DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment bt and Mypn

DIOPT Version :10

Sequence 1:NP_001162825.1 Gene:bt / 43814 FlyBaseID:FBgn0005666 Length:8933 Species:Drosophila melanogaster
Sequence 2:NP_001355746.1 Gene:Mypn / 309760 RGDID:1308510 Length:1306 Species:Rattus norvegicus


Alignment Length:1409 Identity:270/1409 - (19%)
Similarity:430/1409 - (30%) Gaps:520/1409 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly  7602 NQIN-CINLIEGRQYEFRIFA-QNVAGLSTESSASQAVKIIDPQAASPPLIVKPLRDANCIQNHN 7664
            |::| .|...|.::.|..:.| :..||.||..|:..::...:| ...||...:.||.....:...
  Rat   215 NELNHAIEQREAKRREAELAAVEAAAGDSTPGSSPSSLYYEEP-LGQPPRFTQKLRSREVPEGSR 278

  Fly  7665 AQFTCTINGVPKPTISWYKGAREISNGARYHMYSEGDNHFLNINDVFGEDADEYVCRAVNKAGAK 7729
            .|..|.:.|:|.|.:.||...:|:.|....|:...|:.|.|.|.:.|.||...|.|.|.|..|..
  Rat   279 VQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTD 343

  Fly  7730 STRATLAI-------------------------MTAP---KLNVPPRFR-------------DTA 7753
            ||.|.:.|                         :::|   ...:||..:             .|.
  Rat   344 STSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSATIPPTVQAQPRVSTIQQCQSPTN 408

  Fly  7754 YF-----------------------DKGENVVIKIPFTGFPKPRIHWVRDGENIESGGHYTVEVK 7795
            |.                       .:|:.||.:....|.|.|::.|.|:|..||....:.:..|
  Rat   409 YLQGLNGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPDFRILQK 473

  Fly  7796 --------ERHAVLIIRDGSHLDSGPYRITAENELGSDTAIIQV------QISD----------- 7835
                    |....|:|.:....|||.:..||.|:.|:.::|.|:      .|||           
  Rat   474 KPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLAVRGNEDISDNETLHSDNSTT 538

  Fly  7836 -------RPDPPR----------FPLIESIGTESLSLSWKAPVWDGCSDITNYYVERREHPLSSW 7883
                   :|.||.          .|.:|.:                   :.|:     ..|.|| 
  Rat   539 NPAATEQQPSPPNPQPPPEEQPPKPKLEGV-------------------LVNH-----NEPRSS- 578

  Fly  7884 IRVGNTRFTSMAVSGLTPGKEYDFRIFADNVYGRSDASDTSTLIKTKESVKKKPIERKWEIDANG 7948
            .|:|      :.|....|..:.|           ::||....:..|.::......||     .||
  Rat   579 SRIG------LRVHFNLPEDDKD-----------TEASSGCGMANTSQTRPDSFPER-----FNG 621

  Fly  7949 RKLR-GKADGPVKDYDSYVFDIYSKFVPQPVEISQQSVYDRYDILEEIGTGAFGVVHRCRERSTG 8012
            ::.| .:...|||:             |.||                                  
  Rat   622 QEARISEPSSPVKE-------------PPPV---------------------------------- 639

  Fly  8013 NIFAAKFIPVSHSVEKDLIRREIDI--MNQLHHQKL---INLHDAF-EDDDEMILILEFLSGGEL 8071
                             |.:.::|.  :.|||:|.|   :.||:.. ....|.......|:....
  Rat   640 -----------------LAKPKLDSTQLQQLHNQVLLEQLQLHNTSPSSPKESPFNTSILNSAPP 687

  Fly  8072 FERITAEGYVMTEAEVINYMRQICEGIRHMHEQN-------------IIHLDIKPENI------- 8116
            ...|:::.......:..|..|.     :|....:             :..|...|:.|       
  Rat   688 TVTISSKQVKSPAPQTFNLARP-----KHFFPASSTSTATVSPSSSPVFTLSNTPQTIQRTVSKE 747

  Fly  8117 -MCQTRSSTNVKLIDFGLATRLDPNEVVKITTGTAEFAAPEIVNREPVGFYTDMWATGVLSYVLL 8180
             :..|..||..: ...||:.:.:|     .....||.|.|.:                  ||.:.
  Rat   748 SLLMTHPSTQGR-SPGGLSIQNEP-----APPSPAEPAVPTV------------------SYSIT 788

  Fly  8181 SG------------LSPFAG-DNDVQTLKNVKACDWDFDVESFKYISEEAKDFIRKLLVRNKEKR 8232
            ||            :||... .|.|..|.:|..........:...:.:.|.....:.|::...|.
  Rat   789 SGNQFQPHCVSPTPVSPTGRIQNPVAFLSSVLPSLPSIPPTNAMGLPKSAPSVPPQGLMKKTTKT 853

  Fly  8233 MTAHECLLHPWLTGDHSAMKQEINRDRYLAYREKLRRKYEDFERFLLPIGRLSEYSSLRKLLMEK 8297
            ..|..                    |.|:.         |.....:|.:|:...:|.:|. ..::
  Rat   854 PQAVS--------------------DDYIR---------ETKNSVILDLGKKVNFSDVRS-HQQE 888

  Fly  8298 YKIHDAVFDRRQAAPRFVIRPSSQFCYEGQSVKFYCRCIAIATPTLTWSHNNIELRQSVKFMKRY 8362
            |||  :.|::|..                                     |.||.|         
  Rat   889 YKI--SSFEQRLM-------------------------------------NEIEFR--------- 905

  Fly  8363 VGDDYYFIINRVKLDDRGEYIIRAENHYGSREEVVFLNVQPLPKEQPRYR-TESTPVRRREPLPY 8426
                    :.|..:|:..:.|...|...|.....:|      .|....:| ||.:||        
  Rat   906 --------LERTPVDESDDEIQHDEIPTGKCIAPIF------DKRLKHFRVTEGSPV-------- 948

  Fly  8427 TFWQEESETAPSFTFLLRPRVMQARDTCKLLCCLSGKPVPNVRWYKDGRELSK-YEYAMTH--SD 8488
                         ||           |||::    |.|||.|.|:|||:::|| .|:....  .|
  Rat   949 -------------TF-----------TCKIV----GIPVPKVYWFKDGKQISKRNEHCKMRRDGD 985

  Fly  8489 GVVTMEIIDCKPSDSGKYSCKATNCHGTDETDCVVIVEGEWVTPEQAQLAHNFLYSGDRKYIEQP 8553
            |..::.|......|.|.|:..|.|..|.......::|:|                          
  Rat   986 GTCSLHIESTHGDDDGNYTIMAANPQGRISCSGHLMVQG-------------------------- 1024

  Fly  8554 IKPAPLPIVTSRQYTSSSVQNTSEPQGDKVNVSNSNSSGISNKKKYASNSLQAPGSPSRSRSATK 8618
                 .||                                       .|.|...|...|.||..:
  Rat  1025 -----FPI---------------------------------------RNRLSPAGQSHRGRSRMQ 1045

  Fly  8619 ELILPPDDSLMCKPEFTKPLHDLTIHDGEQLILTCYVKGDPEPQISWSKNGKSLSSSDILDLRYK 8683
            |....|......:|.|.:...|:..|:|....|.|.|.|.|.|:::|..||:.:    :.|..:|
  Rat  1046 ERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPV----LPDASHK 1106

  Fly  8684 -----NGIATLTINEVFPEDEGVITCTATNSVGAVETKCKLTIQPLDKNINKRKVNAGDNAPKIV 8743
                 .|:.:|.|:.:...|.|..||.|||..|......:||:  :.|.:.|        ||.|:
  Rat  1107 MLVRETGVHSLLIDPLTQRDAGTYTCVATNKTGQNSFSLELTV--VAKEVKK--------APVIL 1161

  Fly  8744 SHLESRFVRDGDAVNLACRIIGAQHFDVVWLHNNKEIKPSKD--FQYTNEANIYRLQIAEIFPED 8806
            ..|::..|.:|..|.|..|:||.......|..:|:.|..:::  ..:.:......|.|......|
  Rat  1162 EKLQNSGVPEGHPVRLEGRVIGMPPPVFYWKKDNETIPFTRERISMHQDTTGYVCLLIQPAKKSD 1226

  Fly  8807 GGTYTCEAFNDIGESFSTCTINVTVPGDETKQPSFVKFPTSVSV 8850
            .|.||..|.|:.|  ..:||..:.:.....:|     .||.:|:
  Rat  1227 AGWYTLSAKNEAG--IVSCTARLDIYAQWHQQ-----IPTPISI 1263

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
btNP_001162825.1 Ig 9..101 CDD:472250
Ig strand B 26..30 CDD:409353
Ig strand C 39..43 CDD:409353
Ig strand E 69..73 CDD:409353
Ig strand F 83..88 CDD:409353
Ig strand G 96..99 CDD:409353
I-set 119..210 CDD:400151
Ig strand B 136..140 CDD:409353
Ig strand C 149..153 CDD:409353
Ig strand E 174..182 CDD:409353
Ig strand F 192..197 CDD:409353
Ig strand G 205..208 CDD:409353
Ig 228..320 CDD:472250
Ig strand B 245..249 CDD:409353
Ig strand C 258..262 CDD:409353
Ig strand E 286..292 CDD:409353
Ig strand F 302..307 CDD:409353
Ig strand G 317..320 CDD:409353
Ig 335..425 CDD:472250
Ig strand B 350..354 CDD:409353
Ig strand C 363..367 CDD:409353
Ig strand E 393..397 CDD:409353
Ig strand F 407..412 CDD:409353
Ig strand G 420..423 CDD:409353
Ig 438..532 CDD:472250
Ig strand B 455..459 CDD:409353
Ig strand C 468..472 CDD:409353
Ig strand E 498..502 CDD:409353
Ig strand F 512..517 CDD:409353
Ig strand G 525..528 CDD:409353
Ig 545..636 CDD:472250
Ig strand B 560..564 CDD:409353
Ig strand C 573..577 CDD:409353
Ig strand E 599..606 CDD:409353
Ig strand F 616..621 CDD:409353
Ig strand G 629..632 CDD:409353
Ig 656..726 CDD:472250
Ig strand B 657..661 CDD:409353
Ig strand C 670..674 CDD:409353
Ig strand E 700..704 CDD:409353
Ig strand F 714..719 CDD:409353
Ig strand G 728..731 CDD:409353
Ig 746..835 CDD:472250
Ig strand C 777..781 CDD:409353
Ig strand E 802..806 CDD:409353
Ig strand F 816..821 CDD:409353
Ig 1508..1588 CDD:472250
Ig strand B 1514..1518 CDD:409353
Ig strand C 1527..1531 CDD:409353
Ig strand E 1554..1558 CDD:409353
Ig strand F 1568..1573 CDD:409353
Ig strand G 1581..1584 CDD:409353
Ig 1639..1724 CDD:472250
IG_like 1750..1821 CDD:214653
Ig strand B 1750..1753 CDD:409353
Ig strand C 1761..1765 CDD:409353
Ig strand E 1788..1792 CDD:409353
Ig strand F 1802..1806 CDD:409353
Ig 1826..1909 CDD:472250
Ig strand B 1842..1846 CDD:409353
Ig strand C 1854..1858 CDD:409353
Ig strand E 1879..1883 CDD:409353
Ig 1914..1998 CDD:472250
Ig 2020..2095 CDD:472250
Ig strand B 2021..2025 CDD:409353
Ig strand C 2038..2042 CDD:409353
Ig strand E 2062..2066 CDD:409353
Ig strand F 2076..2081 CDD:409353
Ig strand G 2089..2092 CDD:409353
FN3 2100..2194 CDD:238020
FN3 2203..2292 CDD:238020
Ig 2314..2395 CDD:472250
Ig strand B 2322..2326 CDD:409353
Ig strand C 2335..2339 CDD:409353
Ig strand E 2361..2365 CDD:409353
Ig strand F 2375..2380 CDD:409353
FN3 <2376..2753 CDD:442628
Ig strand G 2388..2391 CDD:409353
FN3 2501..2590 CDD:238020
FN3 <2673..>2891 CDD:442628
Ig 2902..2995 CDD:472250
Ig strand B 2920..2924 CDD:409353
Ig strand C 2933..2937 CDD:409353
FN3 <2957..>3191 CDD:442628
Ig strand E 2961..2965 CDD:409353
Ig strand F 2975..2980 CDD:409353
Ig strand G 2988..2991 CDD:409353
FN3 2999..3088 CDD:238020
Ig 3212..3292 CDD:472250
Ig strand B 3220..3224 CDD:409353
Ig strand C 3233..3237 CDD:409353
Ig strand E 3258..3262 CDD:409353
Ig strand F 3272..3277 CDD:409353
Ig strand G 3285..3288 CDD:409353
FN3 3296..3390 CDD:238020
FN3 3400..3489 CDD:238020
I-set 3494..3590 CDD:400151
Ig strand B 3517..3521 CDD:409353
Ig strand C 3530..3534 CDD:409353
Ig strand E 3556..3560 CDD:409353
Ig strand F 3570..3575 CDD:409353
Ig strand G 3583..3586 CDD:409353
FN3 3594..3682 CDD:238020
FN3 3694..3781 CDD:238020
I-set 3795..3885 CDD:400151
Ig strand B 3813..3817 CDD:409353
Ig strand C 3826..3830 CDD:409353
Ig strand E 3851..3855 CDD:409353
Ig strand F 3865..3870 CDD:409353
FN3 <3866..4181 CDD:442628
Ig strand G 3878..3881 CDD:409353
FN3 4185..4271 CDD:238020
FN3 4285..4383 CDD:238020
FN3 4356..4776 CDD:442628
FN3 4779..4863 CDD:238020
FN3 4879..4970 CDD:238020
Ig_3 4978..5056 CDD:464046
FN3 <5021..>5264 CDD:442628
FN3 5073..5166 CDD:238020
Ig 5286..5366 CDD:472250
Ig strand B 5294..5298 CDD:409353
Ig strand C 5307..5311 CDD:409353
Ig strand E 5332..5336 CDD:409353
Ig strand F 5346..5351 CDD:409353
Ig strand G 5359..5362 CDD:409353
FN3 5370..5462 CDD:238020
FN3 5470..5561 CDD:238020
Ig 5559..5654 CDD:472250
Ig strand B 5588..5592 CDD:409353
Ig strand C 5601..5605 CDD:409353
Ig strand E 5626..5630 CDD:409353
Ig strand F 5640..5645 CDD:409353
FN3 5664..5755 CDD:238020
FN3 5764..5853 CDD:238020
Ig 5874..5954 CDD:472250
Ig strand B 5882..5886 CDD:409353
Ig strand C 5895..5899 CDD:409353
Ig strand E 5920..5924 CDD:409353
Ig strand F 5934..5939 CDD:409353
Ig strand G 5947..5950 CDD:409353
FN3 <5972..>6384 CDD:442628
Ig_Titin_like 6174..6255 CDD:409406
Ig strand A 6174..6178 CDD:409406
Ig strand B 6183..6189 CDD:409406
Ig strand C 6195..6201 CDD:409406
Ig strand D 6213..6218 CDD:409406
Ig strand E 6219..6225 CDD:409406
Ig strand F 6234..6242 CDD:409406
FN3 <6236..6552 CDD:442628
Ig strand G 6245..6255 CDD:409406
Ig_Titin_like 6570..6650 CDD:409406
Ig strand A 6570..6573 CDD:409406
Ig strand B 6578..6584 CDD:409406
Ig strand C 6590..6596 CDD:409406
Ig strand D 6608..6613 CDD:409406
Ig strand E 6614..6620 CDD:409406
Ig strand F 6629..6637 CDD:409406
FN3 <6630..7006 CDD:442628
Ig strand G 6640..6650 CDD:409406
FN3 <6905..>7189 CDD:442628
FN3 7151..7237 CDD:238020
Ig 7254..7344 CDD:472250
Ig strand B 7271..7275 CDD:409353
Ig strand C 7284..7288 CDD:409353
Ig strand E 7310..7314 CDD:409353
Ig strand F 7324..7329 CDD:409353
Ig strand G 7337..7340 CDD:409353
Ig 7361..7438 CDD:472250
Ig strand B 7365..7369 CDD:409353
Ig strand C 7378..7382 CDD:409353
Ig strand E 7406..7410 CDD:409353
Ig strand F 7420..7425 CDD:409353
FN3 <7421..7762 CDD:442628 48/225 (21%)
Ig strand G 7433..7436 CDD:409353
I-set 7648..7737 CDD:400151 28/88 (32%)
Ig strand B 7665..7669 CDD:409353 1/3 (33%)
Ig strand C 7678..7682 CDD:409353 0/3 (0%)
Ig strand E 7703..7707 CDD:409353 2/3 (67%)
Ig strand F 7717..7722 CDD:409353 2/4 (50%)
Ig strand G 7730..7733 CDD:409353 2/2 (100%)
Ig 7758..7833 CDD:472250 24/88 (27%)
Ig strand B 7761..7765 CDD:409353 2/3 (67%)
Ig strand C 7774..7778 CDD:409353 0/3 (0%)
Ig strand E 7799..7803 CDD:409353 1/3 (33%)
Ig strand F 7813..7818 CDD:409353 0/4 (0%)
Ig strand G 7826..7829 CDD:409353 0/2 (0%)
FN3 7837..7927 CDD:238020 16/99 (16%)
STKc_Twitchin_like 7986..8244 CDD:271016 42/297 (14%)
Ig 8313..8401 CDD:472250 10/87 (11%)
Ig strand B 8329..8333 CDD:409541 0/3 (0%)
Ig strand C 8342..8346 CDD:409541 0/3 (0%)
Ig strand E 8367..8371 CDD:409541 0/3 (0%)
Ig strand F 8381..8386 CDD:409541 1/4 (25%)
Ig strand G 8394..8397 CDD:409541 0/2 (0%)
I-set 8437..8525 CDD:400151 26/90 (29%)
Ig strand B 8454..8458 CDD:409353 2/3 (67%)
Ig strand C 8467..8471 CDD:409353 1/3 (33%)
Ig strand E 8491..8495 CDD:409353 0/3 (0%)
Ig strand F 8505..8510 CDD:409353 1/4 (25%)
Ig strand G 8518..8521 CDD:409353 0/2 (0%)
I-set 8632..8721 CDD:400151 28/93 (30%)
Ig strand B 8649..8653 CDD:409570 1/3 (33%)
Ig strand C 8662..8666 CDD:409570 0/3 (0%)
Ig strand E 8687..8691 CDD:409570 1/3 (33%)
Ig strand F 8701..8706 CDD:409570 2/4 (50%)
Ig strand G 8714..8717 CDD:409570 0/2 (0%)
I-set 8740..8831 CDD:400151 24/92 (26%)
Ig strand B 8757..8761 CDD:409353 2/3 (67%)
Ig strand C 8770..8774 CDD:409353 0/3 (0%)
Ig strand E 8795..8799 CDD:409353 1/3 (33%)
Ig strand F 8809..8814 CDD:409353 2/4 (50%)
Ig strand G 8822..8825 CDD:409353 0/2 (0%)
Ig 8839..8922 CDD:472250 3/12 (25%)
Ig strand B 8856..8860 CDD:409353
Ig strand C 8868..8872 CDD:409353
Ig strand E 8894..8898 CDD:409353
MypnNP_001355746.1 IgI_2_Titin_Z1z2-like 261..351 CDD:409564 29/89 (33%)
Ig strand A 261..264 CDD:409564 2/2 (100%)
Ig strand A' 267..271 CDD:409564 2/3 (67%)
Ig strand B 279..287 CDD:409564 2/7 (29%)
Ig strand C 292..297 CDD:409564 1/4 (25%)
Ig strand C' 300..302 CDD:409564 0/1 (0%)
Ig strand D 308..313 CDD:409564 1/4 (25%)
Ig strand E 316..321 CDD:409564 2/4 (50%)
Ig strand F 330..338 CDD:409564 3/7 (43%)
Ig strand G 341..351 CDD:409564 4/9 (44%)
I-set 422..519 CDD:400151 24/96 (25%)
Ig strand B 439..443 CDD:409564 2/3 (67%)
Ig strand C 452..456 CDD:409564 0/3 (0%)
Ig strand E 485..489 CDD:409564 1/3 (33%)
Ig strand F 499..504 CDD:409564 0/4 (0%)
Ig strand G 512..515 CDD:409564 0/2 (0%)
Ig 931..1022 CDD:472250 33/132 (25%)
Ig strand B 948..952 CDD:409474 3/35 (9%)
Ig strand C 961..965 CDD:409474 1/3 (33%)
Ig strand E 988..992 CDD:409474 0/3 (0%)
Ig strand F 1002..1007 CDD:409474 1/4 (25%)
Ig strand G 1015..1018 CDD:409474 0/2 (0%)
Ig 1059..1149 CDD:472250 28/93 (30%)
Ig strand B 1076..1080 CDD:409582 1/3 (33%)
Ig strand C 1089..1093 CDD:409582 0/3 (0%)
Ig strand E 1115..1119 CDD:409582 1/3 (33%)
Ig strand F 1129..1134 CDD:409582 2/4 (50%)
Ig strand G 1142..1145 CDD:409582 0/2 (0%)
Ig 1158..1249 CDD:472250 24/92 (26%)
Ig strand B 1175..1179 CDD:409353 2/3 (67%)
Ig strand C 1188..1192 CDD:409353 0/3 (0%)
Ig strand E 1215..1219 CDD:409353 1/3 (33%)
Ig strand F 1229..1234 CDD:409353 2/4 (50%)
Ig strand G 1242..1245 CDD:409353 1/2 (50%)
Blue background indicates that the domain is not in the aligned region.

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