DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bt and Myom1

DIOPT Version :9

Sequence 1:	NP_001162825.1	Gene:	bt / 43814	FlyBaseID:	FBgn0005666	Length:	8933	Species:	Drosophila melanogaster
Sequence 2:	NP_001178513.1	Gene:	Myom1 / 316740	RGDID:	631436	Length:	1689	Species:	Rattus norvegicus

Alignment Length:	1854	Identity:	379/1854 - (20%)
Similarity:	603/1854 - (32%)	Gaps:	610/1854 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  5589 GWTLPIEASPRPLITWLYNGKEIGSNSRGESGLFQNEL---TFEIVSSLRSDEGRYTLILKNEHG 5650
            ||       |.|.:||..|...|..::..|..:.::..   |.||......|..:|.....|..|
  Rat   306 GW-------PEPRLTWYKNQVPINVHANPEKYIIESRYGMHTLEISKCDFEDTAQYRASAMNVQG 363

  Fly  5651 SFDASAHATVLDRPSPPKGPLDIT------------KITRDGCHLTWNVPDDD------------ 5691
              :.||:|:|:.:..  ||.||.:            .:|..|....:.:..||
  Rat   364 --EVSAYASVVVKRY--KGELDDSLLRGGVSMPLSFAVTPYGYASKFEIHFDDKFDVSFGREGET 424

  Fly  5692 ------------------------GGSPILHYIIEKMDLSRSTWSDAGMSTHIVHDVTRLVH--- 5729
                                    .|:|:          |.|.|    :..|...|...|..
  Rat   425 MSLGCRVVITPEIKHVQPEVQWYRNGAPV----------SPSKW----VQPHWSGDRATLTFSHL 475

  Fly  5730 RKE----YLFRVKAVNAIGESDPLEAVNTIIAKNEFDEPDAPGKP---IITDWDRDHIDLQWAVP 5787
            .||    |..||:    :||.....:....:...:.:...||..|   :..|.::|:|.:.|..|
  Rat   476 NKEDEGLYTIRVR----MGEYYEQYSAYVFVRDADAEIEGAPAAPLDVVSLDANKDYIIISWKQP 536

  Fly  5788 KSDGGAPISEYIIQKKEKGSPYWTNVRHVPSNKNTTTIPELTEGQEYEFRVIAVNQAGQSEPSEP 5852
            ..|||:||..|.|.|.|.|:..|:.....|.......:..|.||:.|.|||.|||:.|...||..
  Rat   537 AVDGGSPILGYFIDKCEVGTDTWSQCNDTPVKFARFPVTGLIEGRSYIFRVRAVNKTGIGLPSRV 601

  Fly  5853 SDMIMAKPRYLPPKIITPLNEVRIKCGLIFHTDIHFIGEPAPEATWTLNSNPLLSNDRSTITSIG 5917
            |:.:.|         :.|..:.|:|              ..|.|.||
  Rat   602 SEPVAA---------LDPAEKARLK--------------SRPSAPWT------------------ 625

  Fly  5918 HHSVVHTVNCQRSDSGIYHLLLRNSSGIDEGSFELVVLDRPGPPEGPMEYEEITANSVTISWKPP 5982
             ..::.|                     :|...|.|:   ||||. .:...|.|.:.|.:|||||
  Rat   626 -GQIIVT---------------------EEEPTEGVI---PGPPT-DLSVTEATRSYVVLSWKPP 664

  Fly  5983 KDNGGSEISSYVIEKRDLTHGG--GWVPAVNYVSAKYNHAVVPRLLEGTMYELRVMAENLQGRSD 6045
            ...|...| .|.:||.|:   |  .|......:..|.....:..|:||..|..||...|..|..:
  Rat   665 GQRGHEGI-MYFVEKCDV---GTENWQRVNTELPVKSPRFALFDLVEGKSYRFRVRCSNSAGVGE 725

  Fly  6046 PLTSDQPVVAKSQYTVPGAPGKPELTDSDKNHITIKWKQPISNGGSPIIGYDIERRDVNTGRWIK 6110
            |..|.:..|...:..:|.||||...:.:....:.:.|::  |.....::||.||...|.:|:|..
  Rat   726 PSESTEVTVVGDKLDIPKAPGKIIPSRNTDTSVVVSWEE--SKDAKELVGYYIESSVVGSGQWEP 788

  Fly  6111 INGQPVPTAEYQDDRVTSNHQYQYRISAVNAAGNGKTSEPSAIFNARPLREKPRFYFDGLIGKRI 6175
            .|..||..:.:....:|:...|.:|:.||||||..:.|:.|
  Rat   789 CNNNPVKGSRFTCHGLTTGQSYIFRVRAVNAAGLSEYSQDS------------------------ 829

  Fly  6176 KVRAGEPVNLNIPISGAPTPTIEWKRGDLKLEEGKRISYETNSERTLFRIDDSNRRDSGKYTVTA 6240
                 |.:.:...|.|..:|.: |.    :|.:            |...:.||....||....|:
  Rat   830 -----EAIEVKAAIGGGVSPDV-WP----QLSD------------TPGGLTDSGGAMSGASPPTS 872

  Fly  6241 ANEFGKDTADIEVIVVDKPSPPEGPLSYTETAPDHISLHWYSPKDDGGSDITGYIIEFTEFGVDD 6305
            .    ||.  :.....:|||||.                  ||.:.|..:::
  Rat   873 Q----KDA--LPSSKPNKPSPPS------------------SPSNRGQKEVS------------- 900

  Fly  6306 WKPVPGTCPNTNFTVKNLVEGKKYVFRIRAENIYGASEALEGKPVLAKSPFDPPGAPSQPTISAY 6370
                     ..|.:|:..:...       :..:....::..|.|...|.|...|..|...|....
  Rat   901 ---------KVNGSVQEELSPP-------SMEVASKEQSKSGPPEKKKDPVAVPSPPYDITCLES 949

  Fly  6371 TPNSANLEWHPPDDCGGKPITGYIVERRE----RGGEWIKCNNYPTPNTSYTVSNLRDGARYEFR 6431
            ..:|..|.|..||..||..||||.|..||    ..|:|.:.|.....:.:|.:|.|::...|:|:
  Rat   950 FRDSMVLGWKQPDKTGGAEITGYYVNYREVVGGVPGKWREANIKAVSDAAYKISELKENTVYQFQ 1014

  Fly  6432 VLAVNEAGPGHPSKPSDPMTAEHQRYR-PDPPEPPKPDRITRNGVTLSWRPPRTDGKSRIKGYYV 6495
            |.|:|.||.|.||..|:....|..... |.||...|...:.:|.:.|.|:||...|::.:.||:|
  Rat  1015 VSAMNIAGLGAPSAVSECFKCEEWTIAVPGPPHSLKLSEVRKNSLVLQWKPPVYSGRTPVTGYFV 1079

  Fly  6496 EMRPKNGKD--WKTVNDIPINSTVYTVPSLKEGEEYSFRVVAENEVGRSDPSKPSQPITIEEQPN 6558
            :::..:.||  |:.:|:..|.:....|..||||..|.|||.|.|:.|...||..:.|:..|.:|.
  Rat  1080 DLKEASAKDDQWRGLNEAAIPNKYLRVQGLKEGISYVFRVRAINQAGVGKPSDLAGPVVAETRPG 1144

  Fly  6559 KPCMELGKVRDIVCRAGDDFSIHVPY---LAFPKPNAFWYSNDNMLDDNNRVHKHLTDDAASVVV 6620
                    .:::|....||..|.:.:   ...||....|..:....:|:.|:......:...:|.
  Rat  1145 --------TKEVVVNVDDDGVISLNFECDQMTPKSEFVWSKDYVPSEDSPRLEVESKGNKTKMVF 1201

  Fly  6621 KNSKRADSGQYRLQLKNTSGFDTA-TINVRVLDR----------PSPPTRLR-ADEFSGDSLTLY 6673
            |:....|.|.|...:.:|.|..:: .|:...:.|          |:.||:.. |.|........:
  Rat  1202 KDLGPDDLGTYSCDVTDTDGIASSYLIDEEEMKRLLALSQEHKFPTVPTKSELAVEILEKGQVRF 1266

  Fly  6674 WNPPNDDGGSAIQNYIIEKKEARSSTWSKVSSFCTVPFVRIRNLVLNKEYDFRVIAENKYGQSDP 6738
            |.......|:|..|||..:||                                :....||.....
  Rat  1267 WMQAEKLSGNAKVNYIFNEKE--------------------------------IFEGPKYKMHID 1299

  Fly  6739 ANTSEPILARHPFDIPNTPGIPHGIDSTEDSITIAWTKPKHDGGSPITGYI-------IEKRLLS 6796
            .||..               |...::..:|.....:|....||.:  ||:.       :.|:|..
  Rat  1300 RNTGI---------------IEMFMEKLQDEDEGTYTFQIQDGKA--TGHSTLVLIGDVYKKLQK 1347

  Fly  6797 D-----DKWTKAVHALCPDLSCKIPNLIENAEYEFRVAAVNAAGQSAYSGSSDLIFCRRPPHAPK 6856
            :     .:|.:.          :.|:..|...:|             .:|..:::...:..:..|
  Rat  1348 EAEFQRQEWIRK----------QGPHFAEYLSWE-------------VTGECNVLLKCKVANIKK 1389

  Fly  6857 ITSDLSIRDMTVIAGDEFRITVPYHASPRPTASWSLNGLEVIPGERIKFDSND-YASMYYNKSAK 6920
            .|..:..:|...|:.||                              |.|..| ..::...:.:|
  Rat  1390 ETHIVWYKDEREISVDE------------------------------KHDFKDGICTLLITEFSK 1424

  Fly  6921 RDETGSYTITLTNNKGSDTASCHVTVVDRPLPPQGPLNAYDITPDTCTLAWKTPLDDGGSPITNY 6985
            :| .|.|.:.|.:::|.|.:  .:.:||...        .|:..:.|.....:..|
  Rat  1425 KD-AGFYEVILKDDRGKDKS--RLKLVDEAF--------QDLMTEVCRKIALSATD--------- 1469

  Fly  6986 VVEKLDNSGSWVKISSFVRNTHYDVMGLEPHYKYNFRVRAENQYGLSDPLDIIEPIVAKHQFTVP 7050
              .|:.::...:::.|||  .:|                          ||.::
  Rat  1470 --LKIQSTAEGIRLYSFV--CYY--------------------------LDDLK----------- 1493

  Fly  7051 DEPGQPKVIDWDSGNVTLIWTRPLSDGGSRIQGYQIEYRDILNDSSWNAYDYIIKDTKYQLYNLI 7115
                    ::|......:.:|..:..|   :.|.||..:  :|:.:.|.
  Rat  1494 --------VNWSHNGTGIKYTDRVKSG---VTGEQIWLQ--INEPTQND---------------- 1529

  Fly  7116 NGSEYEFRIKAKNAAGLSKPSSPSLRFKLKGKFTVPSPPGAPQVTRVGKNYVDLKWEKPLRDGGS 7180
                                         |||:.:                       .|.||.
  Rat  1530 -----------------------------KGKYVM-----------------------ELFDGK- 1541

  Fly  7181 RITGYIIERRDIGGAVWVKCNDYNVLDTEYTVMNLIEMGDYEFRVF-AVNSAGRSEPSLCTMPIK 7244
              ||: .:..|:.|..:                      |..|..| .:..|..:|.:.
  Rat  1542 --TGH-QKSVDLSGQAF----------------------DEAFAEFQRLKQAAIAEKNR------ 1575

  Fly  7245 VCEVLGGKKPDWITRLQDKVAPFGKDYTLQCAASGKPSPTARWLRNGKEIQMNGGRMTCD----- 7304
             ..|||| .||.:| :|:     ||...|.|...|.|:|...||:|.|.       :|.|
  Rat  1576 -ARVLGG-LPDVVT-IQE-----GKALNLTCNVWGDPTPEVSWLKNEKP-------LTSDDHCSL 1625

  Fly  7305 ----SKDGVFRLHISNVQTGDDGDYTCEAMNSLG 7334
                .|...|.  ||.|.|.|.|.|.....|..|
  Rat  1626 KFEAGKTAFFT--ISGVSTADSGKYGLVVKNKYG 1657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bt	NP_001162825.1	I-set	9..101	CDD:254352
		Ig	26..100	CDD:143165
		I-set	119..210	CDD:254352
		Ig	136..209	CDD:143165
		I-set	228..320	CDD:254352
		IGc2	242..312	CDD:197706
		I-set	335..425	CDD:254352
		Ig	350..423	CDD:143165
		Ig	436..530	CDD:299845
		I-set	438..532	CDD:254352
		I-set	545..636	CDD:254352
		Ig	560..633	CDD:143165
		Ig	657..731	CDD:143165
		I-set	746..835	CDD:254352
		Ig	1496..1586	CDD:299845
		IG_like	1503..1588	CDD:214653
		I-set	1639..1724	CDD:254352
		IG	1750..1821	CDD:214652
		IGc2	1750..1806	CDD:197706
		I-set	1826..1909	CDD:254352
		Ig	1831..1897	CDD:299845
		I-set	1914..1998	CDD:254352
		Ig	2020..2095	CDD:299845
		FN3	2100..2194	CDD:238020
		FN3	2203..2292	CDD:238020
		I-set	2311..2395	CDD:254352
		Ig	2321..2395	CDD:299845
		FN3	2399..2493	CDD:238020
		FN3	2501..2590	CDD:238020
		I-set	2602..2693	CDD:254352
		Ig	2619..2693	CDD:299845
		FN3	2697..2793	CDD:238020
		FN3	2801..2893	CDD:238020
		I-set	2902..2995	CDD:254352
		Ig	2919..2993	CDD:299845
		FN3	2999..3088	CDD:238020
		FN3	3102..3191	CDD:238020
		I-set	3208..3292	CDD:254352
		Ig	3219..3292	CDD:299845
		FN3	3296..3390	CDD:238020
		FN3	3400..3489	CDD:238020
		I-set	3494..3590	CDD:254352
		Ig	3516..3590	CDD:299845
		FN3	3594..3682	CDD:238020
		FN3	3694..3781	CDD:238020
		I-set	3795..3885	CDD:254352
		Ig	3813..3885	CDD:299845
		FN3	3889..3980	CDD:238020
		FN3	3990..4082	CDD:238020
		I-set	4090..4181	CDD:254352
		Ig	4108..4181	CDD:299845
		FN3	4185..4271	CDD:238020
		FN3	4285..4383	CDD:238020
		Ig	4404..4480	CDD:299845
		FN3	4484..4571	CDD:238020
		FN3	4584..4677	CDD:238020
		I-set	4685..4775	CDD:254352
		Ig	4703..4775	CDD:299845
		FN3	4779..4863	CDD:238020
		FN3	4879..4970	CDD:238020
		IG	4989..5069	CDD:214652
		Ig	4996..5069	CDD:299845
		FN3	5073..5166	CDD:238020
		FN3	5175..5265	CDD:238020
I-set	5276..5366	CDD:254352
Ig	5293..5366	CDD:299845
FN3	5370..5462	CDD:238020
FN3	5470..5561	CDD:238020
Ig	5559..5654	CDD:299845	16/67 (24%)
I-set	5570..5660	CDD:254352	19/73 (26%)
FN3	5664..5755	CDD:238020	23/145 (16%)
FN3	5764..5853	CDD:238020	33/91 (36%)
I-set	5865..5954	CDD:254352	10/88 (11%)
Ig	5882..5954	CDD:299845	7/71 (10%)
FN3	5958..6049	CDD:238020	30/92 (33%)
FN3	6062..6153	CDD:238020	28/90 (31%)
I-set	6173..6255	CDD:254352	14/81 (17%)
Ig_Titin_like	6182..6255	CDD:143225	13/72 (18%)
FN3	6259..6350	CDD:238020	10/90 (11%)
FN3	6359..6451	CDD:238020	34/95 (36%)
FN3	6470..6552	CDD:238020	29/83 (35%)
I-set	6564..6650	CDD:254352	17/89 (19%)
Ig_Titin_like	6577..6650	CDD:143225	15/76 (20%)
FN3	6654..6745	CDD:238020	17/91 (19%)
FN3	6754..6840	CDD:238020	13/97 (13%)
I-set	6855..6946	CDD:254352	16/91 (18%)
Ig	6874..6946	CDD:299845	10/72 (14%)
FN3	6950..7042	CDD:238020	10/91 (11%)
FN3	7050..7139	CDD:238020	8/88 (9%)
FN3	7151..7237	CDD:238020	12/86 (14%)
I-set	7254..7334	CDD:254352	27/88 (31%)
Ig	7272..7339	CDD:143165	22/72 (31%)
IG_like	7354..7440	CDD:214653
Ig	7366..7440	CDD:299845
FN3	7444..7531	CDD:238020
FN3	7545..7637	CDD:238020
I-set	7648..7737	CDD:254352
Ig	7665..7734	CDD:143165
Ig	7760..7833	CDD:299845
FN3	7837..7927	CDD:238020
STKc_Twitchin_like	7986..8244	CDD:271016
S_TKc	7989..8244	CDD:214567
Ig	8311..8394	CDD:299845
I-set	8312..8401	CDD:254352
I-set	8437..8525	CDD:254352
Ig	8455..8519	CDD:143165
I-set	8632..8721	CDD:254352
IGc2	8646..8711	CDD:197706
I-set	8740..8831	CDD:254352
Ig	8757..8826	CDD:143165
I-set	8839..8922	CDD:254352
Ig	8845..>8909	CDD:299845
Myom1	NP_001178513.1	IgI_titin_I1-like	281..374	CDD:409543	20/76 (26%)
		Ig strand B	298..302	CDD:409543
		Ig strand C	311..315	CDD:409543	1/3 (33%)
		Ig strand E	339..343	CDD:409543	1/3 (33%)
		Ig strand F	353..358	CDD:409543	1/4 (25%)
		Ig strand G	366..369	CDD:409543	2/2 (100%)
		Ig	420..487	CDD:416386	11/80 (14%)
		Ig strand B	426..429	CDD:409353	0/2 (0%)
		Ig strand C	443..447	CDD:409353	0/3 (0%)
		Ig strand E	468..472	CDD:409353	1/3 (33%)
		Ig strand F	482..487	CDD:409353	1/4 (25%)
		FN3	513..603	CDD:238020	32/89 (36%)
		FN3	641..734	CDD:238020	31/97 (32%)
		FN3	742..832	CDD:238020	29/120 (24%)
		FN3	938..1032	CDD:238020	34/93 (37%)
		FN3	1043..1132	CDD:238020	31/88 (35%)
		Ig	1159..1225	CDD:416386	12/65 (18%)
		Ig strand B	1160..1165	CDD:409353	0/4 (0%)
		Ig strand C	1172..1177	CDD:409353	1/4 (25%)
		Ig strand E	1197..1201	CDD:409353	0/3 (0%)
		Ig strand F	1210..1216	CDD:409353	2/5 (40%)
		Ig	<1382..1447	CDD:416386	16/97 (16%)
		Ig strand C	1391..1397	CDD:409353	1/5 (20%)
		Ig strand C'	1399..1402	CDD:409353	0/2 (0%)
		Ig strand E	1415..1421	CDD:409353	0/5 (0%)
		Ig strand F	1428..1436	CDD:409353	3/7 (43%)
		Ig strand G	1439..1447	CDD:409353	2/9 (22%)
		Ig	1576..1667	CDD:416386	32/98 (33%)
		Ig strand A	1576..1579	CDD:409353	0/2 (0%)
		Ig strand A'	1584..1589	CDD:409353	2/5 (40%)
		Ig strand B	1593..1600	CDD:409353	2/6 (33%)
		Ig strand C	1607..1612	CDD:409353	1/4 (25%)
		Ig strand C'	1615..1617	CDD:409353	1/8 (13%)
		Ig strand D	1622..1628	CDD:409353	0/5 (0%)
		Ig strand E	1632..1637	CDD:409353	1/6 (17%)
		Ig strand F	1647..1654	CDD:409353	1/6 (17%)
		Ig strand G	1657..1667	CDD:409353	1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	71	1.000	Domainoid score	I9197
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13817
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.100