IGc2	1750..1806	CDD:197706
		I-set	1826..1909	CDD:254352
		Ig	1831..1897	CDD:299845
		I-set	1914..1998	CDD:254352
		Ig	2020..2095	CDD:299845
		FN3	2100..2194	CDD:238020
		FN3	2203..2292	CDD:238020
		I-set	2311..2395	CDD:254352
		Ig	2321..2395	CDD:299845
		FN3	2399..2493	CDD:238020
		FN3	2501..2590	CDD:238020
		I-set	2602..2693	CDD:254352
		Ig	2619..2693	CDD:299845
		FN3	2697..2793	CDD:238020
		FN3	2801..2893	CDD:238020
		I-set	2902..2995	CDD:254352
		Ig	2919..2993	CDD:299845
		FN3	2999..3088	CDD:238020
		FN3	3102..3191	CDD:238020
		I-set	3208..3292	CDD:254352
		Ig	3219..3292	CDD:299845
		FN3	3296..3390	CDD:238020
		FN3	3400..3489	CDD:238020
		I-set	3494..3590	CDD:254352
		Ig	3516..3590	CDD:299845
		FN3	3594..3682	CDD:238020
		FN3	3694..3781	CDD:238020
		I-set	3795..3885	CDD:254352
		Ig	3813..3885	CDD:299845
		FN3	3889..3980	CDD:238020
		FN3	3990..4082	CDD:238020
		I-set	4090..4181	CDD:254352
		Ig	4108..4181	CDD:299845
		FN3	4185..4271	CDD:238020
		FN3	4285..4383	CDD:238020
		Ig	4404..4480	CDD:299845
		FN3	4484..4571	CDD:238020
		FN3	4584..4677	CDD:238020	6/20 (30%)
		I-set	4685..4775	CDD:254352	22/110 (20%)
		Ig	4703..4775	CDD:299845	17/85 (20%)
		FN3	4779..4863	CDD:238020	18/107 (17%)
		FN3	4879..4970	CDD:238020	20/108 (19%)
		IG	4989..5069	CDD:214652	19/81 (23%)
		Ig	4996..5069	CDD:299845	18/74 (24%)
		FN3	5073..5166	CDD:238020	8/94 (9%)
		FN3	5175..5265	CDD:238020	18/95 (19%)
I-set	5276..5366	CDD:254352	25/90 (28%)
Ig	5293..5366	CDD:299845	19/73 (26%)
FN3	5370..5462	CDD:238020	18/96 (19%)
FN3	5470..5561	CDD:238020	18/96 (19%)
Ig	5559..5654	CDD:299845	16/103 (16%)
I-set	5570..5660	CDD:254352	16/98 (16%)
FN3	5664..5755	CDD:238020	24/111 (22%)
FN3	5764..5853	CDD:238020	27/91 (30%)
I-set	5865..5954	CDD:254352	20/96 (21%)
Ig	5882..5954	CDD:299845	17/78 (22%)
FN3	5958..6049	CDD:238020	23/117 (20%)
FN3	6062..6153	CDD:238020	17/90 (19%)
I-set	6173..6255	CDD:254352	25/86 (29%)
Ig_Titin_like	6182..6255	CDD:143225	23/77 (30%)
FN3	6259..6350	CDD:238020	22/91 (24%)
FN3	6359..6451	CDD:238020	26/92 (28%)
FN3	6470..6552	CDD:238020	17/88 (19%)
I-set	6564..6650	CDD:254352	21/99 (21%)
Ig_Titin_like	6577..6650	CDD:143225	17/85 (20%)
FN3	6654..6745	CDD:238020	16/98 (16%)
FN3	6754..6840	CDD:238020	19/94 (20%)
I-set	6855..6946	CDD:254352	13/97 (13%)
Ig	6874..6946	CDD:299845	11/78 (14%)
FN3	6950..7042	CDD:238020	5/14 (36%)
FN3	7050..7139	CDD:238020
FN3	7151..7237	CDD:238020
I-set	7254..7334	CDD:254352
Ig	7272..7339	CDD:143165
IG_like	7354..7440	CDD:214653
Ig	7366..7440	CDD:299845
FN3	7444..7531	CDD:238020
FN3	7545..7637	CDD:238020
I-set	7648..7737	CDD:254352
Ig	7665..7734	CDD:143165
Ig	7760..7833	CDD:299845
FN3	7837..7927	CDD:238020
STKc_Twitchin_like	7986..8244	CDD:271016
S_TKc	7989..8244	CDD:214567
Ig	8311..8394	CDD:299845
I-set	8312..8401	CDD:254352
I-set	8437..8525	CDD:254352
Ig	8455..8519	CDD:143165
I-set	8632..8721	CDD:254352
IGc2	8646..8711	CDD:197706
I-set	8740..8831	CDD:254352
Ig	8757..8826	CDD:143165
I-set	8839..8922	CDD:254352
Ig	8845..>8909	CDD:299845
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845	18/97 (19%)
		IG	57..133	CDD:214652	16/81 (20%)
		IG_like	267..343	CDD:214653	14/76 (18%)
		Ig	269..340	CDD:143165	13/71 (18%)
		IG_like	353..425	CDD:214653	20/89 (22%)
		IGc2	361..413	CDD:197706	14/61 (23%)
		I-set	433..527	CDD:254352	26/144 (18%)
		IGc2	446..517	CDD:197706	19/104 (18%)
		I-set	533..618	CDD:254352	24/88 (27%)
		IGc2	544..607	CDD:197706	17/64 (27%)
		Ig	641..714	CDD:143165	17/74 (23%)
		IGc2	735..804	CDD:197706	20/144 (14%)
		I-set	819..914	CDD:254352	23/109 (21%)
		Ig	833..921	CDD:299845	22/106 (21%)
		FN3	918..1011	CDD:238020	27/95 (28%)
		FN3	1018..1116	CDD:238020	26/118 (22%)
		FN3	1124..1217	CDD:238020	20/102 (20%)
		FN3	1222..1312	CDD:238020	17/93 (18%)
		Ig	1339..1406	CDD:299845	23/78 (29%)
		FN3	1409..1499	CDD:238020	23/97 (24%)
		FN3	1504..1584	CDD:238020	24/80 (30%)
		Dscam_C	1890..2008	CDD:289151	21/132 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910