DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment bt and Myom2

DIOPT Version :9

Sequence 1:NP_001162825.1 Gene:bt / 43814 FlyBaseID:FBgn0005666 Length:8933 Species:Drosophila melanogaster
Sequence 2:XP_006508790.1 Gene:Myom2 / 17930 MGIID:1328358 Length:1486 Species:Mus musculus


Alignment Length:1783 Identity:359/1783 - (20%)
Similarity:592/1783 - (33%) Gaps:592/1783 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly  6122 QDDRVTSNHQYQYRISAVNAAGNGKTSEPSAIFNARPLREKPRFYFDGLIGKRIKVRAGEPVNLN 6186
            :|:.....|.::.|:|..          |..:...|          ...|.:|:.||      |.
Mouse   159 EDNLAWERHSFEDRMSRA----------PEILVRLR----------SHTIWERMSVR------LC 197

  Fly  6187 IPISGAPTPTIEW-KRGDLKLEEGKRISYETNSE---RTLFRIDDSNRRDSGKYTVTAANEFGKD 6247
            ..:.|.|||.::| |.|.|..:.|:...|...|.   .|| .|:.:|..|:..|:..|.|..|:.
Mouse   198 FTVQGFPTPVVQWYKDGSLICQAGEPGKYRIESRYGVHTL-EINRANFEDTATYSAVATNSHGQV 261

  Fly  6248 TADIEVIVVDKPSPPEGPLSYTETAPDHISLHWYSPKDDGGSDITGYIIEFTEFGVDDWKPVPGT 6312
            :.:..|:|                       ..|..:::          .|...|:....|:...
Mouse   262 STNAAVVV-----------------------RRYRGEEE----------PFHSVGLPIGLPLSSV 293

  Fly  6313 CPNTNFTVKNLVEGKKYVFRIRAENIYGASEALEGKPVLAKSPFDPPGAPSQPTISAYTPNSANL 6377
            .|.|:|.|:.|.:             :|.:...||:.|..|...     ...|.:....|.:   
Mouse   294 IPYTHFDVQFLEK-------------FGVTFRREGETVTLKCTL-----LVTPDLKRVQPRA--- 337

  Fly  6378 EWHPPDDCGGKPITGYIVERRERGGEWIKCNNYPTPNTSYTVSNLR--DGARYEFRVLA------ 6434
            ||:..|           |..:|  .:|.|. .:.....|.:.|:|.  |...|..|:::      
Mouse   338 EWYRDD-----------VLLKE--SKWTKM-FFGEGQASLSFSHLNKDDEGLYTLRIVSRGGVSD 388

  Fly  6435 ------VNEAGPGHPSKPSDPMTAE-HQRYRPDPPEPPKPDRITRNGVTLSWRPPRTDGKSRIKG 6492
                  |.:|.|.....|..||..: |.              ..|:.|.::|:||.|..:|.:.|
Mouse   389 HSAFMFVRDADPLVTGAPGAPMDLQCHD--------------ANRDYVIVTWKPPNTTTESPVIG 439

  Fly  6493 YYVEMRPKNGKDWKTVNDIPINSTVYTVPSLKEGEEYSFRVVAENEVGRSDPSKPSQPITIEEQP 6557
            |:::.......:|...||.|:....|.|..|.||..|.|||.|.|..|.|.||:.|..:...:. 
Mouse   440 YFIDKCEVGTNNWVQCNDAPVKICKYPVTGLFEGRSYVFRVRAVNNAGISRPSRISDAVAALDP- 503

  Fly  6558 NKPCMELGKVRDIVCRAGDDFSIHVPYLAFPKPNAFWYSNDNMLDDNNRVHKHLTDDAASVVVKN 6622
                ::|.:::.|                                       ||..:...|:.::
Mouse   504 ----VDLRRLQAI---------------------------------------HLEGEKEIVIYQD 525

  Fly  6623 SKRADSGQYRLQLKNTSGFDTATINVRVLDRPSPPTRLRADEFSGDSLTLYWNPPNDDGGSAIQN 6687
            ....|                    |::   |.|||.::|.|.|.:.:.|.|:||:..|...:. 
Mouse   526 DLEGD--------------------VQI---PGPPTNVQASEVSRNYVVLSWDPPSPRGKDPLM- 566

  Fly  6688 YIIEKKEARSSTWSKVSSFCTV--PFVRIRNLVLNKEYDFRVIAENKYGQSDPANTSEPILARHP 6750
            |.|||....|.:|.:|::...|  |...:.:|...|.|.|||::.||:|.|||:..:.||.|:..
Mouse   567 YFIEKSAVGSGSWQRVNAQTAVRSPRYAVFDLAEGKSYVFRVLSANKHGLSDPSEITPPIQAQDM 631

  Fly  6751 FDIPNTPGIPHGIDSTEDSITIAWTKPKHDGGSPITGYIIEKRLLSDDKWTKAVHALCPDLSCKI 6815
            ..:|:.||......:|:.|:.:.|.:|||:  ..:.||.::..:...:.|....|.........:
Mouse   632 IVVPSAPGRVLASRNTKTSVVVQWDRPKHE--EDLLGYYVDCCVAGTNMWEPCNHKPIGYNRFVV 694

  Fly  6816 PNLIENAEYEFRVAAVNAAGQSAYSGSSDLIFCRRPPHAPKITSDLSIRDMTVIAGDEFRITVPY 6880
            ..|....:|.|||.||||.|.|..|..|::|         |:.:.|               |||.
Mouse   695 HGLTTGEQYIFRVKAVNAVGTSENSQESEVI---------KVQAAL---------------TVPS 735

  Fly  6881 HASPRPTASWSLNGLEVIPGERIKFDSNDYASMYYNKSAKRDETGSYTITLTNNKGSDTASCHVT 6945
            |                                            .|.|||.|..|         
Mouse   736 H--------------------------------------------PYGITLLNCDG--------- 747

  Fly  6946 VVDRPLPPQGPLNAYDITPDTCTLAWKTPLDDGGSPITNYVVEKLD-NSGSWVKI-SSFVRNTHY 7008
                               .:.||.||.|...|||.|..|.::|.: :..:|.:: ||.|:....
Mouse   748 -------------------HSMTLGWKVPKFSGGSAIIGYYLDKREVHHKNWHEVNSSPVKERIL 793

  Fly  7009 DVMGLEPHYKYNFRVRAENQYGLSDPLDIIEPIVAKHQFTVPDEPGQP------KVIDWDSGNVT 7067
            .|.||.....|.|::.|.|..|:..|.|..|....: .:|.| |||..      :|.|   .::.
Mouse   794 TVEGLTEGSLYEFKIAATNLAGIGQPSDPSEHFKCE-AWTDP-EPGPAYDLTFCEVRD---TSLV 853

  Fly  7068 LIWTRPLSDGGSRIQGYQIEYRDILNDS-SWNAYDYIIKDTKY-QLYNLINGSEYEFRIKAKNAA 7130
            ::|..|:..|.|.:.||.:::::  .|| .|..........:| ::.:|..|..|.|||:|.||:
Mouse   854 ILWKAPVYSGSSPVSGYFVDFKE--EDSGEWKTTSEAATPNRYLKVCDLQQGKTYVFRIRAVNAS 916

  Fly  7131 GLSKPSSPSLRFKLKGKFTVPSPPGAPQVTRVGKNYVDLKWEKPLRDGGSRITGY-IIERRDIGG 7194
            |..|||..|      ....|.:.||..::: .|   ||        :.|:...|: ..|..|...
Mouse   917 GPGKPSDTS------EPVLVEARPGTKEIS-AG---VD--------EEGNIYLGFDCQEMTDASQ 963

  Fly  7195 AVWVKCNDYNVLDTEYTVMNLIEMGDYEFRVFAVNSAG---------RSEPSLCTMPIKVCE--- 7247
            ..|  |..|.            |:.|.|  .|.|::.|         ..:..|.|..:.|.:   
Mouse   964 FTW--CKAYE------------EIADEE--RFEVHTEGDHSKLYFKNPDKEDLGTYSVSVSDTDG 1012

  Fly  7248 -----VLGGKKPDWITRLQDKV----APFGKDYTLQCAASGK-----------PSPTARWLRNGK 7292
                 ||..::.:.:..|.:::    .|...:...:....|:           |..:.|::.|.:
Mouse  1013 VSSSFVLDEEELERLMALSNEIKNPTIPLKSELAYEIFDKGQVRFWLQAEHLSPDASFRFIINDR 1077

  Fly  7293 EI-QMNGGRMTCDSKDGVFRLHISNVQTGDDGDYTCEAMNSLGFVNTSGYLKIGSP--------- 7347
            |: ..:..|:.||...|:..:.:......::|.||.:..:... .|.|..:.||..         
Mouse  1078 EVSDSDTHRIKCDRSTGMIEMVMDRFTIENEGTYTVQIQDGKA-KNQSSLVLIGDAFKAVLEEAE 1141

  Fly  7348 --------------------PIINRCPSELKLPEGDNSKIKIF--------YSGDQPLTVILKKN 7384
                                .:...|...|.....:..:..:|        |..:.|..  |:|.
Mouse  1142 FQRKEFLRKQGPHFAEYLHWDVTEECEVRLVCKVANTKRETVFKWLKDDVLYETETPPD--LEKG 1204

  Fly  7385 NEVICDSNDDTHVKVNIFDDYVAIYIRNIVKSDGGPYQIEFTNESG------SATGEFY------ 7437
               :|:                 :.|..:.|.|.|.|:....::.|      ...|:.|      
Mouse  1205 ---VCE-----------------LLIPKLSKKDHGEYKATLKDDRGQDVSVLEVGGKVYEDMILA 1249

  Fly  7438 -VHITGMPSAP----TGPMGISYINKNSCMLNWRPPSYDGGLKVSHYVIERKDVSSPHWITVSST 7497
             ..:.|..::|    ..|.||    :..|.:.:    :...:|||.|..|.|..||.|       
Mouse  1250 MSRVCGASASPLKVLCTPEGI----RLQCFMKY----FTEEMKVSWYHKEAKISSSEH------- 1299

  Fly  7498 CKDTAFNVQGLIENQEYIFRVMAVNENGMGPPLEGLNPIRAKDPIDPPSPPGSPQITEIGGDFVH 7562
                                                                    ..|||. ..
Mouse  1300 --------------------------------------------------------MRIGGS-EE 1307

  Fly  7563 LEW----EKPESDGGAHIQGYWIDKREV--GSNTWQRVNATICAANQINCINLIEGRQYEFRIFA 7621
            :.|    |..|.|.|.:       ..|:  |.::.||   ::..:.|.......|.:|.:...||
Mouse  1308 MAWLQICEPTEKDKGKY-------TFEIFDGKDSHQR---SLDLSGQAFDEAYAEFQQLKAAAFA 1362

  Fly  7622 QNVAGLSTESSASQAVKIIDPQAASPPLIVKPLRDANCIQNHNAQFTCTINGVPKPTISWYKGAR 7686
            :...|           |:|   ...|.::       ..::......|||:.|.|.|.:.|:|..:
Mouse  1363 EKNRG-----------KVI---GGLPDVV-------TIMEGKTLNLTCTVFGNPDPEVVWFKNDK 1406

  Fly  7687 EISNGARYHMYSEGDNHF-LNINDVFGEDADEYVCRAVNKAGAKSTRATLAIMTAPKLNVPPRFR 7750
            :|.....:.:..|...:. |.|..|..||:.:|.....||.|.:....|:::             
Mouse  1407 DIELSEHFLVKMEQSKYVSLTIQGVTAEDSGKYSINVKNKYGGEKIDVTVSV------------- 1458

  Fly  7751 DTAYFDKGENVVIKIPFTGFP---KPRI 7775
                :..||    |||....|   ||::
Mouse  1459 ----YKHGE----KIPDISPPQQAKPKL 1478

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
btNP_001162825.1 I-set 9..101 CDD:254352
Ig 26..100 CDD:143165
I-set 119..210 CDD:254352
Ig 136..209 CDD:143165
I-set 228..320 CDD:254352
IGc2 242..312 CDD:197706
I-set 335..425 CDD:254352
Ig 350..423 CDD:143165
Ig 436..530 CDD:299845
I-set 438..532 CDD:254352
I-set 545..636 CDD:254352
Ig 560..633 CDD:143165
Ig 657..731 CDD:143165
I-set 746..835 CDD:254352
Ig 1496..1586 CDD:299845
IG_like 1503..1588 CDD:214653
I-set 1639..1724 CDD:254352
IG 1750..1821 CDD:214652
IGc2 1750..1806 CDD:197706
I-set 1826..1909 CDD:254352
Ig 1831..1897 CDD:299845
I-set 1914..1998 CDD:254352
Ig 2020..2095 CDD:299845
FN3 2100..2194 CDD:238020
FN3 2203..2292 CDD:238020
I-set 2311..2395 CDD:254352
Ig 2321..2395 CDD:299845
FN3 2399..2493 CDD:238020
FN3 2501..2590 CDD:238020
I-set 2602..2693 CDD:254352
Ig 2619..2693 CDD:299845
FN3 2697..2793 CDD:238020
FN3 2801..2893 CDD:238020
I-set 2902..2995 CDD:254352
Ig 2919..2993 CDD:299845
FN3 2999..3088 CDD:238020
FN3 3102..3191 CDD:238020
I-set 3208..3292 CDD:254352
Ig 3219..3292 CDD:299845
FN3 3296..3390 CDD:238020
FN3 3400..3489 CDD:238020
I-set 3494..3590 CDD:254352
Ig 3516..3590 CDD:299845
FN3 3594..3682 CDD:238020
FN3 3694..3781 CDD:238020
I-set 3795..3885 CDD:254352
Ig 3813..3885 CDD:299845
FN3 3889..3980 CDD:238020
FN3 3990..4082 CDD:238020
I-set 4090..4181 CDD:254352
Ig 4108..4181 CDD:299845
FN3 4185..4271 CDD:238020
FN3 4285..4383 CDD:238020
Ig 4404..4480 CDD:299845
FN3 4484..4571 CDD:238020
FN3 4584..4677 CDD:238020
I-set 4685..4775 CDD:254352
Ig 4703..4775 CDD:299845
FN3 4779..4863 CDD:238020
FN3 4879..4970 CDD:238020
IG 4989..5069 CDD:214652
Ig 4996..5069 CDD:299845
FN3 5073..5166 CDD:238020
FN3 5175..5265 CDD:238020
I-set 5276..5366 CDD:254352
Ig 5293..5366 CDD:299845
FN3 5370..5462 CDD:238020
FN3 5470..5561 CDD:238020
Ig 5559..5654 CDD:299845
I-set 5570..5660 CDD:254352
FN3 5664..5755 CDD:238020
FN3 5764..5853 CDD:238020
I-set 5865..5954 CDD:254352
Ig 5882..5954 CDD:299845
FN3 5958..6049 CDD:238020
FN3 6062..6153 CDD:238020 5/30 (17%)
I-set 6173..6255 CDD:254352 25/85 (29%)
Ig_Titin_like 6182..6255 CDD:143225 22/76 (29%)
FN3 6259..6350 CDD:238020 12/90 (13%)
FN3 6359..6451 CDD:238020 20/105 (19%)
FN3 6470..6552 CDD:238020 29/81 (36%)
I-set 6564..6650 CDD:254352 7/85 (8%)
Ig_Titin_like 6577..6650 CDD:143225 5/72 (7%)
FN3 6654..6745 CDD:238020 33/92 (36%)
FN3 6754..6840 CDD:238020 24/85 (28%)
I-set 6855..6946 CDD:254352 12/90 (13%)
Ig 6874..6946 CDD:299845 10/71 (14%)
FN3 6950..7042 CDD:238020 26/93 (28%)
FN3 7050..7139 CDD:238020 29/96 (30%)
FN3 7151..7237 CDD:238020 18/95 (19%)
I-set 7254..7334 CDD:254352 14/95 (15%)
Ig 7272..7339 CDD:143165 13/78 (17%)
IG_like 7354..7440 CDD:214653 15/106 (14%)
Ig 7366..7440 CDD:299845 14/94 (15%)
FN3 7444..7531 CDD:238020 14/90 (16%)
FN3 7545..7637 CDD:238020 18/97 (19%)
I-set 7648..7737 CDD:254352 20/89 (22%)
Ig 7665..7734 CDD:143165 19/69 (28%)
Ig 7760..7833 CDD:299845 6/19 (32%)
FN3 7837..7927 CDD:238020
STKc_Twitchin_like 7986..8244 CDD:271016
S_TKc 7989..8244 CDD:214567
Ig 8311..8394 CDD:299845
I-set 8312..8401 CDD:254352
I-set 8437..8525 CDD:254352
Ig 8455..8519 CDD:143165
I-set 8632..8721 CDD:254352
IGc2 8646..8711 CDD:197706
I-set 8740..8831 CDD:254352
Ig 8757..8826 CDD:143165
I-set 8839..8922 CDD:254352
Ig 8845..>8909 CDD:299845
Myom2XP_006508790.1 I-set 177..269 CDD:369462 28/108 (26%)
Ig 313..395 CDD:386229 19/103 (18%)
FN3 406..498 CDD:238020 33/105 (31%)
FN3 534..626 CDD:238020 33/92 (36%)
FN3 635..725 CDD:238020 26/91 (29%)
FN3 734..824 CDD:238020 33/161 (20%)
FN3 836..926 CDD:238020 28/100 (28%)
IG <963..1018 CDD:214652 12/70 (17%)
Ig_M-protein_C 1367..1458 CDD:143299 24/111 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR13817
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.100

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