DRSC/TRiP Functional Genomics Resources

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Protein Alignment bt and AKT2

DIOPT Version :9

Sequence 1:	NP_001162825.1	Gene:	bt / 43814	FlyBaseID:	FBgn0005666	Length:	8933	Species:	Drosophila melanogaster
Sequence 2:	NP_001617.1	Gene:	AKT2 / 208	HGNCID:	392	Length:	481	Species:	Homo sapiens

Alignment Length:	422	Identity:	102/422 - (24%)
Similarity:	173/422 - (40%)	Gaps:	86/422 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  7938 IERKWEID---------------ANGRKLRGKADGPVKDY------DSYVFDIYSKFVPQPVEIS 7981
            |||.:.:|               ||..|.|...:.|: ||      ||      |......|.:|
Human    84 IERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPM-DYKCGSPSDS------STTEEMEVAVS 141

  Fly  7982 Q---QSVYDRYDILEEIGTGAFGVVHRCRERSTGNIFAAKFIPVSHSVEKDLIRR---EIDIMNQ 8040
            :   :...:.:|.|:.:|.|.||.|...||::||..:|.|.:.....:.||.:..   |..::..
Human   142 KARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQN 206

  Fly  8041 LHHQKLINLHDAFEDDDEMILILEFLSGGELFERITAEGYVMTEAEVINYMRQICEGIRHMHEQN 8105
            ..|..|..|..||:..|.:..::|:.:|||||..::.| .|.||.....|..:|...:.::|.::
Human   207 TRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRE-RVFTEERARFYGAEIVSALEYLHSRD 270

  Fly  8106 IIHLDIKPENIMCQTRSSTNVKLIDFGLATR-LDPNEVVKITTGTAEFAAPEIVNREPVGFYTDM 8169
            :::.|||.||:|..  ...::|:.||||... :.....:|...||.|:.|||::.....|...|.
Human   271 VVYRDIKLENLMLD--KDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDW 333

  Fly  8170 WATGVLSYVLLSGLSPFAGDNDVQTLKNVKACDWDFDVESFKY---ISEEAKDFIRKLLVRNKEK 8231
            |..||:.|.::.|..||...:..:..:.:.       :|..::   :|.|||..:..||.::.::
Human   334 WGLGVVMYEMMCGRLPFYNQDHERLFELIL-------MEEIRFPRTLSPEAKSLLAGLLKKDPKQ 391

  Fly  8232 RMTAHECLLHPWLTGDHSAMKQEINRDRYLAYREKLRRKYEDFERFLLPIGRLSEYSSLRKLLME 8296
            |           |.|..|..|:.:.                  .||.|.|   :....::|.|:.
Human   392 R-----------LGGGPSDAKEVME------------------HRFFLSI---NWQDVVQKKLLP 424

  Fly  8297 KYK------IHDAVFDRRQAAPRFVIRPSSQF 8322
            .:|      :....||....|....|.|..::
Human   425 PFKPQVTSEVDTRYFDDEFTAQSITITPPDRY 456

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

Gene	Sequence	Domain	Region	External ID	Identity
bt	NP_001162825.1	I-set	9..101	CDD:254352
		Ig	26..100	CDD:143165
		I-set	119..210	CDD:254352
		Ig	136..209	CDD:143165
		I-set	228..320	CDD:254352
		IGc2	242..312	CDD:197706
		I-set	335..425	CDD:254352
		Ig	350..423	CDD:143165
		Ig	436..530	CDD:299845
		I-set	438..532	CDD:254352
		I-set	545..636	CDD:254352
		Ig	560..633	CDD:143165
		Ig	657..731	CDD:143165
		I-set	746..835	CDD:254352
		Ig	1496..1586	CDD:299845
		IG_like	1503..1588	CDD:214653
		I-set	1639..1724	CDD:254352
		IG	1750..1821	CDD:214652
		IGc2	1750..1806	CDD:197706
		I-set	1826..1909	CDD:254352
		Ig	1831..1897	CDD:299845
		I-set	1914..1998	CDD:254352
		Ig	2020..2095	CDD:299845
		FN3	2100..2194	CDD:238020
		FN3	2203..2292	CDD:238020
		I-set	2311..2395	CDD:254352
		Ig	2321..2395	CDD:299845
		FN3	2399..2493	CDD:238020
		FN3	2501..2590	CDD:238020
		I-set	2602..2693	CDD:254352
		Ig	2619..2693	CDD:299845
		FN3	2697..2793	CDD:238020
		FN3	2801..2893	CDD:238020
		I-set	2902..2995	CDD:254352
		Ig	2919..2993	CDD:299845
		FN3	2999..3088	CDD:238020
		FN3	3102..3191	CDD:238020
		I-set	3208..3292	CDD:254352
		Ig	3219..3292	CDD:299845
		FN3	3296..3390	CDD:238020
		FN3	3400..3489	CDD:238020
		I-set	3494..3590	CDD:254352
		Ig	3516..3590	CDD:299845
		FN3	3594..3682	CDD:238020
		FN3	3694..3781	CDD:238020
		I-set	3795..3885	CDD:254352
		Ig	3813..3885	CDD:299845
		FN3	3889..3980	CDD:238020
		FN3	3990..4082	CDD:238020
		I-set	4090..4181	CDD:254352
		Ig	4108..4181	CDD:299845
		FN3	4185..4271	CDD:238020
		FN3	4285..4383	CDD:238020
		Ig	4404..4480	CDD:299845
		FN3	4484..4571	CDD:238020
		FN3	4584..4677	CDD:238020
		I-set	4685..4775	CDD:254352
		Ig	4703..4775	CDD:299845
		FN3	4779..4863	CDD:238020
		FN3	4879..4970	CDD:238020
		IG	4989..5069	CDD:214652
		Ig	4996..5069	CDD:299845
		FN3	5073..5166	CDD:238020
		FN3	5175..5265	CDD:238020
I-set	5276..5366	CDD:254352
Ig	5293..5366	CDD:299845
FN3	5370..5462	CDD:238020
FN3	5470..5561	CDD:238020
Ig	5559..5654	CDD:299845
I-set	5570..5660	CDD:254352
FN3	5664..5755	CDD:238020
FN3	5764..5853	CDD:238020
I-set	5865..5954	CDD:254352
Ig	5882..5954	CDD:299845
FN3	5958..6049	CDD:238020
FN3	6062..6153	CDD:238020
I-set	6173..6255	CDD:254352
Ig_Titin_like	6182..6255	CDD:143225
FN3	6259..6350	CDD:238020
FN3	6359..6451	CDD:238020
FN3	6470..6552	CDD:238020
I-set	6564..6650	CDD:254352
Ig_Titin_like	6577..6650	CDD:143225
FN3	6654..6745	CDD:238020
FN3	6754..6840	CDD:238020
I-set	6855..6946	CDD:254352
Ig	6874..6946	CDD:299845
FN3	6950..7042	CDD:238020
FN3	7050..7139	CDD:238020
FN3	7151..7237	CDD:238020
I-set	7254..7334	CDD:254352
Ig	7272..7339	CDD:143165
IG_like	7354..7440	CDD:214653
Ig	7366..7440	CDD:299845
FN3	7444..7531	CDD:238020
FN3	7545..7637	CDD:238020
I-set	7648..7737	CDD:254352
Ig	7665..7734	CDD:143165
Ig	7760..7833	CDD:299845
FN3	7837..7927	CDD:238020
STKc_Twitchin_like	7986..8244	CDD:271016	70/264 (27%)
S_TKc	7989..8244	CDD:214567	70/261 (27%)
Ig	8311..8394	CDD:299845	3/12 (25%)
I-set	8312..8401	CDD:254352	2/11 (18%)
I-set	8437..8525	CDD:254352
Ig	8455..8519	CDD:143165
I-set	8632..8721	CDD:254352
IGc2	8646..8711	CDD:197706
I-set	8740..8831	CDD:254352
Ig	8757..8826	CDD:143165
I-set	8839..8922	CDD:254352
Ig	8845..>8909	CDD:299845
AKT2	NP_001617.1	PH_PKB	4..111	CDD:269947	6/26 (23%)
		STKc_PKB_beta	156..478	CDD:173686	84/343 (24%)
		Inhibitor binding	230..232		1/1 (100%)
		Inhibitor binding	277..279		1/1 (100%)