DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bt and Mybpc2

DIOPT Version :9

Sequence 1:	NP_001162825.1	Gene:	bt / 43814	FlyBaseID:	FBgn0005666	Length:	8933	Species:	Drosophila melanogaster
Sequence 2:	NP_666301.2	Gene:	Mybpc2 / 233199	MGIID:	1336170	Length:	1136	Species:	Mus musculus

Alignment Length:	1504	Identity:	342/1504 - (22%)
Similarity:	520/1504 - (34%)	Gaps:	515/1504 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  5551 PSDPS----DPSSTIICKPRFLAPFFDKSLLNDITVHAGKRL-------GWTLPIEASPRPLITW 5604
            |.|.|    :|:...:.||            :.::|..||..       |..||    .:|.|.|
Mouse    36 PEDQSPTAEEPTGIFLKKP------------DSVSVETGKDAVILAKVNGKELP----GKPTIKW 84

  Fly  5605 LYNGK--EIGSNSRGESGLFQ-------NELTFE--IVSSLRSDEGRYTLILKN----EHGSFDA 5654
             :.||  |:||.| |...:|:       |..|.|  |...:..|.|.|.|.:|.    :..||:.
Mouse    85 -FKGKWQELGSKS-GARFIFKESHDSTSNVYTVELHIGKVVLGDRGDYRLEIKAKDVCDSCSFNV 147

  Fly  5655 SAHATVLDRPSPPKGPLDITKITRDGCHLTWNVPDDDGG----SPIL--HYIIEKMDLSRSTWSD 5713
            ...|   .|.......|:..|.:.||       ..:|.|    |.:|  ..::|:....:....|
Mouse   148 DVEA---PRQDSSGQSLESFKRSGDG-------KSEDAGELDFSGLLKKREVVEEEKKKKKDDDD 202

  Fly  5714 AGMSTHI--------------------VHDVTRLVHR-KEYLFRVKAVNAIGES-DPLEAV---N 5753
            .|:...|                    :.|:..::.| |:....||...|..:. ||...|   |
Mouse   203 LGIPPEIWELLKGAKKSEYEKIAFQYGITDLRGMLKRLKKAKVEVKKSAAFTKKLDPAYQVDRGN 267

  Fly  5754 TIIAKNEFDEPDAPGKPIITDWDRDHIDLQWAVPKSDGGAPISEYIIQKKEKGSPYWTNVRHVPS 5818
            .|....|..:||.|.|     |.::..:::          |.|:|:.:...|
Mouse   268 KIKLVVEISDPDLPLK-----WFKNGQEIK----------PSSKYVFENVGK------------- 304

  Fly  5819 NKNTTTIPELTEGQEYEFRVIAVNQAGQSEPSEPSDMIMAKPRYLPPKIITPLNEVRIKCGLIFH 5883
             |...||.:.|...:..:.|     |.|.|... :::.:.:|   |..|:|||.:.::..|....
Mouse   305 -KRILTINKCTLADDAAYEV-----AVQDEKCF-TELFVKEP---PVLIVTPLEDQQVFVGDRVE 359

  Fly  5884 TDIHFIGEPAPEATWTLNSNPLLSNDRSTITSIGHHSVVHTVNCQRSDS----------GIYHLL 5938
            ..:. :.|...:..|..:.                      |...|.||          |..|:|
Mouse   360 MSVE-VSEEGAQVMWMKDG----------------------VEMTREDSYKARYRFKKDGKRHIL 401

  Fly  5939 LRNSSGIDEGSFELVVLDRPGPPEGPMEYEEITANSVTISWKPPKDNGGSEISSYVIEKRDLTHG 6003
            :.:....::|.                .|:.||             |||...:..::|::.|
Mouse   402 IYSDVAQEDGG----------------RYQVIT-------------NGGQCEAELIVEEKQL--- 434

  Fly  6004 GGWVPAVNYVSAKYNHAVVPRLLEGTMYELRVMAENLQGRSDPLTSDQPVVAKSQYTVPGAPGKP 6068
                                              |.||..:| ||    |.|..|     |..|.
Mouse   435 ----------------------------------EVLQDIAD-LT----VKAAEQ-----AVFKC 455

  Fly  6069 ELTDSDKNHITIKWKQPISNGGSPIIGYDIERRDVNTGRWIKINGQPVPTAEYQDDRVTSNHQYQ 6133
            |::|                             :..||:|.| ||..|..::    |:|.:|..:
Mouse   456 EVSD-----------------------------EKVTGKWYK-NGVEVRPSK----RITISHVGR 486

  Fly  6134 YR---ISAVNAAGNGK-TSEP-------SAIFNAR-------PLREKPRFYFDGLIGK----RIK 6176
            :.   |..|.....|. |..|       ||..|..       |.:|.|:.:.| ..||    .|.
Mouse   487 FHKLVIDDVRPEDEGDYTFVPDGYALSLSAKLNFLEIKVEYVPKQEPPKIHLD-CSGKTSDNSIV 550

  Fly  6177 VRAGEPVNLNIPISGAPTPTIEWKRGD--LKLEEGKRISYETNSERTLFRIDDSNRRDSGKYTVT 6239
            |.||..:.|::.|:|.|.||..|.|||  ....|| |...|...:.:.|.|:.:.|.|.|:||:.
Mouse   551 VVAGNKLRLDVAITGEPPPTATWLRGDEVFTATEG-RTHIEQRPDCSSFVIESAERSDEGRYTIK 614

  Fly  6240 AANEFGKDTADIEVIVVDKPSPPEGPLSYTETAPDHISLHWYSPKDDGGSDITGYIIEFTEFGVD 6304
            ..|..|:|.|.|.:.|||.|.|||.                               :..|..| :
Mouse   615 VTNPVGEDVASIFLRVVDVPDPPEA-------------------------------VRVTSVG-E 647

  Fly  6305 DWKPVPGTCPNTNFTVKNLVEGKKYVFRIRAENIYGASEALEGKPVLAKSPFDPPGAPSQPTISA 6369
            ||
Mouse   648 DW--------------------------------------------------------------- 649

  Fly  6370 YTPNSANLEWHPPDDCGGKPITGYIVERRERGGE-WIKCNNYPTPNTSYTVSNLRDGARYEFRVL 6433
                 |.|.|.||...||:|:|||::||:::|.: |:|.|.....:|:|..:.:.:|..||.||.
Mouse   650 -----AILVWEPPKYDGGQPVTGYLMERKKKGSQRWMKINFEVFTDTTYESTKMIEGVLYEMRVF 709

  Fly  6434 AVNEAGPGHPS---KPSDPMTAEHQRYRPDPPEPPK---PDRITRNGVTLSWRPPRTDGKSRIKG 6492
            |||..|...||   ||..|:.         |...|:   .:.:|....||.||||...|...|.|
Mouse   710 AVNAIGVSQPSMNTKPFMPIA---------PTSAPQHLTVEDVTDTTTTLKWRPPDRIGAGGIDG 765

  Fly  6493 YYVEMRPKNGKDWKTVNDIPINSTVYTVPSLKEGEEYSFRVVAENEVGRSDPSKPSQPITIEEQP 6557
            |.||...:..::|...|..|:....:||..|..|....||||..|..|||:|:...||:||.|..
Mouse   766 YLVEYCLEGSEEWVPANKEPVERCGFTVKDLPTGARILFRVVGVNIAGRSEPATLLQPVTIREIV 830

  Fly  6558 NKPCMELGK-VRDIVCR-AGDDFSIHVPYLAFPKPNAFWYSNDNMLDDNNRVHKHLTDDAASVVV 6620
            .:|.:.|.: :|....| .|:..::.:|:...|:|...|......| |.:||:...:|......|
Mouse   831 EQPKIRLPRHLRQTYIRKVGEALNLVIPFQGKPRPQVVWTKGGAPL-DTSRVNVRTSDFDTVFFV 894

  Fly  6621 KNSKRADSGQYRLQLKNTSGFDTATINVRVLDRPSPPTRLRADEFSGDSLTLYWNPPNDDGGSAI 6685
            :.:.|:|||:|.|.::..:..|||||.:||:::..|...:...|..|.:..:.|.||.|||.|.|
Mouse   895 RQAARSDSGEYELSVQIENMKDTATIRIRVVEKAGPAENVMVKEVWGTNALVEWQPPKDDGNSEI 959

  Fly  6686 QNYIIEKKEARSSTWSKV-----SSFCTVPFVRIRNLVLNKEYDFRVIAENKYGQSDPANTSEPI 6745
            ..|.::|.:.::..|..|     .:.|||     .:|::..||.||:.:||..|.||....|:
Mouse   960 TGYFVQKADKKTMEWFNVYEHNRHTSCTV-----SDLIVGNEYYFRIFSENICGLSDSPGVSK-- 1017

  Fly  6746 LARHPFDIPNTPGIPHGIDSTEDSITIAWTKPKHDGGSPITGYIIEKRLLSDDKWTKAVHALCPD 6810
                     ||..|      .:..||:   ||
Mouse  1018 ---------NTARI------LKTGITL---KP--------------------------------- 1031

  Fly  6811 LSCKIPNLIENAEYEFRVAAVNAAGQSAYSGSSDLIFCRRPPHAPKITSDLSIRDMTVIAGDEFR 6875
                    :|..|::||.                         |||..:.|  .|..|:||....
Mouse  1032 --------LEYKEHDFRT-------------------------APKFLTPL--MDRVVVAGYTAA 1061

  Fly  6876 ITVPYHASPRPTASWSLNGLEVIPGERIKFDSNDYASMYYNKSAKRD---ETGSYTITLTNNKGS 6937
            :.......|:|...|..|.:|:  .|..||...:|..: ...:.:|.   :.|:|:....|..|.
Mouse  1062 LNCAVRGHPKPKVVWMKNKMEI--HEDPKFLITNYQGI-LTLNIRRPSPFDAGTYSCRAFNELGE 1123

  Fly  6938 DTASCHVTV 6946
            ..|.|.:.|
Mouse  1124 ALAECKLDV 1132

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bt	NP_001162825.1	I-set	9..101	CDD:254352
		Ig	26..100	CDD:143165
		I-set	119..210	CDD:254352
		Ig	136..209	CDD:143165
		I-set	228..320	CDD:254352
		IGc2	242..312	CDD:197706
		I-set	335..425	CDD:254352
		Ig	350..423	CDD:143165
		Ig	436..530	CDD:299845
		I-set	438..532	CDD:254352
		I-set	545..636	CDD:254352
		Ig	560..633	CDD:143165
		Ig	657..731	CDD:143165
		I-set	746..835	CDD:254352
		Ig	1496..1586	CDD:299845
		IG_like	1503..1588	CDD:214653
		I-set	1639..1724	CDD:254352
		IG	1750..1821	CDD:214652
		IGc2	1750..1806	CDD:197706
		I-set	1826..1909	CDD:254352
		Ig	1831..1897	CDD:299845
		I-set	1914..1998	CDD:254352
		Ig	2020..2095	CDD:299845
		FN3	2100..2194	CDD:238020
		FN3	2203..2292	CDD:238020
		I-set	2311..2395	CDD:254352
		Ig	2321..2395	CDD:299845
		FN3	2399..2493	CDD:238020
		FN3	2501..2590	CDD:238020
		I-set	2602..2693	CDD:254352
		Ig	2619..2693	CDD:299845
		FN3	2697..2793	CDD:238020
		FN3	2801..2893	CDD:238020
		I-set	2902..2995	CDD:254352
		Ig	2919..2993	CDD:299845
		FN3	2999..3088	CDD:238020
		FN3	3102..3191	CDD:238020
		I-set	3208..3292	CDD:254352
		Ig	3219..3292	CDD:299845
		FN3	3296..3390	CDD:238020
		FN3	3400..3489	CDD:238020
		I-set	3494..3590	CDD:254352
		Ig	3516..3590	CDD:299845
		FN3	3594..3682	CDD:238020
		FN3	3694..3781	CDD:238020
		I-set	3795..3885	CDD:254352
		Ig	3813..3885	CDD:299845
		FN3	3889..3980	CDD:238020
		FN3	3990..4082	CDD:238020
		I-set	4090..4181	CDD:254352
		Ig	4108..4181	CDD:299845
		FN3	4185..4271	CDD:238020
		FN3	4285..4383	CDD:238020
		Ig	4404..4480	CDD:299845
		FN3	4484..4571	CDD:238020
		FN3	4584..4677	CDD:238020
		I-set	4685..4775	CDD:254352
		Ig	4703..4775	CDD:299845
		FN3	4779..4863	CDD:238020
		FN3	4879..4970	CDD:238020
		IG	4989..5069	CDD:214652
		Ig	4996..5069	CDD:299845
		FN3	5073..5166	CDD:238020
		FN3	5175..5265	CDD:238020
I-set	5276..5366	CDD:254352
Ig	5293..5366	CDD:299845
FN3	5370..5462	CDD:238020
FN3	5470..5561	CDD:238020	4/13 (31%)
Ig	5559..5654	CDD:299845	30/116 (26%)
I-set	5570..5660	CDD:254352	29/111 (26%)
FN3	5664..5755	CDD:238020	22/121 (18%)
FN3	5764..5853	CDD:238020	17/88 (19%)
I-set	5865..5954	CDD:254352	15/98 (15%)
Ig	5882..5954	CDD:299845	10/81 (12%)
FN3	5958..6049	CDD:238020	13/90 (14%)
FN3	6062..6153	CDD:238020	20/101 (20%)
I-set	6173..6255	CDD:254352	31/87 (36%)
Ig_Titin_like	6182..6255	CDD:143225	26/74 (35%)
FN3	6259..6350	CDD:238020	8/90 (9%)
FN3	6359..6451	CDD:238020	33/95 (35%)
FN3	6470..6552	CDD:238020	31/81 (38%)
I-set	6564..6650	CDD:254352	25/87 (29%)
Ig_Titin_like	6577..6650	CDD:143225	21/72 (29%)
FN3	6654..6745	CDD:238020	29/95 (31%)
FN3	6754..6840	CDD:238020	11/85 (13%)
I-set	6855..6946	CDD:254352	23/93 (25%)
Ig	6874..6946	CDD:299845	16/74 (22%)
FN3	6950..7042	CDD:238020
FN3	7050..7139	CDD:238020
FN3	7151..7237	CDD:238020
I-set	7254..7334	CDD:254352
Ig	7272..7339	CDD:143165
IG_like	7354..7440	CDD:214653
Ig	7366..7440	CDD:299845
FN3	7444..7531	CDD:238020
FN3	7545..7637	CDD:238020
I-set	7648..7737	CDD:254352
Ig	7665..7734	CDD:143165
Ig	7760..7833	CDD:299845
FN3	7837..7927	CDD:238020
STKc_Twitchin_like	7986..8244	CDD:271016
S_TKc	7989..8244	CDD:214567
Ig	8311..8394	CDD:299845
I-set	8312..8401	CDD:254352
I-set	8437..8525	CDD:254352
Ig	8455..8519	CDD:143165
I-set	8632..8721	CDD:254352
IGc2	8646..8711	CDD:197706
I-set	8740..8831	CDD:254352
Ig	8757..8826	CDD:143165
I-set	8839..8922	CDD:254352
Ig	8845..>8909	CDD:299845
Mybpc2	NP_666301.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55		6/30 (20%)
		IG_like	54..149	CDD:214653	29/112 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..177		7/35 (20%)
		I-set	253..337	CDD:254352	23/118 (19%)
		Ig	278..325	CDD:299845	14/80 (18%)
		I-set	343..429	CDD:254352	21/137 (15%)
		Ig	358..436	CDD:143165	18/166 (11%)
		Ig	451..>504	CDD:143165	17/86 (20%)
		Ig_C5_MyBP-C	545..630	CDD:143302	30/85 (35%)
		IG_like	548..630	CDD:214653	30/82 (37%)
		FN3	634..720	CDD:238020	36/185 (19%)
		FN3	733..825	CDD:238020	32/91 (35%)
		IG_like	843..924	CDD:214653	23/81 (28%)
		Ig_Titin_like	853..924	CDD:143225	21/71 (30%)
		FN3	929..1011	CDD:238020	26/86 (30%)
		I-set	1043..1132	CDD:254352	23/93 (25%)
		Ig	1062..1127	CDD:143165	14/67 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	57	1.000	Domainoid score	I10802
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13817
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.100