DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment bt and Myom3

DIOPT Version :9

Sequence 1:NP_001162825.1 Gene:bt / 43814 FlyBaseID:FBgn0005666 Length:8933 Species:Drosophila melanogaster
Sequence 2:NP_001078978.1 Gene:Myom3 / 242702 MGIID:2685280 Length:1439 Species:Mus musculus


Alignment Length:1764 Identity:359/1764 - (20%)
Similarity:577/1764 - (32%) Gaps:632/1764 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly  6090 GSPIIGYDIERRDVNTGRWIKINGQPVPTAEYQDDRVTSNH--------------QYQYRISAVN 6140
            |||.......:.|      |:|:.:..|..:|   |:|:|:              ...|.:...|
Mouse   179 GSPPFQVTWYKND------IRIDPRLFPAGKY---RITNNYGLLTLEIMRCTVEDSATYTVLVKN 234

  Fly  6141 AAGN-----------------GKTSE--------PSAIFNARPLREKPRFYFDGLIGKRIKVRAG 6180
            |.|.                 |..||        |||.|.:              :.|.|..:..
Mouse   235 AYGQASSFAKVLIRNYLGKDAGFDSEIFKRSMFGPSAEFTS--------------VLKPIFAQEK 285

  Fly  6181 EPVNLNIPISG---APTPTIEWKRGDLKLEEGKRISYETNSERTLFRIDDSNRRDSGKYTVTAAN 6242
            ||.:|....|.   .....|:|.|....|....|........:...::..:.:.|.|.||:..::
Mouse   286 EPFSLTCLFSDDVLEAEQRIQWYRDGRLLRSSTRRQILYADRQASVKVSCAYKEDEGFYTIRVSS 350

  Fly  6243 EFGKDTADIEVIVVD----KPSPPEGPLSY--TETAPDHISLHWYSPKDDGGSDITGYIIEFTEF 6301
            .||.......|.:.|    ||..|..||:.  .....|.::|.|..|.|..||.||||.||..:.
Mouse   351 PFGPQEQSAYVFIRDAAAEKPGAPGSPLNVRCLNVHRDCLTLTWVPPSDTRGSTITGYSIEMCQG 415

  Fly  6302 GVDDWKP---VPG---TCPNTNFTVKNLVEGKKYVFRIRAENIYG------ASEA---------- 6344
            ..::|.|   .||   .||     ::.||||:.|.||:||.:..|      ||||          
Mouse   416 DSEEWMPCLKAPGGTCRCP-----IQGLVEGQSYQFRVRAISKAGTSLPSKASEAVVTGDYDAVH 475

  Fly  6345 --------LEGKPVLAKSPFDP----PGAPSQPTISAYTPNSANLEWHPPDDCGGKPITGYIVER 6397
                    |..|..::|:.|:.    |.||:....|......|.|.|..|...|..|:| |.:|:
Mouse   476 KSTEIPYDLGSKITISKNDFEDAVTIPSAPTNVHASEIREAYAVLSWEEPRPRGRAPLT-YTLEK 539

  Fly  6398 RERG-GEWIKCN-NYPTPNTSYTVSNLRDGARYEFRVLAVNEAGPGHPSKPSDPMTAEHQRYRPD 6460
            ...| |.|...: ..|..:..:.:.:|..|..|.|||.|:|:.|...||:||:|:..:.:.....
Mouse   540 SVIGSGTWEAISTETPIKSPRFALLDLEKGKSYVFRVRALNQYGMSDPSEPSEPVALKGKPATLP 604

  Fly  6461 PPEPPKPDRITRNGVTLSWRPPRTDGKSRIKGYYVEMRPKNGKDWKTVNDIPINSTVYTVPSLKE 6525
            ||...:..|.|:..|:|:|.|  .||.|.:.|||:..|.....:|:|||:.||..|.:|||.|:.
Mouse   605 PPAQVQAFRNTQTSVSLAWEP--VDGGSELLGYYIYSREAGASEWQTVNNKPIQDTKFTVPGLRT 667

  Fly  6526 GEEYSFRVVAENEVGRSDPSKPSQPITIEEQPNKPCMELGKVRDIVCRAGDDFSIHVPYLAFPKP 6590
            |:||.|.:.:.:|.|..:.|..:||:.:::.                            ||.|  
Mouse   668 GKEYDFCIRSVSEAGVGESSAATQPVRVKQA----------------------------LATP-- 702

  Fly  6591 NAFWYSNDNMLDDNNRVHKHLTDDAASVVVKNSKRADSGQYRLQLKNTSGFDTATINVRVLDRPS 6655
                                                           ::.:|.|.:|.       
Mouse   703 -----------------------------------------------SAPYDFALLNC------- 713

  Fly  6656 PPTRLRADEFSGDSLTLYWNPPNDDGGSAIQNYIIEKKEARSSTWSKV------SSFCTVPFVRI 6714
                      ..:.:.:.|.||...||..|..|.:::.::..|.|..|      |..|     ::
Mouse   714 ----------GKNEMVIGWKPPKRRGGGKILGYFMDQHDSVESDWHPVNRQPIPSRVC-----KV 763

  Fly  6715 RNLVLNKEYDFRVIAENKYGQSDPANTSEPILARHPFDIPNTPGIPHGIDSTE---DSITIAWTK 6776
            .||.....|:||..|.|..|..:.:..|. :.....:.:|. ||.|:.:..:|   .|:.:.|..
Mouse   764 TNLHEGHFYEFRARAVNWAGIGELSAPSS-LFECKEWTMPE-PGPPYDVRVSEVQATSVMLQWEP 826

  Fly  6777 PKHDGGSPITGYIIEKRLLSDDKWTKAVHALCPDLSCKIPNLIENAEYEFRVAAVNAAGQSAYSG 6841
            |.:.|..|:|||.:..:....::|.........|...::.:|....:|.|||.|:|:||....|.
Mouse   827 PLYIGAGPVTGYHVSFQEKGSEEWKPVTPDATSDTHLRVSDLQPGKQYMFRVQAMNSAGLGQPSV 891

  Fly  6842 SSDLIFCRRPPHAPKITSDLSIRDMTVIAGDEFRITVPYHASPR---PTASWSLNGLEVIPGERI 6903
            .:|.:.....|.|         :::.|...||.:|.:.:.|...   |...||.:.......:|:
Mouse   892 PTDPVLLEDKPDA---------QEIEVGVDDEGQIYLAFEAPEAPDFPEFQWSKDYQGPPDPQRV 947

  Fly  6904 KFDSNDYASMYYNKSAKRDETGSYTITLTNNKGSDTASCHVTVVDRPLPPQGPLNAYDITPDTCT 6968
            :.:.....|....|.....:.|.|::.:. :...||::.| |:.:..|.....| :::|......
Mouse   948 EVEDEISKSKVILKEPDLQDLGIYSVVVP-DADEDTSASH-TLTEEELNKLKKL-SHEIRNPVIK 1009

  Fly  6969 L--AWKTPLDDGGSPITNYVVEKLDNSGSWVKISSFVRNTHYDVMGLEPHYKYNFRVRAENQYGL 7031
            |  .|...:.:.|.......||||..:.....|.:     ..::.. .|:.|.||    :.:.||
Mouse  1010 LISGWNVEILEQGEVRLWLEVEKLSPAAELHLIFN-----EKEIFS-SPNRKINF----DREKGL 1064

  Fly  7032 SDPLDIIEPIVAKHQFTVPDEPGQPKVIDWDSGNVTLIWTRPLSDGGSRIQGYQIEYRDILNDSS 7096
                  :|.|:   |....|:.|.              :|..|.||                   
Mouse  1065 ------VEVII---QQLSEDDKGS--------------YTAQLQDG------------------- 1087

  Fly  7097 WNAYDYIIKDTKYQLYNLINGSEYEFRIKAKNAAGLSKPSSPSLRFKLKGKFTVPSPPGAPQVTR 7161
                                        ||||                             |:|.
Mouse  1088 ----------------------------KAKN-----------------------------QITL 1095

  Fly  7162 VGKNYVDLKWEKPLRDGGSRITGYIIERRDIGGAVWVKCNDYNVLDTEYTVMNLIEMGDYEFRVF 7226
            .   .||.:::|.||...::       |||     |.:                 :.|.| |:  
Mouse  1096 A---LVDDEFDKLLRKADAK-------RRD-----WKR-----------------KQGPY-FQ-- 1125

  Fly  7227 AVNSAGRSEPSL------CTMPIKVCEVLGGKKP---DWITRLQDKVAPFGKDYTLQCAASGKPS 7282
                    ||..      |.:.:. |:|...||.   .|.  .|.|.||.|: |.         .
Mouse  1126 --------EPLTWKVTDDCQVLLS-CKVTNTKKESRFQWF--FQKKEAPHGQ-YN---------P 1169

  Fly  7283 PTARWLRNGKEIQMNGGRMTCD--SKD--GVFRLHISNVQTGDDG--DYTCEAMNSLGFVNTSGY 7341
            ||            ..|.::.:  ||:  ||:|..:|:.:..||.  |.|.||::::       .
Mouse  1170 PT------------GDGSLSIEGFSKENQGVYRAVVSDERGEDDTVLDLTGEALDAV-------L 1215

  Fly  7342 LKIGSPPIINRCPSELK-LPEGDN--SKIKIFYSGDQPLTVILKKNNEVICDSNDDTHVKVNIFD 7403
            .::|....::..|.::: ..||..  ||:| :|:.|...|....|:..:  :|.|  .|:.....
Mouse  1216 TELGRIGALSATPLKIQGTEEGIRLFSKVK-YYNVDYMKTAWFHKDKRL--ESGD--RVRAGTTL 1275

  Fly  7404 DYVAIYIRNIVKSDGGPYQIEFTNESGSATGEFYVHITGMPSAPTGPMGISYINKNSCMLNWRPP 7468
            |.:.::|.:...||.|.|.:|.|  :|....:....::|.                         
Mouse  1276 DEIWLHILDPKDSDKGKYTLEIT--AGKEVRQLSADLSGQ------------------------- 1313

  Fly  7469 SYDGGLKVSHYVIERKDVSSPHWITVSSTCKDTAFNVQGLIENQEYIFRVMAVNENGMGPPLEGL 7533
                                             ||: ..|.|:|.  .:.:||.|......:.||
Mouse  1314 ---------------------------------AFD-DALAEHQR--LKALAVIEKNRAKVVRGL 1342

  Fly  7534 NPIRAKDPIDPPSPPGSPQITEIGGDFVHLEWEKPESDGGAHIQGYWIDKREVGSNTWQRVNATI 7598
                             |.:..|..|                                    .|:
Mouse  1343 -----------------PDVATIMED------------------------------------KTL 1354

  Fly  7599 CAANQINCINLIEGRQYEFRIFAQNVAGLSTESSASQAVKIIDPQAASPPLIVKPLRDANCIQNH 7663
            |                                                                
Mouse  1355 C---------------------------------------------------------------- 1355

  Fly  7664 NAQFTCTINGVPKPTISWYKGAREISNGARYHMYSEGDNHFLNINDVFGEDADEYVCRAVNKAGA 7728
               .||.|:|.|.|.|||.|..:.||...||||..:|....:.|:.|..||:..|.....||.|:
Mouse  1356 ---LTCVISGDPSPEISWLKNDQPISFFDRYHMEVKGTEVTVTIDKVTSEDSGRYGIFVKNKYGS 1417

  Fly  7729 KSTRATLAI 7737
            ::.:.|:::
Mouse  1418 ETGQVTISV 1426

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
btNP_001162825.1 I-set 9..101 CDD:254352
Ig 26..100 CDD:143165
I-set 119..210 CDD:254352
Ig 136..209 CDD:143165
I-set 228..320 CDD:254352
IGc2 242..312 CDD:197706
I-set 335..425 CDD:254352
Ig 350..423 CDD:143165
Ig 436..530 CDD:299845
I-set 438..532 CDD:254352
I-set 545..636 CDD:254352
Ig 560..633 CDD:143165
Ig 657..731 CDD:143165
I-set 746..835 CDD:254352
Ig 1496..1586 CDD:299845
IG_like 1503..1588 CDD:214653
I-set 1639..1724 CDD:254352
IG 1750..1821 CDD:214652
IGc2 1750..1806 CDD:197706
I-set 1826..1909 CDD:254352
Ig 1831..1897 CDD:299845
I-set 1914..1998 CDD:254352
Ig 2020..2095 CDD:299845
FN3 2100..2194 CDD:238020
FN3 2203..2292 CDD:238020
I-set 2311..2395 CDD:254352
Ig 2321..2395 CDD:299845
FN3 2399..2493 CDD:238020
FN3 2501..2590 CDD:238020
I-set 2602..2693 CDD:254352
Ig 2619..2693 CDD:299845
FN3 2697..2793 CDD:238020
FN3 2801..2893 CDD:238020
I-set 2902..2995 CDD:254352
Ig 2919..2993 CDD:299845
FN3 2999..3088 CDD:238020
FN3 3102..3191 CDD:238020
I-set 3208..3292 CDD:254352
Ig 3219..3292 CDD:299845
FN3 3296..3390 CDD:238020
FN3 3400..3489 CDD:238020
I-set 3494..3590 CDD:254352
Ig 3516..3590 CDD:299845
FN3 3594..3682 CDD:238020
FN3 3694..3781 CDD:238020
I-set 3795..3885 CDD:254352
Ig 3813..3885 CDD:299845
FN3 3889..3980 CDD:238020
FN3 3990..4082 CDD:238020
I-set 4090..4181 CDD:254352
Ig 4108..4181 CDD:299845
FN3 4185..4271 CDD:238020
FN3 4285..4383 CDD:238020
Ig 4404..4480 CDD:299845
FN3 4484..4571 CDD:238020
FN3 4584..4677 CDD:238020
I-set 4685..4775 CDD:254352
Ig 4703..4775 CDD:299845
FN3 4779..4863 CDD:238020
FN3 4879..4970 CDD:238020
IG 4989..5069 CDD:214652
Ig 4996..5069 CDD:299845
FN3 5073..5166 CDD:238020
FN3 5175..5265 CDD:238020
I-set 5276..5366 CDD:254352
Ig 5293..5366 CDD:299845
FN3 5370..5462 CDD:238020
FN3 5470..5561 CDD:238020
Ig 5559..5654 CDD:299845
I-set 5570..5660 CDD:254352
FN3 5664..5755 CDD:238020
FN3 5764..5853 CDD:238020
I-set 5865..5954 CDD:254352
Ig 5882..5954 CDD:299845
FN3 5958..6049 CDD:238020
FN3 6062..6153 CDD:238020 20/101 (20%)
I-set 6173..6255 CDD:254352 18/84 (21%)
Ig_Titin_like 6182..6255 CDD:143225 15/75 (20%)
FN3 6259..6350 CDD:238020 39/122 (32%)
FN3 6359..6451 CDD:238020 31/93 (33%)
FN3 6470..6552 CDD:238020 32/81 (40%)
I-set 6564..6650 CDD:254352 6/85 (7%)
Ig_Titin_like 6577..6650 CDD:143225 6/72 (8%)
FN3 6654..6745 CDD:238020 21/96 (22%)
FN3 6754..6840 CDD:238020 24/88 (27%)
I-set 6855..6946 CDD:254352 16/93 (17%)
Ig 6874..6946 CDD:299845 13/74 (18%)
FN3 6950..7042 CDD:238020 18/93 (19%)
FN3 7050..7139 CDD:238020 10/88 (11%)
FN3 7151..7237 CDD:238020 15/85 (18%)
I-set 7254..7334 CDD:254352 22/88 (25%)
Ig 7272..7339 CDD:143165 15/72 (21%)
IG_like 7354..7440 CDD:214653 22/88 (25%)
Ig 7366..7440 CDD:299845 18/73 (25%)
FN3 7444..7531 CDD:238020 8/86 (9%)
FN3 7545..7637 CDD:238020 5/91 (5%)
I-set 7648..7737 CDD:254352 26/88 (30%)
Ig 7665..7734 CDD:143165 25/68 (37%)
Ig 7760..7833 CDD:299845
FN3 7837..7927 CDD:238020
STKc_Twitchin_like 7986..8244 CDD:271016
S_TKc 7989..8244 CDD:214567
Ig 8311..8394 CDD:299845
I-set 8312..8401 CDD:254352
I-set 8437..8525 CDD:254352
Ig 8455..8519 CDD:143165
I-set 8632..8721 CDD:254352
IGc2 8646..8711 CDD:197706
I-set 8740..8831 CDD:254352
Ig 8757..8826 CDD:143165
I-set 8839..8922 CDD:254352
Ig 8845..>8909 CDD:299845
Myom3NP_001078978.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..57
I-set 154..247 CDD:254352 15/76 (20%)
Ig 171..244 CDD:143165 15/73 (21%)
I-set 272..363 CDD:254352 19/104 (18%)
Ig 289..360 CDD:143165 13/70 (19%)
FN3 374..467 CDD:238020 36/97 (37%)
FN3 502..592 CDD:238020 29/90 (32%)
FN3 604..691 CDD:238020 33/88 (38%)
FN3 702..792 CDD:238020 24/160 (15%)
FN3 804..893 CDD:238020 24/88 (27%)
IG_like 1137..1207 CDD:214653 23/94 (24%)
Ig 1138..1200 CDD:143165 20/86 (23%)
Ig 1336..1426 CDD:299845 33/209 (16%)
I-set 1343..1426 CDD:254352 31/185 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR13817
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.100

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