DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment bt and Ncam1

DIOPT Version :9

Sequence 1:NP_001162825.1 Gene:bt / 43814 FlyBaseID:FBgn0005666 Length:8933 Species:Drosophila melanogaster
Sequence 2:XP_006510118.1 Gene:Ncam1 / 17967 MGIID:97281 Length:1162 Species:Mus musculus


Alignment Length:1360 Identity:284/1360 - (20%)
Similarity:460/1360 - (33%) Gaps:371/1360 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 GNRLIFECQLLSSPK-PDIEWFRSDNKVVEDVRTKFKIQPVGENKYTVVLELDDVVE-------- 78
            |....|.||:....| .||.||..:.:         |:.| .:.:.:||...||...        
Mouse    34 GESKFFLCQVAGDAKDKDISWFSPNGE---------KLSP-NQQRISVVWNDDDSSTLTIYNANI 88

  Fly    79 TDAGLYKVKAKNKSGEVS-ASINLNFTPADEPKEKQIDGFAPTFAKKPAIRQEEDGKRLLFECRV 142
            .|||:||.....:.|..| |::|:...      :|.:      |...|..::.::|:..:..|.|
Mouse    89 DDAGIYKCVVTAEDGTQSEATVNVKIF------QKLM------FKNAPTPQEFKEGEDAVIVCDV 141

  Fly   143 NADPIPAIIWFHNGAAVKESERHKITVDKDV------HSYFATLEILNVTVEDAGKY----KVNA 197
            .:...|.|||.|.|        ..:.:.|||      ::|   |:|..:...|.|.|    ::.|
Mouse   142 VSSLPPTIIWKHKG--------RDVILKKDVRFIVLSNNY---LQIRGIKKTDEGTYRCEGRILA 195

  Fly   198 KNELGESNATISLNFDSDEAPVPESAEGIKPTFTERPVI--RQSEDGGNVTFECRCVGDPTPTVT 260
            :.|:...:..:.:|              :.||...|..|  ..:..|.:||..|...|.|.||::
Mouse   196 RGEINFKDIQVIVN--------------VPPTVQARQSIVNATANLGQSVTLVCDADGFPEPTMS 246

  Fly   261 WS-HGETELNESNRYKMSLTMDQKLYHIACLEISSVVSSDQGEYRAQAKNKHGSGVATINLNFES 324
            |: .||...||....:..:..|..    :.|.|.:|..:|:.||...|:||.|...|:|:|    
Mouse   247 WTKDGEPIENEEEDDEKHIFSDDS----SELTIRNVDKNDEAEYVCIAENKAGEQDASIHL---- 303

  Fly   325 GSKKIPDGKSPRFPKKPTIRQEEDLLIMECVLEAHPVPDIVWYCSEKEICNNQRTKMTR--KAIT 387
               |:.......:.:..|..:.|:.:.:.|.....|:|.|.|..|.:.|.:.::...||  |..|
Mouse   304 ---KVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQET 365

  Fly   388 KDSYIL--------TLEIQNPTKEDGGNYRCNAINMYGESNANIALNFQGASDANGFAPSFIEKP 444
            .|.:::        :|.:::....|.|.|.|.|.|..|:.:.::.|..|       :||. ::.|
Mouse   366 LDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQ-------YAPK-LQGP 422

  Fly   445 RIIPNESGTLITMKCKCKAKPEPTVTWYRGQDLVEKS--KKIKINTTVIAEDTYELTLEIKDPGA 507
            ..:....|..:.:.|:..|.|..|::|:|...|:..|  ..|||..|..|  :|   ||:.....
Mouse   423 VAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSA--SY---LEVTPDSE 482

  Fly   508 TDGGTYRCNVKNEYGESNANLNLNIEAEP---------EP-EGEGPTFIEKPRIVSENNGKLVIM 562
            .|.|.|.|...|..|:.:....| ::|:.         || ........::|    |..|.:.|:
Mouse   483 NDFGNYNCTAVNRIGQESLEFIL-VQADTPSSPSIDRVEPYSSTAQVQFDEP----EATGGVPIL 542

  Fly   563 ECKVKADPKPDVIWFRNGEVIKESNK--IKTFIEQRGD-QYYIKLELLDPQLEDSGLYKCNIKNT 624
            :.|.:.....:..|.......||:|.  |.|.:..:.: :|.::|..|:.:             .
Mouse   543 KYKAEWKSLGEESWHFKWYDAKEANMEGIVTIMGLKPETRYSVRLAALNGK-------------G 594

  Fly   625 LGELNANLTLNIEIVPVIKDKP-------KIIKIIKKRTV----VIECTVASKFEPKCTWYKETS 678
            |||::|  ....:..||....|       .::.:..:.|.    |:..|..||.||.        
Mouse   595 LGEISA--ATEFKTQPVHSPPPLAPANSSTLVPLSPRATTWPLPVLPTTDLSKGEPS-------- 649

  Fly   679 TVKESKRHVYQVEQTKEGEFAVKLEINDVEESDKGAYKLVASNEKGEAVSQIVNLVDIPEEERKP 743
                                |.|||....|:.:.....|:..::.|..:...  ||....:....
Mouse   650 --------------------APKLEGQMGEDGNSIKVNLIKQDDGGSPIRHY--LVKYRAKLASE 692

  Fly   744 CKPEISRKLADQKV--------AESKTFELLVSLSQTDRKCKVEWYKGSTVIRET---------- 790
            .||||........|        ||   :|:.|.......|.|...:...|..:.|          
Mouse   693 WKPEIRLPSGSDHVMLKSLDWNAE---YEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTA 754

  Fly   791 ---------------------KDITTTFDGTTARLTFSSARTEHTSNYKVIVTNEVGKDESSCKI 834
                                 .|||..|......|             ..|..|..||.....| 
Mouse   755 GLSTGAIVGILIVIFVLLLVVMDITCYFLNKCGLL-------------MCIAVNLCGKAGPGAK- 805

  Fly   835 TVEKVAKKKEEKPKEKEKTKNEKEVEQKEMEEDKNESGQSVAQTEGRINIEQISEGDPKEELTVK 899
                 .|..||......|.::::.:.:...||::..:......||            |.|...:.
Mouse   806 -----GKDMEEGKAAFSKDESKEPIVEVRTEEERTPNHDGGKHTE------------PNETTPLT 853

  Fly   900 EEILDKRDTQEVKESSVELQDSAGHEVPEPKKATSDSKLDQ-----SNQKNLDKKHKTDQSE--S 957
            |.                       |:|....||.:..|..     :|...:.:...|.|:.  |
Mouse   854 EP-----------------------ELPADTTATVEDMLPSVTTVTTNSDTITETFATAQNSPTS 895

  Fly   958 KTNKNVSLAEPIKSNKQESEE---QQATEQIGL-------KKVDRKASIVSVKE---EISSDVRR 1009
            :|....|...|..:...:|..   .|||...|:       ....:.|.:|.:.:   ...|....
Mouse   896 ETTTLTSSIAPPATTVPDSNSVPAGQATPSKGVTASSSSPASAPKVAPLVDLSDTPTSAPSASNL 960

  Fly  1010 KSTIKAKE-EITVDDKKASSRRSSLAVEESN-------TESRRSSIIDKKPLEQVDNKPIDANKN 1066
            .||:.|.: .:......||:..:|.|...|.       |.:..:|     ||..|.....||   
Mouse   961 SSTVLANQGAVLSPSTPASAGETSKAPPASKASPAPTPTPAGAAS-----PLAAVAAPATDA--- 1017

  Fly  1067 PQPLKEEIPRLKPAEKRRTSKVIEEPKPDEGLPKLRKASIAQVKEEA-KPAAPKLKAKAKAKPKY 1130
            || .|:|.|..|            .|.|:...|    .::....|.| .||:||.||......:.
Mouse  1018 PQ-AKQEAPSTK------------GPDPEPTQP----GTVKNPPEAATAPASPKSKAATTNPSQG 1065

  Fly  1131 EELPEIPDYERPQLEKYEKSDF-TPS-DFARDLEIPNKMEKPIIDSGKKEPAVLAQKNGIPKKTD 1193
            |:|            |.::.:| ||. |.|:|:         ....|...||..|.    .:.::
Mouse  1066 EDL------------KMDEGNFKTPDIDLAKDV---------FAALGSPAPATGAS----GQASE 1105

  Fly  1194 IIEQYADE---PKGLKVGKGKL-----PDEGDGRDGAVLKPVIIEPEKEILDLGNKKNNQ 1245
            :....||.   |...|..||.:     |.|.:.      ||...|.:....|....|.|:
Mouse  1106 LAPSTADSAVPPAPAKTEKGPVETKSEPPESEA------KPAPTEVKTVPNDATQTKENE 1159

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
btNP_001162825.1 I-set 9..101 CDD:254352 23/87 (26%)
Ig 26..100 CDD:143165 22/83 (27%)
I-set 119..210 CDD:254352 22/100 (22%)
Ig 136..209 CDD:143165 19/82 (23%)
I-set 228..320 CDD:254352 30/94 (32%)
IGc2 242..312 CDD:197706 23/70 (33%)
I-set 335..425 CDD:254352 22/99 (22%)
Ig 350..423 CDD:143165 20/82 (24%)
Ig 436..530 CDD:299845 26/95 (27%)
I-set 438..532 CDD:254352 26/95 (27%)
I-set 545..636 CDD:254352 18/93 (19%)
Ig 560..633 CDD:143165 15/75 (20%)
Ig 657..731 CDD:143165 13/77 (17%)
I-set 746..835 CDD:254352 22/127 (17%)
Ig 1496..1586 CDD:299845
IG_like 1503..1588 CDD:214653
I-set 1639..1724 CDD:254352
IG 1750..1821 CDD:214652
IGc2 1750..1806 CDD:197706
I-set 1826..1909 CDD:254352
Ig 1831..1897 CDD:299845
I-set 1914..1998 CDD:254352
Ig 2020..2095 CDD:299845
FN3 2100..2194 CDD:238020
FN3 2203..2292 CDD:238020
I-set 2311..2395 CDD:254352
Ig 2321..2395 CDD:299845
FN3 2399..2493 CDD:238020
FN3 2501..2590 CDD:238020
I-set 2602..2693 CDD:254352
Ig 2619..2693 CDD:299845
FN3 2697..2793 CDD:238020
FN3 2801..2893 CDD:238020
I-set 2902..2995 CDD:254352
Ig 2919..2993 CDD:299845
FN3 2999..3088 CDD:238020
FN3 3102..3191 CDD:238020
I-set 3208..3292 CDD:254352
Ig 3219..3292 CDD:299845
FN3 3296..3390 CDD:238020
FN3 3400..3489 CDD:238020
I-set 3494..3590 CDD:254352
Ig 3516..3590 CDD:299845
FN3 3594..3682 CDD:238020
FN3 3694..3781 CDD:238020
I-set 3795..3885 CDD:254352
Ig 3813..3885 CDD:299845
FN3 3889..3980 CDD:238020
FN3 3990..4082 CDD:238020
I-set 4090..4181 CDD:254352
Ig 4108..4181 CDD:299845
FN3 4185..4271 CDD:238020
FN3 4285..4383 CDD:238020
Ig 4404..4480 CDD:299845
FN3 4484..4571 CDD:238020
FN3 4584..4677 CDD:238020
I-set 4685..4775 CDD:254352
Ig 4703..4775 CDD:299845
FN3 4779..4863 CDD:238020
FN3 4879..4970 CDD:238020
IG 4989..5069 CDD:214652
Ig 4996..5069 CDD:299845
FN3 5073..5166 CDD:238020
FN3 5175..5265 CDD:238020
I-set 5276..5366 CDD:254352
Ig 5293..5366 CDD:299845
FN3 5370..5462 CDD:238020
FN3 5470..5561 CDD:238020
Ig 5559..5654 CDD:299845
I-set 5570..5660 CDD:254352
FN3 5664..5755 CDD:238020
FN3 5764..5853 CDD:238020
I-set 5865..5954 CDD:254352
Ig 5882..5954 CDD:299845
FN3 5958..6049 CDD:238020
FN3 6062..6153 CDD:238020
I-set 6173..6255 CDD:254352
Ig_Titin_like 6182..6255 CDD:143225
FN3 6259..6350 CDD:238020
FN3 6359..6451 CDD:238020
FN3 6470..6552 CDD:238020
I-set 6564..6650 CDD:254352
Ig_Titin_like 6577..6650 CDD:143225
FN3 6654..6745 CDD:238020
FN3 6754..6840 CDD:238020
I-set 6855..6946 CDD:254352
Ig 6874..6946 CDD:299845
FN3 6950..7042 CDD:238020
FN3 7050..7139 CDD:238020
FN3 7151..7237 CDD:238020
I-set 7254..7334 CDD:254352
Ig 7272..7339 CDD:143165
IG_like 7354..7440 CDD:214653
Ig 7366..7440 CDD:299845
FN3 7444..7531 CDD:238020
FN3 7545..7637 CDD:238020
I-set 7648..7737 CDD:254352
Ig 7665..7734 CDD:143165
Ig 7760..7833 CDD:299845
FN3 7837..7927 CDD:238020
STKc_Twitchin_like 7986..8244 CDD:271016
S_TKc 7989..8244 CDD:214567
Ig 8311..8394 CDD:299845
I-set 8312..8401 CDD:254352
I-set 8437..8525 CDD:254352
Ig 8455..8519 CDD:143165
I-set 8632..8721 CDD:254352
IGc2 8646..8711 CDD:197706
I-set 8740..8831 CDD:254352
Ig 8757..8826 CDD:143165
I-set 8839..8922 CDD:254352
Ig 8845..>8909 CDD:299845
Ncam1XP_006510118.1 Ig1_NCAM-1 20..115 CDD:143273 24/90 (27%)
IG 124..190 CDD:214652 19/76 (25%)
Ig3_NCAM-1_like 211..308 CDD:143207 32/107 (30%)
Ig_NCAM-1 307..413 CDD:143277 23/105 (22%)
Ig_3 417..494 CDD:372822 23/82 (28%)
FN3 509..606 CDD:238020 20/115 (17%)
fn3 649..731 CDD:365830 19/114 (17%)
PHA03247 <905..1140 CDD:223021 62/290 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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