DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment bt and Dapk1

DIOPT Version :9

Sequence 1:NP_001162825.1 Gene:bt / 43814 FlyBaseID:FBgn0005666 Length:8933 Species:Drosophila melanogaster
Sequence 2:XP_008769663.1 Gene:Dapk1 / 306722 RGDID:1311629 Length:1442 Species:Rattus norvegicus


Alignment Length:582 Identity:189/582 - (32%)
Similarity:275/582 - (47%) Gaps:104/582 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly  7982 QQSVYDRYDILEEIGTGAFGVVHRCRERSTGNIFAAKFIPVSHS------VEKDLIRREIDIMNQ 8040
            |::|.|.||..||:|:|.|.||.:|||:|||..:|||||....:      |.::.|.||:.|:.:
  Rat     6 QENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKE 70

  Fly  8041 LHHQKLINLHDAFEDDDEMILILEFLSGGELFERITAEGYVMTEAEVINYMRQICEGIRHMHEQN 8105
            :.|..:|.||:.:|:..::|||||.::|||||: ..||...:||.|...:::||..|:.::|...
  Rat    71 IRHPNVITLHEVYENKTDVILILELVAGGELFD-FLAEKESLTEEEATEFLKQILSGVYYLHSLQ 134

  Fly  8106 IIHLDIKPENIMCQTRS--STNVKLIDFGLATRLDPNEVVKITTGTAEFAAPEIVNREPVGFYTD 8168
            |.|.|:||||||...|:  ...:|:||||||.::|.....|...||.||.||||||.||:|...|
  Rat   135 IAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVNYEPLGLEAD 199

  Fly  8169 MWATGVLSYVLLSGLSPFAGDNDVQTLKNVKACDWDFDVESFKYISEEAKDFIRKLLVRNKEKRM 8233
            ||:.||::|:||||.|||.||...:||.||.|.::||:.|.|:..|..||||||:|||::.:|||
  Rat   200 MWSIGVITYILLSGASPFLGDTKQETLANVSAVNYDFEEEFFRNTSTLAKDFIRRLLVKDPKKRM 264

  Fly  8234 TAHECLLHPWLTGDHSAMKQEINRDRYLAYREKL-----RRKYEDFERFLLPIGRLSEYSSLRKL 8293
            |..:.|.|||:....:  :|.::|.......||.     |:|::...|.:....|||. |.|.:.
  Rat   265 TIQDSLQHPWIKPKDT--QQALSRKASAVNMEKFKKFAARKKWKQSVRLISLCQRLSR-SFLSRS 326

  Fly  8294 LMEKYKIHDAVFDRRQAAPRFVIR-------PSSQFCYEGQSVKFYCRCIAIATPTLTWSH--NN 8349
            .|...:..|.:.:......:.:|.       |..|......|.....:.....||.|..:.  .|
  Rat   327 NMSVARSDDTLDEEDSFVMKAIIHAINDDNVPGLQHLLGSLSSYDVNQPNKHGTPPLLIAAGCGN 391

  Fly  8350 IELRQSVKFMKRYVGDDYYFIINRVKLDDRG--EYIIRAENHYGSREEVVFLNVQPLPKEQPRYR 8412
            |::.|.:  :||.         :|:.:.|:|  ..|..|..| |..:.:.|||....|.:..   
  Rat   392 IQMLQLL--IKRG---------SRIDVQDKGGSNAIYWASRH-GHVDTLKFLNENKCPLDVK--- 441

  Fly  8413 TESTPVRRREPLPYTFWQEESETAPSFTFLLRPRVMQAR----DTCKLLCCLSGKPVPNVRWYKD 8473
                             .:..|||..         :.||    |..:|||.....|.     ::|
  Rat   442 -----------------DKSGETALH---------VAARYGHADVVQLLCSFGSNPD-----FQD 475

  Fly  8474 GRELSKYEYAMTHSDGVVTMEIIDCKPSDSGKYSCKATNCHGTDETDCVVIV---EGEWVTP 8532
            ..|.:....|..|                 |.||.....|    |..|.|.:   |||  ||
  Rat   476 KEEETPLHCAAWH-----------------GYYSVARALC----EVGCNVNIKNREGE--TP 514

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
btNP_001162825.1 I-set 9..101 CDD:254352
Ig 26..100 CDD:143165
I-set 119..210 CDD:254352
Ig 136..209 CDD:143165
I-set 228..320 CDD:254352
IGc2 242..312 CDD:197706
I-set 335..425 CDD:254352
Ig 350..423 CDD:143165
Ig 436..530 CDD:299845
I-set 438..532 CDD:254352
I-set 545..636 CDD:254352
Ig 560..633 CDD:143165
Ig 657..731 CDD:143165
I-set 746..835 CDD:254352
Ig 1496..1586 CDD:299845
IG_like 1503..1588 CDD:214653
I-set 1639..1724 CDD:254352
IG 1750..1821 CDD:214652
IGc2 1750..1806 CDD:197706
I-set 1826..1909 CDD:254352
Ig 1831..1897 CDD:299845
I-set 1914..1998 CDD:254352
Ig 2020..2095 CDD:299845
FN3 2100..2194 CDD:238020
FN3 2203..2292 CDD:238020
I-set 2311..2395 CDD:254352
Ig 2321..2395 CDD:299845
FN3 2399..2493 CDD:238020
FN3 2501..2590 CDD:238020
I-set 2602..2693 CDD:254352
Ig 2619..2693 CDD:299845
FN3 2697..2793 CDD:238020
FN3 2801..2893 CDD:238020
I-set 2902..2995 CDD:254352
Ig 2919..2993 CDD:299845
FN3 2999..3088 CDD:238020
FN3 3102..3191 CDD:238020
I-set 3208..3292 CDD:254352
Ig 3219..3292 CDD:299845
FN3 3296..3390 CDD:238020
FN3 3400..3489 CDD:238020
I-set 3494..3590 CDD:254352
Ig 3516..3590 CDD:299845
FN3 3594..3682 CDD:238020
FN3 3694..3781 CDD:238020
I-set 3795..3885 CDD:254352
Ig 3813..3885 CDD:299845
FN3 3889..3980 CDD:238020
FN3 3990..4082 CDD:238020
I-set 4090..4181 CDD:254352
Ig 4108..4181 CDD:299845
FN3 4185..4271 CDD:238020
FN3 4285..4383 CDD:238020
Ig 4404..4480 CDD:299845
FN3 4484..4571 CDD:238020
FN3 4584..4677 CDD:238020
I-set 4685..4775 CDD:254352
Ig 4703..4775 CDD:299845
FN3 4779..4863 CDD:238020
FN3 4879..4970 CDD:238020
IG 4989..5069 CDD:214652
Ig 4996..5069 CDD:299845
FN3 5073..5166 CDD:238020
FN3 5175..5265 CDD:238020
I-set 5276..5366 CDD:254352
Ig 5293..5366 CDD:299845
FN3 5370..5462 CDD:238020
FN3 5470..5561 CDD:238020
Ig 5559..5654 CDD:299845
I-set 5570..5660 CDD:254352
FN3 5664..5755 CDD:238020
FN3 5764..5853 CDD:238020
I-set 5865..5954 CDD:254352
Ig 5882..5954 CDD:299845
FN3 5958..6049 CDD:238020
FN3 6062..6153 CDD:238020
I-set 6173..6255 CDD:254352
Ig_Titin_like 6182..6255 CDD:143225
FN3 6259..6350 CDD:238020
FN3 6359..6451 CDD:238020
FN3 6470..6552 CDD:238020
I-set 6564..6650 CDD:254352
Ig_Titin_like 6577..6650 CDD:143225
FN3 6654..6745 CDD:238020
FN3 6754..6840 CDD:238020
I-set 6855..6946 CDD:254352
Ig 6874..6946 CDD:299845
FN3 6950..7042 CDD:238020
FN3 7050..7139 CDD:238020
FN3 7151..7237 CDD:238020
I-set 7254..7334 CDD:254352
Ig 7272..7339 CDD:143165
IG_like 7354..7440 CDD:214653
Ig 7366..7440 CDD:299845
FN3 7444..7531 CDD:238020
FN3 7545..7637 CDD:238020
I-set 7648..7737 CDD:254352
Ig 7665..7734 CDD:143165
Ig 7760..7833 CDD:299845
FN3 7837..7927 CDD:238020
STKc_Twitchin_like 7986..8244 CDD:271016 123/265 (46%)
S_TKc 7989..8244 CDD:214567 122/262 (47%)
Ig 8311..8394 CDD:299845 19/93 (20%)
I-set 8312..8401 CDD:254352 21/99 (21%)
I-set 8437..8525 CDD:254352 18/91 (20%)
Ig 8455..8519 CDD:143165 12/63 (19%)
I-set 8632..8721 CDD:254352
IGc2 8646..8711 CDD:197706
I-set 8740..8831 CDD:254352
Ig 8757..8826 CDD:143165
I-set 8839..8922 CDD:254352
Ig 8845..>8909 CDD:299845
Dapk1XP_008769663.1 STKc_DAPK1 7..275 CDD:271096 124/268 (46%)
S_TKc 13..275 CDD:214567 122/262 (47%)
Ank_2 <337..409 CDD:289560 13/82 (16%)
ANK 373..497 CDD:238125 36/186 (19%)
ANK repeat 378..409 CDD:293786 9/41 (22%)
Ank_2 383..475 CDD:289560 27/137 (20%)
ANK repeat 412..442 CDD:293786 8/50 (16%)
ANK 439..564 CDD:238125 26/133 (20%)
ANK repeat 444..475 CDD:293786 10/44 (23%)
Ank_2 449..541 CDD:289560 23/103 (22%)
ANK repeat 477..508 CDD:293786 10/51 (20%)
ANK 505..629 CDD:238125 5/12 (42%)
ANK repeat 510..541 CDD:293786 5/7 (71%)
ANK repeat 543..574 CDD:293786
Ank_2 548..638 CDD:289560
ANK repeat 576..607 CDD:293786
ANK repeat 609..638 CDD:293786
Death_DAPK1 1308..1393 CDD:260052
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

Return to query results.
Submit another query.