DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment bt and Mybpc3

DIOPT Version :9

Sequence 1:NP_001162825.1 Gene:bt / 43814 FlyBaseID:FBgn0005666 Length:8933 Species:Drosophila melanogaster
Sequence 2:NP_032679.2 Gene:Mybpc3 / 17868 MGIID:102844 Length:1278 Species:Mus musculus


Alignment Length:1354 Identity:311/1354 - (22%)
Similarity:490/1354 - (36%) Gaps:391/1354 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly  1398 PKIEVIREKRPSLAPEPPSRRGSLIPPADTGRRPSLIINDEKKLRPGEV---------------- 1446
            |.:.|::      .|||             |::|....|  ||.|..||                
Mouse     2 PGVTVLK------MPEP-------------GKKPVSAFN--KKPRSAEVTAGSAAVFEAETERSG 45

  Fly  1447 MDTRLLRPGE----------VGEGQRRRPSIDVRRPSVQ--------------DLEDLINKPSTP 1487
            :..|..|.|.          ..||:|...::....|..|              ||:  :.:|:.|
Mouse    46 VKVRWQRDGSDITANDKYGLAAEGKRHTLTVRDASPDDQGSYAVIAGSSKVKFDLK--VTEPAPP 108

  Fly  1488 LR---DVGDGGPPSI----VDVQE-------SYSVVEDSTAYLTVGVEGSPAPTFKFYKGVSEIL 1538
            .:   :|..|.|..:    .:::|       |.||.:|.:|....|....|...|.......|:.
Mouse   109 EKAESEVAPGAPKEVPAPATELEESVSSPEGSVSVTQDGSAAEHQGAPDDPIGLFLMRPQDGEVT 173

  Fly  1539 EGGRFKF---------------------------------------------------LTDGQTN 1552
            .||...|                                                   :||.||.
Mouse   174 VGGSIVFSARVAGASLLKPPVVKWFKGKWVDLSSKVGQHLQLHDSYDRASKVYLFELHITDAQTT 238

  Fly  1553 TITLCMRKCKPNDESKYKIVVSNIHGEDSAEMQLYVSDSSG------------------------ 1593
            :            ...|:..||.....||....|.|.::.|                        
Mouse   239 S------------AGGYRCEVSTKDKFDSCNFNLTVHEAIGSGDLDLRSAFRRTSLAGAGRRTSD 291

  Fly  1594 -------MDFRAMLKK----RRYQKWDKDEQDPNW--------------------GDLKETEKPL 1627
                   :||.::|||    ||..|.:...::..|                    .||:...|.|
Mouse   292 SHEDAGTLDFSSLLKKRDSFRRDSKLEAPAEEDVWEILRQAPPSEYERIAFQHGVTDLRGMLKRL 356

  Fly  1628 PALKKVERKVESFLSPLIDQFAKEGKDKKVVFEARFSKPNCKPKWLFRKDEV-FTGSKFKFKQEN 1691
            ..:|:.|:|..:|...|...: :..|..|:......:.|:.:.|||....|: .:|||:.|:...
Mouse   357 KGMKQDEKKSTAFQKKLEPAY-QVNKGHKIRLTVELADPDAEVKWLKNGQEIQMSGSKYIFESVG 420

  Fly  1692 DTYQLIITTPKVEDTGKYTIEIGGVSSTAFLNVEEADPTYTFTKPLKKKLEGFTQHETTLECSVS 1756
            ....|.|:...:.|...|...:||...:..|.|:|  |....|:.|:.:|....| ....||.||
Mouse   421 AKRTLTISQCSLADDAAYQCVVGGEKCSTELFVKE--PPVLITRSLEDQLVMVGQ-RVEFECEVS 482

  Fly  1757 SSMANVHWFKNNTKLESDDP-RYLISKDINGNLKLIIKDSVLDDAGLYRCQLDKQPDKTECNLKV 1820
            ...|.|.|.|:..:|..::. :|...|| .....|||.::.|:|||.|..:........|  |.|
Mouse   483 EEGAQVKWLKDGVELTREETFKYRFKKD-GRKHHLIINEATLEDAGHYAVRTSGGQSLAE--LIV 544

  Fly  1821 TEYPYKFVKVLKSQQCI------EKDTVTLACEIDDAMGEVQWLRNGEEIKPDKRIQIVKDGRKR 1879
            .|      |.|:..|.|      .||.....||:.|......||:||:|:.||.||::...||..
Mouse   545 QE------KKLEVYQSIADLAVGAKDQAVFKCEVSDENVRGVWLKNGKELVPDNRIKVSHIGRVH 603

  Fly  1880 KLVIKDCKVTDAGQ---------FKCTTNADTTESEIIINYQNRFNK---------KLKDT-EAV 1925
            ||.|.|  ||.|.:         |.|..:|.....|:.|::..|...         ...|| ..|
Mouse   604 KLTIDD--VTPADEADYSFVPEGFACNLSAKLHFMEVKIDFVPRQEPPKIHLDCPGSTPDTIVVV 666

  Fly  1926 EREKLILDIELQDQTAP-CDWKFNGEPIVPSESIEIKNMGGGKHQLIFSSLDMSNEGEITCESGQ 1989
            ...||.||:.:....|| ..|:              |.:..||                      
Mouse   667 AGNKLRLDVPISGDPAPTVVWQ--------------KTVTQGK---------------------- 695

  Fly  1990 LSSKCKLSIRKGESRPNIDCPDKFSGPISAPVLLEVPFKVSGTKQTPVEAKLF--KDGKPLPVKD 2052
                      |..:.|:.|.|:                .....::...:.||.  .:|:      
Mouse   696 ----------KASTGPHPDAPE----------------DAGADEEWVFDKKLLCETEGR------ 728

  Fly  2053 VEVAVTDDKVTFKIKKPSRDLSGPYQIKISNGQGEDTKDVQIICQDVPQPPQDVDITDVYQTSCV 2117
            |.|..|.|:..|.::...::..|.|.:.:.|..|||..::.:...|||..|....|::|.:.||.
Mouse   729 VRVETTKDRSVFTVEGAEKEDEGVYTVTVKNPVGEDQVNLTVKVIDVPDAPAAPKISNVGEDSCT 793

  Fly  2118 VSFNPPSDDGGTPITKYVIERQDLSKKHGW-----ESVAEVLPSEPCLKKIDDLIPKKQYRFRIR 2177
            |.:.||:.|||.|:..|::||:. .|.:.|     :.:.|:  |....:.|:.:    .|..|:.
Mouse   794 VQWEPPAYDGGQPVLGYILERKK-KKSYRWMRLNFDLLREL--SHEARRMIEGV----AYEMRVY 851

  Fly  2178 AVNAIGQSDPATFKNTILAKDPWDEPGKPKAVDLTDWDKDHADLKWEAPETDGGDPITAYIVEYK 2242
            ||||:|.|.|:......:   |...||:|..:.:.|.......|||..||..|...:..|.|||.
Mouse   852 AVNAVGMSRPSPASQPFM---PIGPPGEPTHLAVEDVSDTTVSLKWRPPERVGAGGLDGYSVEYC 913

  Fly  2243 EKFSNDWVSGKEVDGDARTATVDGLKEGQQYEFRVRAVNRAGPGEPSDKTKSIIAKCRFVKPFIV 2307
            ::..::|....:...:..:..|..|..|.:..|||||.|.||||.|      |:.|    :|..|
Mouse   914 QEGCSEWTPALQGLTERTSMLVKDLPTGARLLFRVRAHNVAGPGGP------IVTK----EPVTV 968

  Fly  2308 GEGL------------KNVTVKKGQTIRFDIKYDGEPEPAATWVKGTDNLKFDNQRICLDQLE-R 2359
            .|.|            :.:..|.|:.:...|.:.|:|.|..||.|       :.|.:..:::. |
Mouse   969 QEILQRPRLQLPRHLRQTIQKKVGEPVNLLIPFQGKPRPQVTWTK-------EGQPLAGEEVSIR 1026

  Fly  2360 NSS----ITIKKSVRKDTGKYKLVLSNSSGTIESEAQVV--VLDRPLPPGGPFEPEEIR-----A 2413
            ||.    :.|:.:.|..:|.|::.:...:  :|.:|.::  ::|:|.|      |::||     .
Mouse  1027 NSPTDTILFIRAARRTHSGTYQVTVRIEN--MEDKATLILQIVDKPSP------PQDIRIVETWG 1083

  Fly  2414 SHIKMKWKRPDDDGGCEISGYALERMDEETGRWIPAGEVGPNETSFDFKGLTPNKKYKFRVKAIN 2478
            .::.::||.|.|||..||.||.:::.|::|..|....| ....|......|.....|.|||.:.|
Mouse  1084 FNVALEWKPPQDDGNTEIWGYTVQKADKKTMEWFTVLE-HYRRTHCVVSELIIGNGYYFRVFSHN 1147

  Fly  2479 KEGESE-PLETFDAIVARNP---YDPP--------SPPS--QPVIDDYDNKSVL 2518
            ..|.|: ...|.:.:....|   |:||        ..||  ||:.    |:|::
Mouse  1148 MVGSSDKAAATKEPVFIPRPGITYEPPKYKALDFSEAPSFTQPLA----NRSII 1197

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
btNP_001162825.1 I-set 9..101 CDD:254352
Ig 26..100 CDD:143165
I-set 119..210 CDD:254352
Ig 136..209 CDD:143165
I-set 228..320 CDD:254352
IGc2 242..312 CDD:197706
I-set 335..425 CDD:254352
Ig 350..423 CDD:143165
Ig 436..530 CDD:299845
I-set 438..532 CDD:254352
I-set 545..636 CDD:254352
Ig 560..633 CDD:143165
Ig 657..731 CDD:143165
I-set 746..835 CDD:254352
Ig 1496..1586 CDD:299845 23/151 (15%)
IG_like 1503..1588 CDD:214653 23/142 (16%)
I-set 1639..1724 CDD:254352 20/85 (24%)
IG 1750..1821 CDD:214652 22/71 (31%)
IGc2 1750..1806 CDD:197706 20/56 (36%)
I-set 1826..1909 CDD:254352 31/97 (32%)
Ig 1831..1897 CDD:299845 27/80 (34%)
I-set 1914..1998 CDD:254352 14/94 (15%)
Ig 2020..2095 CDD:299845 14/76 (18%)
FN3 2100..2194 CDD:238020 30/98 (31%)
FN3 2203..2292 CDD:238020 29/88 (33%)
I-set 2311..2395 CDD:254352 20/102 (20%)
Ig 2321..2395 CDD:299845 17/80 (21%)
FN3 2399..2493 CDD:238020 29/99 (29%)
FN3 2501..2590 CDD:238020 7/28 (25%)
I-set 2602..2693 CDD:254352
Ig 2619..2693 CDD:299845
FN3 2697..2793 CDD:238020
FN3 2801..2893 CDD:238020
I-set 2902..2995 CDD:254352
Ig 2919..2993 CDD:299845
FN3 2999..3088 CDD:238020
FN3 3102..3191 CDD:238020
I-set 3208..3292 CDD:254352
Ig 3219..3292 CDD:299845
FN3 3296..3390 CDD:238020
FN3 3400..3489 CDD:238020
I-set 3494..3590 CDD:254352
Ig 3516..3590 CDD:299845
FN3 3594..3682 CDD:238020
FN3 3694..3781 CDD:238020
I-set 3795..3885 CDD:254352
Ig 3813..3885 CDD:299845
FN3 3889..3980 CDD:238020
FN3 3990..4082 CDD:238020
I-set 4090..4181 CDD:254352
Ig 4108..4181 CDD:299845
FN3 4185..4271 CDD:238020
FN3 4285..4383 CDD:238020
Ig 4404..4480 CDD:299845
FN3 4484..4571 CDD:238020
FN3 4584..4677 CDD:238020
I-set 4685..4775 CDD:254352
Ig 4703..4775 CDD:299845
FN3 4779..4863 CDD:238020
FN3 4879..4970 CDD:238020
IG 4989..5069 CDD:214652
Ig 4996..5069 CDD:299845
FN3 5073..5166 CDD:238020
FN3 5175..5265 CDD:238020
I-set 5276..5366 CDD:254352
Ig 5293..5366 CDD:299845
FN3 5370..5462 CDD:238020
FN3 5470..5561 CDD:238020
Ig 5559..5654 CDD:299845
I-set 5570..5660 CDD:254352
FN3 5664..5755 CDD:238020
FN3 5764..5853 CDD:238020
I-set 5865..5954 CDD:254352
Ig 5882..5954 CDD:299845
FN3 5958..6049 CDD:238020
FN3 6062..6153 CDD:238020
I-set 6173..6255 CDD:254352
Ig_Titin_like 6182..6255 CDD:143225
FN3 6259..6350 CDD:238020
FN3 6359..6451 CDD:238020
FN3 6470..6552 CDD:238020
I-set 6564..6650 CDD:254352
Ig_Titin_like 6577..6650 CDD:143225
FN3 6654..6745 CDD:238020
FN3 6754..6840 CDD:238020
I-set 6855..6946 CDD:254352
Ig 6874..6946 CDD:299845
FN3 6950..7042 CDD:238020
FN3 7050..7139 CDD:238020
FN3 7151..7237 CDD:238020
I-set 7254..7334 CDD:254352
Ig 7272..7339 CDD:143165
IG_like 7354..7440 CDD:214653
Ig 7366..7440 CDD:299845
FN3 7444..7531 CDD:238020
FN3 7545..7637 CDD:238020
I-set 7648..7737 CDD:254352
Ig 7665..7734 CDD:143165
Ig 7760..7833 CDD:299845
FN3 7837..7927 CDD:238020
STKc_Twitchin_like 7986..8244 CDD:271016
S_TKc 7989..8244 CDD:214567
Ig 8311..8394 CDD:299845
I-set 8312..8401 CDD:254352
I-set 8437..8525 CDD:254352
Ig 8455..8519 CDD:143165
I-set 8632..8721 CDD:254352
IGc2 8646..8711 CDD:197706
I-set 8740..8831 CDD:254352
Ig 8757..8826 CDD:143165
I-set 8839..8922 CDD:254352
Ig 8845..>8909 CDD:299845
Mybpc3NP_032679.2 Ig 20..102 CDD:386229 16/85 (19%)
Ig 163..262 CDD:386229 15/110 (14%)
THB 324..357 CDD:375788 4/32 (13%)
Ig 369..453 CDD:386229 20/84 (24%)
Ig 460..544 CDD:386229 26/87 (30%)
Ig 557..621 CDD:386229 23/65 (35%)
Ig_C5_MyBP-C 660..772 CDD:143302 31/179 (17%)
FN3 776..866 CDD:238020 30/96 (31%)
FN3 874..967 CDD:238020 32/102 (31%)
Ig_Titin_like 994..1066 CDD:319305 17/80 (21%)
FN3 1070..1153 CDD:238020 27/89 (30%)
I-set 1185..1274 CDD:369462 6/17 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 57 1.000 Domainoid score I10802
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR13817
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
33.100

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