DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bt and Lar

DIOPT Version :9

Sequence 1:	NP_001162825.1	Gene:	bt / 43814	FlyBaseID:	FBgn0005666	Length:	8933	Species:	Drosophila melanogaster
Sequence 2:	NP_001260594.1	Gene:	Lar / 35259	FlyBaseID:	FBgn0000464	Length:	2032	Species:	Drosophila melanogaster

Alignment Length:	2308	Identity:	468/2308 - (20%)
Similarity:	775/2308 - (33%)	Gaps:	681/2308 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  5275 PPKIDRNFMSDIKIKAGNVFEFDVPVTGEPLPSKDWTHEGNMIINTDRVKISNFDDRTKIRILDA 5339
            ||:|.|...:. .::.|.|..|.....|:|.||..|...|
  Fly    35 PPEIIRKPQNQ-GVRVGGVASFYCAARGDPPPSIVWRKNG------------------------- 73

  Fly  5340 KRSDTGVYTLTARNINGTDRHNVKVTILDAPSVPEGPLRNGDVSKNSIVLRWRP---PKDDGGSE 5401
                        :.::||..   :.|:|:.|         |.:|    :||..|   .:||...|
  Fly    74 ------------KKVSGTQS---RYTVLEQP---------GGIS----ILRIEPVRAGRDDAPYE 110

  Fly  5402 ITHYVVEKMDNEAMRWVPVGDCTDTEIRADNLIENHDYSFRVRAVNKQGQSQPLTTSQPITAKDP 5466
            .   |.|.         .|||....           |.:..:...:|.....|:.|..|.|....
  Fly   111 C---VAEN---------GVGDAVSA-----------DATLTIYEGDKTPAGFPVITQGPGTRVIE 152

  Fly  5467 YSHP-----DKPGQPQAT-DWGKHFVDLEWSTPK---RDGGAPISSYIIEKRPKFGQWERAAVVL 5522
            ..|.     ...|.|... .|.|:...::.|.|:   :||...|.:...|.:.|:
  Fly   153 VGHTVLMTCKAIGNPTPNIYWIKNQTKVDMSNPRYSLKDGFLQIENSREEDQGKY---------- 207

  Fly  5523 GDNCKAHVPELTNGGEYEFRVIAVNRGGPSDPSDPSSTIICKPRFLAPFFDKSLLNDITVHAGKR 5587
              .|   |.|.:.|.|:                ..::.:..|.|.:.|.|.:.......|..|..
  Fly   208 --EC---VAENSMGTEH----------------SKATNLYVKVRRVPPTFSRPPETISEVMLGSN 251

  Fly  5588 LGWTLPIEASPRPLITWLYNGKEIGSNSRGESGLFQNELTFEIVSSLRSDEGRYTLILKNEHGSF 5652
            |..:.....||.|.:.|:...:::  ....|..:.:|.|  ::::.  .:...||.|..:..|..
  Fly   252 LNLSCIAVGSPMPHVKWMKGSEDL--TPENEMPIGRNVL--QLINI--QESANYTCIAASTLGQI 310

  Fly  5653 DASAHATVLDRPSPPKGPLD--ITKITRDGCHLTWNV--PDDDGGSPILHYIIE-KMDLSRSTWS 5712
            |:   .:|:...|.|..|.|  |:::|.....|.|:.  |:|     :.:|:|: |...:...:|
  Fly   311 DS---VSVVKVQSLPTAPTDVQISEVTATSVRLEWSYKGPED-----LQYYVIQYKPKNANQAFS 367

  Fly  5713 DAGMSTHIVHDVTRLVHRKEYLFRVKAVNAIGESDPLEAVNTIIAKNEF---DEPDAPGKPIITD 5774
            :......:.:.|..|....||.|.|.|||.||...|............|   ....||....:..
  Fly   368 EISGIITMYYVVRALSPYTEYEFYVIAVNNIGRGPPSAPATCTTGDFSFGGTKMESAPRNVQVRT 432

  Fly  5775 WDRDHIDLQWAVPKSDGGAPISEYIIQKKEKGSPYWTNVRHVP---------SNKNTTTIPELTE 5830
            .....:.:.|..|::..| .::.|.:        |:|...:.|         .|...||:.|||.
  Fly   433 LSSSTMVITWEPPETPNG-QVTGYKV--------YYTTNSNQPEASWNSQMVDNSELTTVSELTP 488

  Fly  5831 GQEYEFRVIAVNQAG-------------QSEPSEPSDMIMAKPRYLPPKIITPLNEVRIKCGLIF 5882
            ...|..||.|....|             |..||:||:...
  Fly   489 HAIYTVRVQAYTSMGAGPMSTPVQVKAQQGVPSQPSNFRA------------------------- 528

  Fly  5883 HTDIHFIGEPAPEATWTLNSNPLLSND---------RSTITSIGHH-----SVVHTVNCQRSDSG 5933
             ||   |||.|....||   .|..|::         ..|..:..||     |..:|::....|:
  Fly   529 -TD---IGETAVTLQWT---KPTHSSENIVHYELYWNDTYANQAHHKRISNSEAYTLDGLYPDT- 585

  Fly  5934 IYHLLLRNSSGIDEGSFELVVLDRPGPPEGPMEY----EEITA-----NSVTISWKPP---KDNG 5986
            :|::.|...|...||:      ..|..|....:|    ..|||     .::::||.||   :.||
  Fly   586 LYYIWLAARSQRGEGA------TTPPIPVRTKQYGAPPRNITAIATSSTTISLSWLPPPVERSNG 644

  Fly  5987 GSEISSYVI-------EKRDLTHGGGWVPAVNYVSAKYNHAVVPRLLEGTMYELRVMAENLQG-- 6042
              .|..|.:       |..:.|     ...:|..|     .|:..|...|.|::.|:|....|
  Fly   645 --RIIYYKVFFVEVGREDDEAT-----TMTLNMTS-----IVLDELKRWTEYKIWVLAGTSVGDG 697

  Fly  6043 -RSDPLTSDQPVVAKSQYTVPGAPGKPELTDSDKNHITIKWKQPISNGGSPII-GYDI---ERRD 6102
             ||      .|::.::|..|||.|...:.|..:...|.:.||.|:....:.|| ||.|   |.||
  Fly   698 PRS------HPIILRTQEDVPGDPQDVKATPLNSTSIHVSWKPPLEKDRNGIIRGYHIHAQELRD 756

  Fly  6103 VNTGRWIKINGQP-----VPTAEYQDDRVTSNHQYQYRISAVNAAGNGKTSEPSAIFNARPLREK 6162
            ...|    ...:|     |.|.|:....:..:.:|..:::|:...|:|..|....:.....:..:
  Fly   757 EGKG----FLNEPFKFDVVDTLEFNVTGLQPDTKYSIQVAALTRKGDGDRSAAIVVKTPGGVPVR 817

  Fly  6163 PRFYFDGLIGKRIKVRAGEPVNLNIPISGAPTPTIEWKR-----GDLKLEEGKRISYE------- 6215
            |..        .:|:...||:   :.|.      :||:|     |:|:   |.|:.:.
  Fly   818 PTV--------SLKIMEREPI---VSIE------LEWERPAQTYGELR---GYRLRWGVKDQALK 862

  Fly  6216 ----TNSERTLFRIDDSNRRDSGKYTVTAANE--FGKDTADIEVIVVDKPSPPEGPLSYTETAPD 6274
                :..:.|..|.|:..|....::.|..:|.  .|::|..|.......|..|...::.....||
  Fly   863 EEMLSGPQMTKKRFDNLERGVEYEFRVAGSNHIGIGQETVKIFQTPEGTPGGPPSNITIRFQTPD 927

  Fly  6275 HISLHWYSP-KDDGGSDITGYIIEFTEFGVDDWKPVPGTCPNTNFTVK-----NLVEGKKYVFRI 6333
            .:.:.|..| ::.....||.|.::|.:      |...|.....|.|::     ||.|..:|:||:
  Fly   928 VLCVTWDPPTREHRNGIITRYDVQFHK------KIDHGLGSERNMTLRKAVFTNLEENTEYIFRV 986

  Fly  6334 RAENIYGASEALEGKPVLAKSPFDPPGAPSQPTISAYTPNSANLEWHPPDDCGGKPITGYIVERR 6398
            ||....||....:  .::.::..|...||......|.:..:|.:.|.|....|  .:.||.:...
  Fly   987 RAYTKQGAGPFSD--KLIVETERDMGRAPMSLQAEATSEQTAEIWWEPVTSRG--KLLGYKIFYT 1047

  Fly  6399 ERGGEWIKCNNYPTPNTSYTVS----NLRDGARYEFRVLAVNEAGPGHPSKPSDPMTAEHQRYRP 6459
            ....|  ..:::.|.....|.|    ||...|:|...:.|..:.|.|   :.|:.:|.   |.:|
  Fly  1048 MTAVE--DLDDWQTKTVGLTESADLVNLEKFAQYAVAIAARFKNGLG---RLSEKVTV---RIKP 1104

  Fly  6460 -DPPEPPKPDRITRNGVTLSWRPP-------------------RTDGKSR---------IKGYYV 6495
             |.|...:...::.:.:||||.||                   .:.|.|:         |..:||
  Fly  1105 EDVPLNLRAHDVSTHSMTLSWSPPIRLTPVNYKISFDAMKVFVDSQGFSQTQIVPKREIILKHYV 1169

  Fly  6496 EMRPKNGKDWKTVNDI----PINSTVYTVPSLKEGEEYSFRVVAENEVGRSDPSKPSQPITIEEQ 6556
            :..        |:|::    ..|..|..:||     :||:|              |...||:..|
  Fly  1170 KTH--------TINELSPFTTYNVNVSAIPS-----DYSYR--------------PPTKITVTTQ 1207

  Fly  6557 PNKP----------CMELGKVRDIVCRAGDDFSIHVPYLAFPKPNAFWYSNDNMLDDNNRVHK-- 6609
            ...|          .:...::..|:.:|.:::.....|.....|           :|.:.:||
  Fly  1208 MAAPQPMVKPDFYGVVNGEEILVILPQASEEYGPISHYYLVVVP-----------EDKSNLHKIP 1261

  Fly  6610 --HLTDD------------AASVVVKNSKRADSGQYRLQLKNTSGFDTATINVRVLDR------- 6653
              .||||            |..:..|..:|:....:.|    .||.|......|.|:|
  Fly  1262 DQFLTDDLLPGRNKPERPNAPYIAAKFPQRSIPFTFHL----GSGDDYHNFTNRKLEREKRYRIF 1322

  Fly  6654 -----PSPPTRLRA----DEFSGDSLTLYWNPPNDDGGSAIQNYIIE-------KKEARSSTW-- 6700
                 .:|...|..    .||.  ||.:...||.:.......|:..|       .|:.....|
  Fly  1323 VRAVVDTPQKHLYTSSPFSEFL--SLDMREAPPGERPHRPDPNWPAEPEVSVNRNKDEPEILWVV 1385

  Fly  6701 --SKVSSFCTVPFVRIRNLVLNKEYDFRVIAENKYGQSDPANTSEPILA---------RHPFDIP 6754
              ..||:|.....:.:..:|..:....:.        .|.|..:.|::|         ..|.|:.
  Fly  1386 LPLMVSTFIVSTALIVLCVVKRRRQPCKT--------PDQAAVTRPLMAADLGAGPTPSDPVDMR 1442

  Fly  6755 ----NTPG-IPHGIDSTEDSITIAWTKPKHDGGSPITGYIIEKRLLSDD--KWTKAVHALCPDLS 6812
                .||| |.|      ..|.|          |....:|  :||.|:|  |:::...::.|...
  Fly  1443 RLNFQTPGMISH------PPIPI----------SEFANHI--ERLKSNDNQKFSQEYESIEPGQQ 1489

  Fly  6813 CKIPNL-IENAEYEFRVAAVNAAGQS-----AYSG--SSDLI---FCRRPPHAPKITSDLSIRDM 6866
            ....|. :|:.:.:.|.|.|.|...|     |..|  .||.|   :|
  Fly  1490 FTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYC------------------ 1536

  Fly  6867 TVIAGDEFRITVPYHASPRPTAS---------WSLNGLEVIPGERIKFDSNDYASMYYNKSAKRD 6922
                 |.:|....|.|:..|...         |.|....::...|::..:......|:  ..:..
  Fly  1537 -----DGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYW--PTRGT 1594

  Fly  6923 ET-GSYTITLTNNKGSDTAS------CHVTVVDRPLPPQGPLNAYDITPD--------------- 6965
            || |...:|:|..:...|.|      |.....||....|....|:   ||
  Fly  1595 ETYGQIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAW---PDHGVPDHPAPFLQFLR 1656

  Fly  6966 TCTLAWKTPLDDGGSPITNYVVEKLDNSGSWVKISSFV-RNTHYDVMGLEPHY-----KYNFRVR 7024
            .|...  ||.:.|  |:..:....:..:|.::.|.|.: |..|..::.:..|.     :.|:.|:
  Fly  1657 RCRAL--TPPESG--PVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQ 1717

  Fly  7025 AENQY-GLSDPLDIIEPIVAKHQFTVPDEPGQPKVIDWDSGNV-----TLIWTRPLSDGGSRIQG 7083
            .|:|| .:.|.  |:|.|:.    .|.:.|.:         |:     .|:.|.|    |..|.|
  Fly  1718 TEDQYIFIHDA--ILEAIIC----GVTEVPAR---------NLHTHLQKLLITEP----GETISG 1763

  Fly  7084 YQIEYRDILN---DSS------------WNAYDYIIKDTKYQLY----NLINGSEYEFRIKAKNA 7129
            .::|::.:.|   |||            .|...:|:.....::|    :.|.||:|   :.|...
  Fly  1764 MEVEFKKLSNVKMDSSKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDY---VNASFI 1825

  Fly  7130 AGLSKPSSPSLRFKLKGKFTVPSPPGAPQVTRVGKNYVDLKWEKPLRDGGSRITGYIIERRDIGG 7194
            .|          ::.:..:.....|    |....:::..:.||.     .|.|...:.:.:::|.
  Fly  1826 DG----------YRYRSAYIAAQGP----VQDAAEDFWRMLWEH-----NSTIVVMLTKLKEMGR 1871

  Fly  7195 AVWVKCNDY----NVLDTEYTVMNLI---EMGDYEFRVFAVNSA--GRSEP----SLCTMPIKVC 7246
            .   ||..|    ..:..:|.|::.|   .|..|:.|.|.|..|  |.|..    .....|.:..
  Fly  1872 E---KCFQYWPHERSVRYQYYVVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGV 1933

  Fly  7247 EVLGGKKPDWITRLQDKVAPFGKD--YTLQCAA 7277
            ...|....|:|.::......||:|  .|:.|:|
  Fly  1934 PKSGEGFIDFIGQVHKTKEQFGQDGPITVHCSA 1966

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bt	NP_001162825.1	I-set	9..101	CDD:254352
		Ig	26..100	CDD:143165
		I-set	119..210	CDD:254352
		Ig	136..209	CDD:143165
		I-set	228..320	CDD:254352
		IGc2	242..312	CDD:197706
		I-set	335..425	CDD:254352
		Ig	350..423	CDD:143165
		Ig	436..530	CDD:299845
		I-set	438..532	CDD:254352
		I-set	545..636	CDD:254352
		Ig	560..633	CDD:143165
		Ig	657..731	CDD:143165
		I-set	746..835	CDD:254352
		Ig	1496..1586	CDD:299845
		IG_like	1503..1588	CDD:214653
		I-set	1639..1724	CDD:254352
		IG	1750..1821	CDD:214652
		IGc2	1750..1806	CDD:197706
		I-set	1826..1909	CDD:254352
		Ig	1831..1897	CDD:299845
		I-set	1914..1998	CDD:254352
		Ig	2020..2095	CDD:299845
		FN3	2100..2194	CDD:238020
		FN3	2203..2292	CDD:238020
		I-set	2311..2395	CDD:254352
		Ig	2321..2395	CDD:299845
		FN3	2399..2493	CDD:238020
		FN3	2501..2590	CDD:238020
		I-set	2602..2693	CDD:254352
		Ig	2619..2693	CDD:299845
		FN3	2697..2793	CDD:238020
		FN3	2801..2893	CDD:238020
		I-set	2902..2995	CDD:254352
		Ig	2919..2993	CDD:299845
		FN3	2999..3088	CDD:238020
		FN3	3102..3191	CDD:238020
		I-set	3208..3292	CDD:254352
		Ig	3219..3292	CDD:299845
		FN3	3296..3390	CDD:238020
		FN3	3400..3489	CDD:238020
		I-set	3494..3590	CDD:254352
		Ig	3516..3590	CDD:299845
		FN3	3594..3682	CDD:238020
		FN3	3694..3781	CDD:238020
		I-set	3795..3885	CDD:254352
		Ig	3813..3885	CDD:299845
		FN3	3889..3980	CDD:238020
		FN3	3990..4082	CDD:238020
		I-set	4090..4181	CDD:254352
		Ig	4108..4181	CDD:299845
		FN3	4185..4271	CDD:238020
		FN3	4285..4383	CDD:238020
		Ig	4404..4480	CDD:299845
		FN3	4484..4571	CDD:238020
		FN3	4584..4677	CDD:238020
		I-set	4685..4775	CDD:254352
		Ig	4703..4775	CDD:299845
		FN3	4779..4863	CDD:238020
		FN3	4879..4970	CDD:238020
		IG	4989..5069	CDD:214652
		Ig	4996..5069	CDD:299845
		FN3	5073..5166	CDD:238020
		FN3	5175..5265	CDD:238020
I-set	5276..5366	CDD:254352	14/89 (16%)
Ig	5293..5366	CDD:299845	10/72 (14%)
FN3	5370..5462	CDD:238020	19/94 (20%)
FN3	5470..5561	CDD:238020	16/99 (16%)
Ig	5559..5654	CDD:299845	18/94 (19%)
I-set	5570..5660	CDD:254352	17/89 (19%)
FN3	5664..5755	CDD:238020	26/95 (27%)
FN3	5764..5853	CDD:238020	23/110 (21%)
I-set	5865..5954	CDD:254352	21/102 (21%)
Ig	5882..5954	CDD:299845	21/85 (25%)
FN3	5958..6049	CDD:238020	27/112 (24%)
FN3	6062..6153	CDD:238020	26/99 (26%)
I-set	6173..6255	CDD:254352	20/99 (20%)
Ig_Titin_like	6182..6255	CDD:143225	18/90 (20%)
FN3	6259..6350	CDD:238020	24/96 (25%)
FN3	6359..6451	CDD:238020	21/95 (22%)
FN3	6470..6552	CDD:238020	21/113 (19%)
I-set	6564..6650	CDD:254352	18/101 (18%)
Ig_Titin_like	6577..6650	CDD:143225	16/88 (18%)
FN3	6654..6745	CDD:238020	18/105 (17%)
FN3	6754..6840	CDD:238020	23/98 (23%)
I-set	6855..6946	CDD:254352	17/106 (16%)
Ig	6874..6946	CDD:299845	16/87 (18%)
FN3	6950..7042	CDD:238020	23/113 (20%)
FN3	7050..7139	CDD:238020	22/112 (20%)
FN3	7151..7237	CDD:238020	21/98 (21%)
I-set	7254..7334	CDD:254352	8/26 (31%)
Ig	7272..7339	CDD:143165	3/6 (50%)
IG_like	7354..7440	CDD:214653
Ig	7366..7440	CDD:299845
FN3	7444..7531	CDD:238020
FN3	7545..7637	CDD:238020
I-set	7648..7737	CDD:254352
Ig	7665..7734	CDD:143165
Ig	7760..7833	CDD:299845
FN3	7837..7927	CDD:238020
STKc_Twitchin_like	7986..8244	CDD:271016
S_TKc	7989..8244	CDD:214567
Ig	8311..8394	CDD:299845
I-set	8312..8401	CDD:254352
I-set	8437..8525	CDD:254352
Ig	8455..8519	CDD:143165
I-set	8632..8721	CDD:254352
IGc2	8646..8711	CDD:197706
I-set	8740..8831	CDD:254352
Ig	8757..8826	CDD:143165
I-set	8839..8922	CDD:254352
Ig	8845..>8909	CDD:299845
Lar	NP_001260594.1	Ig	35..129	CDD:299845	32/170 (19%)
		I-set	36..129	CDD:254352	31/169 (18%)
		IG_like	146..227	CDD:214653	19/111 (17%)
		Ig	159..228	CDD:299845	16/99 (16%)
		I-set	234..318	CDD:254352	18/92 (20%)
		Ig3_RPTP_IIa_LAR_like	249..317	CDD:143216	15/76 (20%)
		fn3	324..404	CDD:278470	23/84 (27%)
		FN3	423..514	CDD:238020	20/99 (20%)
		FN3	520..610	CDD:238020	27/128 (21%)
		FN3	616..707	CDD:238020	25/108 (23%)
		FN3	712..810	CDD:238020	26/101 (26%)
		FN3	832..907	CDD:238020	17/83 (20%)
		FN3	914..1005	CDD:238020	23/98 (23%)
		FN3	1012..1101	CDD:238020	22/98 (22%)
		fn3	1106..1198	CDD:278470	22/118 (19%)
		PTPc	1476..1731	CDD:214550	56/288 (19%)
		PTPc	1503..1731	CDD:238006	52/261 (20%)
		PTPc	1763..2022	CDD:214550	46/229 (20%)
		PTPc	1791..2022	CDD:238006	40/201 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910