DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment bt and musk

DIOPT Version :9

Sequence 1:NP_001162825.1 Gene:bt / 43814 FlyBaseID:FBgn0005666 Length:8933 Species:Drosophila melanogaster
Sequence 2:NP_001004503.1 Gene:musk / 334526 ZFINID:ZDB-GENE-030131-6458 Length:941 Species:Danio rerio


Alignment Length:1265 Identity:241/1265 - (19%)
Similarity:378/1265 - (29%) Gaps:539/1265 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly  7068 LIWTRPLSDGGSRIQGYQIEYRDILNDSSWNAYD--YIIKDTKYQLY--NLINGSEYEFRIKAKN 7128
            :||||         ..|.|.|           ||  |:|::....|.  |:.:....|:...|.|
Zfish    57 IIWTR---------NNYPIRY-----------YDSRYVIQENGQMLIIPNVKDSDSGEYCCIANN 101

  Fly  7129 AAGLSKPSSPSLRFKLKGKFTVPSPPGAPQVTR-------------------VGKNYVDLKWEKP 7174
            ..|.:| |..:|:.|:|           ||:.|                   :|....::.|.|.
Zfish   102 GVGEAK-SCGALQLKMK-----------PQIKRHPTNMTLILESKAVLPCLSLGYPKPEISWIKE 154

  Fly  7175 ------------LRDGGSRITGYIIERRDIGGAVWVKCNDYNVLDTEYTVMNLIEMGDYEFRVFA 7227
                        |..|..:||.  |::.|.|                            ::|..|
Zfish   155 DDLIKANNRIAILESGSLKITN--IKKEDAG----------------------------QYRCVA 189

  Fly  7228 VNSAGRSEPSLCTM----PIKVCEVLGGKKPDWITRLQDKVAPFGKDYTLQCAASGKPSPTARWL 7288
            .||.|.:.....|:    |.|:.:|     |      ::|....|.:.||:|.|:|.|.|:..||
Zfish   190 RNSFGIAFSRPVTIEVQAPAKILKV-----P------KEKRVQIGSEVTLECNATGNPIPSITWL 243

  Fly  7289 RNGKEIQMNGGRMTCDSKDGVFRLHISNVQTGDDGDYTCEAMN--SLGFVNTSGYLKIGSPPIIN 7351
            .||..|   .|....::..|...|.:..|.......|||:|.|  |.|........||       
Zfish   244 ENGNTI---SGASVVETLVGEVILSVLQVVVHKPALYTCQATNRHSGGENTVKATAKI------- 298

  Fly  7352 RCPSELKLPEGDNSKIKIFYSGDQPLTVILKKNNEVICDSNDDTHVKVNIFDDYVAIYIRNIVKS 7416
             ..||.:|.:|....... |.||             :|                     ||:::.
Zfish   299 -TVSEWRLYKGHAGYCST-YRGD-------------VC---------------------RNVLRR 327

  Fly  7417 DGGPYQIEFTNESGSATGEFYVHITGMPSAPTGPMGISYINKNSCMLNWRPPSYDGGLKVSHYVI 7481
            |.    :.|.|.                |.|.......|:.:::    |  |..||         
Zfish   328 DA----LVFFNY----------------SLPNPEDAQEYLAQSA----W--PELDG--------- 357

  Fly  7482 ERKDVSSPHWITVSSTCKDTAFNVQGLIENQEYIFRVMAVNENGMGPPLEGLNPIRAKDPIDPPS 7546
                        |||.|:..|   :.|:.:..:    ...|.:|:||               .|.
Zfish   358 ------------VSSFCRPAA---RSLLCHSTF----QDCNPSGLGP---------------APK 388

  Fly  7547 PPGSPQITEIGGDFVHLEWEKPESDGGAHIQGYWIDKREVGSNTWQRVNATICAA--------NQ 7603
            |........:...:.:.||...|.......|  .|...|..|...|:.:.:.|.|        :|
Zfish   389 PVCREHCLTVKELYCYKEWRSAEERSQRGFQ--HITLPECTSLPSQQADPSSCTAVPYVDIKKDQ 451

  Fly  7604 I--NCINLIEGRQYEFRIFAQNVAGLSTESSASQAVKIIDPQAASPPLIVKP-LRDA-NCIQNHN 7664
            :  .|.| .:||      |.|....::..|...|.....||......:.|.| ||:| |..:|..
Zfish   452 VTSTCYN-DKGR------FYQGTHNVTASSIPCQRWNQQDPHQHRLSVDVIPELRNAENYCRNPG 509

  Fly  7665 AQ----FTCTINGVPKPTISWYKGAREISNGARYHMYSEGDNHFLNINDVFGEDADEYVCRAVNK 7725
            .:    :..|.|    |.:.|                                   || | .|.|
Zfish   510 GESDRPWCYTTN----PNVRW-----------------------------------EY-C-LVPK 533

  Fly  7726 AGAKSTRATLAIMTAPKLNVPPRFR-----DTAYFDKGENVVIKIPFTGFPKPRIHWVRDGENIE 7785
            .|     ..::|.|||.:..|..|.     .|||   ..:|:|.: ..||              .
Zfish   534 CG-----EVISIRTAPSITKPAHFYPPPSVSTAY---SMSVIIFV-IAGF--------------A 575

  Fly  7786 SGGHYTVEVK--ERHAVLIIRDGSHLDSGPYRITAENELGSDTAIIQVQISDR--PDP--PRFPL 7844
            ....:||.:.  .|...:..:..|.:...|...|..:||          :.||  |:|  .|.||
Zfish   576 GAAFFTVLILMCHRRKKMWKKRKSRVLETPTLTTLPSEL----------LLDRLHPNPMYQRLPL 630

  Fly  7845 IESIGTESLSLSWKAPVWDGCSDITNYYVERREHPLSSWIRVGNTRFTSMAVSGLTPGKEYDFRI 7909
            :  :.::.|||                     |:|                              
Zfish   631 L--LNSKLLSL---------------------EYP------------------------------ 642

  Fly  7910 FADNVYGRSDASDTSTLIKTKESVKKKPIERKWEIDANGRKLRGKADGPVKDYDSYVFDIYSKFV 7974
             .:|:                                                 .||.|      
Zfish   643 -RNNI-------------------------------------------------EYVRD------ 651

  Fly  7975 PQPVEISQQSVYDRYDILEEIGTGAFGVVHRCRERSTG-------NIFAAKFI--PVSHSVEKDL 8030
                                ||.||||.|.:.  |:.|       .:.|.|.:  ..|..::.| 
Zfish   652 --------------------IGEGAFGRVFQA--RAPGLLPTEPFTMVAVKMLKEEASTDMQND- 693

  Fly  8031 IRREIDIMNQLHHQKLINLHDAFEDDDEMILILEFLSGGELFE----------------RITAEG 8079
            .:||..:|::..|..::.|.........|.|:.|:::.|:|.|                .:|:..
Zfish   694 FQREAALMSEFDHPNIVRLLGVCAVGKPMCLMFEYMAYGDLNEFLRRRCATQQPSLSRDTLTSSS 758

  Fly  8080 YV--------MTEAEVINYMRQICEGIRHMHEQNIIHLDIKPENIMCQTRSSTNVKLIDFGLATR 8136
            .|        ::..|.::..:|:..|:.::.|:..:|.|:...|  |....:..||:.||||:..
Zfish   759 LVSEPERYPPLSCQEQLSISKQVAAGMAYLSERKFVHRDLATRN--CLVAENLVVKIADFGLSRN 821

  Fly  8137 LDPNEVVKITTGTA---EFAAPEIV--NREPVGFYT---DMWATGVLSYVLLS-GLSPFAG---- 8188
            :...:..|.:...|   .:..||.:  ||     ||   |:||.||:.:.:.| |:.|:.|    
Zfish   822 IYAADYYKASENDAIPIRWMPPESIFYNR-----YTSESDVWAYGVVLWEIFSYGMQPYYGMAHE 881

  Fly  8189 ---------------DNDVQTLKNVKACDW 8203
                           :|..|.|.|:....|
Zfish   882 EVIYYVRDGNVLSCPENCPQELYNLMRLCW 911

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
btNP_001162825.1 I-set 9..101 CDD:254352
Ig 26..100 CDD:143165
I-set 119..210 CDD:254352
Ig 136..209 CDD:143165
I-set 228..320 CDD:254352
IGc2 242..312 CDD:197706
I-set 335..425 CDD:254352
Ig 350..423 CDD:143165
Ig 436..530 CDD:299845
I-set 438..532 CDD:254352
I-set 545..636 CDD:254352
Ig 560..633 CDD:143165
Ig 657..731 CDD:143165
I-set 746..835 CDD:254352
Ig 1496..1586 CDD:299845
IG_like 1503..1588 CDD:214653
I-set 1639..1724 CDD:254352
IG 1750..1821 CDD:214652
IGc2 1750..1806 CDD:197706
I-set 1826..1909 CDD:254352
Ig 1831..1897 CDD:299845
I-set 1914..1998 CDD:254352
Ig 2020..2095 CDD:299845
FN3 2100..2194 CDD:238020
FN3 2203..2292 CDD:238020
I-set 2311..2395 CDD:254352
Ig 2321..2395 CDD:299845
FN3 2399..2493 CDD:238020
FN3 2501..2590 CDD:238020
I-set 2602..2693 CDD:254352
Ig 2619..2693 CDD:299845
FN3 2697..2793 CDD:238020
FN3 2801..2893 CDD:238020
I-set 2902..2995 CDD:254352
Ig 2919..2993 CDD:299845
FN3 2999..3088 CDD:238020
FN3 3102..3191 CDD:238020
I-set 3208..3292 CDD:254352
Ig 3219..3292 CDD:299845
FN3 3296..3390 CDD:238020
FN3 3400..3489 CDD:238020
I-set 3494..3590 CDD:254352
Ig 3516..3590 CDD:299845
FN3 3594..3682 CDD:238020
FN3 3694..3781 CDD:238020
I-set 3795..3885 CDD:254352
Ig 3813..3885 CDD:299845
FN3 3889..3980 CDD:238020
FN3 3990..4082 CDD:238020
I-set 4090..4181 CDD:254352
Ig 4108..4181 CDD:299845
FN3 4185..4271 CDD:238020
FN3 4285..4383 CDD:238020
Ig 4404..4480 CDD:299845
FN3 4484..4571 CDD:238020
FN3 4584..4677 CDD:238020
I-set 4685..4775 CDD:254352
Ig 4703..4775 CDD:299845
FN3 4779..4863 CDD:238020
FN3 4879..4970 CDD:238020
IG 4989..5069 CDD:214652
Ig 4996..5069 CDD:299845
FN3 5073..5166 CDD:238020
FN3 5175..5265 CDD:238020
I-set 5276..5366 CDD:254352
Ig 5293..5366 CDD:299845
FN3 5370..5462 CDD:238020
FN3 5470..5561 CDD:238020
Ig 5559..5654 CDD:299845
I-set 5570..5660 CDD:254352
FN3 5664..5755 CDD:238020
FN3 5764..5853 CDD:238020
I-set 5865..5954 CDD:254352
Ig 5882..5954 CDD:299845
FN3 5958..6049 CDD:238020
FN3 6062..6153 CDD:238020
I-set 6173..6255 CDD:254352
Ig_Titin_like 6182..6255 CDD:143225
FN3 6259..6350 CDD:238020
FN3 6359..6451 CDD:238020
FN3 6470..6552 CDD:238020
I-set 6564..6650 CDD:254352
Ig_Titin_like 6577..6650 CDD:143225
FN3 6654..6745 CDD:238020
FN3 6754..6840 CDD:238020
I-set 6855..6946 CDD:254352
Ig 6874..6946 CDD:299845
FN3 6950..7042 CDD:238020
FN3 7050..7139 CDD:238020 19/74 (26%)
FN3 7151..7237 CDD:238020 18/116 (16%)
I-set 7254..7334 CDD:254352 25/81 (31%)
Ig 7272..7339 CDD:143165 23/68 (34%)
IG_like 7354..7440 CDD:214653 13/85 (15%)
Ig 7366..7440 CDD:299845 9/73 (12%)
FN3 7444..7531 CDD:238020 17/86 (20%)
FN3 7545..7637 CDD:238020 21/101 (21%)
I-set 7648..7737 CDD:254352 17/94 (18%)
Ig 7665..7734 CDD:143165 10/72 (14%)
Ig 7760..7833 CDD:299845 12/74 (16%)
FN3 7837..7927 CDD:238020 11/91 (12%)
STKc_Twitchin_like 7986..8244 CDD:271016 62/279 (22%)
S_TKc 7989..8244 CDD:214567 62/276 (22%)
Ig 8311..8394 CDD:299845
I-set 8312..8401 CDD:254352
I-set 8437..8525 CDD:254352
Ig 8455..8519 CDD:143165
I-set 8632..8721 CDD:254352
IGc2 8646..8711 CDD:197706
I-set 8740..8831 CDD:254352
Ig 8757..8826 CDD:143165
I-set 8839..8922 CDD:254352
Ig 8845..>8909 CDD:299845
muskNP_001004503.1 I-set 26..108 CDD:254352 18/71 (25%)
Ig 37..108 CDD:299845 18/71 (25%)
IG_like 124..205 CDD:214653 16/110 (15%)
Ig 136..198 CDD:299845 15/91 (16%)
I-set 210..298 CDD:254352 28/101 (28%)
Ig 212..300 CDD:299845 29/109 (27%)
CRD_TK_ROR_related 309..449 CDD:143578 38/245 (16%)
KR 454..536 CDD:214527 27/134 (20%)
PTKc_Musk 640..930 CDD:133181 68/388 (18%)
Pkinase_Tyr 646..928 CDD:285015 65/351 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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