DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bt and HMCN2

DIOPT Version :9

Sequence 1:	NP_001162825.1	Gene:	bt / 43814	FlyBaseID:	FBgn0005666	Length:	8933	Species:	Drosophila melanogaster
Sequence 2:	NP_001278744.1	Gene:	HMCN2 / 256158	HGNCID:	21293	Length:	5079	Species:	Homo sapiens

Alignment Length:	5108	Identity:	1031/5108 - (20%)
Similarity:	1639/5108 - (32%)	Gaps:	1681/5108 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 CQLLSSPKPDIEWFRSDNKVVEDVRTKFKIQPVGENKYTVVLELDDVVETDAGLYKVKAKNKSGE 94
            |.....|.|.|.|.|....:.||.|.....|.      |::::  .|...|||.|..:|.|:.|.
Human   629 CSASGYPTPHISWSRESQALQEDSRIHVDAQG------TLIIQ--GVAPEDAGNYSCQATNEVGT 685

  Fly    95 VSASINLNFTPADEPKEKQIDGFAPTFAKKPAIRQEEDGKRLLFECRVNADPIPAIIWFHNG--- 156
            ...::.|.:|  |.|....::          |:.....|:..:..|..:..|.|.:||:..|
Human   686 DQETVTLYYT--DPPSVSAVN----------AVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEM 738

  Fly   157 -AAVKESERHKITVDKDVHSYFATLEILNVTVEDAGKYKVNAKNELGESNATISLNFDSDEAPVP 220
             .|.:.|...|:.:.       |..|      .|||.|...|.||||:::|.|.|
Human   739 ILAPEGSSSGKLRIP-------AAQE------RDAGTYTCRAVNELGDASAEIQL---------- 780

  Fly   221 ESAEGIKPTFTERPVIRQSEDGGNVTFECRCVGDPTPTVTWSHGETE-----LNESNRYKMSLTM 280
              |.|..|..||.|.....|.|.:....||..|.|.|||||..|:.:     |. :.|...|...
Human   781 --AVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLG-AGRGSRSRQP 842

  Fly   281 DQKLYHIACLEISSVVSSDQGEYRAQAKNKHGSGVATINLNFESGSKKIPDGKSPRFPK----KP 341
            |.     ..|...||...||..|..:|:|..|        ..::.::.|..|.:|  |:    .|
Human   843 DS-----GVLFFESVAPEDQAPYVCEARNVFG--------KVQAEARLIVTGHAP--PQIASSAP 892

  Fly   342 TIR-QEEDLLIMEC-VLEAHPVPDIVWYCSEKEICNNQRTKMTRKAITKDSYILTLEIQNPTKED 404
            |:| .|...:.:.| ||...|:|:..|....:.:     ...:|.:|..|.   :|.:....:|.
Human   893 TVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPL-----PPGSRHSIRADG---SLHLDRALQEH 949

  Fly   405 GGNYRCNAINMYGESNANIALNFQGASDANGFAPSFIEKPRIIP-------NESGTLITMKCKCK 462
            .|.|.|.|.|..|..:.::.|..|        .|     |||.|       || |...::.|...
Human   950 AGRYSCVATNTAGSQHRDVELVVQ--------VP-----PRIHPTATHHITNE-GVAASLPCVAS 1000

  Fly   463 AKPEPTVTWYRGQD-LVEKSKKIKINTTVIAEDTYELTLEIKDPGATDGGTYRCNVKNEYGESNA 526
            ..|.||:||.:..: |..:.....::.        |.||.|..|.|.|.|.|.|...|..|.|:.
Human  1001 GVPAPTITWTKETNALTSRGPHYNVSK--------EGTLLIAQPSAQDAGAYVCTATNTVGFSSQ 1057

  Fly   527 NLNLNIEAEPEPEGEGPTFIEKPRIVSENNGKLVIMECKVKADPKPDVIWFRNGEVIKESNKIKT 591
            .:.|::..:|.....|....:.|..|:...|:.|.::|:.|..|.|.|.|      .|:|..:..
Human  1058 EMRLSVNTKPRIHMNGSRNADVPLQVTAKAGEEVTLDCEAKGSPPPLVTW------TKDSRPVPP 1116

  Fly   592 FIEQRGDQYYIKLELLDPQLEDSGLYKCNIKNTLGELNANLTLNIEIVPVIKDKPKIIKIIKKRT 656
            ...:.|......|.|...|:.|||.|:|...|..|..:....|.:::.|.::..|:::|::....
Human  1117 ITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQPGPRVLKVLVGEA 1181

  Fly   657 VVIECTVASKFEPKCTWYKETSTVKESKRHVYQVEQTKEGEFAVKLEINDVEESDKGAYKLVASN 721
            :.:.|......||:.:|.|: ..|.:.:.....|      .||.      :..||.|.|:..|||
Human  1182 LDLNCVAEGNPEPQLSWSKD-GVVLQGRGPQGSV------HFAA------IRTSDAGRYRCEASN 1233

  Fly   722 EKGEAVSQIVNLVDIPEEERKPCKP-----EISRKLADQKVAESKTFELLVSLSQTDRKCKVEWY 781
            ..|         ||..|.|.:..:|     :.:..|.::...|:.:   |...::...|.:|.|.
Human  1234 SAG---------VDAWEVELRVLEPPHWGADETSGLLERVAGENAS---LPCPARGTPKPQVTWR 1286

  Fly   782 KG--STVIRETKDITTTFDGTTARLTFSSARTEHTSNYKVIVTNEVGKDESSCKITVEKVAKKKE 844
            ||  |..:.....:....:|:   |..:|.....:.:|:...|||||......|:.|......:|
Human  1287 KGPSSEPLHGQPGVAVLEEGS---LFLASVSPADSGDYECQATNEVGSTSRRAKLVVYVPPSIRE 1348

  Fly   845 EKPKEKEKTKNEKEVEQKEMEEDKNESGQSVAQTEGRINIEQISEGDPKEELTVKEEILDKRDTQ 909
            :..|...                ...:|||       :.:|..:.|.|      ..||:..:|.|
Human  1349 DGRKANV----------------SGMAGQS-------LTLECDANGFP------VPEIVWLKDAQ 1384

  Fly   910 EV-KESSVELQDSAGHEVPEPKKATSDSKLDQSNQKNLDKKHKTDQSESKTNKNVSLAEPIKSNK 973
            .: |.....|.|. |..:..|:....||.|.....:|
Human  1385 LIPKVGGHRLLDE-GQSLHFPRIQEGDSGLYSCRAEN---------------------------- 1420

  Fly   974 QESEEQQATEQIGLKKVDRKASIVSVKEEISSDVRRKSTIKAKEEITVDDKKASSRRSSLAVEES 1038
                      |.|..:.|....:::....:.:.        |.:|:.           .||..:.
Human  1421 ----------QAGTAQRDFHLLVLTPPSVLGAG--------AAQEVL-----------GLAGADV 1456

  Fly  1039 NTESRRSSIIDKKPLEQVDNKPIDANKNPQPLKEEIPRLKPAEKRRTSKVIEEPKPDEGLPKLRK 1103
            ..:...|.:    |..||     :..|:.||:....|.|:..|..:..::......|||
Human  1457 ELQCWTSGV----PTPQV-----EWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEG------ 1506

  Fly  1104 ASIAQVKEEAKPAAPKLKAKAKAKPKYEELPEIPDYERPQLEKYEKSDFTPS-DFARDLEIPNKM 1167
                                                      :|:...|:|: ..|||.::  ::
Human  1507 ------------------------------------------RYQCVAFSPAGQQARDFQL--RV 1527

  Fly  1168 EKPIIDSGKKEPAVLAQKNGIPKKTDIIEQYADEPKGLKVGKGKLPDEGDGRDGAVLKPVIIEPE 1232
            ..|....|..|...:|...      |.:.|...|.:|:..     |:....:|||:|
Human  1528 HAPPTIWGSNETGEVAVME------DHLVQLLCEARGVPT-----PNITWFKDGALL-------- 1573

  Fly  1233 KEILDLGNKKNNQHADKPTVLDIIKQRRRSSIRNLMTKEPIQNESFLGVVLKPVIKDTREQAAPQ 1297
                             ||...::..|....::             ||          |.|::..
Human  1574 -----------------PTSTKVVYTRGGRQLQ-------------LG----------RAQSSDA 1598

  Fly  1298 QAIQLTKANATEQFSPTKAVKAQVADLKKPETLATLEDNYERPVLEKYDPFSIDKTKSEKSTPSI 1362
            .......:||.     ..|.||...|:..|   .|:|....||.:.|
Human  1599 GVYTCKASNAV-----GAAEKATRLDVYVP---PTIEGAGGRPYVVK------------------ 1637

  Fly  1363 ITPDIRGPEVKLPVQETKEEKQKVPKMQPPAPGDPPKIEVIREKRPSLAPEPPS----RRGSLIP 1423
                                         ...|.|..:|.:....||     |:    ..|  :|
Human  1638 -----------------------------AVAGRPVALECVARGHPS-----PTLSWHHEG--LP 1666

  Fly  1424 PADTGRRPSLIINDEKKLRPGEVMDTRLLRPGEVGEGQRR------------RPSIDVRRPSVQD 1476
            .|::        |:.:....|.|:  ||..|||...|...            :.|::|:.|....
Human  1667 VAES--------NESRLETDGSVL--RLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLL 1721

  Fly  1477 LEDLINKPSTPLRDVGDGGPPSIVDVQESYSVVEDSTAYLTVGVEGSPAPTFKFYKGVSEILEGG 1541
            :.:.:.:.:|.:      |.|..:..|.|                |||.||.::       |:.|
Human  1722 VAEGLGQVTTIV------GQPLELPCQAS----------------GSPVPTIQW-------LQNG 1757

  Fly  1542 R-------FKFLTDGQTNTITLCMRKCKPNDESKYKIVVSNIHGEDSAEMQLYVSDSSGMDFRAM 1599
            |       .:..:.|    .||.:...:.:....:....:|..|...||:::.|.
Human  1758 RPAEELAGVQVASQG----TTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVH---------- 1808

  Fly  1600 LKKRRYQKWDKDEQDPNWGDLKETEKPLPALKKVERKVESFLSPLIDQFAKEGKDKKVVFEARFS 1664
                                    |.|..::...|.....||.|:..|...:|
Human  1809 ------------------------EFPSVSIIGGENITAPFLQPVTLQCIGDG------------ 1837

  Fly  1665 KPNCKPKWLFRKDEV----FTGSKFKFKQENDTYQLIITTPKVEDTGKYT---IEIGGVSSTAFL 1722
            .|....:|.  ||.|    |.|:            |.|....:.|.|.||   ..:.|.|.....
Human  1838 VPTPSLRWW--KDGVALAAFGGN------------LQIEKVDLRDEGIYTCAATNLAGESKREVA 1888

  Fly  1723 -------NVEEADPTYTFTKPLKKKLEGFTQHETTLECSVSS-SMANVHWFKNNTKLESDDPRYL 1779
                   |:|..        |:.|.:  ......||||..|. ...:|.|||.:..:.|    ::
Human  1889 LKVLVPPNIEPG--------PVNKAV--LENASVTLECLASGVPPPDVSWFKGHQPVSS----WM 1939

  Fly  1780 -ISKDINGNLKLIIKDSVLDDAGLYRCQLDKQPDKTEC--NLKVTEYPYKFVKVLKSQQCIEKDT 1841
             ::..::|.: |.|:.:.|.|||.|||........||.  .|:|...|...:........:....
Human  1940 GVTVSVDGRV-LRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTP 2003

  Fly  1842 VTLACEIDDAMG-EVQWLRNGEEIKP--DKRIQIVKDGRKRKLVIKDCKVTDAGQFKCTTNADTT 1903
            |.|.|....|.. .:.||::|..:.|  ...:|:...|  |.|.:...:.:|:|::.|...:...
Human  2004 VRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGG--RVLTLASARASDSGRYSCVAVSAVG 2066

  Fly  1904 ESEIIINYQNRFNKKLKDTE----AVEREKLILDIELQDQTAP-CDWKFNGEPIVPSESIEIKNM 1963
            |....:..|......:...|    .|..|.:.|:.:......| ..|..:|.|:.|...:   ::
Human  2067 EDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGV---HL 2128

  Fly  1964 GGGKHQLIFSSLDMSNEGEITCE----SGQ----------------LSSKCKLSIRKGE-SRPNI 2007
            ...|..|.....|:.:.|..|||    :|.                |.....|::|:|. :|.:.
Human  2129 SADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTRLSC 2193

  Fly  2008 DCPDKFSGPISAPVLLEVPF-KVSGTKQTPVEAKLFKDGKPLPVKDVEVAVTDDKVTFKIKKPSR 2071
            :|..             ||| |:|..          |||:|||.:...:.        .:....|
Human  2194 ECRG-------------VPFPKISWR----------KDGQPLPGEGAGLQ--------HVSAVGR 2227

  Fly  2072 DL---------SGPYQIKISNGQGEDTKDVQIICQDVPQ------PPQDVDITD--VYQTSCVVS 2119
            .|         .|.|..:.||..|..::|:|:.....||      ||..|.:..  |....|..:
Human  2228 LLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNAT 2292

  Fly  2120 FNPPS----DDGGTPITKYV------------IERQDLSKKHGWESVAEVLPSEPCLK-KIDDLI 2167
            ..||.    :..|.|:...:            :||...:....:..|||.|......| ::..|:
Human  2293 GKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLV 2357

  Fly  2168 PKKQYRFRIRAVNAIGQSDPATFKNTILAKDP----WDEPGKPKAVDLTDWDKDHADLKW---EA 2225
            |.:          .||..||.| ..|.....|    .:..|.|...           ::|   |.
Human  2358 PPE----------LIGDLDPLT-NITAALHSPLTLLCEAMGIPPPA-----------IRWFRGEE 2400

  Fly  2226 PETDGGDPITAYIVEYKEKFSNDWVSGKEVDGDARTATVDGLKEGQQYE-----FRVRAVNRAGP 2285
            |.:.|.|   .|::      :..|:                ||..|..|     :...|.|.||.
Human  2401 PVSPGED---TYLL------AGGWM----------------LKMTQTQEQDSGLYSCLASNEAGE 2440

  Fly  2286 GEPSDKTKSIIAKCRFVKPFIVGEGLKNV-TVKKGQTIRFDIKYDGEPEPAATWVK-GTDNLKFD 2348
            ...:...:.:      |.|.|..|.|:.| .|..|||........|.|:|..||.| |....:.|
Human  2441 ARRNFSVEVL------VPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGD 2499

  Fly  2349 NQRI-----CLDQLERNSSITIKKSVRKDTGKYKLVLSNSSGTIESEAQVVVLDRPLPPGGPFE- 2407
            ...|     .|..|:.|.|         ..|.|..:.:|:.|......|:.||..|...||..:
Human  2500 AHHISPDGVLLQVLQANLS---------SAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDS 2555

  Fly  2408 -PEEIRA---SHIKMKWKRPDDDGGCEISGYALERMDEETGRWIPAGEVGPNETSFDFKGLTPNK 2468
             .||:..   :.|.:.         ||...:....:     .|:..|  .|.|.|.:.: |.|.
Human  2556 ADEEVTVTVNNPISLI---------CEALAFPSPNI-----TWMKDG--APFEASRNIQ-LLPG- 2602

  Fly  2469 KYKFRVKAINKEGESEPLETFDAIVARNPYDPPSPPSQPVIDDYDNKSVLLKWKRPPSDGGRPIT 2533
            .:..::....||...:    :..:|.                               ::.|..:.
Human  2603 THGLQILNAQKEDAGQ----YTCVVT-------------------------------NELGEAVK 2632

  Fly  2534 HYIVEIKDKFAPSWSEVAKTDDPNPECNVEGLKEKMVYQFRVRAVNKAGPSEPSQPTDNHLCKHK 2598
            :|.||:  ...||.|:    |||..|..|:.:|.|:
Human  2633 NYHVEV--LIPPSISK----DDPLAEVGVKEVKTKV----------------------------- 2662

  Fly  2599 NLKPQIDRSTFKRVTIKSGRTHKWSVDVLGEPIPELHWSWRDDIPLTNGDRIKIENVDYHTDFSI 2663
                   .||   :|::   ...|:|     |.|.:.| ::|..|:|...|:::...........
Human  2663 -------NST---LTLE---CESWAV-----PPPTIRW-YKDGQPVTPSSRLQVLGEGRLLQIQP 2708

  Fly  2664 TNVLRKDSGFYTLKAENRNGIDRETVELVVLGKPSSPKGPLAVSDVTASGCKLQWKKPEDDGGVP 2728
            |.|  .|||.|...|.|..|.|.:...:::...|...|    |.|.:|: .::..::.|..|||.
Human  2709 TQV--SDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQK----VGDFSAA-FEILSREEEARGGVT 2766

  Fly  2729 IKEYVVEK------MDT-----ATGKWVRVGRSPGEKEPPSFDVTGLSLGSEY------------ 2770
            ....:||.      .||     ....|.|      |.:|       ||.|.|.
Human  2767 EYREIVENNPAYLYCDTNAIPPPDLTWYR------EDQP-------LSAGDEVSVLQGGRVLQIP 2818

  Fly  2771 --------MFRVSAVNEEGES----EPLTTLVGVVAKDPFDEPNKPGTPEVTDYDNQSISLKWAA 2823
                    .:...|.||.||.    |.|.....|:..|     .:....|||...:.::||:..|
Human  2819 LVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGD-----TEELVEEVTVNASSTVSLQCPA 2878

  Fly  2824 PNN--------DGGAPIQKYIIEKKNKNKTEWEKALEIPGDQLEATVAGLQEYGEYQFRVIAVNK 2880
            ..|        ..|.|.          :.:...:.|| .|..|:.:.|.:.:...|.  .:|.|:
Human  2879 LGNPVPTISWLQNGLPF----------SPSPRLQVLE-DGQVLQVSTAEVADAASYM--CVAENQ 2930

  Fly  2881 AGLSPPSDASVPQIVKYK-KLKPRIDRSNLKPLLIRAGKPIRYDVNVRGEPAPVITWYQNDKELK 2944
            ||       |..::...: ::.|||...:|:.:.......:....:|...|.|.:|||::.:.|.
Human  2931 AG-------SAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALS 2988

  Fly  2945 PEELPSSSEIKNIPYNTKISIIETVRKHTGIYKIIAVNEHGQDEATVEVNILAPPS---KPRGPL 3006
            ..|     |:..:|....:.:.......:|:|...|:|..|:|:..|::::|.||:   .||||.
Human  2989 LGE-----EVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQ 3048

  Fly  3007 D-----VKDVTKDSCK--------LKWKKPEDDGGKPISAYQVEKFDKKQGRWVPLGRTSANDTE 3058
            |     |.|....||:        :.|.|    .|:|:...|               ||.|
Human  3049 DAVLVRVGDKAVLSCETDALPEPTVTWYK----DGQPLVLAQ---------------RTQA---- 3090

  Fly  3059 FDVKGLQEGHEYQFRVKAINEEGESDPLDSDDSIIAKNPYDAASKPGTPNIVDYNEHMVKLKWEA 3123
                 |:.|...:.:...::::|.                             |:..:..:..||
Human  3091 -----LRGGQRLEIQEAQVSDKGL-----------------------------YSCKVSNVAGEA 3121

  Fly  3124 PRSDGGAPISGYIIEKKDKFSPIWDEILSTNTSVPEATVEGLVEGNIYQFRVRAVNKAGFSDPSD 3188
            .|:                        .:....||
Human  3122 VRT------------------------FTLTVQVP------------------------------ 3132

  Fly  3189 ATEPHLAKPRNLKPYINRDKMKPIKVRAGQPVKFDVDVKGEPAPSLTWFLKETELTSTGQVRLEN 3253
                         |.....|.:.:...||.|:....||.|.|||::|| ||:.....:..|. ..
Human  3133 -------------PTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTW-LKDRMPVESSAVH-GV 3182

  Fly  3254 IDYNTKLTLLDTDRKQSGQYKLRAENINGVDEA----VVEVIILDKPSKPEGPIEVSDIHKE--- 3311
            :....:|.|......|:|.|...|||...  ||    ||.|::..:       |..|.:.:|
Human  3183 VSRGGRLQLSRLQPAQAGTYTCVAENTQA--EARKDFVVAVLVAPR-------IRSSGVAREHHV 3238

  Fly  3312 --------GCKLKWRKPKD----DGGIPITGYVIEKMDTATGKWVPAGSVDPEKYDIEIKGLDPN 3364
                    .|:...:.|.|    ..|.|:.    :.|......::..||       :.:|||..:
Human  3239 LEGQEVRLDCEADGQPPPDVAWLKDGSPLG----QDMGPHLRFYLDGGS-------LVLKGLRAS 3292

  Fly  3365 HRYQFRVKAVNEEGESEPLETESAI---TAKNPFD-----VSAPPGLPELEDWDEHHVKLKWEPP 3421
            ....:...|.|..||...|.|.:.:   |.|...|     ||.|..|..:.      ..::..||
Human  3293 DAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMV------CPVRGSPP 3351

  Fly  3422 I-----RDG------------GSPITNYIIEVMDKDSGEFVKAVETDSPVCKGVVKKLEEGQQYK 3469
            |     :||            ||..|..|.:|...|:|.|         .|.
Human  3352 IHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIF---------TCV------------- 3394

  Fly  3470 FRVRAVNKAGPSDPSEQTNWHVAKPRFLKPHIDRVNLKPVIVKTGLSISLDINIRGEPAPKVEWF 3534
                |.:.||.:|  ......|..|..|:| ::..|  .|:|..|..:.|....||.|.|.|.|.
Human  3395 ----AASPAGVAD--RNFTLQVQVPPVLEP-VEFQN--DVVVVRGSLVELPCEARGVPLPLVSWM 3450

  Fly  3535 FNNSSVTSDE----HSVKIDNVDYNTKFFVMRAQRSQSGKYIIKATNEVGEDEAELEVTVLGKPG 3595
            .:...:.|..    .|::::.|.           ...||.|...|.:|.||.....::||:..|
Human  3451 KDGEPLLSQSLEQGPSLQLEAVG-----------AGDSGTYSCVAVSEAGEARRHFQLTVMEPP- 3503

  Fly  3596 KPKGPLQVNDITKHSCKLKWEKPDDDGGSPIDYYEIEKLDPHTGQWLPCGKSTEPEAKVIGLHEG 3660
                         |.         :|.|.|.:.    .|.|.....|.|.....|:..:....:|
Human  3504 -------------HI---------EDSGQPTEL----SLTPGAPMELLCDAQGTPQPNITWHKDG 3542

  Fly  3661 KAYKFRVRAVNKEGESEDLETEKPIIAKNPYDEPDRPGKPEPTNWDKDFVDLAWDPPKNDGGAPI 3725
            :|.   .|..|....:..|..|.
Human  3543 QAL---TRLENNSRATRVLRVEN------------------------------------------ 3562

  Fly  3726 QKYVIQMRDKSGRAWVDSATVPGDKCNGTVTGVEEGH----EYEFRI---VAVNKAGPSDPSDVS 3783
                :|:||.                 |..|.:.|..    |..||:   ...|..||..
Human  3563 ----VQVRDA-----------------GLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRG----- 3601

  Fly  3784 KSVIAKPRF---LKPHIDRKNLQKKIMRSGQMLHIDALIKAEPPAKVTWTYNKTEIKTSDHIKIE 3845
                  |||   |.|              ||:: ::..::|||..|:||        ..|.|.::
Human  3602 ------PRFVVGLAP--------------GQLV-LECSVEAEPAPKITW--------HRDGIVLQ 3637

  Fly  3846 NEDYKTTF-------IMPKVKRADRGIYIVTAKNDSGSDTVEVELEVLCKPSKPKGPLAVSNVTA 3903
             ||..|.|       .:..:..||.|.|..||:|.:||.:|...:|:...|:...||.||:....
Human  3638 -EDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVN 3701

  Fly  3904 ETLHLKWEKPEDDGGDPIEQYLVERMDTETGRWVPVLTTKTPEADVTGLTEGKEYLFRVKAV--- 3965
            :|..|..:  .|....|:..:..:|        || |..::|..::  |.||.   .|::.|
Human  3702 QTALLPCQ--ADGVPAPLVSWRKDR--------VP-LDPRSPRFEI--LPEGS---LRIQPVLAQ 3750

  Fly  3966 ----------NSEGESE----------PLVTDIP--------TKAKNPFDAADTPGKPQIVDW-S 4001
                      ||.|...          |.:...|        |.|..|.:|:.:| ||.:|.| .
Human  3751 DAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSP-KPLVVWWKD 3814

  Fly  4002 GNHCDLKWRAPEDDGGASITGYIVERKDPNTGKWQKALETSTPDCKARVNDLIAGNKYQFRIMAV 4066
            |...|.:.:.     ||       .|..|:     .||..:.|..:         :..||..:..
Human  3815 GQKLDFRLQQ-----GA-------YRLLPS-----NALLLTAPGPQ---------DSAQFECVVS 3853

  Fly  4067 NKAGKSKPSEPSDQMTAKDRFAPPKI--DRTNIKDITIKAGQHIRFDIKVSGEPPATKVWLHNKA 4129
            |:.|:   :....|:|.   ..||.|  |:|   |.|:.....:......:|.|..|..|....|
Human  3854 NEVGE---AHRLYQVTV---HVPPTIADDQT---DFTVTMMAPVVLTCHSTGIPAPTVSWSKAGA 3909

  Fly  4130 RLENDDSNYNIDMESYRTKLTVPISKRFHSGKYTLKAENESGRDEASFEVIVLDKPGPPEGPLR- 4193
            :|....|.|.:   |....|.:..:...|:|:||..|.|.:|  .|...|.:..:..|...||.
Human  3910 QLGARGSGYRV---SPSGALEIGQALPIHAGRYTCSARNSAG--VAHKHVFLTVQASPVVKPLPS 3969

  Fly  4194 -VTDVHKEGCKLKWNAPLDDGGLPIDHYIIEK--MDVESG---RWLPSGRFKESFAELNNLEPSH 4252
             |..|.:|...|    |.:..|:|......:|  ::|.:|   :.||.|:.:.:.|     .|..
Human  3970 VVRAVAEEEVLL----PCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHA-----SPED 4025

  Fly  4253 EYKFRVLAVNTEGESEPLTGEQSVIAKNPFDEPGKP-----------------GTPEA-VDWDKD 4299
            ...:..:|.|:.|.:...|  :.|:...|..|.|.|                 |:||. :.||||
Human  4026 AGNYLCIAKNSAGSAMGKT--RLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKD 4088

  Fly  4300 HVDLVWRPPINDGGSPITG----YVVEKREKGTDKWIKGTEI-TIPCLGEECKATVPTLNENCEY 4359
                         |.|::|    :.::...:...|.::|.:. |..|..|.   .|.........
Human  4089 -------------GQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAEN---AVGRARRRVHL 4137

  Fly  4360 EFRVKAINAAGPGEPSDASKPIITKPRKLAPKIDRKNIRTYNFKSGEPIFLDINISGEPAPDVTW 4424
            ...|..:....||:.|                          .:.|:.::|.....|.|.|.:.|
Human  4138 TILVLPVFTTLPGDRS--------------------------LRLGDRLWLRCAARGSPTPRIGW 4176

  Fly  4425 NQNNKSVQTTSFSHIENLPYNTKYINNNPERKDTGLYKISAHNFYGQDQVEFQINIITKPGKPEG 4489
            ..|::.| |...|..:.   .:........|:|:|.|...|.|..|:.|.
Human  4177 TVNDRPV-TEGVSEQDG---GSTLQRAAVSREDSGTYVCWAENRVGRTQA--------------- 4222

  Fly  4490 PLEVSEVH-KDGCKLKWKKPKDDGGEPVESYLVEKFDPDTGIWLPVGRSDGPEYNVDGLVPGHDY 4553
               ||.|| |:...|:        ||.. |||||          |||.|    ..:|.:|.|
Human  4223 ---VSFVHVKEAPVLQ--------GEAF-SYLVE----------PVGGS----IQLDCVVRG--- 4258

  Fly  4554 KFRVKAVNKEGESEPLETLGSIIAKDPFSVPTKPGVPEPTDWTANKVELAWPEPASDGGSPIQGY 4618
                                     ||        ||          ::.|.:    .|.|::|
Human  4259 -------------------------DP--------VP----------DIHWIK----DGLPLRG- 4275

  Fly  4619 IVEVKDKYSPLWEKALETNSPTPTATVQGLIEGNEYQFRVVALNKGGLSE-------PSDPSKIF 4676
                    |.| ...|:..|.|...|.:.  :...||  .:|.|:.|:::       .|.|  :|
Human  4276 --------SHL-RHQLQNGSLTIRRTERD--DAGRYQ--CLAENEMGVAKKVVILVLQSAP--VF 4325

  Fly  4677 TAKPRYLAPKIDRRNLRNITLSSGTALKLDANITGEPAPKVEWKLSNYHLQSGKNVTIETPDYYT 4741
            ..:|            :::|:.||..:.|....||||.|.:||..:...|::.:.:. ..||  .
Human  4326 QVEP------------QDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLR-TLPD--G 4375

  Fly  4742 KLVIRPTQRSDSGEYLVTATNTSGKDSVLVNVVITDKP 4779
            .|.:...:..|:|.|...|.|..|..:....:|:..:|
Human  4376 SLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEP 4413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bt	NP_001162825.1	I-set	9..101	CDD:254352	19/70 (27%)
		Ig	26..100	CDD:143165	19/69 (28%)
		I-set	119..210	CDD:254352	24/94 (26%)
		Ig	136..209	CDD:143165	21/76 (28%)
		I-set	228..320	CDD:254352	29/96 (30%)
		IGc2	242..312	CDD:197706	23/74 (31%)
		I-set	335..425	CDD:254352	23/95 (24%)
		Ig	350..423	CDD:143165	17/73 (23%)
		Ig	436..530	CDD:299845	28/101 (28%)
		I-set	438..532	CDD:254352	29/101 (29%)
		I-set	545..636	CDD:254352	24/90 (27%)
		Ig	560..633	CDD:143165	20/72 (28%)
		Ig	657..731	CDD:143165	17/73 (23%)
		I-set	746..835	CDD:254352	20/95 (21%)
		Ig	1496..1586	CDD:299845	18/96 (19%)
		IG_like	1503..1588	CDD:214653	17/91 (19%)
		I-set	1639..1724	CDD:254352	20/98 (20%)
		IG	1750..1821	CDD:214652	23/74 (31%)
		IGc2	1750..1806	CDD:197706	19/57 (33%)
		I-set	1826..1909	CDD:254352	16/85 (19%)
		Ig	1831..1897	CDD:299845	14/68 (21%)
		I-set	1914..1998	CDD:254352	19/108 (18%)
		Ig	2020..2095	CDD:299845	20/84 (24%)
		FN3	2100..2194	CDD:238020	25/118 (21%)
		FN3	2203..2292	CDD:238020	17/96 (18%)
		I-set	2311..2395	CDD:254352	24/90 (27%)
		Ig	2321..2395	CDD:299845	19/79 (24%)
		FN3	2399..2493	CDD:238020	17/98 (17%)
		FN3	2501..2590	CDD:238020	14/88 (16%)
		I-set	2602..2693	CDD:254352	22/90 (24%)
		Ig	2619..2693	CDD:299845	19/73 (26%)
		FN3	2697..2793	CDD:238020	28/130 (22%)
		FN3	2801..2893	CDD:238020	20/99 (20%)
		I-set	2902..2995	CDD:254352	21/92 (23%)
		Ig	2919..2993	CDD:299845	17/73 (23%)
		FN3	2999..3088	CDD:238020	21/104 (20%)
		FN3	3102..3191	CDD:238020	6/88 (7%)
		I-set	3208..3292	CDD:254352	28/87 (32%)
		Ig	3219..3292	CDD:299845	25/76 (33%)
		FN3	3296..3390	CDD:238020	20/111 (18%)
		FN3	3400..3489	CDD:238020	20/105 (19%)
		I-set	3494..3590	CDD:254352	24/99 (24%)
		Ig	3516..3590	CDD:299845	17/77 (22%)
		FN3	3594..3682	CDD:238020	15/87 (17%)
		FN3	3694..3781	CDD:238020	12/93 (13%)
		I-set	3795..3885	CDD:254352	25/96 (26%)
		Ig	3813..3885	CDD:299845	22/78 (28%)
		FN3	3889..3980	CDD:238020	24/121 (20%)
		FN3	3990..4082	CDD:238020	19/92 (21%)
		I-set	4090..4181	CDD:254352	25/92 (27%)
		Ig	4108..4181	CDD:299845	19/72 (26%)
		FN3	4185..4271	CDD:238020	21/92 (23%)
		FN3	4285..4383	CDD:238020	22/120 (18%)
		Ig	4404..4480	CDD:299845	18/75 (24%)
		FN3	4484..4571	CDD:238020	20/87 (23%)
		FN3	4584..4677	CDD:238020	19/99 (19%)
		I-set	4685..4775	CDD:254352	21/89 (24%)
		Ig	4703..4775	CDD:299845	18/71 (25%)
		FN3	4779..4863	CDD:238020	1/1 (100%)
		FN3	4879..4970	CDD:238020
		IG	4989..5069	CDD:214652
		Ig	4996..5069	CDD:299845
		FN3	5073..5166	CDD:238020
		FN3	5175..5265	CDD:238020
I-set	5276..5366	CDD:254352
Ig	5293..5366	CDD:299845
FN3	5370..5462	CDD:238020
FN3	5470..5561	CDD:238020
Ig	5559..5654	CDD:299845
I-set	5570..5660	CDD:254352
FN3	5664..5755	CDD:238020
FN3	5764..5853	CDD:238020
I-set	5865..5954	CDD:254352
Ig	5882..5954	CDD:299845
FN3	5958..6049	CDD:238020
FN3	6062..6153	CDD:238020
I-set	6173..6255	CDD:254352
Ig_Titin_like	6182..6255	CDD:143225
FN3	6259..6350	CDD:238020
FN3	6359..6451	CDD:238020
FN3	6470..6552	CDD:238020
I-set	6564..6650	CDD:254352
Ig_Titin_like	6577..6650	CDD:143225
FN3	6654..6745	CDD:238020
FN3	6754..6840	CDD:238020
I-set	6855..6946	CDD:254352
Ig	6874..6946	CDD:299845
FN3	6950..7042	CDD:238020
FN3	7050..7139	CDD:238020
FN3	7151..7237	CDD:238020
I-set	7254..7334	CDD:254352
Ig	7272..7339	CDD:143165
IG_like	7354..7440	CDD:214653
Ig	7366..7440	CDD:299845
FN3	7444..7531	CDD:238020
FN3	7545..7637	CDD:238020
I-set	7648..7737	CDD:254352
Ig	7665..7734	CDD:143165
Ig	7760..7833	CDD:299845
FN3	7837..7927	CDD:238020
STKc_Twitchin_like	7986..8244	CDD:271016
S_TKc	7989..8244	CDD:214567
Ig	8311..8394	CDD:299845
I-set	8312..8401	CDD:254352
I-set	8437..8525	CDD:254352
Ig	8455..8519	CDD:143165
I-set	8632..8721	CDD:254352
IGc2	8646..8711	CDD:197706
I-set	8740..8831	CDD:254352
Ig	8757..8826	CDD:143165
I-set	8839..8922	CDD:254352
Ig	8845..>8909	CDD:299845
HMCN2	NP_001278744.1	VWA_2	39..209	CDD:290253
		IG_like	434..513	CDD:214653
		Ig	442..503	CDD:299845
		IG	524..604	CDD:214652
		Ig	534..601	CDD:143165
		I-set	608..692	CDD:254352	19/70 (27%)
		IGc2	621..684	CDD:197706	18/62 (29%)
		IG_like	712..782	CDD:214653	24/94 (26%)
		Ig	715..779	CDD:143165	21/76 (28%)
		Ig	785..869	CDD:299845	28/89 (31%)
		IG	792..879	CDD:214652	26/100 (26%)
		I-set	885..972	CDD:254352	23/94 (24%)
		IGc2	898..962	CDD:197706	17/71 (24%)
		IG	988..1063	CDD:214652	24/83 (29%)
		Ig	995..1062	CDD:299845	20/74 (27%)
		I-set	1079..1161	CDD:254352	24/87 (28%)
		IGc2	1088..1151	CDD:197706	20/68 (29%)
		I-set	1165..1246	CDD:254352	24/102 (24%)
		IGc2	1179..1236	CDD:197706	16/69 (23%)
		IG	1258..1340	CDD:214652	19/87 (22%)
		Ig	1266..1340	CDD:299845	18/79 (23%)
		IG	1354..1433	CDD:214652	22/146 (15%)
		IGc2	1360..1423	CDD:197706	20/114 (18%)
		IG	1446..1527	CDD:214652	22/150 (15%)
		IGc2	1453..1517	CDD:197706	16/120 (13%)
		IG	1540..1620	CDD:214652	22/143 (15%)
		Ig	1540..1620	CDD:299845	22/143 (15%)
		I-set	1632..1716	CDD:254352	23/147 (16%)
		IGc2	1641..1704	CDD:197706	18/79 (23%)
		IG	1727..1807	CDD:214652	20/112 (18%)
		IGc2	1734..1797	CDD:197706	16/89 (18%)
		Ig	1820..1893	CDD:299845	20/98 (20%)
		IG_like	1827..1891	CDD:214653	18/89 (20%)
		I-set	1895..1975	CDD:254352	24/94 (26%)
		Ig	1912..1975	CDD:143165	20/67 (30%)
		I-set	1986..2076	CDD:254352	17/91 (19%)
		IGc2	2001..2066	CDD:197706	15/66 (23%)
		Ig	2079..2169	CDD:299845	17/92 (18%)
		I-set	2080..2167	CDD:254352	17/89 (19%)
		I-set	2171..2261	CDD:254352	26/120 (22%)
		IGc2	2185..2251	CDD:197706	20/96 (21%)
		I-set	2273..2355	CDD:254352	16/81 (20%)
		Ig	2285..2352	CDD:143165	12/66 (18%)
		I-set	2367..2449	CDD:254352	21/118 (18%)
		Ig	2379..2449	CDD:299845	17/105 (16%)
		Ig	2452..2542	CDD:299845	27/98 (28%)
		IG_like	2462..2542	CDD:214653	23/88 (26%)
		IG	2558..2638	CDD:214652	18/132 (14%)
		IGc2	2565..2628	CDD:197706	13/115 (11%)
		IG	2656..2736	CDD:214652	24/129 (19%)
		IGc2	2663..2726	CDD:197706	20/76 (26%)
		IG_like	2770..2847	CDD:214653	18/89 (20%)
		IGc2	2773..2837	CDD:197706	14/76 (18%)
		IG	2862..2942	CDD:214652	20/99 (20%)
		Ig	2868..2942	CDD:299845	17/93 (18%)
		IG_like	2954..3034	CDD:214653	17/84 (20%)
		IGc2	2961..3024	CDD:197706	14/67 (21%)
		I-set	3038..3129	CDD:254352	25/171 (15%)
		IGc2	3056..3119	CDD:197706	15/119 (13%)
		I-set	3133..3221	CDD:254352	28/91 (31%)
		IGc2	3148..3208	CDD:197706	19/61 (31%)
		IG	3234..3318	CDD:214652	18/94 (19%)
		IGc2	3240..3306	CDD:197706	13/76 (17%)
		IG	3329..3410	CDD:214652	22/114 (19%)
IGc2	3336..3400	CDD:197706	17/95 (18%)
IG_like	3424..3499	CDD:214653	20/85 (24%)
IGc2	3430..3489	CDD:197706	16/69 (23%)
I-set	3503..3590	CDD:254352	25/179 (14%)
IGc2	3518..3580	CDD:197706	16/127 (13%)
I-set	3602..3683	CDD:254352	29/104 (28%)
IGc2	3610..3673	CDD:197706	22/86 (26%)
IG	3693..3774	CDD:214652	20/96 (21%)
Ig	3693..3774	CDD:299845	20/96 (21%)
Ig	3777..3859	CDD:299845	24/111 (22%)
IG	3784..3867	CDD:214652	24/112 (21%)
IG_like	3887..3958	CDD:214653	19/75 (25%)
IGc2	3887..3948	CDD:197706	16/63 (25%)
IG	3968..4048	CDD:214652	19/90 (21%)
Ig	3979..4040	CDD:299845	15/69 (22%)
I-set	4052..4139	CDD:254352	20/102 (20%)
IGc2	4065..4129	CDD:197706	15/79 (19%)
I-set	4143..4228	CDD:254352	24/132 (18%)
IGc2	4157..4218	CDD:197706	16/64 (25%)
I-set	4246..4317	CDD:254352	25/138 (18%)
IGc2	4247..4309	CDD:197706	23/129 (18%)
Ig	4322..4405	CDD:299845	24/99 (24%)
I-set	4323..4409	CDD:254352	24/102 (24%)
G2F	4411..4593	CDD:284812	1/3 (33%)
FXa_inhibition	4652..4687	CDD:291342
EGF_CA	4689..4732	CDD:214542
EGF_CA	4733..4774	CDD:284955
EGF_CA	4776..4815	CDD:284955
EGF_CA	4883..4922	CDD:214542
EGF_CA	4923..4963	CDD:214542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100287
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810