DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment bt and LAMA1

DIOPT Version :9

Sequence 1:NP_001162825.1 Gene:bt / 43814 FlyBaseID:FBgn0005666 Length:8933 Species:Drosophila melanogaster
Sequence 2:NP_005550.2 Gene:LAMA1 / 284217 HGNCID:6481 Length:3075 Species:Homo sapiens


Alignment Length:1684 Identity:290/1684 - (17%)
Similarity:524/1684 - (31%) Gaps:613/1684 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   704 INDVEESDKGAYKLVASNEKGEAV--SQIVNLVDIPEEERKPCKPEISRKLADQKVAESKTFELL 766
            :||::|.             |:||  ..:..::.:|                         :.:|
Human  1565 LNDLDEI-------------GDAVLSLNLTGIIPVP-------------------------YGIL 1591

  Fly   767 VSLSQTDRKCKVEWYKGSTVIRET--KD--------ITTTFDGTTARLTFSSARTEHTSNYKVIV 821
            .:|..|.:      |...::::|.  ||        :....|....:||...|.|:..:.    .
Human  1592 SNLENTTK------YLQESLLKENMQKDLGKIKLEGVAEETDNLQKKLTRMLASTQKVNR----A 1646

  Fly   822 TNEVGKDESSCKITVEKVAKKKEEKPKEKEKTKNEKEVEQKEMEED---KNESGQSVAQTEGRIN 883
            |..:.|:.....|.:|::.....|        ..||....:.::||   .|.:.|::.|..    
Human  1647 TERIFKESQDLAIAIERLQMSITE--------IMEKTTLNQTLDEDFLLPNSTLQNMQQNG---- 1699

  Fly   884 IEQISEGDPKEELTVKEEILDKRD-TQEVKESSVELQDSAGHEVPEPKKATSD--SKLDQSNQKN 945
                         |...||:..|| ||..:.:::||            ||..|  |::.::.||.
Human  1700 -------------TSLLEIMQIRDFTQLHQNATLEL------------KAAEDLLSQIQENYQKP 1739

  Fly   946 LDK----KHKTDQSESKTNKNVSLAEPI----KSNKQESEEQQATEQIGLKKVDRKASIVSVKEE 1002
            |::    |.......||.|..:..||.:    ::..|||..........|::...|...|..::.
Human  1740 LEELEVLKEAASHVLSKHNNELKAAEALVREAEAKMQESNHLLLMVNANLREFSDKKLHVQEEQN 1804

  Fly  1003 ISSD--VRRKSTIKAKEEIT--VDDKKASSRRSSLAVEESNTESRRSSIIDKKPLEQVDNKPID- 1062
            ::|:  |:.:..|.|....|  |.|          |:|.......:..:...|....:|:..:. 
Human  1805 LTSELIVQGRGLIDAAAAQTDAVQD----------ALEHLEDHQDKLLLWSAKIRHHIDDLVMHM 1859

  Fly  1063 ANKNPQPLKEEIPRLK--PAEKRRTSKVIEEPKPDEGLPKLRKASIAQVKEEAKPAAPKLKAKAK 1125
            :.:|...|   :.|.:  .||.:|.:.|:.     .||..:|..|              |.|.:.
Human  1860 SQRNAVDL---VYRAEDHAAEFQRLADVLY-----SGLENIRNVS--------------LNATSA 1902

  Fly  1126 AKPKYEELPEIPDYERPQLEKYEKSDFTPSDFARDLEIPNKMEKPIIDSGK----KEPAVLAQKN 1186
            |...|.....|           |:|:....|..|.:...:.:.:.::.:||    :....|.:.|
Human  1903 AYVHYNIQSLI-----------EESEELARDAHRTVTETSLLSESLVSNGKAAVQRSSRFLKEGN 1956

  Fly  1187 GIPKKTDIIEQYADEPKGLKVGKGKLPDEGDGRDGAVLKPVIIEPEKEILDLGNKKNNQHADKPT 1251
            .:.:                    |||       |..|         |:.:|.||.|.   .:..
Human  1957 NLSR--------------------KLP-------GIAL---------ELSELRNKTNR---FQEN 1982

  Fly  1252 VLDIIKQRRRSSIRNLMTKEPIQNESFLGVVLKPVIKDTREQ---------AAPQQAIQLTK--- 1304
            .::|.:|               .|||.|  :|:.:.|..|::         :|.|.|:...:   
Human  1983 AVEITRQ---------------TNESLL--ILRAIPKGIRDKGAKTKELATSASQSAVSTLRDVA 2030

  Fly  1305 ------ANATEQFSPTKAVKAQVADLKKPETLATLEDNYERPVLEKYDPFSIDKTKSEKSTPSII 1363
                  .|.:...|.......:...|.:..|:|||....:...:|.......|:.|..|.....:
Human  2031 GLSQELLNTSASLSRVNTTLRETHQLLQDSTMATLLAGRKVKDVEIQANLLFDRLKPLKMLEENL 2095

  Fly  1364 TPDIRGPEVKLPVQETKEEKQKVPKMQPPAPGDPPKIEVIREKRPSLA-------------PEPP 1415
            :.::  .|:||.:.:.:::...: |:...|..|     .||..:|.::             .||.
Human  2096 SRNL--SEIKLLISQARKQAASI-KVAVSADRD-----CIRAYQPQISSTNYNTLTLNVKTQEPD 2152

  Fly  1416 S------------------RRGSLIPPADTG------RRPSLIINDEKKLRPGEVMDTRLLRPGE 1456
            :                  |||.:....|.|      ..|...|:|.:      .....:.|.|.
Human  2153 NLLFYLGSSTASDFLAVEMRRGRVAFLWDLGSGSTRLEFPDFPIDDNR------WHSIHVARFGN 2211

  Fly  1457 VGEGQRRRPSIDVRRPSVQDLEDLINKPSTPLRDVGDGGPPSIVDVQESYSVVEDSTAYLTVGVE 1521
            :|       |:.|:        ::.:...:|.:.....|..:::|       |.:||.....|:.
Human  2212 IG-------SLSVK--------EMSSNQKSPTKTSKSPGTANVLD-------VNNSTLMFVGGLG 2254

  Fly  1522 G----SPAPTFKFYKG-VSEILEGGRFKFLTDGQTNTITLCMRKCK----------PN---DESK 1568
            |    |||.....:|| :.|....|:    :.|..|.|.. ..||:          |:   |.|.
Human  2255 GQIKKSPAVKVTHFKGCLGEAFLNGK----SIGLWNYIER-EGKCRGCFGSSQNEDPSFHFDGSG 2314

  Fly  1569 YKIVVSNI----------------HGEDSAEMQLYVSDSSGMDFRA------------------- 1598
            |.:|..::                :|     :.||:......||.:                   
Human  2315 YSVVEKSLPATVTQIIMLFNTFSPNG-----LLLYLGSYGTKDFLSIELFRGRVKVMTDLGSGPI 2374

  Fly  1599 -MLKKRRYQK--WDK---------------DEQDPNWGDLKETEKP------------------L 1627
             :|..|||..  |.|               |..:.:..:.|:.|.|                  |
Human  2375 TLLTDRRYNNGTWYKIAFQRNRKQGVLAVIDAYNTSNKETKQGETPGASSDLNRLDKDPIYVGGL 2439

  Fly  1628 PALKKVERKV--ESFLSPLIDQFAKEGKDKKVVFEARFSKPNCKPKWL---FRKDEVFTGSKFKF 1687
            |..:.|.|.|  :||:..:     |..:..:..|:...:....:...|   .|......|...:.
Human  2440 PRSRVVRRGVTTKSFVGCI-----KNLEISRSTFDLLRNSYGVRKGCLLEPIRSVSFLKGGYIEL 2499

  Fly  1688 --KQENDTYQLIITTPKVEDTGKYTIEIGG--------------------VSSTAFLNVEEADPT 1730
              |..:...:.::|......:|.....:||                    :.....::|...|.|
Human  2500 PPKSLSPESEWLVTFATTNSSGIILAALGGDVEKRGDREEAHVPFFSVMLIGGNIEVHVNPGDGT 2564

  Fly  1731 YTFTKPLKKKLEGFTQHETTLECSVSSSMANVHWFKN----NTKLESDDPRYLISKDINGNLKLI 1791
                 .|:|.|    .|..|..|| .....::...:|    ..:|:.::|       :...|..:
Human  2565 -----GLRKAL----LHAPTGTCS-DGQAHSISLVRNRRIITVQLDENNP-------VEMKLGTL 2612

  Fly  1792 IKDSVLDDAGLYRCQLDKQPDKTECNLKVTEYPYKFVKVLKSQQCIEKDTVTL-ACEIDDAMGEV 1855
            ::...::.:.||   :...|:....:|......:        ..||:.....| ..:.:.|:|..
Human  2613 VESRTINVSNLY---VGGIPEGEGTSLLTMRRSF--------HGCIKNLIFNLELLDFNSAVGHE 2666

  Fly  1856 Q------WLRNGEEIKPDKRIQIVKDGR---KRKLVIKDCKVTDAG--------QFKCTTNADTT 1903
            |      ||....::.||     .:|.:   :.:...:.| |.||.        ||..|.|    
Human  2667 QVDLDTCWLSERPKLAPD-----AEDSKLLPEPRAFPEQC-VVDAALEYVPGAHQFGLTQN---- 2721

  Fly  1904 ESEIIINY-QNRFNKKLKDTEAVEREKLILDIELQDQTAPCDWKFNGEPIV------PSESIEIK 1961
             |..|:.: |:...||             |.:||..:|      |....::      ......:.
Human  2722 -SHFILPFNQSAVRKK-------------LSVELSIRT------FASSGLIYYMAHQNQADYAVL 2766

  Fly  1962 NMGGGKHQLIFSSLDMSNEGEITCESGQLSSKCKLSIRKGESRPNIDCPDKFSGPISAPVLLEVP 2026
            .:.||:...:|                        .:.||.::            :|.|.||. .
Human  2767 QLHGGRLHFMF------------------------DLGKGRTK------------VSHPALLS-D 2794

  Fly  2027 FKVSGTKQTPVEAKLF--KDGKPLPVKDVEVAVTDDKVTFKIK-------KPSRDLSGPYQI-KI 2081
            .|....|...|:.|.|  .||:..|:    |.|..|.....::       .||:     ||. ||
Human  2795 GKWHTVKTDYVKRKGFITVDGRESPM----VTVVGDGTMLDVEGLFYLGGLPSQ-----YQARKI 2850

  Fly  2082 SNGQGEDTKDVQIICQDVPQPPQDVDITDVYQTSCV--VSFNPPSDDGGTPITKYVIER 2138
            .|           |...:|              :|:  |:.|....|..:|::.:.:.|
Human  2851 GN-----------ITHSIP--------------ACIGDVTVNSKQLDKDSPVSAFTVNR 2884

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
btNP_001162825.1 I-set 9..101 CDD:254352
Ig 26..100 CDD:143165
I-set 119..210 CDD:254352
Ig 136..209 CDD:143165
I-set 228..320 CDD:254352
IGc2 242..312 CDD:197706
I-set 335..425 CDD:254352
Ig 350..423 CDD:143165
Ig 436..530 CDD:299845
I-set 438..532 CDD:254352
I-set 545..636 CDD:254352
Ig 560..633 CDD:143165
Ig 657..731 CDD:143165 6/28 (21%)
I-set 746..835 CDD:254352 14/98 (14%)
Ig 1496..1586 CDD:299845 24/123 (20%)
IG_like 1503..1588 CDD:214653 24/118 (20%)
I-set 1639..1724 CDD:254352 12/109 (11%)
IG 1750..1821 CDD:214652 11/74 (15%)
IGc2 1750..1806 CDD:197706 9/59 (15%)
I-set 1826..1909 CDD:254352 20/100 (20%)
Ig 1831..1897 CDD:299845 17/83 (20%)
I-set 1914..1998 CDD:254352 10/89 (11%)
Ig 2020..2095 CDD:299845 21/84 (25%)
FN3 2100..2194 CDD:238020 7/41 (17%)
FN3 2203..2292 CDD:238020
I-set 2311..2395 CDD:254352
Ig 2321..2395 CDD:299845
FN3 2399..2493 CDD:238020
FN3 2501..2590 CDD:238020
I-set 2602..2693 CDD:254352
Ig 2619..2693 CDD:299845
FN3 2697..2793 CDD:238020
FN3 2801..2893 CDD:238020
I-set 2902..2995 CDD:254352
Ig 2919..2993 CDD:299845
FN3 2999..3088 CDD:238020
FN3 3102..3191 CDD:238020
I-set 3208..3292 CDD:254352
Ig 3219..3292 CDD:299845
FN3 3296..3390 CDD:238020
FN3 3400..3489 CDD:238020
I-set 3494..3590 CDD:254352
Ig 3516..3590 CDD:299845
FN3 3594..3682 CDD:238020
FN3 3694..3781 CDD:238020
I-set 3795..3885 CDD:254352
Ig 3813..3885 CDD:299845
FN3 3889..3980 CDD:238020
FN3 3990..4082 CDD:238020
I-set 4090..4181 CDD:254352
Ig 4108..4181 CDD:299845
FN3 4185..4271 CDD:238020
FN3 4285..4383 CDD:238020
Ig 4404..4480 CDD:299845
FN3 4484..4571 CDD:238020
FN3 4584..4677 CDD:238020
I-set 4685..4775 CDD:254352
Ig 4703..4775 CDD:299845
FN3 4779..4863 CDD:238020
FN3 4879..4970 CDD:238020
IG 4989..5069 CDD:214652
Ig 4996..5069 CDD:299845
FN3 5073..5166 CDD:238020
FN3 5175..5265 CDD:238020
I-set 5276..5366 CDD:254352
Ig 5293..5366 CDD:299845
FN3 5370..5462 CDD:238020
FN3 5470..5561 CDD:238020
Ig 5559..5654 CDD:299845
I-set 5570..5660 CDD:254352
FN3 5664..5755 CDD:238020
FN3 5764..5853 CDD:238020
I-set 5865..5954 CDD:254352
Ig 5882..5954 CDD:299845
FN3 5958..6049 CDD:238020
FN3 6062..6153 CDD:238020
I-set 6173..6255 CDD:254352
Ig_Titin_like 6182..6255 CDD:143225
FN3 6259..6350 CDD:238020
FN3 6359..6451 CDD:238020
FN3 6470..6552 CDD:238020
I-set 6564..6650 CDD:254352
Ig_Titin_like 6577..6650 CDD:143225
FN3 6654..6745 CDD:238020
FN3 6754..6840 CDD:238020
I-set 6855..6946 CDD:254352
Ig 6874..6946 CDD:299845
FN3 6950..7042 CDD:238020
FN3 7050..7139 CDD:238020
FN3 7151..7237 CDD:238020
I-set 7254..7334 CDD:254352
Ig 7272..7339 CDD:143165
IG_like 7354..7440 CDD:214653
Ig 7366..7440 CDD:299845
FN3 7444..7531 CDD:238020
FN3 7545..7637 CDD:238020
I-set 7648..7737 CDD:254352
Ig 7665..7734 CDD:143165
Ig 7760..7833 CDD:299845
FN3 7837..7927 CDD:238020
STKc_Twitchin_like 7986..8244 CDD:271016
S_TKc 7989..8244 CDD:214567
Ig 8311..8394 CDD:299845
I-set 8312..8401 CDD:254352
I-set 8437..8525 CDD:254352
Ig 8455..8519 CDD:143165
I-set 8632..8721 CDD:254352
IGc2 8646..8711 CDD:197706
I-set 8740..8831 CDD:254352
Ig 8757..8826 CDD:143165
I-set 8839..8922 CDD:254352
Ig 8845..>8909 CDD:299845
LAMA1NP_005550.2 LamNT 16..268 CDD:214532
EGF_Lam 270..317 CDD:238012
Laminin_EGF 397..456 CDD:278482
Laminin_EGF 454..500 CDD:278482
Laminin_B 568..696 CDD:278481
EGF_Lam 741..789 CDD:238012
Laminin_EGF 791..846 CDD:278482
EGF_Lam 848..900 CDD:238012
Laminin_EGF 902..948 CDD:278482
Laminin_EGF 951..998 CDD:278482
Laminin_EGF 998..1041 CDD:278482
Laminin_EGF 1044..1092 CDD:278482
Laminin_EGF 1090..1147 CDD:278482
LamB 1213..1344 CDD:214597
Laminin_EGF 1403..1449 CDD:278482
Laminin_EGF 1452..1506 CDD:278482
Laminin_EGF 1509..1556 CDD:278482
Laminin_I 1567..1830 CDD:283627 65/357 (18%)
BAR 1609..1841 CDD:299863 56/282 (20%)
Laminin_II 2011..2145 CDD:283628 23/141 (16%)
LamG 2141..2280 CDD:214598 29/166 (17%)
LamG 2307..2463 CDD:238058 27/165 (16%)
Laminin_G_1 2514..2658 CDD:278483 24/171 (14%)
Laminin_G_1 2743..2872 CDD:278483 34/205 (17%)
LamG 2892..3043 CDD:238058
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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