DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment bt and Pvr

DIOPT Version :9

Sequence 1:NP_001162825.1 Gene:bt / 43814 FlyBaseID:FBgn0005666 Length:8933 Species:Drosophila melanogaster
Sequence 2:NP_001162911.1 Gene:Pvr / 34127 FlyBaseID:FBgn0032006 Length:1577 Species:Drosophila melanogaster


Alignment Length:1500 Identity:280/1500 - (18%)
Similarity:482/1500 - (32%) Gaps:515/1500 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    40 IEWF---RSDNKVV-----EDVRTKFKIQPVGENKYTVVLELDDVVETDAGLY------------ 84
            :|||   |.:|::.     .|.:|:......|.:..||:    :...:|.|||            
  Fly   363 MEWFTPSRDENRIFASQSRTDPKTRNSTHQTGRSTLTVL----NAQPSDTGLYKCVTTDNSNQNV 423

  Fly    85 -------KVKAKNKS----GEVSASINLNFTPADEPKEKQIDGFAPTFAKKPAIRQEEDGKRLLF 138
                   ||..:|:|    ||.|...|:                           ||...:.:..
  Fly   424 QRATYRIKVLKQNESYLNVGEPSGHYNV---------------------------QEYANRTIQM 461

  Fly   139 ECRVNADPIPAIIWFH-NGAAVKESERHKITVDKDVHSYFATLEILNVTVEDAGKYKVNAKNELG 202
            .......|.|:..||. :|..|::||.:...:..::.:   .|::||..::|:|.|.:...|..|
  Fly   462 TANFEGFPTPSFSWFKPDGTEVRQSENNFKILSTELST---MLQVLNAQLQDSGTYVLRGSNSFG 523

  Fly   203 ----ESNATISLNFDSDEAPVPESAEGIKPTFTERPVIRQSED----GGNVTFECRCVGDPTPTV 259
                |.|.::                      .:.|.::.|:.    |.....||.....|...|
  Fly   524 VVQREYNVSV----------------------MDAPALKMSDAYVQVGSVARLECTVRSYPPAIV 566

  Fly   260 TWSHGETELNESNRYKMSLTMDQKLYHIACLEISSVVSSDQGEYRAQAKNKHGS-GVATI-NLNF 322
            |:            :....:::.:....:.|..:..:.|:|.:|:.|.:.:.|. .|..| .::|
  Fly   567 TF------------FFRPCSLEPQWPTCSVLNQNFSLPSEQEKYQFQTRPRPGKLSVERIYEVSF 619

  Fly   323 ---ESG-----SKKIPDGKSPRFPKKPTIRQEEDLLIMECVLEAHPVPDIVWYCSEKEICNNQRT 379
               |.|     ::.|.|||..|                 .:.:||            .:..|...
  Fly   620 LPTEPGILTCIAQNIIDGKERR-----------------TLTKAH------------VLLGNISE 655

  Fly   380 KMTRKAITKDSYILTLEIQNPTKEDGGNYRCNAINMYGESNANIALNFQGASDANGFAPSFIEKP 444
            .||.....||..|        .|||..|:.|.|          :|.:|.|               
  Fly   656 NMTIYGFDKDHKI--------AKEDNVNFTCEA----------LAYHFDG--------------- 687

  Fly   445 RIIPNESGTLITMKCKCKAKPEPTVTWY-RGQDLVEKSKKIKINTTVIAEDTYELTLEIKDPGAT 508
                                   .:.|: .|:||.| |..:.|.|: ..:.:|:.|:.|......
  Fly   688 -----------------------NLKWFINGEDLKE-SDSVHIETS-HTKYSYKSTVHITTISDR 727

  Fly   509 DGGTYRCNVKNE-----YGESNANLNLNIEAEPEPEGEGPTFIEKPRIVSENNGKLVIMECKVKA 568
            |.|||.|...:.     |.....:|.::..:.|:....|.....|   :.....:.:.:||...|
  Fly   728 DRGTYECRAYHNDKDAVYSSREIDLYVHDPSAPQWTNGGQEGHSK---IKRKLSQTLELECASTA 789

  Fly   569 DPKPDVIWFRNGEVIKESNKIKTFIEQRGDQYYIKLELLDPQLEDSGLYKCNIKNTLGELNANLT 633
            .|...|.||::.:.:.|| |::..||:..     ||.:......|.|:|||.::|.|..:..:.|
  Fly   790 VPVAIVRWFKDDKEVTES-KLRHIIEKES-----KLLITHLYPGDEGVYKCVVENRLDRIERSFT 848

  Fly   634 LNIEIVPVIKDKPKI-----------------------IKIIK--KRTVVIECTVASKFE----- 668
            :      ||.|.|.|                       ::..|  ||.:.::....:.||     
  Fly   849 V------VISDLPGISMAWVWFGVILFLILIGLCVFLAVRYQKEHKRHLALKAAGLANFEEGAVG 907

  Fly   669 ---PKCTWYKETSTVKESKRHVYQVEQTK------EGEFAVKLE-----INDVEESDKGAYKLVA 719
               |..|..::...:..::...:..|..|      .|.|.|.|:     |...|.:...|.|:|.
  Fly   908 HINPDLTLDEQAELLPYNREFEFPRENLKLGKQLGAGAFGVVLKGEAKGIRREEPTTTVAVKMVK 972

  Fly   720 SNEKGEAVSQIV-------------NLVDIPEEERKPCKPEISRKLADQK---VAESKTFELLVS 768
            :....|.|..:|             |:|::        ...:::.:|.::   :.|...|..:.:
  Fly   973 ATADNEVVRALVSELKIMVHLGQHLNVVNL--------LGAVTKNIAKRELMVIVEYCRFGNIQN 1029

  Fly   769 LSQTDRKCKVEWYKGSTVIRETKDITTTFDGTTARLTFSSARTEHTS-NYKVIVTNEVGKDESSC 832
            ....:|||         .|.:....|...|        .|..|:..| ||      |:.:|.:..
  Fly  1030 FLLRNRKC---------FINQINPDTDHID--------PSIMTQRMSDNY------ELHRDTNGG 1071

  Fly   833 KITVEKVAKKKEEKPKEKEKTKNEKEVEQKEMEEDKNESGQSVAQTEGRINIEQISEGDPKEELT 897
            .:....|.........|......:....::..:.|. .||....:|           |......:
  Fly  1072 GLKYANVGFPIHSYINEPHNNNTQPPTHRRNSDNDP-RSGTRAGRT-----------GSGTATYS 1124

  Fly   898 VKEEILDKRDTQEVKESSVELQDSAGHEVPEPKKATSDSKLDQSNQKNLDKKHKTDQSESKTNKN 962
            ...::    ||.....::          |||..:..|::.:..:.:.|    :|||.:|:.|...
  Fly  1125 YDRQM----DTCATVMTT----------VPEDDQIMSNNSVQPAWRSN----YKTDSTEAMTVTT 1171

  Fly   963 VSLAEPIKSNKQESEEQQATEQIGLKKVDRKASIVSVKEEISSDVRRKSTIKAKEEITV------ 1021
            |.|..                  ...:|.|....:|.|:.:..|:..::.:..::.:..      
  Fly  1172 VDLIS------------------WAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVVKICDFGL 1218

  Fly  1022 ------DDKKASSRRSSLAVE----ESNTESRRSSIID---------------KKPLEQVD---- 1057
                  .|....|....|.::    ||.::...|:..|               |.|...:|    
  Fly  1219 ARSMYRGDNYKKSENGKLPIKWLALESLSDHVFSTYSDVWSYGIVLWEMFSLAKVPYPGIDPNQE 1283

  Fly  1058 -----------NKPIDAN------------KNPQ--PLKEEIPRLKPAEKRRTSKVIEE------ 1091
                       .||..||            |||:  ||..|:      |||..:.:.|:      
  Fly  1284 LFNKLNDGYRMEKPKFANQELYEIMLECWRKNPESRPLFAEL------EKRFANMLGEDVASHYL 1342

  Fly  1092 ----PKPDEGLPKLRKAS-----IAQVKEEAKPAAPK-LKAKAKAKPKYEELPEIPDYER----- 1141
                |.....:..::|.|     :....:|..||||: :........:.||||:  ||..     
  Fly  1343 DLNNPYMQSNIEYMKKQSTDYLALMGSPDELAPAAPRYVNGHIVPDIRIEELPD--DYMEMSRDS 1405

  Fly  1142 ----------PQLEKYEKSDFTPSDFARD--LEIPNKMEKPI----IDSGKKEPAVLAQKNGIPK 1190
                      |...:.|.|||  .||:.:  ...|...:.|.    ::||..:|  |.:|||:| 
  Fly  1406 DPDACTAIFSPTRLEGESSDF--PDFSSETTFNFPGARQSPTLSNNLNSGSSKP--LRKKNGMP- 1465

  Fly  1191 KTDIIEQYADE-PKGLKVGKGKLPDEGDGRDGAVLKPVIIEPEKEILDLGNKKN---NQHADKPT 1251
            ..|:.:|..:| |        .|.....|.||:        ||:     |.:.|   .|....||
  Fly  1466 TVDVADQAPEEIP--------MLHRSSTGSDGS--------PEQ-----GRRFNQALKQQYVTPT 1509

  Fly  1252 VLDIIKQRRRSSIRNLMTKEPIQNESFLGVVLKPVIKD----TREQAAPQQAIQLTKANATEQFS 1312
                  ...|..:...:..||.:|.    |.:||..|:    |........|...|:|.:...:.
  Fly  1510 ------PSPRHHVETKLNGEPSENY----VNMKPPRKNIPGKTTTGGGGAAAGASTEAFSNPSYQ 1564

  Fly  1313 PTKAV 1317
            |...|
  Fly  1565 PLSTV 1569

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
btNP_001162825.1 I-set 9..101 CDD:254352 21/91 (23%)
Ig 26..100 CDD:143165 21/90 (23%)
I-set 119..210 CDD:254352 20/95 (21%)
Ig 136..209 CDD:143165 18/77 (23%)
I-set 228..320 CDD:254352 16/97 (16%)
IGc2 242..312 CDD:197706 11/69 (16%)
I-set 335..425 CDD:254352 15/89 (17%)
Ig 350..423 CDD:143165 14/72 (19%)
Ig 436..530 CDD:299845 18/99 (18%)
I-set 438..532 CDD:254352 18/99 (18%)
I-set 545..636 CDD:254352 23/90 (26%)
Ig 560..633 CDD:143165 21/72 (29%)
Ig 657..731 CDD:143165 17/92 (18%)
I-set 746..835 CDD:254352 16/92 (17%)
Ig 1496..1586 CDD:299845
IG_like 1503..1588 CDD:214653
I-set 1639..1724 CDD:254352
IG 1750..1821 CDD:214652
IGc2 1750..1806 CDD:197706
I-set 1826..1909 CDD:254352
Ig 1831..1897 CDD:299845
I-set 1914..1998 CDD:254352
Ig 2020..2095 CDD:299845
FN3 2100..2194 CDD:238020
FN3 2203..2292 CDD:238020
I-set 2311..2395 CDD:254352
Ig 2321..2395 CDD:299845
FN3 2399..2493 CDD:238020
FN3 2501..2590 CDD:238020
I-set 2602..2693 CDD:254352
Ig 2619..2693 CDD:299845
FN3 2697..2793 CDD:238020
FN3 2801..2893 CDD:238020
I-set 2902..2995 CDD:254352
Ig 2919..2993 CDD:299845
FN3 2999..3088 CDD:238020
FN3 3102..3191 CDD:238020
I-set 3208..3292 CDD:254352
Ig 3219..3292 CDD:299845
FN3 3296..3390 CDD:238020
FN3 3400..3489 CDD:238020
I-set 3494..3590 CDD:254352
Ig 3516..3590 CDD:299845
FN3 3594..3682 CDD:238020
FN3 3694..3781 CDD:238020
I-set 3795..3885 CDD:254352
Ig 3813..3885 CDD:299845
FN3 3889..3980 CDD:238020
FN3 3990..4082 CDD:238020
I-set 4090..4181 CDD:254352
Ig 4108..4181 CDD:299845
FN3 4185..4271 CDD:238020
FN3 4285..4383 CDD:238020
Ig 4404..4480 CDD:299845
FN3 4484..4571 CDD:238020
FN3 4584..4677 CDD:238020
I-set 4685..4775 CDD:254352
Ig 4703..4775 CDD:299845
FN3 4779..4863 CDD:238020
FN3 4879..4970 CDD:238020
IG 4989..5069 CDD:214652
Ig 4996..5069 CDD:299845
FN3 5073..5166 CDD:238020
FN3 5175..5265 CDD:238020
I-set 5276..5366 CDD:254352
Ig 5293..5366 CDD:299845
FN3 5370..5462 CDD:238020
FN3 5470..5561 CDD:238020
Ig 5559..5654 CDD:299845
I-set 5570..5660 CDD:254352
FN3 5664..5755 CDD:238020
FN3 5764..5853 CDD:238020
I-set 5865..5954 CDD:254352
Ig 5882..5954 CDD:299845
FN3 5958..6049 CDD:238020
FN3 6062..6153 CDD:238020
I-set 6173..6255 CDD:254352
Ig_Titin_like 6182..6255 CDD:143225
FN3 6259..6350 CDD:238020
FN3 6359..6451 CDD:238020
FN3 6470..6552 CDD:238020
I-set 6564..6650 CDD:254352
Ig_Titin_like 6577..6650 CDD:143225
FN3 6654..6745 CDD:238020
FN3 6754..6840 CDD:238020
I-set 6855..6946 CDD:254352
Ig 6874..6946 CDD:299845
FN3 6950..7042 CDD:238020
FN3 7050..7139 CDD:238020
FN3 7151..7237 CDD:238020
I-set 7254..7334 CDD:254352
Ig 7272..7339 CDD:143165
IG_like 7354..7440 CDD:214653
Ig 7366..7440 CDD:299845
FN3 7444..7531 CDD:238020
FN3 7545..7637 CDD:238020
I-set 7648..7737 CDD:254352
Ig 7665..7734 CDD:143165
Ig 7760..7833 CDD:299845
FN3 7837..7927 CDD:238020
STKc_Twitchin_like 7986..8244 CDD:271016
S_TKc 7989..8244 CDD:214567
Ig 8311..8394 CDD:299845
I-set 8312..8401 CDD:254352
I-set 8437..8525 CDD:254352
Ig 8455..8519 CDD:143165
I-set 8632..8721 CDD:254352
IGc2 8646..8711 CDD:197706
I-set 8740..8831 CDD:254352
Ig 8757..8826 CDD:143165
I-set 8839..8922 CDD:254352
Ig 8845..>8909 CDD:299845
PvrNP_001162911.1 IG 346..432 CDD:214652 14/72 (19%)
Ig <363..432 CDD:299845 14/72 (19%)
Ig 466..533 CDD:299845 18/69 (26%)
IG_like 672..754 CDD:214653 25/131 (19%)
Ig 674..739 CDD:143165 22/114 (19%)
IGc2 779..840 CDD:197706 20/66 (30%)
PKc_like 927..1332 CDD:304357 81/489 (17%)
Pkinase_Tyr 935..1329 CDD:285015 79/478 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.