DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment bt and DSCAM

DIOPT Version :9

Sequence 1:NP_001162825.1 Gene:bt / 43814 FlyBaseID:FBgn0005666 Length:8933 Species:Drosophila melanogaster
Sequence 2:NP_001380.2 Gene:DSCAM / 1826 HGNCID:3039 Length:2012 Species:Homo sapiens


Alignment Length:1893 Identity:418/1893 - (22%)
Similarity:654/1893 - (34%) Gaps:547/1893 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly  5437 HDYSFRVRAVNKQGQSQPLTTSQPITAKDPYSHPDKPGQPQATDWGKHFVDLEWSTPKRDGGAPI 5501
            ||.::...|.|..|:.:..........::||:                 |.:|.....|...|..
Human    96 HDNTYYCTAENPSGKIRSQDVHIKAVLREPYT-----------------VRVEDQKTMRGNVAVF 143

  Fly  5502 SSYI---IEKRPKFGQWERAAVVLGDNCK--------AHVPELTN-GGEYEFRVIAVNR-GGPSD 5553
            ...|   :|.......||:..|.|....:        .::.::.| .|.|.:|.|..:| .|.:.
Human   144 KCIIPSSVEAYITVVSWEKDTVSLVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETR 208

  Fly  5554 PSDPSSTIICKPRFLAPFFDKSLLNDI---TVHAGKRLGWTLPIEA--SPRPLITWLYNGKEIGS 5613
            .|:.:...:..|...||    |:|:..   ...||:|:  .||.:|  .|.|...||.:...:..
Human   209 QSNSARLFVSDPANSAP----SILDGFDHRKAMAGQRV--ELPCKALGHPEPDYRWLKDNMPLEL 267

  Fly  5614 NSRGESGLFQNELTFEIVSSLR-SDEGRYTLILKNEHGSFDASAHATVLDR---PSPPKGPLDIT 5674
                 ||.||..:|..::.::| ||.|.|...:.|.:|:      |.|:.|   ..|.|..:...
Human   268 -----SGRFQKTVTGLLIENIRPSDSGSYVCEVSNRYGT------AKVIGRLYVKQPLKATISPR 321

  Fly  5675 KITRD-------GCHLTWNVPDDDGGSPILHYIIEKMDLSRSTWSDAGMSTHIVHDVTRLVHRKE 5732
            |:...       .|.:|..               |..:||   |...|                 
Human   322 KVKSSVGSQVSLSCSVTGT---------------EDQELS---WYRNG----------------- 351

  Fly  5733 YLFRVKAVNAIGESDPLEAVNTIIAKNEFDEPDAPGKPI-ITDWDRDHIDLQWAVPKSDGGAPIS 5796
                             |.:|             |||.: ||..:.:::.:...| ||||||   
Human   352 -----------------EILN-------------PGKNVRITGINHENLIMDHMV-KSDGGA--- 382

  Fly  5797 EYIIQKKEKGSPYWTNVRHVPSNKNTTTIPELTEGQEYEFRVIAVNQAGQSEPSEPSDMIMAKPR 5861
                        |...||           .:....|:|...|:        |...|. :|.|   
Human   383 ------------YQCFVR-----------KDKLSAQDYVQVVL--------EDGTPK-IISA--- 412

  Fly  5862 YLPPKIITPLNEVRIKCGLIFHTDIHFIGEPAPEATWTLNSNPLLSND----RSTITSIGHHSVV 5922
             ...|:::|...|.:.|.:        .|.|.|..||||:.:|:|...    ...|||.|  :||
Human   413 -FSEKVVSPAEPVSLMCNV--------KGTPLPTITWTLDDDPILKGGSHRISQMITSEG--NVV 466

  Fly  5923 HTVNCQRS---DSGIYHLLLRNSSGIDEGSFELVVLDRP-----GPPE-GPMEYEEITANSVTIS 5978
            ..:|...|   |.|:|.....||:|        |||.:.     ||.. .||  :.|||      
Human   467 SYLNISSSQVRDGGVYRCTANNSAG--------VVLYQARINVRGPASIRPM--KNITA------ 515

  Fly  5979 WKPPKDNGGSEISSYVIEKRDLTHGGGWVPAVNYVSAK---------YNHAVVPRLLEGTMYELR 6034
                            |..|| |:....|....|.|.|         :||..|.....||:    
Human   516 ----------------IAGRD-TYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTL---- 559

  Fly  6035 VMAENLQGRSDPLTSDQPVVAKSQYTVPGAPGKPELTDSDKNHITIK---WKQP----------- 6085
                       .|:..|..|.:.:||. ....:|:|:.|...|:|:|   :.||           
Human   560 -----------KLSDVQKEVDEGEYTC-NVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQR 612

  Fly  6086 ------ISNGGSPIIGYDIERRDVNTGRWIKINGQPVP-----TAEYQDDRVTSNHQYQYRISAV 6139
                  :.:|..||           |..|.| :|:|:|     |.:..|  .||:    .|||.:
Human   613 VFIPCVVVSGDLPI-----------TITWQK-DGRPIPGSLGVTIDNID--FTSS----LRISNL 659

  Fly  6140 NAAGNGK-----TSEPSAIFNARPL--REKPRFYF-----DGLIGKRIKVRAGEPVNLNIPISGA 6192
            :...||.     .:|.:|:.:...|  |..|:|..     ||:.||        .|.||....|.
Human   660 SLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGK--------AVILNCSAEGY 716

  Fly  6193 PTPTIEWKRGDLKLEEGK------------RISYETNSERTLFRIDDSNRRDSGKYTVTAANEFG 6245
            |.|||.|     |..:|.            ||...:|....:..:.:   .|||.|....:|:.|
Human   717 PVPTIVW-----KFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVE---EDSGYYLCKVSNDVG 773

  Fly  6246 KD-------TADIEVIVVDKPSP------PEGPLSYTETAPDHISLHWYSPKDDG--GSDITGYI 6295
            .|       |..|..::...|:.      .:..:|.|......|.:.|  .|:|.  ..::..|:
Human   774 ADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRW--EKEDRIINPEMARYL 836

  Fly  6296 IEFTEFG---VDDWKPVPGTCPNTNFTVKNLVEGKKYVFRIRAENIYGASEALEGKPVLAKSPFD 6357
            :...|.|   :...:.:|....::.|            |...|.|.||     |.:.::..:..:
Human   837 VSTKEVGEEVISTLQILPTVREDSGF------------FSCHAINSYG-----EDRGIIQLTVQE 884

  Fly  6358 PPGAPSQPTISAYTPNSANLEWHPPDDCGGKPITGYIVERRERGGEWIKCNN----YPTPNTSYT 6418
            ||. |.:..|......:..|.|....| |..|||||.:|.:.:...|.....    .|..| |.|
Human   885 PPD-PPEIEIKDVKARTITLRWTMGFD-GNSPITGYDIECKNKSDSWDSAQRTKDVSPQLN-SAT 946

  Fly  6419 VSNLRDGARYEFRVLAVNEAGPGHPSKPSDPMTAEHQRYRPD-PPEPPKPDRITRNGVTLSWRPP 6482
            :.::...:.|..|:.|.|..|   .|:||:.:|.......|| ||:....:.|:...:.::|:.|
Human   947 IIDIHPSSTYSIRMYAKNRIG---KSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAP 1008

  Fly  6483 RTDGKSR-IKGYYVEMRPKNGKDWKTVNDIPIN---------STVYTVPSLKEGEEYSFRVVAEN 6537
            :...::. |:||.:..|     ::.|..:...|         |.|||:.:|.:..:|...|.|.|
Human  1009 KKHLQNGIIRGYQIGYR-----EYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACN 1068

  Fly  6538 EVGRSDPSKPSQPITIEEQPNKPCMELGKVRDIVCRAGDDFSIHVPYLAFPKPNAFWYSNDNMLD 6602
            ..|....|:.....|:|:.|:.|...:    ..:..:.:..||.            |.:      
Human  1069 RAGTGPSSQEIITTTLEDVPSYPPENV----QAIATSPESISIS------------WST------ 1111

  Fly  6603 DNNRVHKHLTDDAASVVVKNSKRADSGQYRLQLKNTSGFDTATINVRVLDRPSPPTRLRADEFSG 6667
                    |:.:|.:.:::                  ||       ||                 
Human  1112 --------LSKEALNGILQ------------------GF-------RV----------------- 1126

  Fly  6668 DSLTLYWNPPNDDGGSAIQNYIIEKKEARSSTWSKVSSFCTVPFVRIRNLVLNKEYDFRVIAENK 6732
                :||....|.....|:|..                 .|.|.:.:..|.....|..:|:|..:
Human  1127 ----IYWANLMDGELGEIKNIT-----------------TTQPSLELDGLEKYTNYSIQVLAFTR 1170

  Fly  6733 YGQSDPANTSEPILARHPFDIPNTPGIPHGIDSTEDSITIAWTKPKHDGGSPITGYIIEKRLLSD 6797
            .|.   ...||.|..|...|:|..|.......::...:.::|..|     ..:.|.|.:..:...
Human  1171 AGD---GVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPP-----LKLNGIIRKYTVFCS 1227

  Fly  6798 DKWTKAVHAL--CPD-LSCKIPNLIENAEYEFRVAAVNAAGQSAYSGSSDLIFCRRPPHAPKITS 6859
            ..:...:...  .|| .|.:||||..|.:|...|.||.:||:   ..||::|.......||....
Human  1228 HPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGR---GNSSEIITVEPLAKAPARIL 1289

  Fly  6860 DLSIRDMTVIAGDEFRITVPYHA--SPRPTASW--SLNG---LEVIPGERIKFDSNDYASMYYNK 6917
            ..|....|....|   |.:|..|  .|.|...|  ..||   |..|.|.|..|.:..:..    :
Human  1290 TFSGTVTTPWMKD---IVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFII----R 1347

  Fly  6918 SAKRDETGSYTITLTNNKGSDTASCHVTVVDRPLPPQGP-LNAYDITPDTCTLAWKTPLDDGGSP 6981
            :.|.:::|.|:....||.|||....::.|   .:||..| |.....|..:.||:| .|.|:|||.
Human  1348 TVKAEDSGYYSCIANNNWGSDEIILNLQV---QVPPDQPRLTVSKTTSSSITLSW-LPGDNGGSS 1408

  Fly  6982 ITNYVVE-KLDNSGSWVKISSFVRNTHYDVMGLEPHYKYNFRVRAENQYGLSDPLDIIEPIVAKH 7045
            |..|::: ..|||..|...........|.:..|:....|.|.:.|:|..|   |..|.|.|.|| 
Human  1409 IRGYILQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVG---PGRISEIIEAK- 1469

  Fly  7046 QFTVPDEPGQPKVID-WDSGNVTLI------WTRPLSDGGSRIQGYQIEYRDILNDSSWNAYDYI 7103
              |:..||...|..: :.|.|.|.:      |    :|||..|..:.:|||. ...:.|......
Human  1470 --TLGKEPQFSKEQELFASINTTRVRLNLIGW----NDGGCPITSFTLEYRP-FGTTVWTTAQRT 1527

  Fly  7104 IKDTKYQLYNLINGSEYEFRIKAKNAAGLSKPSSPSLRFKLKGKFTVPSPPGAPQVTRVGKNYVD 7168
            .....|.||:|...:.||.:::..|:||.::..:........|. |:|     |.:..|.:|...
Human  1528 SLSKSYILYDLQEATWYELQMRVCNSAGCAEKQANFATLNYDGS-TIP-----PLIKSVVQNEEG 1586

  Fly  7169 LKWEKPLR 7176
            |...:.|:
Human  1587 LTTNEGLK 1594

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
btNP_001162825.1 I-set 9..101 CDD:254352
Ig 26..100 CDD:143165
I-set 119..210 CDD:254352
Ig 136..209 CDD:143165
I-set 228..320 CDD:254352
IGc2 242..312 CDD:197706
I-set 335..425 CDD:254352
Ig 350..423 CDD:143165
Ig 436..530 CDD:299845
I-set 438..532 CDD:254352
I-set 545..636 CDD:254352
Ig 560..633 CDD:143165
Ig 657..731 CDD:143165
I-set 746..835 CDD:254352
Ig 1496..1586 CDD:299845
IG_like 1503..1588 CDD:214653
I-set 1639..1724 CDD:254352
IG 1750..1821 CDD:214652
IGc2 1750..1806 CDD:197706
I-set 1826..1909 CDD:254352
Ig 1831..1897 CDD:299845
I-set 1914..1998 CDD:254352
Ig 2020..2095 CDD:299845
FN3 2100..2194 CDD:238020
FN3 2203..2292 CDD:238020
I-set 2311..2395 CDD:254352
Ig 2321..2395 CDD:299845
FN3 2399..2493 CDD:238020
FN3 2501..2590 CDD:238020
I-set 2602..2693 CDD:254352
Ig 2619..2693 CDD:299845
FN3 2697..2793 CDD:238020
FN3 2801..2893 CDD:238020
I-set 2902..2995 CDD:254352
Ig 2919..2993 CDD:299845
FN3 2999..3088 CDD:238020
FN3 3102..3191 CDD:238020
I-set 3208..3292 CDD:254352
Ig 3219..3292 CDD:299845
FN3 3296..3390 CDD:238020
FN3 3400..3489 CDD:238020
I-set 3494..3590 CDD:254352
Ig 3516..3590 CDD:299845
FN3 3594..3682 CDD:238020
FN3 3694..3781 CDD:238020
I-set 3795..3885 CDD:254352
Ig 3813..3885 CDD:299845
FN3 3889..3980 CDD:238020
FN3 3990..4082 CDD:238020
I-set 4090..4181 CDD:254352
Ig 4108..4181 CDD:299845
FN3 4185..4271 CDD:238020
FN3 4285..4383 CDD:238020
Ig 4404..4480 CDD:299845
FN3 4484..4571 CDD:238020
FN3 4584..4677 CDD:238020
I-set 4685..4775 CDD:254352
Ig 4703..4775 CDD:299845
FN3 4779..4863 CDD:238020
FN3 4879..4970 CDD:238020
IG 4989..5069 CDD:214652
Ig 4996..5069 CDD:299845
FN3 5073..5166 CDD:238020
FN3 5175..5265 CDD:238020
I-set 5276..5366 CDD:254352
Ig 5293..5366 CDD:299845
FN3 5370..5462 CDD:238020 5/24 (21%)
FN3 5470..5561 CDD:238020 18/103 (17%)
Ig 5559..5654 CDD:299845 27/100 (27%)
I-set 5570..5660 CDD:254352 26/95 (27%)
FN3 5664..5755 CDD:238020 12/97 (12%)
FN3 5764..5853 CDD:238020 19/89 (21%)
I-set 5865..5954 CDD:254352 27/95 (28%)
Ig 5882..5954 CDD:299845 23/78 (29%)
FN3 5958..6049 CDD:238020 21/105 (20%)
FN3 6062..6153 CDD:238020 27/120 (23%)
I-set 6173..6255 CDD:254352 24/100 (24%)
Ig_Titin_like 6182..6255 CDD:143225 23/91 (25%)
FN3 6259..6350 CDD:238020 18/101 (18%)
FN3 6359..6451 CDD:238020 26/95 (27%)
FN3 6470..6552 CDD:238020 20/91 (22%)
I-set 6564..6650 CDD:254352 7/85 (8%)
Ig_Titin_like 6577..6650 CDD:143225 7/72 (10%)
FN3 6654..6745 CDD:238020 14/90 (16%)
FN3 6754..6840 CDD:238020 20/88 (23%)
I-set 6855..6946 CDD:254352 25/97 (26%)
Ig 6874..6946 CDD:299845 21/78 (27%)
FN3 6950..7042 CDD:238020 29/93 (31%)
FN3 7050..7139 CDD:238020 24/95 (25%)
FN3 7151..7237 CDD:238020 6/26 (23%)
I-set 7254..7334 CDD:254352
Ig 7272..7339 CDD:143165
IG_like 7354..7440 CDD:214653
Ig 7366..7440 CDD:299845
FN3 7444..7531 CDD:238020
FN3 7545..7637 CDD:238020
I-set 7648..7737 CDD:254352
Ig 7665..7734 CDD:143165
Ig 7760..7833 CDD:299845
FN3 7837..7927 CDD:238020
STKc_Twitchin_like 7986..8244 CDD:271016
S_TKc 7989..8244 CDD:214567
Ig 8311..8394 CDD:299845
I-set 8312..8401 CDD:254352
I-set 8437..8525 CDD:254352
Ig 8455..8519 CDD:143165
I-set 8632..8721 CDD:254352
IGc2 8646..8711 CDD:197706
I-set 8740..8831 CDD:254352
Ig 8757..8826 CDD:143165
I-set 8839..8922 CDD:254352
Ig 8845..>8909 CDD:299845
DSCAMNP_001380.2 Ig 45..113 CDD:319273 5/16 (31%)
I-set 235..310 CDD:254352 25/87 (29%)
I-set 315..385 CDD:333254 24/150 (16%)
Ig_3 407..488 CDD:316449 27/95 (28%)
IGc2 518..575 CDD:197706 16/72 (22%)
I-set 596..686 CDD:333254 23/107 (21%)
Ig_DSCAM 707..784 CDD:143211 21/84 (25%)
Ig 802..889 CDD:325142 19/106 (18%)
FN3 885..978 CDD:238020 28/98 (29%)
FN3 986..1083 CDD:238020 22/101 (22%)
FN3 1091..1184 CDD:238020 25/188 (13%)
FN3 1189..1278 CDD:238020 23/96 (24%)
Ig 1303..1369 CDD:319273 20/69 (29%)
FN3 1380..1470 CDD:238020 31/96 (32%)
FN3 1486..1555 CDD:238020 19/73 (26%)
Required for netrin-mediated axon repulsion of neuronal growth cones. /evidence=ECO:0000250|UniProtKB:Q9ERC8 1617..2012
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1718..1810
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1855..1883
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1971..2012
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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