DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment bt and Egflam

DIOPT Version :9

Sequence 1:NP_001162825.1 Gene:bt / 43814 FlyBaseID:FBgn0005666 Length:8933 Species:Drosophila melanogaster
Sequence 2:NP_001276425.1 Gene:Egflam / 268780 MGIID:2146149 Length:1017 Species:Mus musculus


Alignment Length:1288 Identity:243/1288 - (18%)
Similarity:387/1288 - (30%) Gaps:477/1288 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly  6358 PPGAPSQPT---------------ISAYTPNSANLEWHPPDDCGGKPITGYIVERRERGGEWI-- 6405
            ||||.|..|               :.|....:.:::|..|.. .|..|.||.|...|.|.:..  
Mouse    19 PPGAVSLRTALRKSGKVGPPLDIKLGALNCTAFSIQWKTPKR-SGSSIIGYTVFYSEVGSDKSLR 82

  Fly  6406 -KCNNYP----TPNTSYTVSNLRDGARYEFRVLAVNEAGPGHPSKPSDPMTAEHQRYRPDPPEPP 6465
             :.:|.|    |..|...:.:|:.|..|:..|.|.::.|.|..|.|....|.......| |..|.
Mouse    83 ERSHNVPVGQDTLITEEVIGDLKPGTEYQVSVAAYSQTGKGRLSFPRHVTTLSQDSCLP-PAAPQ 146

  Fly  6466 KPD--RITRNGVTLSWRPPRTDGKSRIKGYYVE-MRPKNGKDWKTVND-IPINSTVYTVPSLKEG 6526
            :|.  .::.:.|.|||||...:|.:.|:.|.|| :||...|.|..:.: :.::|.|  :..|...
Mouse   147 QPHVLVVSDSEVALSWRPGENEGSAPIQSYSVEFIRPDFDKSWTIIQERLQMDSMV--IKGLDPD 209

  Fly  6527 EEYSFRVVAENEVGRSDPSKPSQPITIEEQPNKPCMELGKVRDIVCRAGDDFSIHVPYLAFPKPN 6591
            ..|.|.|.|.|..|.|..|.||..:          ..||        .|:..|.|.        .
Mouse   210 TNYQFAVKAMNAHGFSPRSWPSNTV----------RTLG--------PGEAGSGHY--------G 248

  Fly  6592 AFWYSNDNMLDDNNRVHKHLTDDAASVVVK--NSKRADSGQYRLQLKNTS--------------- 6639
            ..:.:|..:.:|::.....|..|.:...||  .:.:..:.::.::.|.||               
Mouse   249 PGYITNPGVSEDDDGSEDELDLDVSFEEVKPLPATKVGNKKFSVESKKTSVSNSVMGSRLAQPTS 313

  Fly  6640 ------------------GFDTATINVRVLDRPSPPTRLRADEFSGDSLTLYWNPPNDDGGSAIQ 6686
                              |.::..:..|:.|.....|...||.|..:...  |      |||...
Mouse   314 ASLHETTVAIPPTPAQRKGKNSVAMMSRLFDMSCDETLCSADSFCVNDYA--W------GGSRCH 370

  Fly  6687 NYIIEKKEARSS----TWSKVSSFCTVPFVRIRN--LVLNKEYDFRVIA---------ENKYGQS 6736
            ..:.:..||.|.    .:.:......|.|..::|  .......:||..|         |:::|:.
Mouse   371 CNLGKGGEACSEDIFIQYPQFFGHSYVTFEPLKNSYQAFQVTLEFRAEAEDGLLLYCGESEHGRG 435

  Fly  6737 DPANTSEPILARHPFDIPNTPGIPHGIDSTEDSITI-AWTKPKH------DG---------GSPI 6785
            |..:.:   |.|.........|....|..:|..|.: ||    |      ||         |:|:
Mouse   436 DFMSLA---LIRRSLHFRFNCGTGIAIIISETKIKLGAW----HTVTLYRDGLNGMLQLNNGTPV 493

  Fly  6786 TGYIIEKRLLSDDKWTKAVHALCPDLSCKIPNLIENAEYEFRVAAVNAAGQSAYSGSSDLIFCRR 6850
            ||                                              ..|..||          
Mouse   494 TG----------------------------------------------QSQGQYS---------- 502

  Fly  6851 PPHAPKITSDLSIRDMTVIAGDEFRITVPYHASPRPTASWSLNGLEVIPGERIKFDSNDYASMYY 6915
                 |||               ||  .|.:....|:|.|.:..                     
Mouse   503 -----KIT---------------FR--TPLYLGGAPSAYWLVRA--------------------- 524

  Fly  6916 NKSAKRDETGSYTITLTNNKGSDTASCHVTVVDRPLPPQGPLNAYDITPDTCTLAWKTPLDDGGS 6980
             ....|...|.......|.|..|.         ||.|....||..|:...:..:..:.....||:
Mouse   525 -TGTNRGFQGCVQSLSVNGKKIDM---------RPWPLGKALNGADVGECSSGICDEASCIHGGT 579

  Fly  6981 PITNYVVEKLDNSGSWVKISSFV-------RNTH-YDVMGLE-PHYKYNFRVRAENQYGLSDPLD 7036
            ...             :|..|::       |..| .|...|. |.::.:.|..|...:       
Mouse   580 CAA-------------IKADSYICLCPLGFRGRHCEDAFALTIPQFRESLRSYAATPW------- 624

  Fly  7037 IIEPIVAKH-----QFTVPDEPGQPKVIDWDSGNVTLIWTRPLSDGGSRIQGYQIEYRDILNDSS 7096
               |:..:|     :|.:...|        |||:..|:::   .|.||         :|.|:   
Mouse   625 ---PLEPQHYLSFTEFEITFRP--------DSGDGVLLYS---YDTGS---------KDFLS--- 663

  Fly  7097 WNAYDYIIKDTKYQLYNLINGSEYEFRIKAKNAAGLSKPSSP-------SLRFKLKGKFTVPSPP 7154
                           .|:..| ..|||....:..|:.:..:|       .||             
Mouse   664 ---------------INMAAG-HVEFRFDCGSGTGVLRSEAPLTLGQWHDLR------------- 699

  Fly  7155 GAPQVTRVGKNYVDLKWEKPLRDGGSRITGYIIERRDIGGAVWVKCNDYNVLDTEYTVMNLIEMG 7219
                |:|..||.: |:.:|.          .::|....||...:|||      |:..:..:....
Mouse   700 ----VSRTAKNGI-LQVDKQ----------KVVEGMAEGGFTQIKCN------TDIFIGGVPNYD 743

  Fly  7220 DYEFRVFAVNSAGRSEPSLCTMPIKVCEVLGGKKPDWITRLQDKVAPFGKDYT------------ 7272
            |.:      .::|...|            ..|.....|  |.|:......|:|            
Mouse   744 DVK------KNSGILHP------------FSGSIQKII--LNDRTIHVKHDFTSGVNVENAAHPC 788

  Fly  7273 --LQCAASGKPSPTARWLRNGKEIQMNGGRMTCDSKDGVFRLHISNVQTGDDGDYTC-----EAM 7330
              ..||..|...|.    :.|.|         ||...|...|:...    :.|:: |     ||:
Mouse   789 VGAPCAHGGSCRPR----KEGYE---------CDCPLGFEGLNCQK----ECGNH-CLNTIIEAI 835

  Fly  7331 NSLGFVNTSGYLKIGSPPIINRCPSELKLPEGDNS----KIK-------IFYSGDQPLTVILKKN 7384
            ....|:..| ||...:|.|:.|.       .|..|    :.|       :.:.||.|    ::.|
Mouse   836 EIPQFIGRS-YLTYDNPNILKRV-------SGSRSNAFMRFKTTAKDGLLLWRGDSP----MRPN 888

  Fly  7385 NEVICDSNDDTHV--KVNIFDDYVAIYIRNIVKSDGGPYQIEFT--NESGSATGEFYVHITGMPS 7445
            ::.|.....|..:  ..|:.....:|.: |...|||..::::..  .:||..|.:.|...||   
Mouse   889 SDFISLGLRDGALIFSYNLGSGVASIMV-NGSFSDGRWHRVKAVRDGQSGKITVDDYGARTG--- 949

  Fly  7446 APTGPMGISYINKNSCMLNWRPPSYDGGLK-----------------VSHYVI 7481
              ..|..:..:|.|..:       |.||:|                 :||:.:
Mouse   950 --KSPGLMRQLNINGAL-------YVGGMKEIALHTNRQYLRGLVGCISHFTL 993

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
btNP_001162825.1 I-set 9..101 CDD:254352
Ig 26..100 CDD:143165
I-set 119..210 CDD:254352
Ig 136..209 CDD:143165
I-set 228..320 CDD:254352
IGc2 242..312 CDD:197706
I-set 335..425 CDD:254352
Ig 350..423 CDD:143165
Ig 436..530 CDD:299845
I-set 438..532 CDD:254352
I-set 545..636 CDD:254352
Ig 560..633 CDD:143165
Ig 657..731 CDD:143165
I-set 746..835 CDD:254352
Ig 1496..1586 CDD:299845
IG_like 1503..1588 CDD:214653
I-set 1639..1724 CDD:254352
IG 1750..1821 CDD:214652
IGc2 1750..1806 CDD:197706
I-set 1826..1909 CDD:254352
Ig 1831..1897 CDD:299845
I-set 1914..1998 CDD:254352
Ig 2020..2095 CDD:299845
FN3 2100..2194 CDD:238020
FN3 2203..2292 CDD:238020
I-set 2311..2395 CDD:254352
Ig 2321..2395 CDD:299845
FN3 2399..2493 CDD:238020
FN3 2501..2590 CDD:238020
I-set 2602..2693 CDD:254352
Ig 2619..2693 CDD:299845
FN3 2697..2793 CDD:238020
FN3 2801..2893 CDD:238020
I-set 2902..2995 CDD:254352
Ig 2919..2993 CDD:299845
FN3 2999..3088 CDD:238020
FN3 3102..3191 CDD:238020
I-set 3208..3292 CDD:254352
Ig 3219..3292 CDD:299845
FN3 3296..3390 CDD:238020
FN3 3400..3489 CDD:238020
I-set 3494..3590 CDD:254352
Ig 3516..3590 CDD:299845
FN3 3594..3682 CDD:238020
FN3 3694..3781 CDD:238020
I-set 3795..3885 CDD:254352
Ig 3813..3885 CDD:299845
FN3 3889..3980 CDD:238020
FN3 3990..4082 CDD:238020
I-set 4090..4181 CDD:254352
Ig 4108..4181 CDD:299845
FN3 4185..4271 CDD:238020
FN3 4285..4383 CDD:238020
Ig 4404..4480 CDD:299845
FN3 4484..4571 CDD:238020
FN3 4584..4677 CDD:238020
I-set 4685..4775 CDD:254352
Ig 4703..4775 CDD:299845
FN3 4779..4863 CDD:238020
FN3 4879..4970 CDD:238020
IG 4989..5069 CDD:214652
Ig 4996..5069 CDD:299845
FN3 5073..5166 CDD:238020
FN3 5175..5265 CDD:238020
I-set 5276..5366 CDD:254352
Ig 5293..5366 CDD:299845
FN3 5370..5462 CDD:238020
FN3 5470..5561 CDD:238020
Ig 5559..5654 CDD:299845
I-set 5570..5660 CDD:254352
FN3 5664..5755 CDD:238020
FN3 5764..5853 CDD:238020
I-set 5865..5954 CDD:254352
Ig 5882..5954 CDD:299845
FN3 5958..6049 CDD:238020
FN3 6062..6153 CDD:238020
I-set 6173..6255 CDD:254352
Ig_Titin_like 6182..6255 CDD:143225
FN3 6259..6350 CDD:238020
FN3 6359..6451 CDD:238020 28/113 (25%)
FN3 6470..6552 CDD:238020 28/83 (34%)
I-set 6564..6650 CDD:254352 15/120 (13%)
Ig_Titin_like 6577..6650 CDD:143225 12/107 (11%)
FN3 6654..6745 CDD:238020 20/105 (19%)
FN3 6754..6840 CDD:238020 14/101 (14%)
I-set 6855..6946 CDD:254352 14/90 (16%)
Ig 6874..6946 CDD:299845 11/71 (15%)
FN3 6950..7042 CDD:238020 17/100 (17%)
FN3 7050..7139 CDD:238020 17/95 (18%)
FN3 7151..7237 CDD:238020 15/85 (18%)
I-set 7254..7334 CDD:254352 19/98 (19%)
Ig 7272..7339 CDD:143165 16/85 (19%)
IG_like 7354..7440 CDD:214653 19/100 (19%)
Ig 7366..7440 CDD:299845 17/84 (20%)
FN3 7444..7531 CDD:238020 9/55 (16%)
FN3 7545..7637 CDD:238020
I-set 7648..7737 CDD:254352
Ig 7665..7734 CDD:143165
Ig 7760..7833 CDD:299845
FN3 7837..7927 CDD:238020
STKc_Twitchin_like 7986..8244 CDD:271016
S_TKc 7989..8244 CDD:214567
Ig 8311..8394 CDD:299845
I-set 8312..8401 CDD:254352
I-set 8437..8525 CDD:254352
Ig 8455..8519 CDD:143165
I-set 8632..8721 CDD:254352
IGc2 8646..8711 CDD:197706
I-set 8740..8831 CDD:254352
Ig 8757..8826 CDD:143165
I-set 8839..8922 CDD:254352
Ig 8845..>8909 CDD:299845
EgflamNP_001276425.1 FN3 36..133 CDD:238020 23/97 (24%)
FN3 142..236 CDD:238020 31/105 (30%)
LamG 391..541 CDD:238058 38/256 (15%)
EGF_CA 560..602 CDD:238011 7/54 (13%)
LamG 618..765 CDD:238058 41/249 (16%)
EGF_CA 790..820 CDD:238011 10/42 (24%)
Laminin_G_2 868..993 CDD:280389 28/141 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0613
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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