DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bt and HSPG2

DIOPT Version :9

Sequence 1:	NP_001162825.1	Gene:	bt / 43814	FlyBaseID:	FBgn0005666	Length:	8933	Species:	Drosophila melanogaster
Sequence 2:	XP_011539620.1	Gene:	HSPG2 / 3339	HGNCID:	5273	Length:	4574	Species:	Homo sapiens

Alignment Length:	4945	Identity:	922/4945 - (18%)
Similarity:	1424/4945 - (28%)	Gaps:	1856/4945 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly  4657 RVVALNKG-----GLSEPSDPSKIFTAKPRY-----------LAPKIDRRNLRNITLSSG----T 4701
            |::|:..|     |||.|.|...:..::.|:           ||..|...:|.:..|.||    .
Human    18 RLLAVTHGLRAYDGLSLPEDIETVTASQMRWTHSYLSDDEDMLADSISGDDLGSGDLGSGDFQMV 82

  Fly  4702 ALKLDANITG--EPAPKVEWKLSNYHLQSGKNVTIETPDYYTKLVIRPTQRSDSGEYLVTAT--- 4761
            ..:...|.|.  |.:|::|...|....:..:.|.......|.|:         .|:.:|:..
Human    83 YFRALVNFTRSIEYSPQLEDAGSREFREVSEAVVDTLESEYLKI---------PGDQVVSVVFIK 138

  Fly  4762 ----------------NTSGK--DSVLVNVV---------------------ITDKPSPPNGPLQ 4787
                            |..|.  ..:|:.|:                     ....|.||...:.
Human   139 ELDGWVFVELDVGSEGNADGAQIQEMLLRVISSGSVASYVTSPQGFQFRRLGTAQTPPPPPAAVA 203

  Fly  4788 ISDVHKEGCHLKWKRPSDDGGTPIEYFQIDKLEPETGCWI--------------PSCRSTEPQVD 4838
            ::                  .||:..|.....|.|..|..              |.||....:::
Human   204 VA------------------VTPVPQFPRACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELN 250

  Fly  4839 ----VTGLSPGNEYKFRVSAVNAEGES------------QPLV---------GDESIVARN---- 4874
                |.|:||........:::....|:            |||:         |.:....||
Human   251 CEEPVLGISPTFSLLVETTSLPPRPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCI 315

  Fly  4875 PFD---------EPGKPENLKATDWDKDHVDLAWTPPLIDGGSPISCYIIEKQDKYGK-----WE 4925
            |.|         |.|..|                    :|.|.|..|...|.....|.     |.
Human   316 PRDYLCDGQEDCEDGSDE--------------------LDCGPPPPCEPNEFPCGNGHCALKLWR 360

  Fly  4926 RALDVPAD------QCKATIPDLVEGQTYKFRVSAVN-----AAGTGEPSD---------STPPI 4970
            ...|...:      .|....|:.|.|.| :||..:.|     :....|.||         ..||.
Human   361 CDGDFDCEDRTDEANCPTKRPEEVCGPT-QFRCVSTNMCIPASFHCDEESDCPDRSDEFGCMPPQ 424

  Fly  4971 IAKARNKPPIIDRSSLVEVRIKAGQSFTFDCKVSGEPAPQTKWLLKKKEVYSKDNVKVTNVDYNT 5035
            :.    .||   |.|   ::...||:.||.|...|.|.|...|.|....:.|...|.||:.....
Human   425 VV----TPP---RES---IQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRG 479

  Fly  5036 KLKVNSATRSDSGIYTVFAENANG---------------------------EDSA---------- 5063
            .|.:.....||.|.||..|.||.|                           |.||
Human   480 TLIIRDVKESDQGAYTCEAMNARGMVFGIPDGVLELVPQRAGPCPDGHFYLEHSAACLPCFCFGI 544

  Fly  5064 ----------------------DVKVTVIDKPAPPNGP------LKVDEINSESCTLH------- 5093
                                  |.|...:..||.|..|      |::|.      :||
Human   545 TSVCQSTRRFRDQIRLRFDQPDDFKGVNVTMPAQPGTPPLSSTQLQIDP------SLHEFQLVDL 603

  Fly  5094 ----------WNPPDDDGGQPIDNYVVEKLDETTGRWIPAGETDGPVTALKVGGLTPGHKYKFRV 5148
                      |..|:...|..:|:|                                |...::.|
Human   604 SRRFLVHDSFWALPEQFLGNKVDSY--------------------------------GGSLRYNV 636

  Fly  5149 RAKNRQGTSEPLTTAQAIIAKNPF------DVPTKPGTPTIKDFDKEFVDLEWTRPEADGGSPI- 5206
            |.:..:|..||:.....::....:      ..||:||  .:.....:|.:..|..   :.|.|:
Human   637 RYELARGMLEPVQRPDVVLMGAGYRLLSRGHTPTQPG--ALNQRQVQFSEEHWVH---ESGRPVQ 696

  Fly  5207 -----------------TGYVVEKRDKFSPDWEKCAEISDDITNAHVPDLIEGLKYEFRVRAVNK 5254
                             |.|..:...      ...::|:.|.|..|...       ..|..:|.:
Human   697 RAELLQVLQSLEAVLIQTVYNTKMAS------VGLSDIAMDTTVTHATS-------HGRAHSVEE 748

  Fly  5255 AG-----PGSPSDATETHVARPKNTP-----PKIDRNFMSDIKIKAGNVFEFDVPVTGEPLPSKD 5309
            ..     .|...::.:.|..|....|     ...:.|         |:....| ||.|..|..:.
Human   749 CRCPIGYSGLSCESCDAHFTRVPGGPYLGTCSGCNCN---------GHASSCD-PVYGHCLNCQH 803

  Fly  5310 WTHEGNMIINTDRVKISNFDDRTKIR----------ILDAKR--SDT------GVYTLTARNING 5356
            .| ||.   ..::.|...|.|..|..          .:||.|  |||      |..|..|.....
Human   804 NT-EGP---QCNKCKAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCDACAPGY 864

  Fly  5357 TDRHNVKVTILDAPSVPEGPLRNGDVSK--NSIVLRWRPPKDDGGSEITHYVVEKMDNEAMRWVP 5419
            |.|.....    ||.....|::.|...:  |..::|.    |:.||..|       ..||.|
Human   865 TGRRCESC----APGYEGNPIQPGGKCRPVNQEIVRC----DERGSMGT-------SGEACR--- 911

  Fly  5420 VGDCTDTEI-RADNLIENHDYSFRVRAVNK--------QGQSQPLTTSQPITAKDPYSHPDKPGQ 5475
               |.:..: |..|  |..|.||.:...|.        .|.|:..|:|....|: .:...::||.
Human   912 ---CKNNVVGRLCN--ECADGSFHLSTRNPDGCLKCFCMGVSRHCTSSSWSRAQ-LHGASEEPGH 970

  Fly  5476 PQATD----------------------------WGKHFVDLEWSTPKRDGGAPISSYIIEKR--- 5509
            ...|:                            .|.:|    ||.|.|..|..::||..|.|
Human   971 FSLTNAASTHTTNEGIFSPTPGELGFSSFHRLLSGPYF----WSLPSRFLGDKVTSYGGELRFTV 1031

  Fly  5510 ---------PKFGQWERAAVVLGDN--CKAHVPELTNGGEYEFRVIAVNRGGPSDPSDPSSTIIC 5563
                     |..||  ...|:.|:|  .:.||.:                 .|| |..||:
Human  1032 TQRSQPGSTPLHGQ--PLVVLQGNNIILEHHVAQ-----------------EPS-PGQPST---- 1072

  Fly  5564 KPRFLAPFFDKSL-------------------LNDITVHA------------GKRLGWTLPIEAS 5597
               |:.||.:::.                   ::.:.:.|            |..:...:|.|..
Human  1073 ---FIVPFREQAWQRPDGQPATREHLLMALAGIDTLLIRASYAQQPAESRVSGISMDVAVPEETG 1134

  Fly  5598 PRPLITWL-------YNGKEI----GSNSRGESGLFQNELTFEIVSSLRSDEGRYTLILKNEHGS 5651
            ..|.:...       |.|...    ...:|..|||:..  |.|..|.....|.     .:.|.|:
Human  1135 QDPALEVEQCSCPPGYRGPSCQDCDTGYTRTPSGLYLG--TCERCSCHGHSEA-----CEPETGA 1192

  Fly  5652 FDASAHATVLDRPSPPKGPL----------DITKITRDGCHL--TWNVP-----------DDDG- 5692
            .....|.|        :||.          |..:.|...|.|  .:..|           |.||
Human  1193 CQGCQHHT--------EGPRCEQCQPGYYGDAQRGTPQDCQLCPCYGDPAAGQAAHTCFLDTDGH 1249

  Fly  5693 -----------------------GSPILHYIIEKMDL-------------SRSTWSDAGMSTHIV 5721
                                   |:|......::...             |.|:..||.......
Human  1250 PTCDACSPGHSGRHCERCAPGYYGNPSQGQPCQRDSQVPGPIGCNCDPQGSVSSQCDAAGQCQCK 1314

  Fly  5722 HDVTRLV--HRKEYLFRVKAVN----------AIGESDPLEAVNTIIAKNEFDEPDAPGKPIITD 5774
            ..|..|.  |.:.:.|.:.|.|          .|.:.....|....:....|...|..|..::..
Human  1315 AQVEGLTCSHCRPHHFHLSASNPDGCLPCFCMGITQQCASSAYTRHLISTHFAPGDFQGFALVNP 1379

  Fly  5775 WDRDHIDLQWAVPKSDGGAPISEYIIQKKEKGSPYWTNVRHVPSNKNTTTIPELTEGQEYEFRVI 5839
            .....:..::.|.....||.:|.....:....|.||             .:||..:|.:.|....
Human  1380 QRNSRLTGEFTVEPVPEGAQLSFGNFAQLGHESFYW-------------QLPETYQGDKGEAYFA 1431

  Fly  5840 AVNQAGQSEPSEPSDMIMAK------PRYLPP--KIITPLNEVRIKCGLIFHTDIHFIGEPAPEA 5896
            .:.:|.|    ....|.:|.      .|.|||  :..|.|:|.:::..:....    |.||....
Human  1432 RMRRAHQ----RTLPMALAPGLWEVLARLLPPFHQNRTSLSEEQLRAAVTAGR----IPEPPEGR 1488

  Fly  5897 TWTLNSNPLLSNDRSTITSIGHHSVVHTVNCQRSDSGIYHLLLRNSSGIDEGSFELVVLDRPGPP 5961
            .|...::.:....|                  |.|:.|:.||         .||  ....:| ||
Human  1489 DWAQRASQVDEAQR------------------RMDAEIWQLL---------SSF--AAQPQP-PP 1523

  Fly  5962 EGPMEYEEITANSVTISWKPPKDNGGSEISSYVIEKRDLTHGGGWVPAVNYVSAKYNHAVVPRLL 6026
            :|...:.:..|   .:...||..:..|..||    ...|:...|...:::|....        ||
Human  1524 QGLSPHPQPAA---ALRAAPPPSSSSSSSSS----SASLSFSPGSQFSLSYEGFS--------LL 1573

  Fly  6027 EGTMYELRVMAENLQGRSDPLTSDQPVVA---KSQYTV---PGAPGKPELTDSD----KNHITIK 6081
            .|::|..::....|..:         |.|   |.:||:   .|..|.| |:|.|    .|:|.:.
Human  1574 PGSLYYWQLPRAFLGDK---------VAAYGGKLRYTLSYTAGPQGSP-LSDPDVQITGNNIMLV 1628

  Fly  6082 WKQPISNGGSPIIGYDIERRDVNTGRWIKINGQPVPTAEY-------QDD---RVT-SNHQYQYR 6135
            ..||...|... ..|:|..|:   ..|.:.:|||. |.|:       .|:   |.| |:......
Human  1629 ASQPALQGPER-RSYEIMFRE---EFWRRPDGQPA-TREHLLMALADLDELLIRATFSSVPLAAS 1688

  Fly  6136 ISAVN--AAGNGKTSEPSAIFNARPLREKPRFYFDGLIGKRIK------VRAGEPVNLNIPISGA 6192
            ||||:  .|..|.::.|.|: .....|..|     |.||...:      .|.|..:.|
Human  1689 ISAVSLEVAQPGPSNRPRAL-EVEECRCPP-----GYIGLSCQDCAPGYTRTGSGLYL------- 1740

  Fly  6193 PTPTIEWKRGDLKLEEGKRISYETNSERTLFR-----IDDSNRRDSGKY-TVTAANEFGKDTADI 6251
                     |..:|       .|.|....|..     ........:|:: .:.|...:|..||
Human  1741 ---------GHCEL-------CECNGHSDLCHPETGACSQCQHNAAGEFCELCAPGYYGDATA-- 1787

  Fly  6252 EVIVVDKPSPPEG--PLSYTETAPDHISLHWYSPKDDGGSDIT----GYIIEFTEFGVDDWKPVP 6310
                    ..||.  |.:...|.|:::..........||...|    ||..::.|.....:...|
Human  1788 --------GTPEDCQPCACPLTNPENMFSRTCESLGAGGYRCTACEPGYTGQYCEQCGPGYVGNP 1844

  Fly  6311 ----GTC-PNTN--------FTVKNLV-EGKKYVFRIRAEN-----IYGASEALEGKPVLAKSPF 6356
                |.| |.||        ...:::| :|..:..|.:...     .|.:.|  :|:||
Human  1845 SVQGGQCLPETNQAPLVVEVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSRE--DGRPV------ 1901

  Fly  6357 DPPGA-----------PS-QPT-ISAYTPNSANLEWHPPD---------DCGGKPITGYIVERRE 6399
             |.|.           || ||: ...|.....||  |..:         :...||||..:.|:|.
Human  1902 -PSGTQQRHQGSELHFPSVQPSDAGVYICTCRNL--HQSNTSRAELLVTEAPSKPITVTVEEQRS 1963

  Fly  6400 R----GGE-----------------WIKCNNYPTP------NTSYTVSN--LRDGARY------- 6428
            :    |.:                 |.:.:|...|      |...|:.|  |.|...|
Human  1964 QSVRPGADVTFICTAKSKSPAYTLVWTRLHNGKLPTRAMDFNGILTIRNVQLSDAGTYVCTGSNM 2028

  Fly  6429 -----EFRVLAVNEAGPGHPSKPSDPMTAEHQRYRPDPPEPPKPDRITRNGVTLSWRPPRTDGKS 6488
                 ....|.|..:|     ..|.|:.:.|      ||:             |:.:|
Human  2029 FAMDQGTATLHVQASG-----TLSAPVVSIH------PPQ-------------LTVQP------- 2062

  Fly  6489 RIKGYYVEMR------PKNGKDWK--TVNDIP----INSTVYTVPSLKEGEEYSFRVVAENEVGR 6541
               |...|.|      |....:|.  ....:|    |:..:..:|:::..::..:...|.:..|:
Human  2063 ---GQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIHGGILRLPAVEPTDQAQYLCRAHSSAGQ 2124

  Fly  6542 ------------SDPSKPSQPITIEEQPNKPCMELGKVRDIVCRAGDDFSIHVPYLAFPKPNAFW 6594
                        ..|       .::..|.:..:..|:...:.|||.          ..|.....|
Human  2125 QVARAVLHVHGGGGP-------RVQVSPERTQVHAGRTVRLYCRAA----------GVPSATITW 2172

  Fly  6595 YSNDNMLDDNNRVHKHLTDDAASVVVKNSKRADSGQYRLQLKNTSGFDTATINVRVL---DRPSP 6656
            ......|....|..:   .|.|::::.....||:|.|.....:.:|...|.|.|.||   |...|
Human  2173 RKEGGSLPPQARSER---TDIATLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPP 2234

  Fly  6657 PTRLRADEFSGDSLTLYWNPPNDDGGSAIQNYIIEKKEARSSTWSKVSSFCTVPFVRIRNLVLNK 6721
            |.::   |.|..|:|        :|.:...|.::........||.:... ...|..::....|
Human  2235 PVKI---ESSSPSVT--------EGQTLDLNCVVAGSAHAQVTWYRRGG-SLPPHTQVHGSRL-- 2285

  Fly  6722 EYDFRVIAENKYGQSDPANTSEPILARHPFDIPNTPGIPHGIDSTEDSITIAWTKPKHDGGS--P 6784
                      :..|..||::.|.:..           :.:|....|.|||::.....|.|.|  |
Human  2286 ----------RLPQVSPADSGEYVCR-----------VENGSGPKEASITVSVLHGTHSGPSYTP 2329

  Fly  6785 ITGYIIEKRLLSDDKWTKAVHALCPDLSCKIPNLIENAEYEFRVAAVNAAGQSAYSGSSDLIFCR 6849
            :.|.....|:............|  ||:|.:|                  ||:
Human  2330 VPGSTRPIRIEPSSSHVAEGQTL--DLNCVVP------------------GQA------------ 2362

  Fly  6850 RPPHAP----KITSDLSIRDMTVIAGDEFRITVPYHASPRPTASWSLNGLEVIPGERIKFDSNDY 6910
               ||.    |....|..|..|             |.|       .|...:|.|.
Human  2363 ---HAQVTWHKRGGSLPARHQT-------------HGS-------LLRLHQVTPA---------- 2394

  Fly  6911 ASMYYNKSAKRDETGSYTITLTNNKGSDTASCHVTVVDRPLPPQGPLNAYDITPDTCTLAWKTPL 6975
                        ::|.|...:....|...||..||:....:|  ||:....|...:.|:|....|
Human  2395 ------------DSGEYVCHVVGTSGPLEASVLVTIEASVIP--GPIPPVRIESSSSTVAEGQTL 2445

  Fly  6976 DDGGSPITNYVVEKLDNSGSWVKISSF------VRNTHYDVMGLEPHYKYNFRVRAENQYGLSDP 7034
            |     ::..|..:.....:|.|....      ||.:...:....|.....:..||.|  |:...
Human  2446 D-----LSCVVAGQAHAQVTWYKRGGSLPARHQVRGSRLYIFQASPADAGQYVCRASN--GMEAS 2503

  Fly  7035 LDIIEPIVAKHQFTVPDEPGQPKVIDWDSGNVTLIWTRPLS---DGGSRIQ------GYQIEYRD 7090
            :.:............|....||..|:..|..|....|..|:   .|.|..|      |..:..|.
Human  2504 ITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSLPVRH 2568

  Fly  7091 ILNDSSWNAYDYIIKDTKYQLYNLINGSEYEFRIKAKNAAGLSKPSSPSLRFKLKGKFTVPSPPG 7155
            ..:.|....|.....|:          .||..|:     .|.|.|...|:...::...:||:...
Human  2569 QTHGSLLRLYQASPADS----------GEYVCRV-----LGSSVPLEASVLVTIEPAGSVPALGV 2618

  Fly  7156 APQVTRV--------------------GKNYVDLKWEKPLRDGGSRITGYIIERRDIGGAVWVKC 7200
            .|.| |:                    |:.:..:.|.|   .|||     :..|..:.|
Human  2619 TPTV-RIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHK---RGGS-----LPARHQVHG------ 2668

  Fly  7201 NDYNVLDTEYTVMNLIEM-----GDYEFRVFAVNSAGRSEPSLCTMPIKVCEVLGGKKPDWI--- 7257
                      :.:.|:::     |:|..||  |.|:|..|.|:.   :.:.:.|.|.....:
Human  2669 ----------SRLRLLQVTPADSGEYVCRV--VGSSGTQEASVL---VTIQQRLSGSHSQGVAYP 2718

  Fly  7258 TRLQDKVAPFGKDYT--LQCAASGKPSPTARWLRNGKEI----QMNGGRMTCDSKDGVFRLHISN 7316
            .|::...|.....:|  |.|..:.:...|..|.:.|..:    |:.|.           ||.|..
Human  2719 VRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIVGS-----------RLRIPQ 2772

  Fly  7317 VQTGDDGDYTCEAMNSLGFVNT----------SGYLKIGSPPIINRCPSELKLPEGDNSKIKIFY 7371
            |...|.|:|.|...|..|...|          |.::...||||.....|. .:.||....:....
Human  2773 VTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSP-TVVEGQTLDLNCVV 2836

  Fly  7372 SGDQPLTVILKKNNEVICDSNDDTHVKVNIFDDYVAIYIRNIVKSDGGPYQIEFTNESGSATGEF 7436
            : .||..:|..........|...||      ..::.::..::  :|.|.|.....|...:.....
Human  2837 A-RQPQAIITWYKRGGSLPSRHQTH------GSHLRLHQMSV--ADSGEYVCRANNNIDALEASI 2892

  Fly  7437 YVHIT---GMPSAPTGPMGISYINKNS-----------CM--------LNWRPPSYDGGLKVSHY 7479
            .:.::   |.||||...|.|...:.:|           |:        :.|..   .||...||:
Human  2893 VISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHK---RGGSLPSHH 2954

  Fly  7480 VIERKDVSSPHWITVSSTCKDTAFNVQGLIENQEYIFRVMAVNENGMGPPLEG--LNPIRA--KD 7540
            ......:...|   ||..            ::.||:.|||     |...|||.  |..|.|  ..
Human  2955 QTRGSRLRLHH---VSPA------------DSGEYVCRVM-----GSSGPLEASVLVTIEASGSS 2999

  Fly  7541 PIDPPSPPGSP---------QITEIGGDFVHLEWEKPESDGGAHIQGYWIDKREVGSNTWQR--V 7594
            .:..|:|.|:|         ::.|  |..:.|:...|   |.||.|..| .||  |.|...|  |
Human  3000 AVHVPAPGGAPPIRIEPSSSRVAE--GQTLDLKCVVP---GQAHAQVTW-HKR--GGNLPARHQV 3056

  Fly  7595 NATICAANQINCINLIEGRQYEFRIFAQNVAGLSTESSASQAVKIIDPQAASP---PLIVKPL-- 7654
            :..:...||::..:..|        ::..|.|.|....||..| .|:|.:..|   |.:.:|:
Human  3057 HGPLLRLNQVSPADSGE--------YSCQVTGSSGTLEASVLV-TIEPSSPGPIPAPGLAQPIYI 3112

  Fly  7655 --RDANCIQNHNAQFTCTINGVPKPTISWYK-----GAREISNGA--RYHMYSEGDNHFLNINDV 7710
              ..::..:.......|.:.|.....::|||     .||..::|:  |.|:.|..
Human  3113 EASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSQLRLHLVSPA---------- 3167

  Fly  7711 FGEDADEYVCRAVNKAGAKSTRATLAIMTAPKLNVPPRFRDTAYFDKGENVVIKIPFTGFPKPRI 7775
               |:.||||||.:..|.:. .|:..:      .|||        .:|.:..::.|......|
Human  3168 ---DSGEYVCRAASGPGPEQ-EASFTV------TVPP--------SEGSSYRLRSPVISIDPP-- 3212

  Fly  7776 HWVRDGENIESGGHYTVEVKERHAVLIIRDGSHLDSGPYRITAENELGSDTAIIQVQISDRPDPP 7840
                 ...::.|                :|.|
Human  3213 -----SSTVQQG----------------QDAS--------------------------------- 3223

  Fly  7841 RFPLIESIGTESLSLSWKAPVWDGCSDITNYYVERREH--PLSSWIRVGNTRFTSMAVSGLTPGK 7903
             |..:...|...:||.||.         .|..:|...|  |..|.|.:..||          |..
Human  3224 -FKCLIHDGAAPISLEWKT---------RNQELEDNVHISPNGSIITIVGTR----------PSN 3268

  Fly  7904 EYDFRIFADNVYGRSDASDTSTLIKTKESVKKKPIERKWEIDANGRKLRGKADGPVKDYDSYVFD 7968
            ...:|..|.|.||.:. |..:..:....:|...|                  :|||
Human  3269 HGTYRCVASNAYGVAQ-SVVNLSVHGPPTVSVLP------------------EGPV--------- 3305

  Fly  7969 IYSKFVPQPVEISQQSVYDRYDILEEIGTGAFGVVHRCRERSTGNIFAAKFIPVSHSVEKDLIRR 8033
                                                              ::.|..:|
Human  3306 --------------------------------------------------WVKVGKAV------- 3313

  Fly  8034 EIDIMNQLHHQKLINLHDAFEDDDEMILILEFLSGGELFERITAEGYVMTEAEVINYMRQICEGI 8098
                                        .||.:|.||
Human  3314 ----------------------------TLECVSAGE---------------------------- 3322

  Fly  8099 RHMHEQNIIHLDIKPENIMCQTR-SSTNVKLID--FGLATRLDPNEVVKITTGTAEFAAPEIVNR 8160
                          |.:....|| |||..||..  :||   :|.:.|::|::.....|.
Human  3323 --------------PRSSARWTRISSTPAKLEQRTYGL---MDSHAVLQISSAKPSDAG------ 3364

  Fly  8161 EPVGFYTDMWATGVLSYVLLSGLSPFAGDNDVQTLKNVKACDWDFDVESFKYISEEAKDFIRKLL 8225
                           :||.|:       .|.:.|
Human  3365 ---------------TYVCLA-------QNALGT------------------------------- 3376

  Fly  8226 VRNKEKRMTAHECLLHPWLTGDHSAMKQ-EINRDRYLAYREKLRRKYEDFERFLLPIGRLSEYSS 8289
                                    |.|| |:                      ::..|.::
Human  3377 ------------------------AQKQVEV----------------------IVDTGAMA---- 3391

  Fly  8290 LRKLLMEKYKIHDAVFDRRQAAPRFVIRPSSQFCYEGQSVKFYCRCIAIATPTLTWSHNNIELRQ 8354
                               ..||:.....:......|.:....|.......||:.||    :||.
Human  3392 -------------------PGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWS----KLRS 3433

  Fly  8355 SVKFMKRYVGDDYYFIINRVKLDDRGEYIIRAENHYGSREEVVFLNVQPLPKEQPRYRTESTPVR 8419
            .:.:..|..||.  .||.||...|.|:||..|.:..|..|..:.|:|     |.|.|.|
Human  3434 PLPWQHRLEGDT--LIIPRVAQQDSGQYICNATSPAGHAEATIILHV-----ESPPYAT------ 3485

  Fly  8420 RREPLPYTFWQEESETAPSFTFLLRPRVMQARDTCKLLCCLSGKPVPNVRWYKDG---------- 8474
                           |.|...      .:||.:|.:|.|...|.|....:|.:.|
Human  3486 ---------------TVPEHA------SVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRATAR 3529

  Fly  8475 RELSKYEYAMTHSDGVVTMEIIDCKPSDSGKYSCKATNCHGTDETDCVVIVEGEWVTPEQAQLAH 8539
            .||..:|.|               .|.|||:|.|:.||..|:.|....::|:|.
Human  3530 NELLHFERA---------------APEDSGRYRCRVTNKVGSAEAFAQLLVQGP----------- 3568

  Fly  8540 NFLYSGDRKYIEQPIKPAPLPIVTSRQYTSS---SVQ-NTSEP-----------QGDKVNVSNSN 8589
                .|.......|....|...||.:..|.|   ||: :.:.|           :|.::...:|.
Human  3569 ----PGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSV 3629

  Fly  8590 SSG---ISNKKKYASNS--LQAPGSPSRSRSATKELILPPDDSLMCKPEFTKPLHDLTIHDGEQL 8649
            ..|   |.|..:....:  .||.| |.....|:.:|::....|::.....:..    |:..|..:
Human  3630 QDGVLRIQNLDQSCQGTYICQAHG-PWGKAQASAQLVIQALPSVLINIRTSVQ----TVVVGHAV 3689

  Fly  8650 ILTCYVKGDPEPQISWSKNGKSLSSSDILDLRYKNGIATLTINEVFPEDEGVITCTATNSVGAVE 8714
            ...|...|||:||::|||.|..|....:    ...|:..:...|:  .|.|...|||||:.|..:
Human  3690 EFECLALGDPKPQVTWSKVGGHLRPGIV----QSGGVVRIAHVEL--ADAGQYRCTATNAAGTTQ 3748

  Fly  8715 TKCKLTIQPLDKNINKRKVNAGDNAPKIVSHLESRFVRDGDAVNLACRIIGAQHFDVVWLHNNKE 8779
            :...|.:|.|               |:|....|.| |..|.|....|...|....|:.|...:..
Human  3749 SHVLLLVQAL---------------PQISMPQEVR-VPAGSAAVFPCIASGYPTPDISWSKLDGS 3797

  Fly  8780 IKPSKDFQYTNEANIYRLQIAEIFPEDGGTYTCEAFNDIG--ESFSTCTINVTVPGDETKQP-SF 8841
            :.|  |.:..|.    .|.:..:.|:|.|||.|.|.|..|  ::|:...:...|....|:.| ||
Human  3798 LPP--DSRLENN----MLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQVPERVVPYFTQTPYSF 3856

  Fly  8842 VKFPT 8846
            :..||
Human  3857 LPLPT 3861

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bt	NP_001162825.1	I-set	9..101	CDD:254352
		Ig	26..100	CDD:143165
		I-set	119..210	CDD:254352
		Ig	136..209	CDD:143165
		I-set	228..320	CDD:254352
		IGc2	242..312	CDD:197706
		I-set	335..425	CDD:254352
		Ig	350..423	CDD:143165
		Ig	436..530	CDD:299845
		I-set	438..532	CDD:254352
		I-set	545..636	CDD:254352
		Ig	560..633	CDD:143165
		Ig	657..731	CDD:143165
		I-set	746..835	CDD:254352
		Ig	1496..1586	CDD:299845
		IG_like	1503..1588	CDD:214653
		I-set	1639..1724	CDD:254352
		IG	1750..1821	CDD:214652
		IGc2	1750..1806	CDD:197706
		I-set	1826..1909	CDD:254352
		Ig	1831..1897	CDD:299845
		I-set	1914..1998	CDD:254352
		Ig	2020..2095	CDD:299845
		FN3	2100..2194	CDD:238020
		FN3	2203..2292	CDD:238020
		I-set	2311..2395	CDD:254352
		Ig	2321..2395	CDD:299845
		FN3	2399..2493	CDD:238020
		FN3	2501..2590	CDD:238020
		I-set	2602..2693	CDD:254352
		Ig	2619..2693	CDD:299845
		FN3	2697..2793	CDD:238020
		FN3	2801..2893	CDD:238020
		I-set	2902..2995	CDD:254352
		Ig	2919..2993	CDD:299845
		FN3	2999..3088	CDD:238020
		FN3	3102..3191	CDD:238020
		I-set	3208..3292	CDD:254352
		Ig	3219..3292	CDD:299845
		FN3	3296..3390	CDD:238020
		FN3	3400..3489	CDD:238020
		I-set	3494..3590	CDD:254352
		Ig	3516..3590	CDD:299845
		FN3	3594..3682	CDD:238020
		FN3	3694..3781	CDD:238020
		I-set	3795..3885	CDD:254352
		Ig	3813..3885	CDD:299845
		FN3	3889..3980	CDD:238020
		FN3	3990..4082	CDD:238020
		I-set	4090..4181	CDD:254352
		Ig	4108..4181	CDD:299845
		FN3	4185..4271	CDD:238020
		FN3	4285..4383	CDD:238020
		Ig	4404..4480	CDD:299845
		FN3	4484..4571	CDD:238020
		FN3	4584..4677	CDD:238020	8/24 (33%)
		I-set	4685..4775	CDD:254352	20/137 (15%)
		Ig	4703..4775	CDD:299845	15/115 (13%)
		FN3	4779..4863	CDD:238020	17/113 (15%)
		FN3	4879..4970	CDD:238020	22/115 (19%)
		IG	4989..5069	CDD:214652	29/138 (21%)
		Ig	4996..5069	CDD:299845	27/131 (21%)
		FN3	5073..5166	CDD:238020	19/115 (17%)
		FN3	5175..5265	CDD:238020	17/112 (15%)
I-set	5276..5366	CDD:254352	25/107 (23%)
Ig	5293..5366	CDD:299845	23/90 (26%)
FN3	5370..5462	CDD:238020	24/102 (24%)
FN3	5470..5561	CDD:238020	27/132 (20%)
Ig	5559..5654	CDD:299845	20/136 (15%)
I-set	5570..5660	CDD:254352	20/131 (15%)
FN3	5664..5755	CDD:238020	24/162 (15%)
FN3	5764..5853	CDD:238020	15/88 (17%)
I-set	5865..5954	CDD:254352	16/90 (18%)
Ig	5882..5954	CDD:299845	12/71 (17%)
FN3	5958..6049	CDD:238020	18/90 (20%)
FN3	6062..6153	CDD:238020	31/107 (29%)
I-set	6173..6255	CDD:254352	13/93 (14%)
Ig_Titin_like	6182..6255	CDD:143225	11/78 (14%)
FN3	6259..6350	CDD:238020	23/115 (20%)
FN3	6359..6451	CDD:238020	30/154 (19%)
FN3	6470..6552	CDD:238020	13/105 (12%)
I-set	6564..6650	CDD:254352	18/85 (21%)
Ig_Titin_like	6577..6650	CDD:143225	14/72 (19%)
FN3	6654..6745	CDD:238020	16/90 (18%)
FN3	6754..6840	CDD:238020	18/87 (21%)
I-set	6855..6946	CDD:254352	15/94 (16%)
Ig	6874..6946	CDD:299845	11/71 (15%)
FN3	6950..7042	CDD:238020	18/97 (19%)
FN3	7050..7139	CDD:238020	22/97 (23%)
FN3	7151..7237	CDD:238020	21/110 (19%)
I-set	7254..7334	CDD:254352	19/88 (22%)
Ig	7272..7339	CDD:143165	19/82 (23%)
IG_like	7354..7440	CDD:214653	13/85 (15%)
Ig	7366..7440	CDD:299845	10/73 (14%)
FN3	7444..7531	CDD:238020	23/105 (22%)
FN3	7545..7637	CDD:238020	27/102 (26%)
I-set	7648..7737	CDD:254352	22/99 (22%)
Ig	7665..7734	CDD:143165	19/75 (25%)
Ig	7760..7833	CDD:299845	5/72 (7%)
FN3	7837..7927	CDD:238020	21/91 (23%)
STKc_Twitchin_like	7986..8244	CDD:271016	26/260 (10%)
S_TKc	7989..8244	CDD:214567	26/257 (10%)
Ig	8311..8394	CDD:299845	23/82 (28%)
I-set	8312..8401	CDD:254352	24/88 (27%)
I-set	8437..8525	CDD:254352	24/97 (25%)
Ig	8455..8519	CDD:143165	19/73 (26%)
I-set	8632..8721	CDD:254352	24/88 (27%)
IGc2	8646..8711	CDD:197706	21/64 (33%)
I-set	8740..8831	CDD:254352	25/92 (27%)
Ig	8757..8826	CDD:143165	18/70 (26%)
I-set	8839..8922	CDD:254352	5/9 (56%)
Ig	8845..>8909	CDD:299845	2/2 (100%)
HSPG2	XP_011539620.1	SEA	80..193	CDD:214554	15/121 (12%)
		LDLa	216..251	CDD:238060	6/34 (18%)
		LDLa	302..336	CDD:238060	8/53 (15%)
		LDLa	342..376	CDD:238060	5/33 (15%)
		LDLa	385..420	CDD:238060	8/35 (23%)
		IG	431..507	CDD:214652	25/78 (32%)
		Ig_Perlecan_D2_like	438..515	CDD:143220	24/76 (32%)
		LamB	608..734	CDD:214597	23/168 (14%)
		EGF_Lam	782..824	CDD:238012	13/55 (24%)
		EGF_Lam	831..888	CDD:238012	15/60 (25%)
		Laminin_EGF	897..939	CDD:278482	15/60 (25%)
		LamB	1003..1130	CDD:214597	29/157 (18%)
		EGF_Lam	1176..1225	CDD:238012	10/61 (16%)
		EGF_Lam	1227..1282	CDD:238012	6/54 (11%)
		Laminin_EGF	1293..1340	CDD:278482	10/46 (22%)
		LamB	1574..1699	CDD:214597	37/139 (27%)
		EGF_Lam	1746..1794	CDD:238012	10/57 (18%)
		Laminin_EGF	1796..1851	CDD:278482	10/54 (19%)
		Ig_2	1866..1958	CDD:290606	22/102 (22%)
		IG_like	1866..1946	CDD:214653	18/90 (20%)
		Ig3_Perlecan_like	1954..2039	CDD:143231	14/84 (17%)
		IG	1961..2040	CDD:214652	12/78 (15%)
		I-set	2049..2133	CDD:254352	16/112 (14%)
		Ig	2063..2133	CDD:299845	10/69 (14%)
		I-set	2139..2225	CDD:254352	20/105 (19%)
		IGc2	2153..2215	CDD:197706	14/74 (19%)
		IG_like	2240..2317	CDD:214653	18/108 (17%)
		IGc2	2247..2307	CDD:197706	11/83 (13%)
		IG	2341..2418	CDD:214652	24/153 (16%)
		IGc2	2348..2408	CDD:197706	20/136 (15%)
		IG_like	2434..2508	CDD:214653	14/80 (18%)
		IGc2	2441..2500	CDD:197706	11/65 (17%)
		IG_like	2530..2607	CDD:214653	19/91 (21%)
		IGc2	2537..2595	CDD:197706	13/72 (18%)
		I-set	2620..2703	CDD:254352	21/112 (19%)
		IGc2	2633..2693	CDD:197706	15/85 (18%)
		IG	2731..2800	CDD:214652	19/79 (24%)
		IGc2	2731..2790	CDD:197706	17/69 (25%)
		IG_like	2819..2896	CDD:214653	13/86 (15%)
		IGc2	2826..2885	CDD:197706	12/67 (18%)
		IG	2916..2993	CDD:214652	20/99 (20%)
		IGc2	2923..2983	CDD:197706	15/82 (18%)
		IG	3016..3093	CDD:214652	24/93 (26%)
		IGc2	3023..3083	CDD:197706	20/75 (27%)
		Ig_2	3112..3192	CDD:290606	20/99 (20%)
		IG_like	3115..3192	CDD:214653	20/96 (21%)
		I-set	3205..3291	CDD:254352	26/162 (16%)
		ig	3209..3289	CDD:278476	25/156 (16%)
		IG	3303..3385	CDD:214652	33/325 (10%)
		Ig	3313..3382	CDD:143165	28/231 (12%)
		IG	3404..3478	CDD:214652	23/79 (29%)
		IGc2	3409..3468	CDD:197706	20/64 (31%)
		I-set	3482..3565	CDD:254352	27/124 (22%)
		IGc2	3496..3555	CDD:197706	19/73 (26%)
		IG_like	3589..3666	CDD:214653	16/77 (21%)
		Ig	3600..3666	CDD:299845	13/66 (20%)
		I-set	3676..3755	CDD:254352	24/88 (27%)
		IGc2	3686..3745	CDD:197706	21/64 (33%)
		I-set	3764..3841	CDD:254352	23/83 (28%)
		Ig	3779..3834	CDD:299845	17/60 (28%)
		LamG	3848..4008	CDD:238058	6/14 (43%)
		EGF_CA	<4035..4064	CDD:238011
		LamG	4117..4266	CDD:238058
		EGF	4291..4321	CDD:278437
EGF_CA	4328..4359	CDD:238011
LamG	4386..4545	CDD:238058
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910