DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment bt and IGSF22

DIOPT Version :9

Sequence 1:NP_001162825.1 Gene:bt / 43814 FlyBaseID:FBgn0005666 Length:8933 Species:Drosophila melanogaster
Sequence 2:XP_011518332.1 Gene:IGSF22 / 283284 HGNCID:26750 Length:1346 Species:Homo sapiens


Alignment Length:1490 Identity:363/1490 - (24%)
Similarity:603/1490 - (40%) Gaps:316/1490 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly  5541 FRVIAVNRGGPSDPSDPSSTIICKPRFLAPFFDKSLLNDITVHAGKRLGWTLPIEASPRPLITWL 5605
            |.::..:...|:..|.|.  .:.||:            .:|...|.:..:...::.:.:|.|:| 
Human    71 FSLVTRSSNIPAGDSVPE--FVEKPQ------------PVTAPEGDKAVFRARVQGNAKPHISW- 120

  Fly  5606 YNGKEIGSNSRGESGLFQNELTFEIVSSLR----SDEGRYTLILKNEHGS--FDASAHAT----- 5659
              .:|.|...:..:.:|.:.:..|.|..|.    .|...|..|..|:|..  :..|...|     
Human   121 --KRESGIPIKESAKIFYDSINKEHVLKLEPLTSDDSDNYKCIASNDHADAIYTVSLLVTEGQEK 183

  Fly  5660 -----VLDRPSPPKGPLDITKIT--RDGCHLTWNVPDDDGGSPILHYIIEKMDLSRSTWSDAGMS 5717
                 :|.:.:||.......|:.  ::...:...||..|.....:.|               |.:
Human   184 MDFKKMLKKRAPPAPKKKQKKVANEKEMLEILSKVPKKDFEKVCMEY---------------GFT 233

  Fly  5718 THIVHDVTRLVHRKEYLFRVKAVNAIGESDPLE----AVNTIIAKNEFDEPDAPGKPIITDWDRD 5778
                 |...|:.:.:.:.:...|.||....|||    .|:|.:..:...|...|...:|.....:
Human   234 -----DFRGLLRKLKEMKKKVEVEAIRILKPLEDKETKVDTTVVFDCIMELKDPNVKMIWIKGTE 293

  Fly  5779 HIDLQWAVPKSDGGAPISEYIIQKKEKGSPYWTNVRHVPSNKNTTTIPELTEGQE---YEFRVIA 5840
            .:.:|:::.|.|           .|:.|:.|...:.:|  |.|...|..|:.|.:   .|..|: 
Human   294 PLRIQYSLGKYD-----------VKQMGTKYMLVISNV--NMNDAGIYSLSVGDKRMSAELTVL- 344

  Fly  5841 VNQAGQSEPSEPSDMIMAKPRYLPPKII---TPLNEVRIKCGLIFHTDIHFIGEPAPEATWTLNS 5902
                     .||...:   ....|.|:.   |.:.|:|             :.:..|...|..|.
Human   345 ---------DEPLKFL---GEMKPVKVTERQTAVFEIR-------------LSKKEPNFVWKFNG 384

  Fly  5903 NPLLSNDRSTITSIGHHSVVHTV---NCQRSDSGIY-----HLLLRNSSGIDEGSFELV------ 5953
            ..|..:|:..|| :....:.||:   :.:.||||.:     :|:.:....:|....:.|      
Human   385 KELKRDDKYEIT-VSEDGLTHTLKIKDARLSDSGEFSAEAGNLVQKAQLTVDRIPIKFVSNLKNV 448

  Fly  5954 -VLDRPGPPEGPMEYEEITANSVTISWKPPKD------------NGGSEISSYVIEKRDLTHGGG 6005
             |.:|   ....:|. |:|:..||:.||  ||            |...:.:..:||...|:.||.
Human   449 RVKER---SRACLEC-ELTSKDVTLRWK--KDGQLLMHGTKYSMNHEGKRAELIIEDAQLSDGGE 507

  Fly  6006 WV-------PAVNYVSAKYNHAVVPRLLEGTMYELRVMAENLQGRSDPLTSDQPVVAKSQYTVPG 6063
            :.       ....|    |:.|:|      |:.|.  :|....|.||               |..
Human   508 YTVVAMQDGDPTEY----YSTAIV------TVEER--LATVKSGMSD---------------VHA 545

  Fly  6064 APGKPE-----LTDSDKNHITIKWKQPISNGGSPIIGYDIERRDVNTGRWIKINGQPVPTAEYQD 6123
            |.|.|.     |.|.....:.:|..:.|::    :.|..|.::..       ::....|:     
Human   546 ATGSPAELCVVLNDEKVEGVWLKDGKEITD----LPGMQIVKQGA-------VHKLIFPS----- 594

  Fly  6124 DRVTSNHQYQYRISAVNAAGNGKTSEPSAIFNARPLREKPRFYFDGLIGKRIKVRAGEPVNLNIP 6188
              :...|:.:|...|     .|..||.| :|.|.|....|. ..:.|....|.|:.|...::.:|
Human   595 --MGPEHEGKYTFRA-----KGTESEAS-VFIADPPTIDPS-VLEALAAHAITVKVGHTAHIKVP 650

  Fly  6189 ISGAPTPTIEWKRGDLKLEEGKRISYETNSERTLFRIDDSNRRDSGKYTVTAANEFGKDTADIEV 6253
            ..|.|.|.:.|.:..:::.|.:|:|.|...::.|..|.:..|.|||...:...|:.|..||.:.:
Human   651 FRGKPLPKVTWYKDGMEVTEEERVSMERGEDQALLTISNCVREDSGLILLKLKNDHGSATATLHL 715

  Fly  6254 IVVDKPSPPEGPLSYTETAPDHISLHWYSPKDDGGSDITGYIIEFTEFGVDDW---KPVPGTCPN 6315
            .|:|:|.||:|.:.:.|.:...:.:.|.:|||:||..:|.:|:|....|...|   ..|.|..  
Human   716 SVLDRPKPPQGRVEFLELSGSCVHMKWKAPKDNGGRPVTQFIVERRAVGKKSWIKIGEVDGKV-- 778

  Fly  6316 TNFTVKNLVEGKKYVFRIRAENIYGASEALEGKPVLAKSPFDPPGAPSQPTISAYTPNSANLEWH 6380
            |||:...:.|||.|.|||.|.|..|.|:.||.:.|.|.:|.:|||..|||.::..|..:..:.|:
Human   779 TNFSTNKVEEGKAYQFRILAVNSEGVSDPLETEEVFAGNPIEPPGFASQPQVTDVTKEAVTITWN 843

  Fly  6381 PPDDCGGKPITGYIVERRERGGE-WIKCNNYPTPNTSYTVSNLRDGARYEFRVLAVNEAGPGHPS 6444
            .|...||.|:.|||||||::|.. |:..|..|...|..||..|.:...|||||:|||:||||.||
Human   844 APTQDGGAPVLGYIVERRKKGSNLWVPVNKDPIQGTKCTVDGLLEDTEYEFRVIAVNKAGPGQPS 908

  Fly  6445 KPSDPMTAEHQRYRPDPPEPP------KPDRITRNGVTLSWRPPRTDGKSRIKGYYVEMRPKNGK 6503
            .||..:.|:      ||.:||      .....:.:.::|:||.| .:|... .||.:|||.::.|
Human   909 VPSSSVVAK------DPVKPPGLVQDLHVSDSSNSSISLAWREP-AEGDPP-SGYILEMRAEDTK 965

  Fly  6504 DWKTVNDIPINSTVYTVPSLKEGEEYSFRVVAENEVGRSDPSKPSQPITIEEQPNKPCMEL-GKV 6567
            :|.....|||:.|.|||..|.|.::|.||:.|.||.|..:|.:..:.:.....|..|..:| .::
Human   966 EWSKCTKIPISGTCYTVGGLIERQKYFFRIRAVNEAGVGEPVELDKGVRAMPPPAAPKFDLSARL 1030

  Fly  6568 RD-IVCRAGDDFSIHVPYLAFPKPNAFWYSNDNMLDDNNRVHKHLTDDAASVVVKNSKRADSGQY 6631
            :. :|.|||....||..:...|.|:..|..:.........:.|  :.:.:..::.::||:|||.|
Human  1031 KSHMVVRAGTALCIHAAFSGSPPPDVIWQKDGVPTKGRETITK--SKNHSQFLINSTKRSDSGVY 1093

  Fly  6632 RLQLKNTSGFDTATINVRVLDRPSPPTRLRADEFSGDSLTLYWN--PPNDDGGSAIQNYIIEKKE 6694
            |:.|:|..|.....|:|||.|.|.|||.||..|...:::||.||  |...:.|.|  :|||.|::
Human  1094 RILLQNEFGEARYDIHVRVADFPRPPTNLRLFEEVPNTVTLTWNHSPDVQEDGEA--HYIIMKRD 1156

  Fly  6695 ARSSTWSKVSSFCTVPFVRIRNLVLNKEYDFRVIAENKYGQSDPANTSEPILARHPFDIPNTPGI 6759
            |.::||...:.........:..|:..::|.|||:|.|:.|.|:|                     
Human  1157 ASTATWYTAAERVFSNKYTVTGLLPGRKYYFRVVARNEIGDSEP--------------------- 1200

  Fly  6760 PHGIDSTEDSITIAWTKPKHDGGSPITGYIIEKRLLSDDKWTKAVHALCPDLSCKIPNLIENAEY 6824
               :||.:     .|                   |::.|:        ..|||.|: ...|..::
Human  1201 ---LDSRD-----TW-------------------LINKDQ--------IQDLSAKL-KPYEKKDW 1229

  Fly  6825 EFRVAAVNAAGQSAYSGSSDLIFCRRPPHAPKITSDLSIRDMTVIAGDEFRITVPYHASPRPTAS 6889
            .                           |||:..:.|  :..||:.|.:..:|..:..:||||.:
Human  1230 R---------------------------HAPRFVTPL--KPHTVLRGQDCTMTCAFLGNPRPTVT 1265

  Fly  6890 WSLNGLEVIPGERIKFDSNDYASMYYNKSAKRDETGSYTITLTNNKGSDTASCHVTVVDR 6949
            .....:.:....:..::|..........:....::|.|::.:.|..|.|.:||.:||.|:
Human  1266 LYKGDVNITANSKFWYNSTSGVCTLVIPTCTLKDSGDYSVLVENELGKDRSSCTLTVYDK 1325

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
btNP_001162825.1 I-set 9..101 CDD:254352
Ig 26..100 CDD:143165
I-set 119..210 CDD:254352
Ig 136..209 CDD:143165
I-set 228..320 CDD:254352
IGc2 242..312 CDD:197706
I-set 335..425 CDD:254352
Ig 350..423 CDD:143165
Ig 436..530 CDD:299845
I-set 438..532 CDD:254352
I-set 545..636 CDD:254352
Ig 560..633 CDD:143165
Ig 657..731 CDD:143165
I-set 746..835 CDD:254352
Ig 1496..1586 CDD:299845
IG_like 1503..1588 CDD:214653
I-set 1639..1724 CDD:254352
IG 1750..1821 CDD:214652
IGc2 1750..1806 CDD:197706
I-set 1826..1909 CDD:254352
Ig 1831..1897 CDD:299845
I-set 1914..1998 CDD:254352
Ig 2020..2095 CDD:299845
FN3 2100..2194 CDD:238020
FN3 2203..2292 CDD:238020
I-set 2311..2395 CDD:254352
Ig 2321..2395 CDD:299845
FN3 2399..2493 CDD:238020
FN3 2501..2590 CDD:238020
I-set 2602..2693 CDD:254352
Ig 2619..2693 CDD:299845
FN3 2697..2793 CDD:238020
FN3 2801..2893 CDD:238020
I-set 2902..2995 CDD:254352
Ig 2919..2993 CDD:299845
FN3 2999..3088 CDD:238020
FN3 3102..3191 CDD:238020
I-set 3208..3292 CDD:254352
Ig 3219..3292 CDD:299845
FN3 3296..3390 CDD:238020
FN3 3400..3489 CDD:238020
I-set 3494..3590 CDD:254352
Ig 3516..3590 CDD:299845
FN3 3594..3682 CDD:238020
FN3 3694..3781 CDD:238020
I-set 3795..3885 CDD:254352
Ig 3813..3885 CDD:299845
FN3 3889..3980 CDD:238020
FN3 3990..4082 CDD:238020
I-set 4090..4181 CDD:254352
Ig 4108..4181 CDD:299845
FN3 4185..4271 CDD:238020
FN3 4285..4383 CDD:238020
Ig 4404..4480 CDD:299845
FN3 4484..4571 CDD:238020
FN3 4584..4677 CDD:238020
I-set 4685..4775 CDD:254352
Ig 4703..4775 CDD:299845
FN3 4779..4863 CDD:238020
FN3 4879..4970 CDD:238020
IG 4989..5069 CDD:214652
Ig 4996..5069 CDD:299845
FN3 5073..5166 CDD:238020
FN3 5175..5265 CDD:238020
I-set 5276..5366 CDD:254352
Ig 5293..5366 CDD:299845
FN3 5370..5462 CDD:238020
FN3 5470..5561 CDD:238020 4/19 (21%)
Ig 5559..5654 CDD:299845 18/100 (18%)
I-set 5570..5660 CDD:254352 18/105 (17%)
FN3 5664..5755 CDD:238020 17/96 (18%)
FN3 5764..5853 CDD:238020 17/91 (19%)
I-set 5865..5954 CDD:254352 20/106 (19%)
Ig 5882..5954 CDD:299845 16/86 (19%)
FN3 5958..6049 CDD:238020 25/109 (23%)
FN3 6062..6153 CDD:238020 17/95 (18%)
I-set 6173..6255 CDD:254352 22/81 (27%)
Ig_Titin_like 6182..6255 CDD:143225 19/72 (26%)
FN3 6259..6350 CDD:238020 34/93 (37%)
FN3 6359..6451 CDD:238020 42/92 (46%)
FN3 6470..6552 CDD:238020 29/81 (36%)
I-set 6564..6650 CDD:254352 23/87 (26%)
Ig_Titin_like 6577..6650 CDD:143225 18/72 (25%)
FN3 6654..6745 CDD:238020 31/92 (34%)
FN3 6754..6840 CDD:238020 10/85 (12%)
I-set 6855..6946 CDD:254352 18/90 (20%)
Ig 6874..6946 CDD:299845 13/71 (18%)
FN3 6950..7042 CDD:238020 363/1490 (24%)
FN3 7050..7139 CDD:238020
FN3 7151..7237 CDD:238020
I-set 7254..7334 CDD:254352
Ig 7272..7339 CDD:143165
IG_like 7354..7440 CDD:214653
Ig 7366..7440 CDD:299845
FN3 7444..7531 CDD:238020
FN3 7545..7637 CDD:238020
I-set 7648..7737 CDD:254352
Ig 7665..7734 CDD:143165
Ig 7760..7833 CDD:299845
FN3 7837..7927 CDD:238020
STKc_Twitchin_like 7986..8244 CDD:271016
S_TKc 7989..8244 CDD:214567
Ig 8311..8394 CDD:299845
I-set 8312..8401 CDD:254352
I-set 8437..8525 CDD:254352
Ig 8455..8519 CDD:143165
I-set 8632..8721 CDD:254352
IGc2 8646..8711 CDD:197706
I-set 8740..8831 CDD:254352
Ig 8757..8826 CDD:143165
I-set 8839..8922 CDD:254352
Ig 8845..>8909 CDD:299845
IGSF22XP_011518332.1 I-set 87..177 CDD:254352 20/106 (19%)
Ig 104..>164 CDD:299845 12/62 (19%)
I-set 255..343 CDD:254352 21/100 (21%)
Ig 264..338 CDD:299845 17/86 (20%)
I-set 349..434 CDD:254352 19/101 (19%)
Ig 372..434 CDD:143165 14/62 (23%)
IG_like 446..529 CDD:214653 21/98 (21%)
Ig 456..512 CDD:143165 15/58 (26%)
IG_like 541..618 CDD:214653 20/115 (17%)
IG_like 637..717 CDD:214653 22/79 (28%)
Ig_Titin_like 647..717 CDD:143225 19/69 (28%)
FN3 721..813 CDD:238020 34/93 (37%)
FN3 822..912 CDD:238020 41/89 (46%)
FN3 923..1008 CDD:238020 30/86 (35%)
IG_like 1032..1112 CDD:214653 22/81 (27%)
Ig_Titin_like 1042..1112 CDD:143225 18/71 (25%)
FN3 1116..1203 CDD:238020 31/112 (28%)
I-set 1233..1322 CDD:254352 18/90 (20%)
Ig 1256..1322 CDD:299845 12/65 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 81 1.000 Domainoid score I8530
eggNOG 1 0.900 - - E1_KOG0613
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.900

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