DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bt and Myom3

DIOPT Version :9

Sequence 1:	NP_001162825.1	Gene:	bt / 43814	FlyBaseID:	FBgn0005666	Length:	8933	Species:	Drosophila melanogaster
Sequence 2:	NP_001101457.2	Gene:	Myom3 / 313625	RGDID:	1310060	Length:	1438	Species:	Rattus norvegicus

Alignment Length:	1740	Identity:	349/1740 - (20%)
Similarity:	564/1740 - (32%)	Gaps:	616/1740 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  6109 IKINGQPVPTAEYQDDRVTSNH--------------QYQYRISAVNAAGNGKTSEPSAI------ 6153
            |:|:.:..|..:|   |:|:|:              ...|.:...||.|...:.....|
  Rat   192 IQIDPRLFPAGKY---RITNNYGLLTLEIRRCTVEDSATYTVLVKNAFGQASSFAKVLIRTYLGK 253

  Fly  6154 ---FNARPLREK---PRFYFDGLIGKRIKVRAGEPVNLNIPISG---APTPTIEWKRGDLKLEEG 6209
               |::...:..   |...|..:: |.|..:..||.:|....|.   .....|:|.|....|...
  Rat   254 DAGFDSEIFKRSMFGPTVEFTSVL-KPIFAQEKEPFSLTCLFSDDVLEAEERIQWFRDGRLLRSS 317

  Fly  6210 KRISYETNSERTLFRIDDSNRRDSGKYTVTAANEFGKDTADIEVIVVD----KPSPPEGPLSY-- 6268
            .|........:...::..:.:.|.|.||:..::.||.......|.:.|    ||..|..||:.
  Rat   318 TRRQILYADRQASVKVSCAYKEDEGFYTIRVSSPFGPQEQSAYVFIRDAAAEKPGAPGSPLNVRC 382

  Fly  6269 TETAPDHISLHWYSPKDDGGSDITGYIIEFTEFGVDDWKP---VPG---TCPNTNFTVKNLVEGK 6327
            .....|.::|.|..|.|..||.||||.||..:...::|.|   .||   .||     ::.|:||:
  Rat   383 LNVHRDCLTLTWVPPSDTRGSTITGYSIELCQGDSEEWVPCLKTPGGTCRCP-----IQGLIEGQ 442

  Fly  6328 KYVFRIRAENIYG------ASEA------------------LEGKPVLAKSPFDP----PGAPSQ 6364
            .|.||:||.:..|      ||.|                  |..|..::|:.|:.    |.||:.
  Rat   443 SYRFRVRAISKAGTSLPSKASAAVVMGDYDTVQKKTEIPFDLGRKITISKNDFEDAVTIPSAPTN 507

  Fly  6365 PTISAYTPNSANLEWHPPDDCGGKPITGYIVERRERG-GEWIKCNN-YPTPNTSYTVSNLRDGAR 6427
            ...|......|.|.|..|...|..|:| |.:|:...| |.|...:: .|..:..:.:.:|..|..
  Rat   508 VHASEIRDTYAVLSWEEPHPRGRAPLT-YTLEKSVIGSGTWEAISSETPIKSPRFALLDLEKGKS 571

  Fly  6428 YEFRVLAVNEAGPGHPSKPSDPMTAEHQRYRPDPPEPPKPDRITRNGVTLSWRPPRTDGKSRIKG 6492
            |.|||.|:|:.|...||:||:|:|.:.:.....||...:..|.|:..|:|:|.|  .||.|.:.|
  Rat   572 YVFRVRALNQYGMSDPSEPSEPITLKGKPATLPPPAQVQSFRNTQTSVSLTWEP--VDGGSELLG 634

  Fly  6493 YYVEMRPKNGKDWKTVNDIPINSTVYTVPSLKEGEEYSFRVVAENEVGRSDPSKPSQPITIEEQP 6557
            ||:..|.....:|:|||:.||..|.:|||.|:.|:||.|.:.:.:|.|..:.|..:|||.:::.
  Rat   635 YYIYSREAGASEWQTVNNKPIQDTKFTVPGLRTGKEYEFCIRSVSEAGVGESSAVTQPIRVKQA- 698

  Fly  6558 NKPCMELGKVRDIVCRAGDDFSIHVPYLAFPKPNAFWYSNDNMLDDNNRVHKHLTDDAASVVVKN 6622
                                       ||.|
  Rat   699 ---------------------------LATP---------------------------------- 702

  Fly  6623 SKRADSGQYRLQLKNTSGFDTATINVRVLDRPSPPTRLRADEFSGDSLTLYWNPPNDDGGSAIQN 6687
                           ::.:|.|.:|.                 ..:.:.:.|.||...||..|..
  Rat   703 ---------------SAPYDFALLNC-----------------GKNEMVIGWKPPKRRGGGKILG 735

  Fly  6688 YIIEKKEARSSTWSKV------SSFCTVPFVRIRNLVLNKEYDFRVIAENKYGQSDPANTSEPIL 6746
            |.:::.::....|..|      |..|     ::.||.....|:||..|.|..|..:.:..|. :.
  Rat   736 YYVDQHDSEELDWHPVSHQPNPSRVC-----KVTNLHEGHFYEFRARAMNWAGIGELSAPSS-LF 794

  Fly  6747 ARHPFDIPNTPGIPHGIDSTE---DSITIAWTKPKHDGGSPITGYIIEKRLLSDDKWTKAVHALC 6808
            ....:.:|. ||.|:.:.::|   .|:.:.|..|.:.|..|:|||.:..:.:..::|........
  Rat   795 ECKEWTMPE-PGPPYDVRASEIQATSVMLQWEPPLYIGAGPVTGYRVSFQEIGSEEWKPVTPDAT 858

  Fly  6809 PDLSCKIPNLIENAEYEFRVAAVNAAGQSAYSGSSDLIFCRRPPHAPKITSDLSIRDMTVIAGD- 6872
            .|...::.:|....:|.|||.|:|:||....|..:|.:.....|.|.:|...:.......:|.:
  Rat   859 SDTHLRVSDLQPGKQYMFRVQAMNSAGLGQPSVPTDPVLLEDKPDAHEIEVGVDEEGQIYLAFEA 923

  Fly  6873 -------EFRITVPYHASPRPTASWSLNGLEVIPGERIKFDSNDYASMYYNKSAKRDETGSYTIT 6930
                   ||:.:..|...|.|              :|::.......|....|.....:.|.|::.
  Rat   924 PEAPDFPEFQWSKDYKGPPDP--------------QRVEVKDEINKSKVILKEPDLQDLGVYSVV 974

  Fly  6931 LTNNKGSDTASCHVTVVDRPLPPQGPLNAYDITPDTCTL--AWKTPLDDGGSPITNYVVEKLDNS 6993
            :| :...||::.| |:.:..|.....| :::|......|  .|...:.:.|.......||||..:
  Rat   975 VT-DADEDTSASH-TLTEEELNKLKKL-SHEIRNPVIKLISGWNVDILEQGEVRLWLEVEKLSPA 1036

  Fly  6994 GSWVKISSFVRNTHYDVMGLEPHYKYNFRVRAENQYGLSDPLDIIEPIVAKHQFTVPDEPGQPKV 7058
            .....|.:     ..::.. .|:.|.||    :.:.||      :|.|:   |....|:.|.
  Rat  1037 AELHLIFN-----EKEIFS-SPNRKINF----DREKGL------VEVII---QQLSEDDKGS--- 1079

  Fly  7059 IDWDSGNVTLIWTRPLSDGGSRIQGYQIEYRDILNDSSWNAYDYIIKDTKYQLYNLINGSEYEFR 7123
                       :|..|.||
  Rat  1080 -----------YTAQLQDG---------------------------------------------- 1087

  Fly  7124 IKAKNAAGLSKPSSPSLRFKLKGKFTVPSPPGAPQVTRVGKNYVDLKWEKPLRDGGSRITGYIIE 7188
             ||||                             |:|..   .||..::|.||...::
  Rat  1088 -KAKN-----------------------------QITLA---LVDDDFDKLLRKADAK------- 1112

  Fly  7189 RRD---------IGGAVWVKCNDYNVLDTEYTVMNLIEMGDYEFRVFAVNSAGRSEPSLCTMPIK 7244
            |||         .....|....|..||.|
  Rat  1113 RRDWKRKQGPYFQDPLTWKVTEDCQVLLT------------------------------------ 1141

  Fly  7245 VCEVLGGKKP---DWITRLQDKVAPFGKDYTLQCAASGKPSPTARWLRNGKEIQMNGGRMTCD-- 7304
             |:|...||.   .|:  .|.|.||           .|:.||           |...|.:..:
  Rat  1142 -CKVTNTKKETRFQWL--FQKKEAP-----------RGQYSP-----------QTGDGSLCIEEF 1181

  Fly  7305 SKD--GVFRLHISNVQTGDDG--DYTCEAMNSLGFVNTSGYLKIGSPPIINRCPSELK-LPEGDN 7364
            ||:  |::|..:|:.:..||.  |.|.||::::       ..::|....::..|.::: ..||..
  Rat  1182 SKEDQGLYRAVVSDERGEDDTVLDLTGEALDAV-------LTELGRISALSATPLKIQGTEEGIR 1239

  Fly  7365 --SKIKIFYSGDQPLTVILKKNNEVICDSNDDTHVKVNIFDDYVAIYIRNIVKSDGGPYQIEFTN 7427
              ||:| :|:.|...|....|:..:  :|.|  .|:.....|.:.::|.:...||.|.|.:|.|
  Rat  1240 LFSKVK-YYNVDYMKTAWFHKDKRL--ESGD--RVRAGTTLDEIWLHILDPKDSDKGKYTLEIT- 1298

  Fly  7428 ESGSATGEFYVHITGMPSAPTGPMGISYINKNSCMLNWRPPSYDGGLKVSHYVIERKDVSSPHWI 7492
                                        ..|..|.|
  Rat  1299 ----------------------------AGKEVCQL----------------------------- 1306

  Fly  7493 TVSSTCKDTAFNVQGLIENQEYIFRVMAVNENGMGPPLEGLNPIRAKDPIDPPSPPGSPQITEIG 7557
              |:.....||: ..|.|:|.  .:.:||.|......:.||                 |.:..|.
  Rat  1307 --SADLSGQAFD-DALAEHQR--LKALAVIEKNRAKVVRGL-----------------PDVATIM 1349

  Fly  7558 GDFVHLEWEKPESDGGAHIQGYWIDKREVGSNTWQRVNATICAANQINCINLIEGRQYEFRIFAQ 7622
            .|                                    .|:|
  Rat  1350 ED------------------------------------KTLC----------------------- 1355

  Fly  7623 NVAGLSTESSASQAVKIIDPQAASPPLIVKPLRDANCIQNHNAQFTCTINGVPKPTISWYKGARE 7687
                                                        .||.|:|.|.|.|||.|..:.
  Rat  1356 --------------------------------------------LTCVISGDPSPEISWLKNDQP 1376

  Fly  7688 ISNGARYHMYSEGDNHFLNINDVFGEDADEYVCRAVNKAGAKSTRATLAI 7737
            :|...||||..:|....:.|:.|..||:..|.....||.|:::.:.|:::
  Rat  1377 VSFLDRYHMEVKGTEVTITIDKVTSEDSGRYGIFVKNKYGSETGQVTISV 1426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bt	NP_001162825.1	I-set	9..101	CDD:254352
		Ig	26..100	CDD:143165
		I-set	119..210	CDD:254352
		Ig	136..209	CDD:143165
		I-set	228..320	CDD:254352
		IGc2	242..312	CDD:197706
		I-set	335..425	CDD:254352
		Ig	350..423	CDD:143165
		Ig	436..530	CDD:299845
		I-set	438..532	CDD:254352
		I-set	545..636	CDD:254352
		Ig	560..633	CDD:143165
		Ig	657..731	CDD:143165
		I-set	746..835	CDD:254352
		Ig	1496..1586	CDD:299845
		IG_like	1503..1588	CDD:214653
		I-set	1639..1724	CDD:254352
		IG	1750..1821	CDD:214652
		IGc2	1750..1806	CDD:197706
		I-set	1826..1909	CDD:254352
		Ig	1831..1897	CDD:299845
		I-set	1914..1998	CDD:254352
		Ig	2020..2095	CDD:299845
		FN3	2100..2194	CDD:238020
		FN3	2203..2292	CDD:238020
		I-set	2311..2395	CDD:254352
		Ig	2321..2395	CDD:299845
		FN3	2399..2493	CDD:238020
		FN3	2501..2590	CDD:238020
		I-set	2602..2693	CDD:254352
		Ig	2619..2693	CDD:299845
		FN3	2697..2793	CDD:238020
		FN3	2801..2893	CDD:238020
		I-set	2902..2995	CDD:254352
		Ig	2919..2993	CDD:299845
		FN3	2999..3088	CDD:238020
		FN3	3102..3191	CDD:238020
		I-set	3208..3292	CDD:254352
		Ig	3219..3292	CDD:299845
		FN3	3296..3390	CDD:238020
		FN3	3400..3489	CDD:238020
		I-set	3494..3590	CDD:254352
		Ig	3516..3590	CDD:299845
		FN3	3594..3682	CDD:238020
		FN3	3694..3781	CDD:238020
		I-set	3795..3885	CDD:254352
		Ig	3813..3885	CDD:299845
		FN3	3889..3980	CDD:238020
		FN3	3990..4082	CDD:238020
		I-set	4090..4181	CDD:254352
		Ig	4108..4181	CDD:299845
		FN3	4185..4271	CDD:238020
		FN3	4285..4383	CDD:238020
		Ig	4404..4480	CDD:299845
		FN3	4484..4571	CDD:238020
		FN3	4584..4677	CDD:238020
		I-set	4685..4775	CDD:254352
		Ig	4703..4775	CDD:299845
		FN3	4779..4863	CDD:238020
		FN3	4879..4970	CDD:238020
		IG	4989..5069	CDD:214652
		Ig	4996..5069	CDD:299845
		FN3	5073..5166	CDD:238020
		FN3	5175..5265	CDD:238020
I-set	5276..5366	CDD:254352
Ig	5293..5366	CDD:299845
FN3	5370..5462	CDD:238020
FN3	5470..5561	CDD:238020
Ig	5559..5654	CDD:299845
I-set	5570..5660	CDD:254352
FN3	5664..5755	CDD:238020
FN3	5764..5853	CDD:238020
I-set	5865..5954	CDD:254352
Ig	5882..5954	CDD:299845
FN3	5958..6049	CDD:238020
FN3	6062..6153	CDD:238020	11/57 (19%)
I-set	6173..6255	CDD:254352	18/84 (21%)
Ig_Titin_like	6182..6255	CDD:143225	15/75 (20%)
FN3	6259..6350	CDD:238020	37/122 (30%)
FN3	6359..6451	CDD:238020	31/93 (33%)
FN3	6470..6552	CDD:238020	32/81 (40%)
I-set	6564..6650	CDD:254352	6/85 (7%)
Ig_Titin_like	6577..6650	CDD:143225	6/72 (8%)
FN3	6654..6745	CDD:238020	20/96 (21%)
FN3	6754..6840	CDD:238020	24/88 (27%)
I-set	6855..6946	CDD:254352	16/98 (16%)
Ig	6874..6946	CDD:299845	13/71 (18%)
FN3	6950..7042	CDD:238020	18/93 (19%)
FN3	7050..7139	CDD:238020	10/88 (11%)
FN3	7151..7237	CDD:238020	15/94 (16%)
I-set	7254..7334	CDD:254352	21/88 (24%)
Ig	7272..7339	CDD:143165	16/72 (22%)
IG_like	7354..7440	CDD:214653	21/88 (24%)
Ig	7366..7440	CDD:299845	17/73 (23%)
FN3	7444..7531	CDD:238020	12/86 (14%)
FN3	7545..7637	CDD:238020	5/91 (5%)
I-set	7648..7737	CDD:254352	25/88 (28%)
Ig	7665..7734	CDD:143165	24/68 (35%)
Ig	7760..7833	CDD:299845
FN3	7837..7927	CDD:238020
STKc_Twitchin_like	7986..8244	CDD:271016
S_TKc	7989..8244	CDD:214567
Ig	8311..8394	CDD:299845
I-set	8312..8401	CDD:254352
I-set	8437..8525	CDD:254352
Ig	8455..8519	CDD:143165
I-set	8632..8721	CDD:254352
IGc2	8646..8711	CDD:197706
I-set	8740..8831	CDD:254352
Ig	8757..8826	CDD:143165
I-set	8839..8922	CDD:254352
Ig	8845..>8909	CDD:299845
Myom3	NP_001101457.2	I-set	154..247	CDD:369462	11/57 (19%)
		Ig	272..363	CDD:386229	19/91 (21%)
		FN3	374..460	CDD:238020	31/90 (34%)
		FN3	502..595	CDD:238020	31/93 (33%)
		FN3	604..693	CDD:238020	34/90 (38%)
		FN3	702..792	CDD:238020	23/160 (14%)
		FN3	804..893	CDD:238020	24/88 (27%)
		IG_like	1127..1207	CDD:214653	27/140 (19%)
		Ig	1336..1426	CDD:386229	32/209 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9467
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13817
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.100