DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment bt and PALLD

DIOPT Version :9

Sequence 1:NP_001162825.1 Gene:bt / 43814 FlyBaseID:FBgn0005666 Length:8933 Species:Drosophila melanogaster
Sequence 2:XP_011530070.1 Gene:PALLD / 23022 HGNCID:17068 Length:1468 Species:Homo sapiens


Alignment Length:1847 Identity:340/1847 - (18%)
Similarity:550/1847 - (29%) Gaps:650/1847 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly  7257 ITRLQ------DKVAPFGKDYTLQCAASGKPSPTARWLRNGKEIQMNGGRMTCDSKDGVFRLHIS 7315
            ::|:|      .|:..|.|..:   :|||.|:.:..      .:..:...|:..|....|...:|
Human    28 LSRIQTAISYLSKITQFQKTVS---SASGLPTESRH------RVHEDRSNMSGTSSHESFYDSLS 83

  Fly  7316 NVQTGDDGDYTCEAMNSLGFVNTSGYLKIGSPPIINRCPSELKLPEGDNSKIKIFYSGDQPLTVI 7380
            ::|.        |:.|:..|...|.:|   |...||:.....:....| |:.:.|.| ::.::.|
Human    84 DMQE--------ESKNTDFFPGLSAFL---SQEEINKSLDLARRAIAD-SETEDFDS-EKEISQI 135

  Fly  7381 LKKNNEVICDSNDDTHVKVNIFDDYVAIYIRNIVKSDGGPYQIEFTNESGSATGEFYVHITGMP- 7444
            ...:...:|:.......|:                                  ||   |.:..| 
Human   136 FSTSPASLCEHPSHKETKL----------------------------------GE---HASRRPQ 163

  Fly  7445 ---SAPTGPMGISYINKNSCMLNWRPPSYDGGLKVSHYV-----IERKDVSSPHWITVSST---- 7497
               |.|..|:........|..::.|.|:....|....|:     .|::...:|.......|    
Human   164 DNRSTPVQPLAEKQTKSISSPVSKRKPAMSPLLTRPSYIRSLRKAEKRGAKTPSTNVKPKTPHQR 228

  Fly  7498 --------CKDTAFNVQGLIENQEYIFRVMAVNENGMGPPLEGLNPIRA-KDPIDPPSPPGSPQI 7553
                    | |.|.|   |||....||:  |.......|..|..:|... ..|.:.||...|...
Human   229 KGGPQSQLC-DKAAN---LIEELTSIFK--AAKPRNRSPNGESSSPDSGYLSPKNQPSALLSASA 287

  Fly  7554 TEIGGDFVHLEWEKPESDGGAHIQGYWIDKREVGSNTWQRVNATICAANQINCINLIEGRQYEFR 7618
            :           :.|..|.|..       :|||.|     ..|..|..:.               
Human   288 S-----------QSPMEDQGEM-------EREVKS-----PGARHCYQDN--------------- 314

  Fly  7619 IFAQNVAGLSTESSASQAVKIIDPQAASPPLIVKPLRDANCIQNHNAQFTCTINGVPKPTISWYK 7683
               |::|......|..|....:...||  |..::.||.....:.......|.:.|.|.|.:.|:.
Human   315 ---QDLAVPHNRKSHPQPHSALHFPAA--PRFIQKLRSQEVAEGSRVYLECRVTGNPTPRVRWFC 374

  Fly  7684 GAREISNGARYHMYSE-GDNHFLNINDVFGEDADEYVCRAVNKAGAKSTRATLAI---------- 7737
            ..:|:.|.....::.| ||.|.|.|.:.|.:|...|.|.|.|.:|:.:|.|.:.|          
Human   375 EGKELHNTPDIQIHCEGGDLHTLIIAEAFEDDTGRYTCLATNPSGSDTTSAEVFIEGASSTDSDS 439

  Fly  7738 ---------------------------MTAPK----------LNVP-------------PRFRDT 7752
                                       .::||          |:||             |....|
Human   440 ESLAFKSRAGAMPQAQKKTTSVSLTIGSSSPKTGVTTAVIQPLSVPVQQVHSPTSYLCRPDGTTT 504

  Fly  7753 AYFD-------------KGENVVIKIPFTGFPKPRIHWVRDGENIESGGHYTVEVK--------E 7796
            |||.             :|:.||::....|.|..::.|.|.|..|:....:.:..|        |
Human   505 AYFPPVFTKELQNTAVAEGQVVVLECRVRGAPPLQVQWFRQGSEIQDSPDFRILQKKPRSTAEPE 569

  Fly  7797 RHAVLIIRDGSHLDSGPYRITAENELGSDTAIIQVQISDR---------------------PDPP 7840
            ....|:|.:....|:|.:..:|.|:.||.|:..|:.::..                     |.||
Human   570 EICTLVIAETFPEDAGIFTCSARNDYGSATSTAQLVVTSANTENCSYESMGESNNDHFQHFPPPP 634

  Fly  7841 RFPLIESIGTESLSLSWKAPVWDGCSDITNYYVERREHPLS---------SWIRVGNTRFTSMAV 7896
              |::|   |.||.|:.|.|     |:|..  |...|..||         :..|..|....|..|
Human   635 --PILE---TSSLELASKKP-----SEIQQ--VNNPELGLSRAALQMQFNAAERETNGVHPSRGV 687

  Fly  7897 SGLTPGKEYDFRIFADNVYGRSDASDTSTLIKTKESVKKKPIERKWEIDANGRKLRGKADGPVKD 7961
            :||..||...         .:|..:....|..|||   ..|:..|.::|            |:| 
Human   688 NGLINGKANS---------NKSLPTPAVLLSPTKE---PPPLLAKPKLD------------PLK- 727

  Fly  7962 YDSYVFDIYSKFVPQPVEISQQSVYDRYDILEEIGT-------------------GAFGVVHRCR 8007
                                .|.:.::..:.:|.|.                   .||..:..|.
Human   728 --------------------LQQLQNQIRLEQEAGARQPPPAPRSAPPSPPFPPPPAFPELAACT 772

  Fly  8008 ERSTGNIFAAKFIPVSHSVEKDLIRREIDIMNQLHHQKLINLHDAFEDDDEMILILEFLSGGELF 8072
            .            |.|......|..|....|.                           |.|.  
Human   773 P------------PASPEPMSALASRSAPAMQ---------------------------SSGS-- 796

  Fly  8073 ERITAEGYVMTEAEVINYMRQICEGIRHMHEQNIIHLDIKPENIMCQTRSSTNVKLI-------- 8129
                           .||.|.         :|.|...::.|.:......||.:...:        
Human   797 ---------------FNYARP---------KQFIAAQNLGPASGHGTPASSPSSSSLPSPMSPTP 837

  Fly  8130 ---------------------DFGLATRLDPNEVVKITTGTAEFAAPEIVNREP----------- 8162
                                 .:|.::...|.....:.:.||.|..|::....|           
Human   838 RQFGRAPVPPFAQPFGAEPEAPWGSSSPSPPPPPPPVFSPTAAFPVPDVFPLPPPPPPLPSPGQA 902

  Fly  8163 -------VGFYTDMWATGVLSYVLLSGLSPFAGDNDVQTLKNVKACDWDFDV-ESFKYISEEAKD 8219
                   ..|.........|| .||....|.|..|.:...|.|....:.... .:.:..|:|...
Human   903 SHCSSPATRFGHSQTPAAFLS-ALLPSQPPPAAVNALGLPKGVTPAGFPKKASRTARIASDEEIQ 966

  Fly  8220 FIRKLLVRNKEKRMTAHECLLHPWLTGDHSAMKQEINRDRYLAYREKLRRKYEDFERFLLPIGRL 8284
            ..:..::::.|:::...|.||:              |....|.|.|::.|               
Human   967 GTKDAVIQDLERKLRFKEDLLN--------------NGQPRLTYEERMAR--------------- 1002

  Fly  8285 SEYSSLRKLLMEKYKIHDAVFDRRQAAPRFVIRPSSQFCYEGQSVKFYCRCIAIATPTLTWSHNN 8349
                  |.|..:...:.:......:.|.:.:..|.:                ::.:|        
Human  1003 ------RLLGADSATVFNIQEPEEETANQDIGSPHA----------------SVGSP-------- 1037

  Fly  8350 IELRQSVKFMKRYVGDDYYFIINRVKLDDRGEYIIRAENHYGSREEVVFLNVQPLPKEQPRYRTE 8414
                                      ||.:.||.:      .|.|:.:...::        ||.|
Human  1038 --------------------------LDGQKEYKV------SSCEQRLISEIE--------YRLE 1062

  Fly  8415 STPV-RRREPLPYTFWQEESETAPSFTFLLRPRVMQARDTCKLLCCLSGKPVPNVRWYKDGRELS 8478
            .:|| ...:.:.|.....|:..||.|...|:...:.........|.::|.|.|.:.|:|||:::|
Human  1063 RSPVDESGDEVQYGDVPVENGMAPFFEMKLKHYKIFEGMPVTFTCRVAGNPKPKIYWFKDGKQIS 1127

  Fly  8479 --KYEYAMTHS-DGVVTMEIIDCKPSDSGKYSCKATNCHGTDETDCVVIVEGEWVTPEQAQLAHN 8540
              ...|.:... ||..::........|.|.|:..|.|                            
Human  1128 PKSDHYTIQRDLDGTCSLHTTASTLDDDGNYTIMAAN---------------------------- 1164

  Fly  8541 FLYSGDRKYIEQPIKPAPLPIVTSRQYTSSSVQNTSEPQG-----DKVNVSNSNSSGISNKKKYA 8600
                                                 |||     .::.|...|..|.|.:....
Human  1165 -------------------------------------PQGRISCTGRLMVQAVNQRGRSPRSPSG 1192

  Fly  8601 SNSLQAPGSPSRSRSATKELILPPDDSLMCKPEFTKPLHDLTIHDGEQLILTCYVKGDPEPQISW 8665
            ...::.|.|.||......|    |......:|.|.:...|||:.:|:...:.|.|.|.|.|.:||
Human  1193 HPHVRRPRSRSRDSGDENE----PIQERFFRPHFLQAPGDLTVQEGKLCRMDCKVSGLPTPDLSW 1253

  Fly  8666 SKNGKSL--SSSDILDLRYKNGIATLTINEVFPEDEGVITCTATNSVGAVETKCKLTIQPLDKNI 8728
            ..:||.:  .|:..:.:| :||:.:|.|..|...|.|:.||.|||..|......:|.:..  |..
Human  1254 QLDGKPVRPDSAHKMLVR-ENGVHSLIIEPVTSRDAGIYTCIATNRAGQNSFSLELVVAA--KEA 1315

  Fly  8729 NKRKVNAGDNAPKIVSHLESRFVRDGDAVNLACRIIGAQHFDVVWLHNNKEIKPSKDFQYTNEAN 8793
            :|        .|..:..|::..|.||..|.|.||::|.....:.|...|:.:..|.|....::.|
Human  1316 HK--------PPVFIEKLQNTGVADGYPVRLECRVLGVPPPQIFWKKENESLTHSTDRVSMHQDN 1372

  Fly  8794 --IYRLQIAEIFPEDGGTYTCEAFNDIGESFSTCTINVTV------PGDETK----QPSFVKFPT 8846
              ...|.|.....||.|.||..|.|:.|  ..:||..:.|      ....||    :||..::  
Human  1373 HGYICLLIQGATKEDAGWYTVSAKNEAG--IVSCTARLDVYTQWHQQSQSTKPKKVRPSASRY-- 1433

  Fly  8847 SVSVLEGEG----TTFECEIDSELLNL 8869
              :.|..:|    ..|:.|.:...|.|
Human  1434 --AALSDQGLDIKAAFQPEANPSHLTL 1458

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
btNP_001162825.1 I-set 9..101 CDD:254352
Ig 26..100 CDD:143165
I-set 119..210 CDD:254352
Ig 136..209 CDD:143165
I-set 228..320 CDD:254352
IGc2 242..312 CDD:197706
I-set 335..425 CDD:254352
Ig 350..423 CDD:143165
Ig 436..530 CDD:299845
I-set 438..532 CDD:254352
I-set 545..636 CDD:254352
Ig 560..633 CDD:143165
Ig 657..731 CDD:143165
I-set 746..835 CDD:254352
Ig 1496..1586 CDD:299845
IG_like 1503..1588 CDD:214653
I-set 1639..1724 CDD:254352
IG 1750..1821 CDD:214652
IGc2 1750..1806 CDD:197706
I-set 1826..1909 CDD:254352
Ig 1831..1897 CDD:299845
I-set 1914..1998 CDD:254352
Ig 2020..2095 CDD:299845
FN3 2100..2194 CDD:238020
FN3 2203..2292 CDD:238020
I-set 2311..2395 CDD:254352
Ig 2321..2395 CDD:299845
FN3 2399..2493 CDD:238020
FN3 2501..2590 CDD:238020
I-set 2602..2693 CDD:254352
Ig 2619..2693 CDD:299845
FN3 2697..2793 CDD:238020
FN3 2801..2893 CDD:238020
I-set 2902..2995 CDD:254352
Ig 2919..2993 CDD:299845
FN3 2999..3088 CDD:238020
FN3 3102..3191 CDD:238020
I-set 3208..3292 CDD:254352
Ig 3219..3292 CDD:299845
FN3 3296..3390 CDD:238020
FN3 3400..3489 CDD:238020
I-set 3494..3590 CDD:254352
Ig 3516..3590 CDD:299845
FN3 3594..3682 CDD:238020
FN3 3694..3781 CDD:238020
I-set 3795..3885 CDD:254352
Ig 3813..3885 CDD:299845
FN3 3889..3980 CDD:238020
FN3 3990..4082 CDD:238020
I-set 4090..4181 CDD:254352
Ig 4108..4181 CDD:299845
FN3 4185..4271 CDD:238020
FN3 4285..4383 CDD:238020
Ig 4404..4480 CDD:299845
FN3 4484..4571 CDD:238020
FN3 4584..4677 CDD:238020
I-set 4685..4775 CDD:254352
Ig 4703..4775 CDD:299845
FN3 4779..4863 CDD:238020
FN3 4879..4970 CDD:238020
IG 4989..5069 CDD:214652
Ig 4996..5069 CDD:299845
FN3 5073..5166 CDD:238020
FN3 5175..5265 CDD:238020
I-set 5276..5366 CDD:254352
Ig 5293..5366 CDD:299845
FN3 5370..5462 CDD:238020
FN3 5470..5561 CDD:238020
Ig 5559..5654 CDD:299845
I-set 5570..5660 CDD:254352
FN3 5664..5755 CDD:238020
FN3 5764..5853 CDD:238020
I-set 5865..5954 CDD:254352
Ig 5882..5954 CDD:299845
FN3 5958..6049 CDD:238020
FN3 6062..6153 CDD:238020
I-set 6173..6255 CDD:254352
Ig_Titin_like 6182..6255 CDD:143225
FN3 6259..6350 CDD:238020
FN3 6359..6451 CDD:238020
FN3 6470..6552 CDD:238020
I-set 6564..6650 CDD:254352
Ig_Titin_like 6577..6650 CDD:143225
FN3 6654..6745 CDD:238020
FN3 6754..6840 CDD:238020
I-set 6855..6946 CDD:254352
Ig 6874..6946 CDD:299845
FN3 6950..7042 CDD:238020
FN3 7050..7139 CDD:238020
FN3 7151..7237 CDD:238020
I-set 7254..7334 CDD:254352 16/82 (20%)
Ig 7272..7339 CDD:143165 12/66 (18%)
IG_like 7354..7440 CDD:214653 9/85 (11%)
Ig 7366..7440 CDD:299845 7/73 (10%)
FN3 7444..7531 CDD:238020 23/107 (21%)
FN3 7545..7637 CDD:238020 16/91 (18%)
I-set 7648..7737 CDD:254352 25/89 (28%)
Ig 7665..7734 CDD:143165 21/69 (30%)
Ig 7760..7833 CDD:299845 20/80 (25%)
FN3 7837..7927 CDD:238020 26/98 (27%)
STKc_Twitchin_like 7986..8244 CDD:271016 43/324 (13%)
S_TKc 7989..8244 CDD:214567 43/321 (13%)
Ig 8311..8394 CDD:299845 8/82 (10%)
I-set 8312..8401 CDD:254352 8/88 (9%)
I-set 8437..8525 CDD:254352 20/90 (22%)
Ig 8455..8519 CDD:143165 17/66 (26%)
I-set 8632..8721 CDD:254352 31/90 (34%)
IGc2 8646..8711 CDD:197706 24/66 (36%)
I-set 8740..8831 CDD:254352 27/92 (29%)
Ig 8757..8826 CDD:143165 20/70 (29%)
I-set 8839..8922 CDD:254352 8/35 (23%)
Ig 8845..>8909 CDD:299845 6/29 (21%)
PALLDXP_011530070.1 I-set 339..429 CDD:254352 25/89 (28%)
Ig 356..426 CDD:143165 21/69 (30%)
I-set 509..606 CDD:254352 21/96 (22%)
Ig 526..603 CDD:143165 19/76 (25%)
I-set 1086..1177 CDD:254352 23/155 (15%)
Ig 1103..1172 CDD:143165 20/133 (15%)
I-set 1220..1310 CDD:254352 31/90 (34%)
Ig 1238..1307 CDD:143165 24/69 (35%)
I-set 1319..1410 CDD:254352 27/92 (29%)
Ig_Palladin_C 1336..1410 CDD:143301 22/75 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165157003
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

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