DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment bt and sax-3

DIOPT Version :9

Sequence 1:NP_001162825.1 Gene:bt / 43814 FlyBaseID:FBgn0005666 Length:8933 Species:Drosophila melanogaster
Sequence 2:NP_001024990.1 Gene:sax-3 / 180637 WormBaseID:WBGene00004729 Length:1273 Species:Caenorhabditis elegans


Alignment Length:1588 Identity:329/1588 - (20%)
Similarity:502/1588 - (31%) Gaps:543/1588 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly  5545 AVNRGGPSDPSDPSSTIICKPRFLAPFFDKSLLNDITVHAGKRLGWTLPIEASPRPL-ITWLYNG 5608
            ||.|....|.|:.:..||..|            .|:.|..|...  ||...|.|... |||..:|
 Worm    17 AVIRSFCEDASNLAPVIIEHP------------IDVVVSRGSPA--TLNCGAKPSTAKITWYKDG 67

  Fly  5609 KEIGSNSRGESG----LFQNELTFEIVSSLR----SDEGRYTLILKNEHGSFDASAHATVLDRPS 5665
            :.:.:|....:.    |....|....|:|.:    ||.|.|..:..||||...::          
 Worm    68 QPVITNKEQVNSHRIVLDTGSLFLLKVNSGKNGKDSDAGAYYCVASNEHGEVKSN---------- 122

  Fly  5666 PPKGPLDITKITRDGCHLTWNVPDDDGGSPILHYIIEKMDLSRSTWSDAGMSTHIVHDVTRLVHR 5730
              :|.|.:..:                                                     |
 Worm   123 --EGSLKLAML-----------------------------------------------------R 132

  Fly  5731 KEYLFRVKAVNAIGESDPLEAVNTIIAKNEFDEPDAPGKPIITDWDRDHIDLQ-WAVPK----SD 5790
            :::..|.:.|.|:|..         :|..|...|....:|::: |.:|..:|: ..:|:    ||
 Worm   133 EDFRVRPRTVQALGGE---------MAVLECSPPRGFPEPVVS-WRKDDKELRIQDMPRYTLHSD 187

  Fly  5791 GGAPISEYIIQKKEKGSPYWTNVRHVPSNKNTTTIPELTEGQEYEFRVIAVNQAGQ--SEPSEPS 5853
            |...|..  :.:.:.|:                            ::.:|.|..|:  |.|:..|
 Worm   188 GNLIIDP--VDRSDSGT----------------------------YQCVANNMVGERVSNPARLS 222

  Fly  5854 DMIMAKPRY-LPPKIITPLNEVRIKCGLIFHTDIHFIGEPAPEATWTLNSNPLLSNDRSTITSIG 5917
              :..||:: ..||.:|    |.:...::|  |....|:|.|:.||...:.| :...|:.|....
 Worm   223 --VFEKPKFEQEPKDMT----VDVGAAVLF--DCRVTGDPQPQITWKRKNEP-MPVTRAYIAKDN 278

  Fly  5918 HHSVVHTVNCQRSDSGIYHLLLRNSSGIDEG----------SFELVVLDRPGPPEGPMEYEEITA 5972
            ....:..|  |.||.|.|....||.:|..|.          ||:....|:..|..|...:|    
 Worm   279 RGLRIERV--QPSDEGEYVCYARNPAGTLEASAHLRVQAPPSFQTKPADQSVPAGGTATFE---- 337

  Fly  5973 NSVTISWKPPKDNGGSEISSYVIEK---RDLTHGGGWVPAVNYVSAKYNHAVVPRLLEGTM--YE 6032
              .|:..:|.        .:|...|   :||..       .:||||.....|.|   .||:  .|
 Worm   338 --CTLVGQPS--------PAYFWSKEGQQDLLF-------PSYVSADGRTKVSP---TGTLTIEE 382

  Fly  6033 LRVMAENLQGRSDPLTSDQPVVAKSQYTVPGAPGKPELTDSDKNHITIKWKQPISNGGSPIIGYD 6097
            :|.:.|                  ..|...|.    ....|..:...:|.......|.:|     
 Worm   383 VRQVDE------------------GAYVCAGM----NSAGSSLSKAALKVTTKAVTGNTP----- 420

  Fly  6098 IERRDVNTGRWIKINGQPVPTAEYQDDRVTSNHQYQYRISAVNAAGNGKTSEPSAIFNARPLREK 6162
                           .:|.||.|:       .||.|                             
 Worm   421 ---------------AKPPPTIEH-------GHQNQ----------------------------- 434

  Fly  6163 PRFYFDGLIGKRIKVRAGEPVNLNIPISGAPTPTIEWKRGDLKLE-EGKRIS-YETNSERTLFRI 6225
                         .:..|....|....||.|||.|.|.|..|.:: ...||| :.|.|    ..|
 Worm   435 -------------TLMVGSSAILPCQASGKPTPGISWLRDGLPIDITDSRISQHSTGS----LHI 482

  Fly  6226 DDSNRRDSGKYTVTAANEFGKDTADIEVIVVDK---------------PSPPEGPL--SYTETAP 6273
            .|..:.|:|.||..|.||.|:.|....:.|.|.               ||.|..|:  :.|:|  
 Worm   483 ADLKKPDTGVYTCIAKNEDGESTWSASLTVEDHTSNAQFVRMPDPSNFPSSPTQPIIVNVTDT-- 545

  Fly  6274 DHISLHWYSPKDDGGSDITGYIIEF--TEFGVDDWKPVPGTCPNTNFTVKNLVEGKKYVFRIRAE 6336
             .:.|||.:|...|...||||||::  .:.| ..|..:|....:|.:.:|.|.....|:|.||||
 Worm   546 -EVELHWNAPSTSGAGPITGYIIQYYSPDLG-QTWFNIPDYVASTEYRIKGLKPSHSYMFVIRAE 608

  Fly  6337 NIYG-----ASEAL--EGKPVLA-----KSPFDPPGAPSQPT---------ISAYTPNSANLEWH 6380
            |..|     .|.||  ..||...     |:..|...|..:.|         :......:..|.| 
 Worm   609 NEKGIGTPSVSSALVTTSKPAAQVALSDKNKMDMAIAEKRLTSEQLIKLEEVKTINSTAVRLFW- 672

  Fly  6381 PPDDCGGKP------ITGYIVE----RRERGGEWIKCNNYPTPNT-SYTVSNLRDGARYEFRVLA 6434
                   |.      |.||.::    .|....:::   |..:|:| :|.||||.....|||.|:.
 Worm   673 -------KKRKLEELIDGYYIKWRGPPRTNDNQYV---NVTSPSTENYVVSNLMPFTNYEFFVIP 727

  Fly  6435 VN---EAGPGHPSKPSDPMTAEHQRYRPDPPE-PPKPDRITRNGVT---LSWRPPRTDGKSRI-K 6491
            .:   .:..|.||...|.:|||      .||. ||:..||....:|   :||:.|:.||.:.| |
 Worm   728 YHSGVHSIHGAPSNSMDVLTAE------APPSLPPEDVRIRMLNLTTLRISWKAPKADGINGILK 786

  Fly  6492 GY---YVEMRPKNGKDWKTVNDIPINSTVYTVPSLKEGEEYSFRVVAENEVGRSDPSKPSQPI-- 6551
            |:   .|...|.|.:: .|.|:...:.|::   .|..|..|..||.|.:..|.......|:.|  
 Worm   787 GFQIVIVGQAPNNNRN-ITTNERAASVTLF---HLVTGMTYKIRVAARSNGGVGVSHGTSEVIMN 847

  Fly  6552 --TIE-----EQPNKPCMELGKVRDIVCRAGDDFSIHVP----------YLAFPKPNAFWYSNDN 6599
              |:|     :|.|:..: .|.:.          ..|||          ::.......:|.::.|
 Worm   848 QDTLEKHLAAQQENESFL-YGLIN----------KSHVPVIVIVAILIIFVVIIIAYCYWRNSRN 901

  Fly  6600 MLDDNNRVHKHLTDDAASVVVKNSKRADSGQYRLQLKNTSGFDTATINVRVLDRPSPPTRLRADE 6664
            . |..:|....:.|.:..:...|.........:..:.||:|  ..|:|.|               
 Worm   902 S-DGKDRSFIKINDGSVHMASNNLWDVAQNPNQNPMYNTAG--RMTMNNR--------------- 948

  Fly  6665 FSGDSLTLYWNPPN-DDGGSAIQNYIIEKKEARSSTWSKVSSFCTVPFVRIRNLVLNKEYDFRVI 6728
               :...||...|| .|..:...:|        |.|..:..|                       
 Worm   949 ---NGQALYSLTPNAQDFFNNCDDY--------SGTMHRPGS----------------------- 979

  Fly  6729 AENKYGQSDPANTSEPILARHPFDIPNTPGIPHGIDSTEDSITIAWTKPKHDGGSPITGYIIEKR 6793
             |:.|               |...:...||         ::::..:....||..||   |.....
 Worm   980 -EHHY---------------HYAQLTGGPG---------NAMSTFYGNQYHDDPSP---YATTTL 1016

  Fly  6794 LLSDDK--WTKAVHALCPDLSCKIPNLIEN-------AEYEFRVAAVNAAGQSAYSGSSDL---I 6846
            :||:.:  |..       |...:.|.:..|       |.|....|...:....|..|...|   :
 Worm  1017 VLSNQQPAWLN-------DKMLRAPAMPTNPVPPEPPARYADHTAGRRSRSSRASDGRGTLNGGL 1074

  Fly  6847 FCR--------RPPHAPKITSDLSIRDMTVIAGDEFRITVPYHASPRPTASWSLNGLEVIPGERI 6903
            ..|        .|||     :|:|.              |..|:|....:|....|....|..:.
 Worm  1075 HHRTSGSQRSDSPPH-----TDVSY--------------VQLHSSDGTGSSKERTGERRTPPNKT 1120

  Fly  6904 KFD------SND-------YASMYYNKSAKRDETGSYTITLTNNKGSDTASCHVTVVDRPLPPQG 6955
            ..|      ||.       |..::...:.::...||.....|.:..||.|...|.|..||.....
 Worm  1121 LMDFIPPPPSNPPPPGGHVYDDIFQTATRRQLNRGSTPREDTYDSVSDGAFARVDVNARPTSRNR 1185

  Fly  6956 PLNAYDITPDTCTLAWKTPL---DDGGS 6980
            .|....:.......:.::.|   |||||
 Worm  1186 NLGGRPLKGKRDDDSQRSSLMMDDDGGS 1213

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
btNP_001162825.1 I-set 9..101 CDD:254352
Ig 26..100 CDD:143165
I-set 119..210 CDD:254352
Ig 136..209 CDD:143165
I-set 228..320 CDD:254352
IGc2 242..312 CDD:197706
I-set 335..425 CDD:254352
Ig 350..423 CDD:143165
Ig 436..530 CDD:299845
I-set 438..532 CDD:254352
I-set 545..636 CDD:254352
Ig 560..633 CDD:143165
Ig 657..731 CDD:143165
I-set 746..835 CDD:254352
Ig 1496..1586 CDD:299845
IG_like 1503..1588 CDD:214653
I-set 1639..1724 CDD:254352
IG 1750..1821 CDD:214652
IGc2 1750..1806 CDD:197706
I-set 1826..1909 CDD:254352
Ig 1831..1897 CDD:299845
I-set 1914..1998 CDD:254352
Ig 2020..2095 CDD:299845
FN3 2100..2194 CDD:238020
FN3 2203..2292 CDD:238020
I-set 2311..2395 CDD:254352
Ig 2321..2395 CDD:299845
FN3 2399..2493 CDD:238020
FN3 2501..2590 CDD:238020
I-set 2602..2693 CDD:254352
Ig 2619..2693 CDD:299845
FN3 2697..2793 CDD:238020
FN3 2801..2893 CDD:238020
I-set 2902..2995 CDD:254352
Ig 2919..2993 CDD:299845
FN3 2999..3088 CDD:238020
FN3 3102..3191 CDD:238020
I-set 3208..3292 CDD:254352
Ig 3219..3292 CDD:299845
FN3 3296..3390 CDD:238020
FN3 3400..3489 CDD:238020
I-set 3494..3590 CDD:254352
Ig 3516..3590 CDD:299845
FN3 3594..3682 CDD:238020
FN3 3694..3781 CDD:238020
I-set 3795..3885 CDD:254352
Ig 3813..3885 CDD:299845
FN3 3889..3980 CDD:238020
FN3 3990..4082 CDD:238020
I-set 4090..4181 CDD:254352
Ig 4108..4181 CDD:299845
FN3 4185..4271 CDD:238020
FN3 4285..4383 CDD:238020
Ig 4404..4480 CDD:299845
FN3 4484..4571 CDD:238020
FN3 4584..4677 CDD:238020
I-set 4685..4775 CDD:254352
Ig 4703..4775 CDD:299845
FN3 4779..4863 CDD:238020
FN3 4879..4970 CDD:238020
IG 4989..5069 CDD:214652
Ig 4996..5069 CDD:299845
FN3 5073..5166 CDD:238020
FN3 5175..5265 CDD:238020
I-set 5276..5366 CDD:254352
Ig 5293..5366 CDD:299845
FN3 5370..5462 CDD:238020
FN3 5470..5561 CDD:238020 5/15 (33%)
Ig 5559..5654 CDD:299845 27/103 (26%)
I-set 5570..5660 CDD:254352 24/98 (24%)
FN3 5664..5755 CDD:238020 7/90 (8%)
FN3 5764..5853 CDD:238020 16/95 (17%)
I-set 5865..5954 CDD:254352 26/98 (27%)
Ig 5882..5954 CDD:299845 22/81 (27%)
FN3 5958..6049 CDD:238020 20/95 (21%)
FN3 6062..6153 CDD:238020 12/90 (13%)
I-set 6173..6255 CDD:254352 27/83 (33%)
Ig_Titin_like 6182..6255 CDD:143225 26/74 (35%)
FN3 6259..6350 CDD:238020 35/101 (35%)
FN3 6359..6451 CDD:238020 25/114 (22%)
FN3 6470..6552 CDD:238020 25/92 (27%)
I-set 6564..6650 CDD:254352 15/95 (16%)
Ig_Titin_like 6577..6650 CDD:143225 14/82 (17%)
FN3 6654..6745 CDD:238020 11/91 (12%)
FN3 6754..6840 CDD:238020 17/94 (18%)
I-set 6855..6946 CDD:254352 19/103 (18%)
Ig 6874..6946 CDD:299845 17/84 (20%)
FN3 6950..7042 CDD:238020 8/34 (24%)
FN3 7050..7139 CDD:238020
FN3 7151..7237 CDD:238020
I-set 7254..7334 CDD:254352
Ig 7272..7339 CDD:143165
IG_like 7354..7440 CDD:214653
Ig 7366..7440 CDD:299845
FN3 7444..7531 CDD:238020
FN3 7545..7637 CDD:238020
I-set 7648..7737 CDD:254352
Ig 7665..7734 CDD:143165
Ig 7760..7833 CDD:299845
FN3 7837..7927 CDD:238020
STKc_Twitchin_like 7986..8244 CDD:271016
S_TKc 7989..8244 CDD:214567
Ig 8311..8394 CDD:299845
I-set 8312..8401 CDD:254352
I-set 8437..8525 CDD:254352
Ig 8455..8519 CDD:143165
I-set 8632..8721 CDD:254352
IGc2 8646..8711 CDD:197706
I-set 8740..8831 CDD:254352
Ig 8757..8826 CDD:143165
I-set 8839..8922 CDD:254352
Ig 8845..>8909 CDD:299845
sax-3NP_001024990.1 Ig 30..129 CDD:299845 29/124 (23%)
I-set 31..121 CDD:254352 27/103 (26%)
I-set 135..223 CDD:254352 23/129 (18%)
Ig2_Robo 137..223 CDD:143201 23/127 (18%)
I-set 227..313 CDD:254352 25/94 (27%)
Ig 244..313 CDD:299845 20/73 (27%)
I-set 317..410 CDD:254352 26/138 (19%)
Ig 331..411 CDD:299845 23/125 (18%)
Ig 424..512 CDD:299845 33/140 (24%)
I-set 432..512 CDD:254352 29/125 (23%)
FN3 531..624 CDD:238020 34/96 (35%)
FN3 659..747 CDD:238020 23/98 (23%)
FN3 755..836 CDD:214495 26/84 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.