DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bt and Myom2

DIOPT Version :9

Sequence 1:	NP_001162825.1	Gene:	bt / 43814	FlyBaseID:	FBgn0005666	Length:	8933	Species:	Drosophila melanogaster
Sequence 2:	NP_001162612.1	Gene:	Myom2 / 306616	RGDID:	631437	Length:	1464	Species:	Rattus norvegicus

Alignment Length:	1735	Identity:	348/1735 - (20%)
Similarity:	572/1735 - (32%)	Gaps:	573/1735 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  6171 IGKRIKVRAGEPVNLNIPISGAPTPTIEW-KRGDLKLEEGKRISYETNSE---RTLFRIDDSNRR 6231
            |.:|:.||      |...:.|.|||.::| |.|.|..:.|:...|...|.   .|| .|:.::..
  Rat   165 IWERMSVR------LCFTVQGFPTPVVQWYKDGSLICQAGEPGKYRIESRYGVHTL-EINRADFE 222

  Fly  6232 DSGKYTVTAANEFGKDTADIEVIVVDKPSPPEGPLSYTETAPDHISLHWYSPKDDGGSDITGYII 6296
            |:..|:..|.|..|:.:.:..|:|.......|         |.|
  Rat   223 DTATYSAVATNPHGQVSTNAAVVVRRYRGDEE---------PYH--------------------- 257

  Fly  6297 EFTEFGVDDWKPVPGTCPNTNFTVKNLVEGKKYVFRIRAENIYGASEALEGKPVLAKSPFDPPGA 6361
               ..|:....|:....|.|:|.|:.|.:             :|.:...||:.|..|...
  Rat   258 ---SVGLPIGLPLSSVIPYTHFDVQFLEK-------------FGVTFRREGETVTLKCTL----- 301

  Fly  6362 PSQPTISAYTPNSANLEWHPPDDCGGKPITGYIVERRERGGEWIKCNNYPTPNTSYTVSNLR--D 6424
            ...|.:....|.:   ||:..|           |..:|  .:|.|. .:.....|.:.|:|.  |
  Rat   302 LVTPDLKRVQPRA---EWYRDD-----------VLLKE--SKWTKM-FFGEGQASLSFSHLNKDD 349

  Fly  6425 GARYEFRVLA------------VNEAGPGHPSKPSDPMTAE-HQRYRPDPPEPPKPDRITRNGVT 6476
            ...|..|:::            |.:|.|.....|..||..: |.              ..|:.|.
  Rat   350 EGLYTLRIVSRGGVSDHSAFMFVRDADPLVTGAPGAPMDLQCHD--------------ANRDYVI 400

  Fly  6477 LSWRPPRTDGKSRIKGYYVEMRPKNGKDWKTVNDIPINSTVYTVPSLKEGEEYSFRVVAENEVGR 6541
            ::|:||.|..:|.:.||:::.......:|...||.|:....|.|..|.||..|.|||.|.|..|.
  Rat   401 VTWKPPNTTTESPVIGYFIDKCEVGTNNWVQCNDAPVKICKYPVTGLFEGRSYVFRVRAVNNAGI 465

  Fly  6542 SDPSKPSQPITIEEQPNKPCMELGKVRDIVCRAGDDFSIHVPYLAFPKPNAFWYSNDNMLDDNNR 6606
            |.||:.|..:...:.     ::|.:::.|
  Rat   466 SRPSRISDAVAALDP-----VDLRRLQAI------------------------------------ 489

  Fly  6607 VHKHLTDDAASVVVKNSKRADSGQYRLQLKNTSGFDTATINVRVLDRPSPPTRLRADEFSGDSLT 6671
               ||..:...|:.::....|                    |::   |.|||.::|.|.|.:.:.
  Rat   490 ---HLEGEKEIVIYQDDLEGD--------------------VQI---PGPPTNVQASEVSRNYVV 528

  Fly  6672 LYWNPPNDDGGSAIQNYIIEKKEARSSTWSKVSSFCTV--PFVRIRNLVLNKEYDFRVIAENKYG 6734
            |.|:||:..|...:. |.|||....|.:|.:|::...|  |...:.:|...|.|.|||::.||:|
  Rat   529 LSWDPPSPRGKEPLM-YFIEKSAVGSGSWQRVNAQTAVRSPRYAVFDLAEGKSYVFRVLSANKHG 592

  Fly  6735 QSDPANTSEPILARHPFDIPNTPGIPHGIDSTEDSITIAWTKPKHDGGSPITGYIIEKRLLSDDK 6799
            .|||:..:.||.|:....:|:.||......:|:.|:.:.|.:|||:  ..:.||.::..:...:.
  Rat   593 LSDPSEITPPIQAQDMIVVPSAPGRVLASRNTKTSVVVQWDRPKHE--EDLLGYYVDCCVAGTNM 655

  Fly  6800 WTKAVHALCPDLSCKIPNLIENAEYEFRVAAVNAAGQSAYSGSSDLIFCRRPPHAPKITSDLSIR 6864
            |....|.........:..|....:|.|||.||||.|.|..|..|::|         |:.:.|
  Rat   656 WEPCNHKPIGYNRFVVHGLTTGEQYIFRVKAVNAVGTSENSQESEVI---------KVQAAL--- 708

  Fly  6865 DMTVIAGDEFRITVPYHASPRPTASWSLNGLEVIPGERIKFDSNDYASMYYNKSAKRDETGSYTI 6929
                        |||.|                                            .|.|
  Rat   709 ------------TVPSH--------------------------------------------PYGI 717

  Fly  6930 TLTNNKGSDTASCHVTVVDRPLPPQGPLNAYDITPDTCTLAWKTPLDDGGSPITNYVVEKLD-NS 6993
            ||.|..|                            .:.||.||.|...|||.|..|.::|.: :.
  Rat   718 TLLNCDG----------------------------HSMTLGWKVPKFSGGSAIIGYYLDKREVHH 754

  Fly  6994 GSWVKI-SSFVRNTHYDVMGLEPHYKYNFRVRAENQYGLSDPLDIIEPIVAKHQFTVPDEPGQP- 7056
            .:|.:| ||.|:.....|.||.....|.|::.|.|..|:..|.|..|....: .:|.| |||..
  Rat   755 KNWHEINSSPVKERILTVEGLTEGSLYEFKIAATNLAGIGQPSDPSEHFKCE-AWTAP-EPGPAY 817

  Fly  7057 -----KVIDWDSGNVTLIWTRPLSDGGSRIQGYQIEYRDILNDS-SWNAYDYIIKDTKY-QLYNL 7114
                 :|.|   .::.::|..|:..|.|.:.||.:::::  .|| .|..........:| ::.:|
  Rat   818 DLTFCEVRD---TSLVILWKAPVYSGSSPVSGYFVDFKE--EDSGEWKTTSEAATPNRYLKVCDL 877

  Fly  7115 INGSEYEFRIKAKNAAGLSKPSSPSLRFKLKGKFTVPSPPGAPQVTRVGKNYVDLKWEKPLRDGG 7179
            ..|..|.||::|.||:|..|||..|      ....|.:.||..::: .|   ||        :.|
  Rat   878 HQGKTYVFRVRAVNASGPGKPSDTS------EPVLVEARPGTKEIS-AG---VD--------EEG 924

  Fly  7180 SRITGY-IIERRDIGGAVWVKCNDYNVLDTE--------------YTVMNLIEMGDYEFRVFAVN 7229
            :...|: ..|..|.....|.|..: .:.|.|              :...:.|::|.|...|...:
  Rat   925 NIYLGFDCQEMTDASQFTWCKAYE-EIADEERFEVHTEGDHSKLYFKNPDKIDIGTYSVSVSDTD 988

  Fly  7230 SAGRSEPSLCTMPIKVCEVLGGKKPDWITRLQDKV----APFGKDYTLQCAASGK---------- 7280
            ....|            .||..::.:.:..|.:::    .|...:...:....|:
  Rat   989 GVSSS------------FVLDEEELERLMALSNEIKNPTIPLKSELAYEIFDKGQVRFWLQAEHL 1041

  Fly  7281 -PSPTARWLRNGKEI-QMNGGRMTCDSKDGVFRLHISNVQTGDDGDYTCEAMNSLGFVNTSGYLK 7343
             |....|::.|.:|: .....|:.||...|:..:.:......::|.||.:..:... .|.|..:.
  Rat  1042 SPDANFRFIINDREVSDSETHRIKCDRSTGMIEMVMDRFTIENEGTYTVQIQDGKA-KNQSSLVL 1105

  Fly  7344 IGSP-----------------------------PIINRCPSELKLPEGDNSKIKIF--------Y 7371
            ||..                             .:...|...|.....:..:..:|        |
  Rat  1106 IGDAFRAVLEEAEFQRKEFLRKQGPHFAEYLHWDVTEECEVRLICKVANTKRETVFKWLKDDVLY 1170

  Fly  7372 SGDQPLTVILKKNNEVICDSNDDTHVKVNIFDDYVAIYIRNIVKSDGGPYQIEFTNESG------ 7430
            ..:.|...:.|.    ||:                 :.|..:.|.|.|.|:....::.|
  Rat  1171 ETETPPPDLEKG----ICE-----------------LLIPKLSKKDHGEYKATLKDDRGQDVSVL 1214

  Fly  7431 SATGEFY-------VHITGMPSAP----TGPMGISYINKNSCMLNWRPPSYDGGLKVSHYVIERK 7484
            ...|:.|       ..:.|..::|    ..|.||    :..|.:.:    :...:|||.|..|.|
  Rat  1215 EVAGKVYEDMILAMSRVCGASASPLKVLCTPEGI----RLQCFMKY----FTEEMKVSWYHKEAK 1271

  Fly  7485 DVSSPH----------WITVSSTCKDTAFNVQGLIENQEYIFRVMAVNENGMGPPLEGLNPIRAK 7539
            ..||.|          |:.:   |:.|.      .:..:|.|.:....:|..          |:.
  Rat  1272 ISSSEHMRIGGSEEMAWLQI---CEPTE------KDKGKYTFEIFDGKDNHQ----------RSL 1317

  Fly  7540 DPIDPPSPPGSPQITEIGGDFVHLEWEKPESDGGAHIQGYWIDKREVGSNTWQRVNATICAANQI 7604
            |                             ..|.|..:.|
  Rat  1318 D-----------------------------LSGQAFDEAY------------------------- 1328

  Fly  7605 NCINLIEGRQYEFRIFAQNVAGLSTESSASQAVKIIDPQAASPPLIVKPLRDANCIQNHNAQFTC 7669
                 .|.:|.:...||:...|           |:|   ...|.::       ..::......||
  Rat  1329 -----AEFQQLKAAAFAEKNRG-----------KVI---GGLPDVV-------TIMEGKTLNLTC 1367

  Fly  7670 TINGVPKPTISWYKGAREISNGARYHMYSEGDNHF-LNINDVFGEDADEYVCRAVNKAGAKSTRA 7733
            |:.|.|.|.:.|:|..::|.....:.:..|...:. |.|..|..||:.:|.....||.|.:....
  Rat  1368 TVFGNPDPEVVWFKNDKDIELSEHFSVKVEQSKYVSLTIKGVTAEDSGKYSINVKNKYGGEKIDV 1432

  Fly  7734 TLAIMTAPKLNVPPRFRDTAYFDKGENVVIKIPFTGFP---KPRI 7775
            |:::                 :..||    |||....|   ||::
  Rat  1433 TVSV-----------------YKHGE----KIPDISAPQQAKPKL 1456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bt	NP_001162825.1	I-set	9..101	CDD:254352
		Ig	26..100	CDD:143165
		I-set	119..210	CDD:254352
		Ig	136..209	CDD:143165
		I-set	228..320	CDD:254352
		IGc2	242..312	CDD:197706
		I-set	335..425	CDD:254352
		Ig	350..423	CDD:143165
		Ig	436..530	CDD:299845
		I-set	438..532	CDD:254352
		I-set	545..636	CDD:254352
		Ig	560..633	CDD:143165
		Ig	657..731	CDD:143165
		I-set	746..835	CDD:254352
		Ig	1496..1586	CDD:299845
		IG_like	1503..1588	CDD:214653
		I-set	1639..1724	CDD:254352
		IG	1750..1821	CDD:214652
		IGc2	1750..1806	CDD:197706
		I-set	1826..1909	CDD:254352
		Ig	1831..1897	CDD:299845
		I-set	1914..1998	CDD:254352
		Ig	2020..2095	CDD:299845
		FN3	2100..2194	CDD:238020
		FN3	2203..2292	CDD:238020
		I-set	2311..2395	CDD:254352
		Ig	2321..2395	CDD:299845
		FN3	2399..2493	CDD:238020
		FN3	2501..2590	CDD:238020
		I-set	2602..2693	CDD:254352
		Ig	2619..2693	CDD:299845
		FN3	2697..2793	CDD:238020
		FN3	2801..2893	CDD:238020
		I-set	2902..2995	CDD:254352
		Ig	2919..2993	CDD:299845
		FN3	2999..3088	CDD:238020
		FN3	3102..3191	CDD:238020
		I-set	3208..3292	CDD:254352
		Ig	3219..3292	CDD:299845
		FN3	3296..3390	CDD:238020
		FN3	3400..3489	CDD:238020
		I-set	3494..3590	CDD:254352
		Ig	3516..3590	CDD:299845
		FN3	3594..3682	CDD:238020
		FN3	3694..3781	CDD:238020
		I-set	3795..3885	CDD:254352
		Ig	3813..3885	CDD:299845
		FN3	3889..3980	CDD:238020
		FN3	3990..4082	CDD:238020
		I-set	4090..4181	CDD:254352
		Ig	4108..4181	CDD:299845
		FN3	4185..4271	CDD:238020
		FN3	4285..4383	CDD:238020
		Ig	4404..4480	CDD:299845
		FN3	4484..4571	CDD:238020
		FN3	4584..4677	CDD:238020
		I-set	4685..4775	CDD:254352
		Ig	4703..4775	CDD:299845
		FN3	4779..4863	CDD:238020
		FN3	4879..4970	CDD:238020
		IG	4989..5069	CDD:214652
		Ig	4996..5069	CDD:299845
		FN3	5073..5166	CDD:238020
		FN3	5175..5265	CDD:238020
I-set	5276..5366	CDD:254352
Ig	5293..5366	CDD:299845
FN3	5370..5462	CDD:238020
FN3	5470..5561	CDD:238020
Ig	5559..5654	CDD:299845
I-set	5570..5660	CDD:254352
FN3	5664..5755	CDD:238020
FN3	5764..5853	CDD:238020
I-set	5865..5954	CDD:254352
Ig	5882..5954	CDD:299845
FN3	5958..6049	CDD:238020
FN3	6062..6153	CDD:238020
I-set	6173..6255	CDD:254352	24/85 (28%)
Ig_Titin_like	6182..6255	CDD:143225	21/76 (28%)
FN3	6259..6350	CDD:238020	13/90 (14%)
FN3	6359..6451	CDD:238020	20/105 (19%)
FN3	6470..6552	CDD:238020	29/81 (36%)
I-set	6564..6650	CDD:254352	7/85 (8%)
Ig_Titin_like	6577..6650	CDD:143225	5/72 (7%)
FN3	6654..6745	CDD:238020	33/92 (36%)
FN3	6754..6840	CDD:238020	24/85 (28%)
I-set	6855..6946	CDD:254352	12/90 (13%)
Ig	6874..6946	CDD:299845	10/71 (14%)
FN3	6950..7042	CDD:238020	27/93 (29%)
FN3	7050..7139	CDD:238020	28/96 (29%)
FN3	7151..7237	CDD:238020	18/100 (18%)
I-set	7254..7334	CDD:254352	14/95 (15%)
Ig	7272..7339	CDD:143165	13/78 (17%)
IG_like	7354..7440	CDD:214653	15/106 (14%)
Ig	7366..7440	CDD:299845	14/94 (15%)
FN3	7444..7531	CDD:238020	20/100 (20%)
FN3	7545..7637	CDD:238020	8/91 (9%)
I-set	7648..7737	CDD:254352	20/89 (22%)
Ig	7665..7734	CDD:143165	19/69 (28%)
Ig	7760..7833	CDD:299845	6/19 (32%)
FN3	7837..7927	CDD:238020
STKc_Twitchin_like	7986..8244	CDD:271016
S_TKc	7989..8244	CDD:214567
Ig	8311..8394	CDD:299845
I-set	8312..8401	CDD:254352
I-set	8437..8525	CDD:254352
Ig	8455..8519	CDD:143165
I-set	8632..8721	CDD:254352
IGc2	8646..8711	CDD:197706
I-set	8740..8831	CDD:254352
Ig	8757..8826	CDD:143165
I-set	8839..8922	CDD:254352
Ig	8845..>8909	CDD:299845
Myom2	NP_001162612.1	IgI_titin_I1-like	154..247	CDD:409543	25/88 (28%)
		Ig strand B	171..175	CDD:409543	3/9 (33%)
		Ig strand C	184..188	CDD:409543	0/3 (0%)
		Ig strand E	212..216	CDD:409543	2/4 (50%)
		Ig strand F	226..231	CDD:409543	1/4 (25%)
		Ig strand G	239..242	CDD:409543	0/2 (0%)
		Ig	290..372	CDD:416386	19/103 (18%)
		Ig strand B	295..299	CDD:409353	1/3 (33%)
		Ig strand C	313..317	CDD:409353	1/6 (17%)
		Ig strand E	338..342	CDD:409353	1/3 (33%)
		Ig strand F	352..357	CDD:409353	1/4 (25%)
		Ig strand G	366..369	CDD:409353	0/2 (0%)
		FN3	383..475	CDD:238020	33/105 (31%)
		FN3	511..603	CDD:238020	33/92 (36%)
		FN3	612..702	CDD:238020	26/91 (29%)
		FN3	711..801	CDD:238020	34/161 (21%)
		FN3	813..903	CDD:238020	27/100 (27%)
		Ig	911..994	CDD:416386	18/107 (17%)
		Ig strand A	912..915	CDD:409353	1/2 (50%)
		Ig strand A'	918..921	CDD:409353	1/5 (20%)
		Ig strand B	925..933	CDD:409353	1/7 (14%)
		Ig strand C	939..945	CDD:409353	1/5 (20%)
		Ig strand C'	947..950	CDD:409353	0/3 (0%)
		Ig strand D	956..961	CDD:409353	0/4 (0%)
		Ig strand E	965..971	CDD:409353	0/5 (0%)
		Ig strand F	978..986	CDD:409353	3/7 (43%)
		Ig	1146..>1200	CDD:409353	11/74 (15%)
		Ig strand B	1146..1150	CDD:409353	1/3 (33%)
		Ig strand C	1159..1164	CDD:409353	1/4 (25%)
		Ig strand E	1184..1188	CDD:409353	1/20 (5%)
		PHA02826	1238..1433	CDD:165173	52/301 (17%)
		IgI_M-protein_C	1345..1436	CDD:143299	24/111 (22%)
		Ig strand B	1363..1367	CDD:143299	0/3 (0%)
		Ig strand C	1376..1380	CDD:143299	0/3 (0%)
		Ig strand E	1402..1406	CDD:143299	1/3 (33%)
		Ig strand F	1416..1421	CDD:143299	1/4 (25%)
		Ig strand G	1429..1432	CDD:143299	0/2 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	71	1.000	Domainoid score	I9197
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13817
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.100