DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment bt and Myom1

DIOPT Version :9

Sequence 1:NP_001162825.1 Gene:bt / 43814 FlyBaseID:FBgn0005666 Length:8933 Species:Drosophila melanogaster
Sequence 2:NP_034997.2 Gene:Myom1 / 17929 MGIID:1341430 Length:1667 Species:Mus musculus


Alignment Length:1893 Identity:374/1893 - (19%)
Similarity:600/1893 - (31%) Gaps:687/1893 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly  5589 GWTLPIEASPRPLITWLYNGKEIGSNSRGESGLFQNEL-----TFEIVSSLRSDEGRYTLILKNE 5648
            ||       |.|.:||..|  ::..|.....|.:..|.     |.||......|..:|.....|.
Mouse   283 GW-------PEPRLTWYKN--QVPINVHANPGKYIIESRYGMHTLEISKCDFEDTAQYRASAMNV 338

  Fly  5649 HGSFDASAHATVLDRPSPPKGPLDIT------------KITRDGCHLTWNVPDDD---------- 5691
            .|  :.||:|:|:.:..  ||.||.:            .:|..|....:.:..||          
Mouse   339 QG--ELSAYASVVVKRY--KGELDESLLRGGVSMPLSFAVTPYGYASKFEIHFDDKFDVSFGREG 399

  Fly  5692 --------------------------GGSPILHYIIEKMDLSRSTWSDAGMSTHIVHDVTRLVH- 5729
                                      .|:|:          |.|.|    :..|...|...|.. 
Mouse   400 ETMSLGCRVVITPEIKHFQPEVQWYRNGAPV----------SPSKW----VQPHWSGDRATLTFS 450

  Fly  5730 --RKE----YLFRVKAVNAIGESDPLEAVNTIIAKNEFDEPDAPGKP---IITDWDRDHIDLQWA 5785
              .||    |..||:    :||.....:....:...:.:...||..|   :..|.::|:|.:.|.
Mouse   451 HLNKEDEGLYTIRVR----MGEYYEQYSAYVFVRDADAEIEGAPAAPLDVVSLDANKDYIIISWK 511

  Fly  5786 VPKSDGGAPISEYIIQKKEKGSPYWTNVRHVPSNKNTTTIPELTEGQEYEFRVIAVNQAGQSEPS 5850
            .|..|||:||..|.|.|.|.|:..|:.....|.......:..|.||:.|.|||.|||:.|...||
Mouse   512 QPAVDGGSPILGYFIDKCEVGTDTWSQCNDTPVKFARFPVTGLIEGRSYIFRVRAVNKTGIGLPS 576

  Fly  5851 EPSDMIMAKPRYLPPKIITPLNEVRIKCGLIFHTDIHFIGEPAPEATWTLNSNPLLSNDRSTITS 5915
            ..|:.:.|         :.|..:.|:|.        |      |.|.||                
Mouse   577 RVSEPVAA---------LDPAEKARLKS--------H------PSAPWT---------------- 602

  Fly  5916 IGHHSVVHTVNCQRSDSGIYHLLLRNSSGIDEGSFELVVLDRPGPPEGPMEYEEITANSVTISWK 5980
               ..::.|                     :|...|.|:   ||||. .:...|.|.:.|.:|||
Mouse   603 ---GQIIVT---------------------EEEPTEGVI---PGPPT-DLSVTEATRSYVVLSWK 639

  Fly  5981 PPKDNGGSEISSYVIEKRDLTHGGGWVPAVNYVSAKYNHAVVPRLLEGTMYELRVMAENLQGRSD 6045
            ||...|...| .|.:||.|: ....|......:..|.....:..|:||..|..||...|..|..:
Mouse   640 PPGQRGHEGI-MYFVEKCDV-GAENWQRVNTELPVKSPRFALFDLVEGKSYRFRVRCSNSAGVGE 702

  Fly  6046 PLTSDQPVVAKSQYTVPGAPGKPELTDSDKNHITIKWKQPISNGGSPIIGYDIERRDVNTGRWIK 6110
            |..:.:..|...:..:|.||||...:.:....:.:.|::  |.....::||.||...|.:|:|..
Mouse   703 PSETTEVTVVGDKLDIPKAPGKIIPSRNTDTSVVVSWEE--SRDAKELVGYYIEASVVGSGKWEP 765

  Fly  6111 INGQPVPTAEYQDDRVTSNHQYQYRISAVNAAGNGKTSEPSAIFNARPLREKPRFYFDGLIGKRI 6175
            .|..||..:.:....:|:...|.:|:.||||||..:.|:.|                        
Mouse   766 CNNNPVKGSRFTCHGLTTAQSYIFRVRAVNAAGLSEYSQDS------------------------ 806

  Fly  6176 KVRAGEPVNLNIPISGAPTPTIEWKR-----GDLKLEEGKRISYETNSERTLFRIDDSNRRDSGK 6235
                 |.:.:...|.|..:|.: |.:     |.|....|              .::.::...|.|
Mouse   807 -----EAIEVKAAIGGGVSPDV-WPQLSDTPGGLTDSRG--------------GMNGASPPTSQK 851

  Fly  6236 YTVTAANEFGKDTADIEVIVVDKPSPPEGPLS--------YTETAPDHISLHWYSPKDDGGSDIT 6292
            ..:..:|.             :|||||..|.|        .:|:..:.:|    ||..:...:  
Mouse   852 DALLGSNP-------------NKPSPPSSPSSRGQKEVSTVSESVQEPLS----SPPQEAAPE-- 897

  Fly  6293 GYIIEFTEFGVDDWKPVPGTCPNTNFTVKNLVEGKKYVFRIRAENIYGASEALEGKPVLAKSPFD 6357
                                                            ..::....|...|.|..
Mouse   898 ------------------------------------------------EEQSQSEPPKKKKDPVA 914

  Fly  6358 PPGAPSQPTISAYTPNSANLEWHPPDDCGGKPITGYIVERRERGGE----WIKCNNYPTPNTSYT 6418
            .|.||...|......:|..|.|..||..||..||||.|..||..||    |.:.|.....:.:|.
Mouse   915 VPSAPYDITCLESFRDSMVLGWKQPDTTGGAEITGYYVNYREVVGEVPGKWREANIKAVSDAAYK 979

  Fly  6419 VSNLRDGARYEFRVLAVNEAGPGHPSKPSDPMTAEHQRYR-PDPPEPPKPDRITRNGVTLSWRPP 6482
            :|||::...|:|:|.|:|.||.|.||..|:....|..... |.||...|...:.:|.:.|.|:||
Mouse   980 ISNLKENTLYQFQVSAMNIAGLGAPSTVSECFKCEEWTIAVPGPPHSVKLSEVRKNSLVLQWKPP 1044

  Fly  6483 RTDGKSRIKGYYVEMRPKNGKD--WKTVNDIPINSTVYTVPSLKEGEEYSFRVVAENEVGRSDPS 6545
            ...|::.:.||:|:::..:.||  |:.:|:..|.:....|..||||..|.|||.|.|:.|...||
Mouse  1045 VYSGRTPVTGYFVDLKEASAKDDQWRGLNEAAIVNKYLRVQGLKEGTSYVFRVRAVNQAGVGKPS 1109

  Fly  6546 KPSQPITIEEQPNKPCMELGKVRDIVCRAGDDFSIHVPY---LAFPKPNAFWYSNDNMLDDNNRV 6607
            ..:.|:..|.:|.        .:::|....||..|.:.:   ...||....|..:....:|:.|:
Mouse  1110 DLAGPVVAETRPG--------TKEVVVSVDDDGVISLNFECDQMTPKSEFVWSKDYVPTEDSPRL 1166

  Fly  6608 HKHLTDDAASVVVKNSKRADSGQYRLQLKNTSGFDTATINVRVLDRPSPPTRLRADEFSGDSLTL 6672
            ......|...:..|:....|.|.|...:.:|.|.                               
Mouse  1167 EVENKGDKTKMTFKDLGTDDLGTYSCDVTDTDGI------------------------------- 1200

  Fly  6673 YWNPPNDDGGSAIQNYIIEKKEARSSTWSKVSSFCTVPFVRIRNLVLNKEYDFRVIAENKYGQSD 6737
                        ..:|:|:::|.:                  |.|.|::|:.|            
Mouse  1201 ------------ASSYLIDEEEMK------------------RLLALSQEHKF------------ 1223

  Fly  6738 PANTSEPILARHPFDIPNTPGIPHGIDSTEDSITIAWTKPKHDGGSPITGYIIEKRLLSDDKWTK 6802
                               |.:|                                        ||
Mouse  1224 -------------------PTVP----------------------------------------TK 1229

  Fly  6803 AVHALCPDLSCKIPNLIENAEYEFRVAAVNAAGQSAYSGSSDLIFCRRPPHAPKITSDLSIRDMT 6867
            :..|:         .::|..:..|.:                        .|.|::|:..:    
Mouse  1230 SELAV---------EILEKGQVRFWM------------------------QAEKLSSNAKV---- 1257

  Fly  6868 VIAGDEFRITVPYHASPRPTASWSLNGLEVIPGERIK--FDSN-DYASMYYNKSAKRDETGSYTI 6929
                                 |:..|..|:..|.:.|  .|.| ....|:..|....|| |:||.
Mouse  1258 ---------------------SYIFNEKEIFEGPKYKMHIDRNTGIIEMFMEKLQDEDE-GTYTF 1300

  Fly  6930 TLTNNKGSDTASCHVTVV-----------------DRPLPPQGPLNA----YDITPDTCTLAWKT 6973
            .:.:.|    |:.|.|:|                 ...:..|||..|    :::|.: |.:..| 
Mouse  1301 QIQDGK----ATGHSTLVLIGDVYKKLQKEAEFQRQEWIRKQGPHFAEYLSWEVTGE-CNVLLK- 1359

  Fly  6974 PLDDGGSPITNYVVEKLDNSGSWVKISSFVRNTHYDVMGLEPHYKYNFRVRAENQYGLSDPL--- 7035
                                   .|:::..:.||.      ..||....:..:.::...|.:   
Mouse  1360 -----------------------CKVANIKKETHI------VWYKDEREISVDEKHDFKDGICTL 1395

  Fly  7036 ---DIIEPIVAKHQFTVPDEPGQPKVIDWDSGNVTLIWTRPLSDGGSRIQGYQIEYRDILND--- 7094
               :..:.....::..:.|:.|:.|                     ||::.....::|::.:   
Mouse  1396 LITEFSKKDAGFYEVILKDDRGKDK---------------------SRLKLVDEAFQDLMTEVCK 1439

  Fly  7095 -SSWNAYDYIIKDTK--YQLYNLINGSEYEFRIK-AKNAAGLSKPSSPSLRFKLKGKFTVPSPPG 7155
             .:.:|.|..|:.|.  .:||:.:.....:.::. :.|..|                        
Mouse  1440 KIALSATDLKIQSTAEGIRLYSFVCYYLDDLKVNWSHNGTG------------------------ 1480

  Fly  7156 APQVTRVGKNYVDLKWEKPLRDGGSRITGYIIERRDIGGAVWVKCNDYNVLDTEYTVMNL----- 7215
                         :|:...::.|   :|         |..:|::.|:....|....||.|     
Mouse  1481 -------------IKYTDRVKSG---VT---------GEQIWLQINEPTPNDKGKYVMELFDGKT 1520

  Fly  7216 -----IEMGDYEF-RVFA----VNSAGRSEPSLCTMPIKVCEVLGGKKPDWITRLQDKVAPFGKD 7270
                 :::....| ..||    :..|..:|.:.       ..|||| .||.:| :|:     ||.
Mouse  1521 GHQKTVDLSGQAFDEAFAEFQRLKQAAIAEKNR-------ARVLGG-LPDVVT-IQE-----GKA 1571

  Fly  7271 YTLQCAASGKPSPTARWLRNGKEIQMNGGRMTCD---------SKDGVFRLHISNVQTGDDGDYT 7326
            ..|.|...|.|.|...||:|.|.       :|.|         .|...|.  ||.|.|.|.|.|.
Mouse  1572 LNLTCNVWGDPPPEVSWLKNEKP-------LTSDDHCSLKFEAGKTAFFT--ISGVSTADSGKYG 1627

  Fly  7327 CEAMNSLG 7334
            ....|..|
Mouse  1628 LVVKNKYG 1635

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
btNP_001162825.1 I-set 9..101 CDD:254352
Ig 26..100 CDD:143165
I-set 119..210 CDD:254352
Ig 136..209 CDD:143165
I-set 228..320 CDD:254352
IGc2 242..312 CDD:197706
I-set 335..425 CDD:254352
Ig 350..423 CDD:143165
Ig 436..530 CDD:299845
I-set 438..532 CDD:254352
I-set 545..636 CDD:254352
Ig 560..633 CDD:143165
Ig 657..731 CDD:143165
I-set 746..835 CDD:254352
Ig 1496..1586 CDD:299845
IG_like 1503..1588 CDD:214653
I-set 1639..1724 CDD:254352
IG 1750..1821 CDD:214652
IGc2 1750..1806 CDD:197706
I-set 1826..1909 CDD:254352
Ig 1831..1897 CDD:299845
I-set 1914..1998 CDD:254352
Ig 2020..2095 CDD:299845
FN3 2100..2194 CDD:238020
FN3 2203..2292 CDD:238020
I-set 2311..2395 CDD:254352
Ig 2321..2395 CDD:299845
FN3 2399..2493 CDD:238020
FN3 2501..2590 CDD:238020
I-set 2602..2693 CDD:254352
Ig 2619..2693 CDD:299845
FN3 2697..2793 CDD:238020
FN3 2801..2893 CDD:238020
I-set 2902..2995 CDD:254352
Ig 2919..2993 CDD:299845
FN3 2999..3088 CDD:238020
FN3 3102..3191 CDD:238020
I-set 3208..3292 CDD:254352
Ig 3219..3292 CDD:299845
FN3 3296..3390 CDD:238020
FN3 3400..3489 CDD:238020
I-set 3494..3590 CDD:254352
Ig 3516..3590 CDD:299845
FN3 3594..3682 CDD:238020
FN3 3694..3781 CDD:238020
I-set 3795..3885 CDD:254352
Ig 3813..3885 CDD:299845
FN3 3889..3980 CDD:238020
FN3 3990..4082 CDD:238020
I-set 4090..4181 CDD:254352
Ig 4108..4181 CDD:299845
FN3 4185..4271 CDD:238020
FN3 4285..4383 CDD:238020
Ig 4404..4480 CDD:299845
FN3 4484..4571 CDD:238020
FN3 4584..4677 CDD:238020
I-set 4685..4775 CDD:254352
Ig 4703..4775 CDD:299845
FN3 4779..4863 CDD:238020
FN3 4879..4970 CDD:238020
IG 4989..5069 CDD:214652
Ig 4996..5069 CDD:299845
FN3 5073..5166 CDD:238020
FN3 5175..5265 CDD:238020
I-set 5276..5366 CDD:254352
Ig 5293..5366 CDD:299845
FN3 5370..5462 CDD:238020
FN3 5470..5561 CDD:238020
Ig 5559..5654 CDD:299845 17/69 (25%)
I-set 5570..5660 CDD:254352 20/75 (27%)
FN3 5664..5755 CDD:238020 23/145 (16%)
FN3 5764..5853 CDD:238020 33/91 (36%)
I-set 5865..5954 CDD:254352 11/88 (13%)
Ig 5882..5954 CDD:299845 8/71 (11%)
FN3 5958..6049 CDD:238020 29/90 (32%)
FN3 6062..6153 CDD:238020 28/90 (31%)
I-set 6173..6255 CDD:254352 11/86 (13%)
Ig_Titin_like 6182..6255 CDD:143225 10/77 (13%)
FN3 6259..6350 CDD:238020 10/98 (10%)
FN3 6359..6451 CDD:238020 37/95 (39%)
FN3 6470..6552 CDD:238020 29/83 (35%)
I-set 6564..6650 CDD:254352 16/88 (18%)
Ig_Titin_like 6577..6650 CDD:143225 14/75 (19%)
FN3 6654..6745 CDD:238020 8/90 (9%)
FN3 6754..6840 CDD:238020 7/85 (8%)
I-set 6855..6946 CDD:254352 19/93 (20%)
Ig 6874..6946 CDD:299845 17/74 (23%)
FN3 6950..7042 CDD:238020 13/101 (13%)
FN3 7050..7139 CDD:238020 14/95 (15%)
FN3 7151..7237 CDD:238020 15/100 (15%)
I-set 7254..7334 CDD:254352 27/88 (31%)
Ig 7272..7339 CDD:143165 22/72 (31%)
IG_like 7354..7440 CDD:214653
Ig 7366..7440 CDD:299845
FN3 7444..7531 CDD:238020
FN3 7545..7637 CDD:238020
I-set 7648..7737 CDD:254352
Ig 7665..7734 CDD:143165
Ig 7760..7833 CDD:299845
FN3 7837..7927 CDD:238020
STKc_Twitchin_like 7986..8244 CDD:271016
S_TKc 7989..8244 CDD:214567
Ig 8311..8394 CDD:299845
I-set 8312..8401 CDD:254352
I-set 8437..8525 CDD:254352
Ig 8455..8519 CDD:143165
I-set 8632..8721 CDD:254352
IGc2 8646..8711 CDD:197706
I-set 8740..8831 CDD:254352
Ig 8757..8826 CDD:143165
I-set 8839..8922 CDD:254352
Ig 8845..>8909 CDD:299845
Myom1NP_034997.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 192..217
IG_like 264..350 CDD:214653 21/77 (27%)
Ig 397..464 CDD:386229 11/80 (14%)
FN3 490..580 CDD:238020 32/89 (36%)
FN3 618..711 CDD:238020 29/95 (31%)
FN3 719..809 CDD:238020 29/120 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 818..915 22/178 (12%)
FN3 916..1010 CDD:238020 37/93 (40%)
FN3 1021..1110 CDD:238020 31/88 (35%)
Ig 1137..1203 CDD:386229 12/108 (11%)
Ig 1356..1425 CDD:386229 12/119 (10%)
Ig 1554..1645 CDD:386229 32/98 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR13817
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.100

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