DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bt and Ptprs

DIOPT Version :9

Sequence 1:	NP_001162825.1	Gene:	bt / 43814	FlyBaseID:	FBgn0005666	Length:	8933	Species:	Drosophila melanogaster
Sequence 2:	XP_038938979.1	Gene:	Ptprs / 25529	RGDID:	3452	Length:	1926	Species:	Rattus norvegicus

Alignment Length:	2278	Identity:	454/2278 - (19%)
Similarity:	715/2278 - (31%)	Gaps:	724/2278 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  5275 PPKIDRNFMSDIKIKAGNVFEFDVPVTGEPLPSKDWTHEGNMIINTDRVKISNFDDRT----KIR 5335
            ||:..|.....|.: :|.|..|....||:|.|...|..:|.. :|:.|.:..:||:.:    :|:
  Rat    32 PPRFIREPKDQIGV-SGGVASFVCQATGDPKPRVTWNKKGKK-VNSQRFETIDFDESSGAVLRIQ 94

  Fly  5336 ILDAKRSDTGVYTLTARNINGTDRHNVKVTILDAPSVPEGPLRNGDVSKNSIVLRWRPPKDDGGS 5400
            .|...| |..||...|:|..|....:.|:|:|....:|.|                 .|..|.|.
  Rat    95 PLRTPR-DENVYECVAQNSVGEITVHAKLTVLREDQLPPG-----------------FPNIDMGP 141

  Fly  5401 EITHYVVEKMDNEAMRWVPVGDCTDTEIRADNLIENHDYSFRVRAVNKQGQSQPLTTSQPITAKD 5465
            ::.  |||:.....|.....|
  Rat   142 QLK--VVERTRTATMLCAASG-------------------------------------------- 160

  Fly  5466 PYSHPDKPGQPQATDWGKHFVDLEWSTPKRDGGAPISSYIIEKRPKFGQWERAAVVLGDNCKAHV 5530
               :||    |:.| |.|.|:.::   |....|. |.....|..|     .|.|:.:..:
  Rat   161 ---NPD----PEIT-WFKDFLPVD---PSASNGR-IKQLRSESTP-----IRGALQIESS----- 203

  Fly  5531 PELTNGGEYEFRVIAVNRGGP--SDPSDPSSTIICKPRFLAPFFDKSLL-NDITVHAGKRLGWTL 5592
             |.|:.|:||  .:|.|..|.  |.|::.....:.:.|.:||.|  |:| ....:..|..:..|.
  Rat   204 -EETDQGKYE--CVATNSAGVRYSSPANLYVRELREVRRVAPRF--SILPMSHEIMPGGNVNITC 263

  Fly  5593 PIEASPRPLITWLYNGKEIGSNSRGESGLFQNELTFEIVSSLRSDEGRYTLILKNEHGSFDASAH 5657
            ....||.|.:.|:...:::........|....||| ::     .|...||.:..:..|..:|.|.
  Rat   264 VAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELT-DV-----KDSANYTCVAMSSLGVIEAVAQ 322

  Fly  5658 ATVLDRPSPPKGPLDITKITRDGCHLTWNVPDDDGGSPILHYIIE------------KMDLSRST 5710
            .||...|..|..|: :|:.|.....:||   |.....|:.:|:||            |.|::.:.
  Rat   323 ITVKSLPKAPGTPV-VTENTATSITVTW---DSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTR 383

  Fly  5711 WSDAGMSTHIVHDVTRLVHRKEYLFRVKAVNAIGESDPLEAVNTIIAKNEFDEPDAPGKPIITDW 5775
            :|..|:|.:           .||...|.|||:||:..|.|:|  :....|.....||........
  Rat   384 YSIGGLSPN-----------SEYEIWVSAVNSIGQGPPSESV--VTRTGEQAPASAPRNVQARML 435

  Fly  5776 DRDHIDLQWAVPKSDGGAPISEYIIQKKEKGSPYWTNVRHVPSNKNTTTIPELTEGQEYEFRVIA 5840
            ....:.:||..|....|......:....|...|.....:|...:...||:..|.|.:.|..||:|
  Rat   436 SATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLA 500

  Fly  5841 VNQAGQSEPSEPSDM-----IMAKPRYLPPKI----------ITPLNEVRIKCGLIFHTDIHFIG 5890
            ....|....|:|..:     :..:|..|..:.          ..|..|..||..|:|..     |
  Rat   501 FTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEAKSETSIGLSWSAPRQESVIKYELLFRE-----G 560

  Fly  5891 EPAPEATWTLN-SNPLLSNDRSTITSIGHHSVVHTVNCQRSDSGIYHLLLRNSSGIDEGSFELVV 5954
            :...|...|.: :...:..|....|...                 :.|..|:..|:  |:|..||
  Rat   561 DRGREVGRTFDPTTAFVVEDLKPNTEYA-----------------FRLAARSPQGL--GAFTAVV 606

  Fly  5955 LDR-----PGPPEGPMEYEEITANSVTISWKPP---KDNGGSEISSYVIEKRDLTHGGGWVPAVN 6011
            ..|     |..|...::...:.:.::.:||:||   ..||.  :..|.:..|.|.........||
  Rat   607 RQRTLQAKPSAPPQDVKCTSLRSTAILVSWRPPPPETHNGA--LVGYSVRYRPLGSEDPDPKEVN 669

  Fly  6012 YVSAKYNHAVVPRLLEGTMYELRVMAENLQGRSDPLTSDQPVVAKSQYTVPGA-PGKPELTDSDK 6075
            .:.......::..|.:.|.|.:..:|....|   |.....|||.::...||.| |.|.|....:.
  Rat   670 NIPPTTTQILLEALEKWTEYRVTAVAYTEVG---PGPESSPVVVRTDEDVPSAPPRKVEAEALNA 731

  Fly  6076 NHITIKWKQPI-SNGGSPIIGYDIERRDVNTGRWIKINGQPV-------------------PTAE 6120
            ..|.:.|:.|. ......|.||.:        .::::.|...                   .|||
  Rat   732 TAIRVLWRSPTPGRQHGQIRGYQV--------HYVRMEGAEARGPPRIKDIMLADAQWEMDDTAE 788

  Fly  6121 YQDDRVTSNHQ----YQYRISAVNAAGNGKTSEPSAIFNARPLREKPRFYFDGLIGKRIKVRAGE 6181
            |  :.|.:|.|    |...::|....|:|..|:|
  Rat   789 Y--EMVITNLQPETAYSITVAAYTMKGDGARSKP------------------------------- 820

  Fly  6182 PVNLNIPISGAPTPTIEWKRGDLKLEEGKRISYETNSERTLFRIDDSNRRDSGKYTVTAANEFGK 6246
                                                                 |..||.....|:
  Rat   821 -----------------------------------------------------KVVVTKGAVLGR 832

  Fly  6247 DTADIEVIVVDKPSPPEGPLSYTETAPDHISLHWYSPKDDGGSDITGYIIEFTEFGVDDWKPVPG 6311
            .|..::       ..|||.|          ...|..|.|.....:.||.:   :||.:|  ..|.
  Rat   833 PTLSVQ-------QTPEGSL----------LARWEPPADAAEDPVLGYRL---QFGRED--AAPA 875

  Fly  6312 TCPNTNFTVKNLV---EGKKYVFRIRAENIYGASEALEGKPVLAKSPFDPPGAP----SQPTISA 6369
            |.....:..:...   :|..||||:.|....|..|  |....|:.....|.|.|    :...:||
  Rat   876 TLELAAWERRFAAPAHKGATYVFRLAARGRAGLGE--EASAALSIPEDAPRGFPQILGAAGNVSA 938

  Fly  6370 YTPNSANLEWHP--PDDCGGKPITGYIVERRERGGEW------IKCNNYPTPNTSYTVSNLRDGA 6426
               .|..|.|.|  |.:..| .|..|.|..||.|...      :.....|...|:.|:..||...
  Rat   939 ---GSVILRWLPPVPAERNG-AIIKYTVSVREAGAPGPATETELAAAAQPGAETALTLQGLRPET 999

  Fly  6427 RYEFRVLAVNEAGPGHPSKPSDPMTAEHQRYR--PDPPEPP--KPDRITRNGVTLSWRPPRTDGK 6487
            .||.||.|....|||..|.|        .|||  .||..|.  |...|.:..|.|||..|  |..
  Rat  1000 AYELRVRAHTRRGPGPFSPP--------LRYRLARDPVSPKNFKVKMIMKTSVLLSWEFP--DNY 1054

  Fly  6488 SRIKGYYVEMRPKNGKDWKTVNDIPINSTVYTVPSLKEGEEYSFRVVAENEVGRSDPSKPSQPIT 6552
            :....|.::.   ||    ...|:...:|...:..||....|:|  |..|. |.|
  Rat  1055 NSPTPYKIQY---NG----LTLDVDGRTTKKLITHLKPHTFYNF--VLTNR-GSS---------- 1099

  Fly  6553 IEEQPNKPCMELGKVRD-IVCRAGDDFSIHVPYLAFPKPNAFWYSNDNMLDDNNRVHKHLTDDAA 6616
                       ||.::. :..|...:.....|.:| |||           |::..:..:|.|..:
  Rat  1100 -----------LGGLQQTVTARTAFNMLSGKPSVA-PKP-----------DNDGSIVVYLPDGQS 1141

  Fly  6617 SVVVKN-------SKRADSGQYRLQLKNTSGFDTATI-------------NVRVLDRPSPPTRLR 6661
            .|.|:|       .:::..||:.:.|.:....|...:             :.|.|:.|.|....|
  Rat  1142 PVTVQNYFIVMVPLRKSRGGQFPILLGSPEDMDLEELIQDLSRLQRRSLRHSRQLEVPRPYIAAR 1206

  Fly  6662 ADEFSGDSLTLYWNPPNDDGGSAIQNYIIEKKEARSSTWSKVSSFCTVPFVRIRNLVLNKEYDFR 6726
               ||  .|...::|.|........|                           |.|.....|...
  Rat  1207 ---FS--ILPAVFHPGNQKQYGGFDN---------------------------RGLEPGHRYVLF 1239

  Fly  6727 VIAENKYGQSDPANTSEPILARHPFDIP---NTPGIPHGIDSTEDSITIAWTKPKHDGGSPITGY 6788
            |:|        ....:||..|..||..|   :.|.....:|..|..|.:.         .|:...
  Rat  1240 VLA--------VLQKNEPTFAASPFSDPFQLDNPDPQPIVDGEEGLIWVI---------GPVLAV 1287

  Fly  6789 -----IIEKRLLSDDKWTKAVHALCPDLSCKIPNLIENAE---------YEFRVAAVNAAGQSAY 6839
                 |:...||..:|.........|...|    |:.||:         .|.|.......|..:
  Rat  1288 VFIICIVIAILLYKNKPDSKRKDSEPRTKC----LLNNADLAPHHPKDPVEMRRINFQTPGMLS- 1347

  Fly  6840 SGSSDLIFCRRPPHAPKITSDLSIRDMTVIAGDEFRITVPYHA-SPRPTASWSLNGLEV-IPGER 6902
                         |.|...:|::.....:.|.|..:::..|.: .|....:|..:.||. .|..|
  Rat  1348 -------------HPPIPITDMAEHMERLKANDSLKLSQEYESIDPGQQFTWEHSNLEANKPKNR 1399

  Fly  6903 ----IKFD-------------SNDYASMYYNKSAKRDETGSYTITLTNNKGSDTASCHVTVVDRP 6950
                |.:|             .:||.:..|....:|.  .:|..|
  Rat  1400 YANVIAYDHSRVILQPLEGIMGSDYINANYVDGYRRQ--NAYIAT-------------------- 1442

  Fly  6951 LPPQGPLNAYDITPDTCTLAWKTPLDDGGSPITNYVVEKLDNSGS------W----VKISSFVRN 7005
               ||||      |:|....|:...:...:.:.  ::.:|:....      |    .:...|::.
  Rat  1443 ---QGPL------PETFGDFWRMVWEQRSATVV--MMTRLEEKSRVKCDQYWPNRGTETYGFIQV 1496

  Fly  7006 THYDVMGLEPHYKYNFRVR--AENQYGLSDPLDIIEPIVAKH-QFT------VPDEP-------- 7053
            |..|.|.|.     .|.||  :.::.|.|:..::      :| |||      ||:.|
  Rat  1497 TLLDTMELA-----TFCVRTFSLHKNGSSEKREV------RHFQFTAWPDHGVPEYPTPFLAFLR 1550

  Fly  7054 ---------GQPKVIDWDS---------------------------GNVTLIWTRPLSDGGSRIQ 7082
                     ..|.|:...:                           |:|||:.::         :
  Rat  1551 RVKTCNPPDAGPVVVHCSAGVGRTGCFIVIDAMLERIRTEKTVDVYGHVTLMRSQ---------R 1606

  Fly  7083 GYQIEYRD---ILNDSSWNA-------------YDYIIKDTKYQLYNLINGSEYEFRIKAKNAAG 7131
            .|.::..|   .::::...|             |.||.|..:.:....:.|.|.||:..|.:.|.
  Rat  1607 NYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYTYIQKLAQVEPGEHVTGMELEFKRLASSKAH 1671

  Fly  7132 LSK---PSSPSLRFKLKGKFTVPSPPGAPQVTRV---------GKNYVDLKWEKPLRDGGSRITG 7184
            .|:   .|.|..:||.:....:|.     :.:||         |.:|::..:    .||..:...
  Rat  1672 TSRFITASLPCNKFKNRLVNILPY-----ESSRVCLQPIRGVEGSDYINASF----IDGYRQQKA 1727

  Fly  7185 YIIER-------RDIGGAVW------------------VKCNDYNVLDT----EYTVMNLI---E 7217
            ||..:       .|...|:|                  .||:.|...:.    :|.|::.:   .
  Rat  1728 YIATQGPLAETTEDFWRALWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYN 1792

  Fly  7218 MGDYEFRVFAVNSA--GRSEP----SLCTMPIKVCEVLGGKKPDWITRLQDKVAPFGKD--YTLQ 7274
            |..|..|.|.|..|  |:|..    .....|.:.....|....|:|.::......||:|  .::.
  Rat  1793 MPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGAPKSGEGFIDFIGQVHKTKEQFGQDGPISVH 1857

  Fly  7275 CAA 7277
            |:|
  Rat  1858 CSA 1860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bt	NP_001162825.1	I-set	9..101	CDD:254352
		Ig	26..100	CDD:143165
		I-set	119..210	CDD:254352
		Ig	136..209	CDD:143165
		I-set	228..320	CDD:254352
		IGc2	242..312	CDD:197706
		I-set	335..425	CDD:254352
		Ig	350..423	CDD:143165
		Ig	436..530	CDD:299845
		I-set	438..532	CDD:254352
		I-set	545..636	CDD:254352
		Ig	560..633	CDD:143165
		Ig	657..731	CDD:143165
		I-set	746..835	CDD:254352
		Ig	1496..1586	CDD:299845
		IG_like	1503..1588	CDD:214653
		I-set	1639..1724	CDD:254352
		IG	1750..1821	CDD:214652
		IGc2	1750..1806	CDD:197706
		I-set	1826..1909	CDD:254352
		Ig	1831..1897	CDD:299845
		I-set	1914..1998	CDD:254352
		Ig	2020..2095	CDD:299845
		FN3	2100..2194	CDD:238020
		FN3	2203..2292	CDD:238020
		I-set	2311..2395	CDD:254352
		Ig	2321..2395	CDD:299845
		FN3	2399..2493	CDD:238020
		FN3	2501..2590	CDD:238020
		I-set	2602..2693	CDD:254352
		Ig	2619..2693	CDD:299845
		FN3	2697..2793	CDD:238020
		FN3	2801..2893	CDD:238020
		I-set	2902..2995	CDD:254352
		Ig	2919..2993	CDD:299845
		FN3	2999..3088	CDD:238020
		FN3	3102..3191	CDD:238020
		I-set	3208..3292	CDD:254352
		Ig	3219..3292	CDD:299845
		FN3	3296..3390	CDD:238020
		FN3	3400..3489	CDD:238020
		I-set	3494..3590	CDD:254352
		Ig	3516..3590	CDD:299845
		FN3	3594..3682	CDD:238020
		FN3	3694..3781	CDD:238020
		I-set	3795..3885	CDD:254352
		Ig	3813..3885	CDD:299845
		FN3	3889..3980	CDD:238020
		FN3	3990..4082	CDD:238020
		I-set	4090..4181	CDD:254352
		Ig	4108..4181	CDD:299845
		FN3	4185..4271	CDD:238020
		FN3	4285..4383	CDD:238020
		Ig	4404..4480	CDD:299845
		FN3	4484..4571	CDD:238020
		FN3	4584..4677	CDD:238020
		I-set	4685..4775	CDD:254352
		Ig	4703..4775	CDD:299845
		FN3	4779..4863	CDD:238020
		FN3	4879..4970	CDD:238020
		IG	4989..5069	CDD:214652
		Ig	4996..5069	CDD:299845
		FN3	5073..5166	CDD:238020
		FN3	5175..5265	CDD:238020
I-set	5276..5366	CDD:254352	26/93 (28%)
Ig	5293..5366	CDD:299845	22/76 (29%)
FN3	5370..5462	CDD:238020	10/91 (11%)
FN3	5470..5561	CDD:238020	24/92 (26%)
Ig	5559..5654	CDD:299845	20/95 (21%)
I-set	5570..5660	CDD:254352	20/90 (22%)
FN3	5664..5755	CDD:238020	28/102 (27%)
FN3	5764..5853	CDD:238020	19/88 (22%)
I-set	5865..5954	CDD:254352	16/99 (16%)
Ig	5882..5954	CDD:299845	11/72 (15%)
FN3	5958..6049	CDD:238020	19/93 (20%)
FN3	6062..6153	CDD:238020	25/115 (22%)
I-set	6173..6255	CDD:254352	5/81 (6%)
Ig_Titin_like	6182..6255	CDD:143225	5/72 (7%)
FN3	6259..6350	CDD:238020	23/93 (25%)
FN3	6359..6451	CDD:238020	31/103 (30%)
FN3	6470..6552	CDD:238020	20/81 (25%)
I-set	6564..6650	CDD:254352	18/106 (17%)
Ig_Titin_like	6577..6650	CDD:143225	15/92 (16%)
FN3	6654..6745	CDD:238020	15/90 (17%)
FN3	6754..6840	CDD:238020	18/102 (18%)
I-set	6855..6946	CDD:254352	19/109 (17%)
Ig	6874..6946	CDD:299845	15/90 (17%)
FN3	6950..7042	CDD:238020	19/103 (18%)
FN3	7050..7139	CDD:238020	23/151 (15%)
FN3	7151..7237	CDD:238020	25/132 (19%)
I-set	7254..7334	CDD:254352	7/26 (27%)
Ig	7272..7339	CDD:143165	2/6 (33%)
IG_like	7354..7440	CDD:214653
Ig	7366..7440	CDD:299845
FN3	7444..7531	CDD:238020
FN3	7545..7637	CDD:238020
I-set	7648..7737	CDD:254352
Ig	7665..7734	CDD:143165
Ig	7760..7833	CDD:299845
FN3	7837..7927	CDD:238020
STKc_Twitchin_like	7986..8244	CDD:271016
S_TKc	7989..8244	CDD:214567
Ig	8311..8394	CDD:299845
I-set	8312..8401	CDD:254352
I-set	8437..8525	CDD:254352
Ig	8455..8519	CDD:143165
I-set	8632..8721	CDD:254352
IGc2	8646..8711	CDD:197706
I-set	8740..8831	CDD:254352
Ig	8757..8826	CDD:143165
I-set	8839..8922	CDD:254352
Ig	8845..>8909	CDD:299845
Ptprs	XP_038938979.1	I-set	33..124	CDD:400151	26/93 (28%)
		Ig strand A	33..36	CDD:409353	1/2 (50%)
		Ig strand A'	42..45	CDD:409353	1/2 (50%)
		Ig strand B	50..57	CDD:409353	1/6 (17%)
		Ig strand C	63..68	CDD:409353	1/4 (25%)
		Ig strand C'	71..73	CDD:409353	0/2 (0%)
		Ig strand D	80..84	CDD:409353	0/3 (0%)
		Ig strand E	86..93	CDD:409353	0/6 (0%)
		Ig strand F	103..111	CDD:409353	3/7 (43%)
		Ig strand G	114..124	CDD:409353	2/9 (22%)
		IgI_2_RPTP_IIa_LAR_like	137..232	CDD:409400	31/165 (19%)
		Ig strand B	152..156	CDD:409400	1/3 (33%)
		Ig strand C	165..169	CDD:409400	1/4 (25%)
		Ig strand E	196..200	CDD:409400	1/3 (33%)
		Ig strand F	210..215	CDD:409400	2/6 (33%)
		Ig strand G	222..225	CDD:409400	0/2 (0%)
		IgI_3_RPTP_IIa_LAR_like	245..326	CDD:409401	19/86 (22%)
		Ig strand B	259..263	CDD:409401	0/3 (0%)
		Ig strand C	272..276	CDD:409401	0/3 (0%)
		Ig strand E	293..297	CDD:409401	0/3 (0%)
		Ig strand F	305..310	CDD:409401	2/4 (50%)
		Ig strand G	318..321	CDD:409401	1/2 (50%)
		FN3	329..418	CDD:238020	28/105 (27%)
		FN3	425..517	CDD:238020	20/91 (22%)
		FN3	522..610	CDD:238020	20/111 (18%)
		FN3	618..712	CDD:238020	21/98 (21%)
		FN3	720..825	CDD:238020	24/198 (12%)
		FN3	833..909	CDD:214495	22/97 (23%)
		FN3	935..1023	CDD:238020	30/99 (30%)
		FN3	1028..1111	CDD:238020	25/115 (22%)
		PTP_tm	<1217..1301	CDD:408631	21/127 (17%)
		R-PTPc-S-1	1348..1629	CDD:350473	55/333 (17%)
		R-PTP-S-2	1631..1920	CDD:350475	49/239 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910