DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment bt and Cd22

DIOPT Version :9

Sequence 1:NP_001162825.1 Gene:bt / 43814 FlyBaseID:FBgn0005666 Length:8933 Species:Drosophila melanogaster
Sequence 2:NP_001100973.1 Gene:Cd22 / 308501 RGDID:1311610 Length:852 Species:Rattus norvegicus


Alignment Length:917 Identity:177/917 - (19%)
Similarity:293/917 - (31%) Gaps:306/917 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   140 CRVNADPIPAIIWFHNGAAVKESERHKITVDK---DVHSYFATLEILNVTVEDAGKYKVNAKNEL 201
            |.:..|||      |...:.|...|.....||   .:|        |||:......| :...:|:
  Rat   108 CTLKIDPI------HANDSGKLGLRLISGTDKWMEHIH--------LNVSERPFQPY-IQLPSEI 157

  Fly   202 GES---NATISLNF--------------DSDEAPVPES-AEGIKPTFTERPVIRQSEDGGNVTFE 248
            .||   :.|..|||              .|:.:||..| ...::..:||          ..:||:
  Rat   158 RESQRVSLTCGLNFTCFGYDISLRWSLDGSEVSPVTSSITSSVENVYTE----------SKLTFQ 212

  Fly   249 CRCVGDPTPTVTWS-HGETELNESNRYKMSLTMDQKLYHIACLEISSVVSSDQGEYRAQAKNKHG 312
            .:          |: ||:             :|..:::|     .|.|:|.              
  Rat   213 PK----------WTDHGK-------------SMMCQVWH-----FSQVLSE-------------- 235

  Fly   313 SGVATINLNFESGSKKIPDGKSPRFPKKPTIRQEEDLLIMECVLEAHPVPDIVWYCSEKEICNNQ 377
               .|:.|:.:...|.       :....||..:|.:.:.|.|.:                  |:.
  Rat   236 ---RTVRLDVKYTPKL-------QITVNPTEVKEGNSVTMTCQV------------------NSS 272

  Fly   378 RTKMTRKAIT--KDSYIL-------TLEIQNPTKEDGGNYRCNAINMYGESNA-NIALNFQGASD 432
            ...::.|.::  ||...|       .|.:.:.||:..|.|:|.|.|..|:..: .:||..     
  Rat   273 NPSLSTKKVSWFKDGSFLKEQQEQEELTLHSVTKDMRGKYQCRASNNIGQGQSKEVALTV----- 332

  Fly   433 ANGFAPSFIEKPRIIPN--ESGTLITMKCKCKAKPEPT-VTWYRGQDLVEKSKKIKINTTVIAED 494
               ..|....|..|.|:  |.|..:.:.|...|.|..| .|||...::|..:...|         
  Rat   333 ---LYPPEPSKVHIYPSPAEEGQSVELICDSLASPRATNYTWYHNGEMVPGASHEK--------- 385

  Fly   495 TYELTLEIKDPGATDGGTYRCNVKNEYGESNANLNLNIEAEPEPEGEGPTFIEKPRIVSENNGKL 559
                 |:|.:......|.|.|..:|..|.........::....|:.. .|.|:....:.|  |..
  Rat   386 -----LQISNVSLWHAGKYSCLAENRLGCGKIEQEAELDVHYVPKAV-TTVIQSVTPIRE--GDS 442

  Fly   560 VIMECKVKADPKPDVI---WFRNGEVIKESNKIKTFIEQRGDQYYIKLELLDPQLEDSGLYKCNI 621
            |.::|:..:. .|:|.   |...|...:.:..:....:...|...||....:        |||: 
  Rat   443 VTLDCRYNSS-NPEVTKYEWSPQGSGSEVTPGVLRIQKATWDSPPIKCAACN--------YKCS- 497

  Fly   622 KNTLGELNANLTLNIEIVPVIKDKPKIIKIIK---------KRTVVIECTVASKF--EPKCTWYK 675
                  .:..::||:...      |:.:||:|         .:.|:::|..:..|  |.:..|.|
  Rat   498 ------WSFPVSLNVHYA------PRAVKILKVSPASEIHAGQHVLLQCDFSGSFPTEVRFFWKK 550

  Fly   676 ETSTVKESKRHVYQVEQTKEGEFAVKLEINDVEESDKGAYKLVASNEKGEAVSQI--VNLVDIPE 738
            ..:.|:|.:                .|..:.:...|.|.|..:..|..||..||.  :.::..|.
  Rat   551 NGNLVQEGR----------------YLNFSSISPEDSGNYNCMVRNSIGETSSQAWSLQVLYAPR 599

  Fly   739 EERKPCKPEISRKLADQKVAESKTFELLVSLSQTDRKCKVEWYKGSTVIRETKDITTTFDGTTAR 803
            ..|....|       ...|.|.|...|...........|..|:       :..|....|.|...|
  Rat   600 RLRVSISP-------GDSVMEGKKATLSCESDAHPPVFKYIWF-------DANDQDLHFSGQKLR 650

  Fly   804 LTFSSARTEHTSNYKVIVTNEVGKDES-SCKITV----EKVAKKKE----------------EKP 847
            |  ...|.:||.:|:....||:|..:| ...:||    |.:.|:..                .|.
  Rat   651 L--EPLRVQHTGSYRCQGINELGTGKSPPSTLTVYYSPETIGKRVALGLGFCLAICILAIWGMKI 713

  Fly   848 KEKEKTKNEKEVEQKEMEEDKNESGQSV---------------AQTEGRINIE----------QI 887
            ::|.|....::..|      .|.||||.               .|::|..|:.          :.
  Rat   714 QKKWKHNRSQQGPQ------DNSSGQSFFVRNKKARRTRLTEGPQSQGCYNLAMDDTVSYAVLRF 772

  Fly   888 SEGD----------------PKEELTVKEEILDKR---DTQEVKESSVE---------LQDSAGH 924
            .|.|                |.::.||...:|.||   |.:.|..:..|         :|..||.
  Rat   773 PESDTHGAGGARSPATQGPPPNDDDTVTYSVLQKRNMGDYENVSPNCPEDESIHYSELVQFGAGK 837

  Fly   925 EVPEPKK 931
            . |:.|:
  Rat   838 R-PQAKE 843

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
btNP_001162825.1 I-set 9..101 CDD:254352
Ig 26..100 CDD:143165
I-set 119..210 CDD:254352 18/75 (24%)
Ig 136..209 CDD:143165 18/74 (24%)
I-set 228..320 CDD:254352 13/92 (14%)
IGc2 242..312 CDD:197706 10/70 (14%)
I-set 335..425 CDD:254352 19/99 (19%)
Ig 350..423 CDD:143165 16/82 (20%)
Ig 436..530 CDD:299845 22/96 (23%)
I-set 438..532 CDD:254352 22/96 (23%)
I-set 545..636 CDD:254352 16/93 (17%)
Ig 560..633 CDD:143165 12/75 (16%)
Ig 657..731 CDD:143165 17/77 (22%)
I-set 746..835 CDD:254352 20/89 (22%)
Ig 1496..1586 CDD:299845
IG_like 1503..1588 CDD:214653
I-set 1639..1724 CDD:254352
IG 1750..1821 CDD:214652
IGc2 1750..1806 CDD:197706
I-set 1826..1909 CDD:254352
Ig 1831..1897 CDD:299845
I-set 1914..1998 CDD:254352
Ig 2020..2095 CDD:299845
FN3 2100..2194 CDD:238020
FN3 2203..2292 CDD:238020
I-set 2311..2395 CDD:254352
Ig 2321..2395 CDD:299845
FN3 2399..2493 CDD:238020
FN3 2501..2590 CDD:238020
I-set 2602..2693 CDD:254352
Ig 2619..2693 CDD:299845
FN3 2697..2793 CDD:238020
FN3 2801..2893 CDD:238020
I-set 2902..2995 CDD:254352
Ig 2919..2993 CDD:299845
FN3 2999..3088 CDD:238020
FN3 3102..3191 CDD:238020
I-set 3208..3292 CDD:254352
Ig 3219..3292 CDD:299845
FN3 3296..3390 CDD:238020
FN3 3400..3489 CDD:238020
I-set 3494..3590 CDD:254352
Ig 3516..3590 CDD:299845
FN3 3594..3682 CDD:238020
FN3 3694..3781 CDD:238020
I-set 3795..3885 CDD:254352
Ig 3813..3885 CDD:299845
FN3 3889..3980 CDD:238020
FN3 3990..4082 CDD:238020
I-set 4090..4181 CDD:254352
Ig 4108..4181 CDD:299845
FN3 4185..4271 CDD:238020
FN3 4285..4383 CDD:238020
Ig 4404..4480 CDD:299845
FN3 4484..4571 CDD:238020
FN3 4584..4677 CDD:238020
I-set 4685..4775 CDD:254352
Ig 4703..4775 CDD:299845
FN3 4779..4863 CDD:238020
FN3 4879..4970 CDD:238020
IG 4989..5069 CDD:214652
Ig 4996..5069 CDD:299845
FN3 5073..5166 CDD:238020
FN3 5175..5265 CDD:238020
I-set 5276..5366 CDD:254352
Ig 5293..5366 CDD:299845
FN3 5370..5462 CDD:238020
FN3 5470..5561 CDD:238020
Ig 5559..5654 CDD:299845
I-set 5570..5660 CDD:254352
FN3 5664..5755 CDD:238020
FN3 5764..5853 CDD:238020
I-set 5865..5954 CDD:254352
Ig 5882..5954 CDD:299845
FN3 5958..6049 CDD:238020
FN3 6062..6153 CDD:238020
I-set 6173..6255 CDD:254352
Ig_Titin_like 6182..6255 CDD:143225
FN3 6259..6350 CDD:238020
FN3 6359..6451 CDD:238020
FN3 6470..6552 CDD:238020
I-set 6564..6650 CDD:254352
Ig_Titin_like 6577..6650 CDD:143225
FN3 6654..6745 CDD:238020
FN3 6754..6840 CDD:238020
I-set 6855..6946 CDD:254352
Ig 6874..6946 CDD:299845
FN3 6950..7042 CDD:238020
FN3 7050..7139 CDD:238020
FN3 7151..7237 CDD:238020
I-set 7254..7334 CDD:254352
Ig 7272..7339 CDD:143165
IG_like 7354..7440 CDD:214653
Ig 7366..7440 CDD:299845
FN3 7444..7531 CDD:238020
FN3 7545..7637 CDD:238020
I-set 7648..7737 CDD:254352
Ig 7665..7734 CDD:143165
Ig 7760..7833 CDD:299845
FN3 7837..7927 CDD:238020
STKc_Twitchin_like 7986..8244 CDD:271016
S_TKc 7989..8244 CDD:214567
Ig 8311..8394 CDD:299845
I-set 8312..8401 CDD:254352
I-set 8437..8525 CDD:254352
Ig 8455..8519 CDD:143165
I-set 8632..8721 CDD:254352
IGc2 8646..8711 CDD:197706
I-set 8740..8831 CDD:254352
Ig 8757..8826 CDD:143165
I-set 8839..8922 CDD:254352
Ig 8845..>8909 CDD:299845
Cd22NP_001100973.1 Ig 24..143 CDD:416386 12/48 (25%)
FR1 24..47 CDD:409353
Ig strand A 24..28 CDD:409353
Ig strand A' 31..35 CDD:409353
Ig strand B 37..48 CDD:409353
CDR1 48..56 CDD:409353
Ig strand C 56..63 CDD:409353
FR2 57..63 CDD:409353
CDR2 64..95 CDD:409353
Ig strand C1 65..68 CDD:409353
Ig strand C2 71..75 CDD:409353
Ig strand C' 79..82 CDD:409353
FR3 96..129 CDD:409353 7/26 (27%)
Ig strand D 97..101 CDD:409353
Ig strand E 106..114 CDD:409353 1/5 (20%)
Ig strand F 121..129 CDD:409353 2/7 (29%)
CDR3 130..132 CDD:409353 0/1 (0%)
FR4 133..143 CDD:409353 4/17 (24%)
Ig strand G 133..143 CDD:409353 4/17 (24%)
IgC1_CD22_d2 147..242 CDD:409532 26/150 (17%)
Ig strand B 163..167 CDD:409532 0/3 (0%)
Ig strand C 179..183 CDD:409532 0/3 (0%)
Ig strand E 207..211 CDD:409532 0/3 (0%)
Ig strand F 221..226 CDD:409532 1/4 (25%)
Ig strand G 235..238 CDD:409532 0/19 (0%)
Ig 246..334 CDD:416386 22/120 (18%)
Ig strand A 246..253 CDD:409353 1/13 (8%)
Ig strand B 260..270 CDD:409353 2/27 (7%)
Ig strand C 277..285 CDD:409353 1/7 (14%)
Ig strand C' 287..290 CDD:409353 0/2 (0%)
Ig strand E 296..303 CDD:409353 1/6 (17%)
Ig strand F 310..318 CDD:409353 4/7 (57%)
Ig strand G 321..334 CDD:409353 3/20 (15%)
IGc2 350..408 CDD:197706 16/71 (23%)
Ig strand B 354..358 CDD:409353 0/3 (0%)
Ig strand C 367..372 CDD:409353 2/4 (50%)
Ig strand F 398..403 CDD:409353 2/4 (50%)
Ig 424..>466 CDD:416386 10/45 (22%)
Ig strand A 424..431 CDD:409353 2/7 (29%)
Ig strand A' 435..439 CDD:409353 0/3 (0%)
Ig strand B 440..450 CDD:409353 3/9 (33%)
Ig strand C 457..463 CDD:409353 1/5 (20%)
IGc2 527..583 CDD:197706 13/71 (18%)
Ig strand B 530..534 CDD:409353 1/3 (33%)
Ig strand C 543..549 CDD:409353 1/5 (20%)
Ig strand F 573..578 CDD:409353 1/4 (25%)
IG 610..682 CDD:214652 19/80 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4475
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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